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UniProtKB - Q5VV42 (CDKAL_HUMAN)

Protein

Threonylcarbamoyladenosine tRNA methylthiotransferase

Gene

CDKAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t6A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) at position 37 in tRNAs that read codons beginning with adenine.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterPROSITE-ProRule annotationNote: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi73Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi109Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi138Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi214Iron-sulfur (4Fe-4S-S-AdoMet)PROSITE-ProRule annotation1
Metal bindingi218Iron-sulfur (4Fe-4S-S-AdoMet)PROSITE-ProRule annotation1
Metal bindingi221Iron-sulfur (4Fe-4S-S-AdoMet)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • maintenance of translational fidelity Source: Ensembl
  • tRNA methylthiolation Source: GO_Central
  • tRNA modification Source: Reactome
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processtRNA processing
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6782315 tRNA modification in the nucleus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Threonylcarbamoyladenosine tRNA methylthiotransferase (EC:2.8.4.51 Publication)
Alternative name(s):
CDK5 regulatory subunit-associated protein 1-like 1
tRNA-t(6)A37 methylthiotransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDKAL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000145996.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:21050 CDKAL1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611259 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5VV42

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei556 – 578HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diabetes mellitus, non-insulin-dependent (NIDDM)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
See also OMIM:125853

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

DisGeNET

More...DisGeNETi		54901

MalaCards human disease database

More...MalaCardsi		CDKAL1
MIMi125853 phenotype

Open Targets

More...OpenTargetsi		ENSG00000145996

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134871999

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CDKAL1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74747199

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002986701 – 579Threonylcarbamoyladenosine tRNA methylthiotransferaseAdd BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei53PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei499PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5VV42

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5VV42

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5VV42

PeptideAtlas

More...PeptideAtlasi		Q5VV42

PRoteomics IDEntifications database

More...PRIDEi		Q5VV42

ProteomicsDB human proteome resource

More...ProteomicsDBi		65438
65439 [Q5VV42-2]
65440 [Q5VV42-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5VV42

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5VV42

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q5VV42

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pancreatic islets.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000145996 Expressed in 159 organ(s), highest expression level in buccal mucosa cell

CleanEx database of gene expression profiles

More...CleanExi		HS_CDKAL1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5VV42 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA057474

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
LCKP062393EBI-10194801,EBI-1348

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		120247, 28 interactors

Protein interaction database and analysis system

More...IntActi		Q5VV42, 22 interactors

Molecular INTeraction database

More...MINTi		Q5VV42

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000274695

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q5VV42

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 172MTTase N-terminalPROSITE-ProRule annotationAdd BLAST109
Domaini431 – 493TRAMPROSITE-ProRule annotationAdd BLAST63

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the methylthiotransferase family. CDKAL1 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4355 Eukaryota
COG0621 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155952

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000224768

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG097712

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5VV42

KEGG Orthology (KO)

More...KOi		K15865

Identification of Orthologs from Complete Genome Data

More...OMAi		HYAYPTG

Database of Orthologous Groups

More...OrthoDBi		EOG091G04Y8

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5VV42

TreeFam database of animal gene trees

More...TreeFami		TF317476

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.12160, 1 hit
3.80.30.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006638 Elp3/MiaB/NifB
IPR005839 Methylthiotransferase
IPR020612 Methylthiotransferase_CS
IPR013848 Methylthiotransferase_N
IPR038135 Methylthiotransferase_N_sf
IPR006466 MiaB-like_B
IPR007197 rSAM
IPR023404 rSAM_horseshoe
IPR002792 TRAM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04055 Radical_SAM, 1 hit
PF01938 TRAM, 1 hit
PF00919 UPF0004, 1 hit

Structure-Function Linkage Database

More...SFLDi		SFLDG01061 methylthiotransferase, 1 hit
SFLDS00029 Radical_SAM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00729 Elp3, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01578 MiaB-like-B, 1 hit
TIGR00089 TIGR00089, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51449 MTTASE_N, 1 hit
PS01278 MTTASE_RADICAL, 1 hit
PS50926 TRAM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5VV42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSASCDTLL DDIEDIVSQE DSKPQDRHFV RKDVVPKVRR RNTQKYLQEE 
        60         70         80         90        100
ENSPPSDSTI PGIQKIWIRT WGCSHNNSDG EYMAGQLAAY GYKITENASD 
       110        120        130        140        150
ADLWLLNSCT VKNPAEDHFR NSIKKAQEEN KKIVLAGCVP QAQPRQDYLK 
       160        170        180        190        200
GLSIIGVQQI DRVVEVVEET IKGHSVRLLG QKKDNGRRLG GARLDLPKIR 
       210        220        230        240        250
KNPLIEIISI NTGCLNACTY CKTKHARGNL ASYPIDELVD RAKQSFQEGV 
       260        270        280        290        300
CEIWLTSEDT GAYGRDIGTN LPTLLWKLVE VIPEGAMLRL GMTNPPYILE 
       310        320        330        340        350
HLEEMAKILN HPRVYAFLHI PVQSASDSVL MEMKREYCVA DFKRVVDFLK 
       360        370        380        390        400
EKVPGITIAT DIICGFPGET DQDFQETVKL VEEYKFPSLF INQFYPRPGT 
       410        420        430        440        450
PAAKMEQVPA QVKKQRTKDL SRVFHSYSPY DHKIGERQQV LVTEESFDSK 
       460        470        480        490        500
FYVAHNQFYE QVLVPKNPAF MGKMVEVDIY ESGKHFMKGQ PVSDAKVYTP 
       510        520        530        540        550
SISKPLAKGE VSGLTKDFRN GLGNQLSSGS HTSAASQCDS ASSRMVLPMP 
       560        570 
RLHQDCALRM SVGLALLGLL FAFFVKVYN
Length:579
Mass (Da):65,111
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90818A8A0A19FD1C
GO
Isoform 2 (identifier: Q5VV42-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: MPSASCDTLL...GQLAAYGYKI → MLSRRYEGEIPKNICKRKKTVHQV
     413-433: Missing.

Show »
Length:488
Mass (Da):54,667
Checksum:i8671593E9CE5F149
GO
Isoform 3 (identifier: Q5VV42-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-97: EN → GE
     98-579: Missing.

Show »
Length:97
Mass (Da):11,043
Checksum:i1558DE995C15E75F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC87494 differs from that shown. Reason: Frameshift at position 575.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti211N → S in BAA91102 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052705484K → R. Corresponds to variant dbSNP:rs9460608Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0274501 – 94MPSAS…YGYKI → MLSRRYEGEIPKNICKRKKT VHQV in isoform 2. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_02745196 – 97EN → GE in isoform 3. 1 Publication2
Alternative sequenceiVSP_02745298 – 579Missing in isoform 3. 1 PublicationAdd BLAST482
Alternative sequenceiVSP_027453413 – 433Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK000349 mRNA Translation: BAA91102.1
AK128546 mRNA Translation: BAC87494.1 Frameshift.
AK291735 mRNA Translation: BAF84424.1
AL022717 Genomic DNA No translation available.
AL033521 Genomic DNA No translation available.
AL035090 Genomic DNA No translation available.
AL451080 Genomic DNA No translation available.
AL512405 Genomic DNA No translation available.
AL513015 Genomic DNA No translation available.
AL513188 Genomic DNA No translation available.
AL513549 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55426.1
BC064145 mRNA Translation: AAH64145.1
BC121020 mRNA Translation: AAI21021.1
BC121021 mRNA Translation: AAI21022.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4546.1 [Q5VV42-1]

NCBI Reference Sequences

More...RefSeqi		NP_060244.2, NM_017774.3 [Q5VV42-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.657604
Hs.672504

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000274695; ENSP00000274695; ENSG00000145996 [Q5VV42-1]
ENST00000378610; ENSP00000367873; ENSG00000145996 [Q5VV42-1]
ENST00000613575; ENSP00000481755; ENSG00000145996 [Q5VV42-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54901

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54901

UCSC genome browser

More...UCSCi		uc003ndb.2 human [Q5VV42-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000349 mRNA Translation: BAA91102.1
AK128546 mRNA Translation: BAC87494.1 Frameshift.
AK291735 mRNA Translation: BAF84424.1
AL022717 Genomic DNA No translation available.
AL033521 Genomic DNA No translation available.
AL035090 Genomic DNA No translation available.
AL451080 Genomic DNA No translation available.
AL512405 Genomic DNA No translation available.
AL513015 Genomic DNA No translation available.
AL513188 Genomic DNA No translation available.
AL513549 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55426.1
BC064145 mRNA Translation: AAH64145.1
BC121020 mRNA Translation: AAI21021.1
BC121021 mRNA Translation: AAI21022.1
CCDSiCCDS4546.1 [Q5VV42-1]
RefSeqiNP_060244.2, NM_017774.3 [Q5VV42-1]
UniGeneiHs.657604
Hs.672504

3D structure databases

ProteinModelPortaliQ5VV42
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120247, 28 interactors
IntActiQ5VV42, 22 interactors
MINTiQ5VV42
STRINGi9606.ENSP00000274695

PTM databases

iPTMnetiQ5VV42
PhosphoSitePlusiQ5VV42
SwissPalmiQ5VV42

Polymorphism and mutation databases

BioMutaiCDKAL1
DMDMi74747199

Proteomic databases

EPDiQ5VV42
MaxQBiQ5VV42
PaxDbiQ5VV42
PeptideAtlasiQ5VV42
PRIDEiQ5VV42
ProteomicsDBi65438
65439 [Q5VV42-2]
65440 [Q5VV42-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274695; ENSP00000274695; ENSG00000145996 [Q5VV42-1]
ENST00000378610; ENSP00000367873; ENSG00000145996 [Q5VV42-1]
ENST00000613575; ENSP00000481755; ENSG00000145996 [Q5VV42-3]
GeneIDi54901
KEGGihsa:54901
UCSCiuc003ndb.2 human [Q5VV42-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54901
DisGeNETi54901
EuPathDBiHostDB:ENSG00000145996.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		CDKAL1
HGNCiHGNC:21050 CDKAL1
HPAiHPA057474
MalaCardsiCDKAL1
MIMi125853 phenotype
611259 gene
neXtProtiNX_Q5VV42
OpenTargetsiENSG00000145996
PharmGKBiPA134871999

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4355 Eukaryota
COG0621 LUCA
GeneTreeiENSGT00940000155952
HOGENOMiHOG000224768
HOVERGENiHBG097712
InParanoidiQ5VV42
KOiK15865
OMAiHYAYPTG
OrthoDBiEOG091G04Y8
PhylomeDBiQ5VV42
TreeFamiTF317476

Enzyme and pathway databases

ReactomeiR-HSA-6782315 tRNA modification in the nucleus and cytosol

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CDKAL1 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CDKAL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54901

Protein Ontology

More...PROi		PR:Q5VV42

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000145996 Expressed in 159 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_CDKAL1
GenevisibleiQ5VV42 HS

Family and domain databases

Gene3Di3.40.50.12160, 1 hit
3.80.30.20, 1 hit
InterProiView protein in InterPro
IPR006638 Elp3/MiaB/NifB
IPR005839 Methylthiotransferase
IPR020612 Methylthiotransferase_CS
IPR013848 Methylthiotransferase_N
IPR038135 Methylthiotransferase_N_sf
IPR006466 MiaB-like_B
IPR007197 rSAM
IPR023404 rSAM_horseshoe
IPR002792 TRAM_dom
PfamiView protein in Pfam
PF04055 Radical_SAM, 1 hit
PF01938 TRAM, 1 hit
PF00919 UPF0004, 1 hit
SFLDiSFLDG01061 methylthiotransferase, 1 hit
SFLDS00029 Radical_SAM, 1 hit
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
TIGRFAMsiTIGR01578 MiaB-like-B, 1 hit
TIGR00089 TIGR00089, 1 hit
PROSITEiView protein in PROSITE
PS51449 MTTASE_N, 1 hit
PS01278 MTTASE_RADICAL, 1 hit
PS50926 TRAM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDKAL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VV42
Secondary accession number(s): A8K6S0
, Q6P385, Q6ZR27, Q9NXB3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 7, 2004
Last modified: December 5, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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