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Protein

OTU domain-containing protein 1

Gene

OTUD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei317By similarity1
Active sitei320NucleophileBy similarity1
Active sitei431By similarity1

GO - Molecular functioni

  • thiol-dependent ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPSiC85.004

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 1 (EC:3.4.19.12)
Alternative name(s):
DUBA-7
Gene namesi
Name:OTUD1
Synonyms:DUBA7, OTDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165312.6
HGNCiHGNC:27346 OTUD1
MIMi612022 gene
neXtProtiNX_Q5VV17

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165312
PharmGKBiPA134932304

Polymorphism and mutation databases

BioMutaiOTUD1
DMDMi74747188

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710181 – 481OTU domain-containing protein 1Add BLAST481

Proteomic databases

EPDiQ5VV17
MaxQBiQ5VV17
PaxDbiQ5VV17
PeptideAtlasiQ5VV17
PRIDEiQ5VV17
ProteomicsDBi65434

PTM databases

iPTMnetiQ5VV17
PhosphoSitePlusiQ5VV17

Expressioni

Gene expression databases

BgeeiENSG00000165312 Expressed in 207 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_OTUD1
GenevisibleiQ5VV17 HS

Organism-specific databases

HPAiHPA038503
HPA038504

Interactioni

Protein-protein interaction databases

BioGridi128638, 10 interactors
IntActiQ5VV17, 11 interactors
STRINGi9606.ENSP00000365678

Structurei

Secondary structure

1481
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ5VV17
SMRiQ5VV17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini309 – 438OTUPROSITE-ProRule annotationAdd BLAST130
Domaini457 – 476UIMCuratedAdd BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni314 – 320Cys-loop7
Regioni369 – 379His-loopAdd BLAST11
Regioni426 – 431Variable-loop6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 155Ala-richAdd BLAST143

Domaini

The UIM repeat increases the specificity and efficiency of the enzyme toward 'Lys-63'-linked polyubiquitin.1 Publication
Specificity is not given by the S1' ubiquitin-binding site within the OTU domain (composed of the Cys-, His- and Variable-loops).1 Publication

Phylogenomic databases

eggNOGiENOG410INQC Eukaryota
ENOG4111V2X LUCA
GeneTreeiENSGT00510000049635
HOGENOMiHOG000115304
HOVERGENiHBG080487
InParanoidiQ5VV17
KOiK13716
OMAiREGPDRN
OrthoDBiEOG091G05T1
PhylomeDBiQ5VV17
TreeFamiTF338508

Family and domain databases

InterProiView protein in InterPro
IPR003323 OTU_dom
IPR038765 Papain_like_cys_pep_sf
PfamiView protein in Pfam
PF02338 OTU, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50802 OTU, 1 hit

Sequencei

Sequence statusi: Complete.

Q5VV17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLYSSVCTH YPAGAPGPTA AAPAPPAAAT PFKVSLQPPG AAGAAPEPET
60 70 80 90 100
GECQPAAAAE HREAAAVPAA KMPAFSSCFE VVSGAAAPAS AAAGPPGASC
110 120 130 140 150
KPPLPPHYTS TAQITVRALG ADRLLLHGPD PVPGAAGSAA APRGRCLLLA
160 170 180 190 200
PAPAAPVPPR RGSSAWLLEE LLRPDCPEPA GLDATREGPD RNFRLSEHRQ
210 220 230 240 250
ALAAAKHRGP AATPGSPDPG PGPWGEEHLA ERGPRGWERG GDRCDAPGGD
260 270 280 290 300
AARRPDPEAE APPAGSIEAA PSSAAEPVIV SRSDPRDEKL ALYLAEVEKQ
310 320 330 340 350
DKYLRQRNKY RFHIIPDGNC LYRAVSKTVY GDQSLHRELR EQTVHYIADH
360 370 380 390 400
LDHFSPLIEG DVGEFIIAAA QDGAWAGYPE LLAMGQMLNV NIHLTTGGRL
410 420 430 440 450
ESPTVSTMIH YLGPEDSLRP SIWLSWLSNG HYDAVFDHSY PNPEYDNWCK
460 470 480
QTQVQRKRDE ELAKSMAISL SKMYIEQNAC S
Length:481
Mass (Da):51,063
Last modified:December 7, 2004 - v1
Checksum:i37B3AEB0B3851982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512603 Genomic DNA No translation available.
CCDSiCCDS44366.1
RefSeqiNP_001138845.1, NM_001145373.2
UniGeneiHs.499042

Genome annotation databases

EnsembliENST00000376495; ENSP00000365678; ENSG00000165312
GeneIDi220213
KEGGihsa:220213
UCSCiuc001irr.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512603 Genomic DNA No translation available.
CCDSiCCDS44366.1
RefSeqiNP_001138845.1, NM_001145373.2
UniGeneiHs.499042

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BOPX-ray2.10A/B287-437[»]
ProteinModelPortaliQ5VV17
SMRiQ5VV17
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128638, 10 interactors
IntActiQ5VV17, 11 interactors
STRINGi9606.ENSP00000365678

Protein family/group databases

MEROPSiC85.004

PTM databases

iPTMnetiQ5VV17
PhosphoSitePlusiQ5VV17

Polymorphism and mutation databases

BioMutaiOTUD1
DMDMi74747188

Proteomic databases

EPDiQ5VV17
MaxQBiQ5VV17
PaxDbiQ5VV17
PeptideAtlasiQ5VV17
PRIDEiQ5VV17
ProteomicsDBi65434

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376495; ENSP00000365678; ENSG00000165312
GeneIDi220213
KEGGihsa:220213
UCSCiuc001irr.3 human

Organism-specific databases

CTDi220213
EuPathDBiHostDB:ENSG00000165312.6
GeneCardsiOTUD1
HGNCiHGNC:27346 OTUD1
HPAiHPA038503
HPA038504
MIMi612022 gene
neXtProtiNX_Q5VV17
OpenTargetsiENSG00000165312
PharmGKBiPA134932304
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INQC Eukaryota
ENOG4111V2X LUCA
GeneTreeiENSGT00510000049635
HOGENOMiHOG000115304
HOVERGENiHBG080487
InParanoidiQ5VV17
KOiK13716
OMAiREGPDRN
OrthoDBiEOG091G05T1
PhylomeDBiQ5VV17
TreeFamiTF338508

Miscellaneous databases

GenomeRNAii220213
PROiPR:Q5VV17
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165312 Expressed in 207 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_OTUD1
GenevisibleiQ5VV17 HS

Family and domain databases

InterProiView protein in InterPro
IPR003323 OTU_dom
IPR038765 Papain_like_cys_pep_sf
PfamiView protein in Pfam
PF02338 OTU, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50802 OTU, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOTUD1_HUMAN
AccessioniPrimary (citable) accession number: Q5VV17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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