AADACL3

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	193	By similarity	1
Active siteⁱ	347	By similarity	1
Active siteⁱ	377	By similarity	1

GO - Molecular functionⁱ

carboxylic ester hydrolase activity Source: InterPro
hydrolase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

catabolic process Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase

Molecular function

Hydrolase

Enzyme and pathway databases

SABIO-RKⁱ	Q5VUY0

SABIO-RKⁱ

Q5VUY0

Protein family/group databases

ESTHERⁱ	human-AADACL3 Arylacetamide_deacetylase

ESTHERⁱ

human-AADACL3 Arylacetamide_deacetylase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Arylacetamide deacetylase-like 3 (EC:3.1.1.-)
Gene namesⁱ	Name:AADACL3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000188984.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:32037 AADACL3
neXtProtⁱ	NX_Q5VUY0

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000188984
PharmGKBⁱ	PA145147526

Polymorphism and mutation databases

BioMutaⁱ	AADACL3
DMDMⁱ	317373552

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000265936	1 – 407	Arylacetamide deacetylase-like 3Add BLAST		407

Proteomic databases

PaxDbⁱ	Q5VUY0
PRIDEⁱ	Q5VUY0
ProteomicsDBⁱ	65428

PTM databases

iPTMnetⁱ	Q5VUY0
PhosphoSitePlusⁱ	Q5VUY0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000188984 Expressed in 7 organ(s), highest expression level in placenta
CleanExⁱ	HS_AADACL3

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000352268

STRINGⁱ

9606.ENSP00000352268

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5VUY0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	119 – 121	Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity		3

Sequence similaritiesⁱ

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1515 Eukaryota COG0657 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074556
HOGENOMⁱ	HOG000231073
HOVERGENⁱ	HBG058974
InParanoidⁱ	Q5VUY0
KEGG Orthology (KO) More...KOⁱ	K14351
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G082E
PhylomeDBⁱ	Q5VUY0
TreeFamⁱ	TF314978

Family and domain databases

InterProⁱ	View protein in InterPro IPR029058 AB_hydrolase IPR013094 AB_hydrolase_3 IPR017157 Arylacetamide_deacetylase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07859 Abhydrolase_3, 2 hits
PIRSFⁱ	PIRSF037251 Arylacetamide_deacetylase, 1 hit
SUPFAMⁱ	SSF53474 SSF53474, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5VUY0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWDLALIFLA AACVFSLGVT LWVICSHFFT VHIPAAVGHP VKLRVLHCIF 
        60         70         80         90        100
QLLLTWGMIF EKLRICSMPQ FFCFMQDLPP LKYDPDVVVT DFRFGTIPVK 
       110        120        130        140        150
LYQPKASTCT LKPGIVYYHG GGGVMGSLKT HHGICSRLCK ESDSVVLAVG 
       160        170        180        190        200
YRKLPKHKFP VPVRDCLVAT IHFLKSLDAY GVDPARVVVC GDSFGGAIAA 
       210        220        230        240        250
VVCQQLVDRP DLPRIRAQIL IYAILQALDL QTPSFQQRKN IPLLTWSFIC 
       260        270        280        290        300
YFFFQNLDFS SSWQEVIMKG AHLPAEVWEK YRKWLGPENI PERFKERGYQ 
       310        320        330        340        350
LKPHEPMNEA AYLEVSVVLD VMCSPLIAED DIVSQLPETC IVSCEYDALR 
       360        370        380        390        400
DNSLLYKKRL EDLGVPVTWH HMEDGFHGVL RTIDMSFLHF PCSMRILSAL 

VQFVKGL

Length:407

Mass (Da):46,155

Last modified:March 28, 2018 - v5

Checksum:ⁱ0BAB3056EEED2B19

GO

Sequence cautionⁱ

The sequence BAG54581 differs from that shown. Aberrant splicing.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_060666	104	P → S. Corresponds to variant dbSNP:rs3010877Ensembl.	1
Natural variantⁱVAR_060667	128	L → M. Corresponds to variant dbSNP:rs3000859Ensembl.	1
Natural variantⁱVAR_060668	186	R → W. Corresponds to variant dbSNP:rs17038445Ensembl.	1
Natural variantⁱVAR_060665	252	F → C. Corresponds to variant dbSNP:rs7513079Ensembl.	1
Natural variantⁱVAR_060670	307	M → I. Corresponds to variant dbSNP:rs3000931Ensembl.	1
Natural variantⁱVAR_060671	337	P → L. Corresponds to variant dbSNP:rs11121969Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK127828 mRNA Translation: BAG54581.1 Sequence problems. AC244670 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41253.2
NCBI Reference Sequences More...RefSeqⁱ	NP_001096640.2, NM_001103170.2
UniGeneⁱ	Hs.464705

Genome annotation databases

Ensemblⁱ	ENST00000359318; ENSP00000352268; ENSG00000188984
GeneIDⁱ	126767
KEGGⁱ	hsa:126767
UCSC genome browser More...UCSCⁱ	uc057ckc.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q5VUY0	AADACL3 isoform 2		PANTR		407	UniRef90_Q5VUY0
AADACL3 isoform 2		PONAB		407
Uncharacterized protein		NOMLE		407
Arylacetamide deacetylase like 3		GORGO		407
Arylacetamide deacetylase like 3		PONAB		350

Protein	Similar proteins		Species	Score	Length	Source
Q5VUY0	Arylacetamide deacetylase-like 3		MOUSE		408	UniRef50_Q5VUY0
Arylacetamide deacetylase-like 4		HUMAN		407
AADACL3 isoform 2		PONAB		407
Arylacetamide deacetylase like 3		GORGO		407
AADACL3 isoform 2		PANTR		407
+170

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK127828 mRNA Translation: BAG54581.1 Sequence problems. AC244670 Genomic DNA No translation available.
CCDSⁱ	CCDS41253.2
RefSeqⁱ	NP_001096640.2, NM_001103170.2
UniGeneⁱ	Hs.464705

3D structure databases

ProteinModelPortalⁱ	Q5VUY0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000352268

STRINGⁱ

9606.ENSP00000352268

Protein family/group databases

ESTHERⁱ	human-AADACL3 Arylacetamide_deacetylase

ESTHERⁱ

human-AADACL3 Arylacetamide_deacetylase

PTM databases

iPTMnetⁱ	Q5VUY0
PhosphoSitePlusⁱ	Q5VUY0

Polymorphism and mutation databases

BioMutaⁱ	AADACL3
DMDMⁱ	317373552

Proteomic databases

PaxDbⁱ	Q5VUY0
PRIDEⁱ	Q5VUY0
ProteomicsDBⁱ	65428

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000359318; ENSP00000352268; ENSG00000188984
GeneIDⁱ	126767
KEGGⁱ	hsa:126767
UCSCⁱ	uc057ckc.1 human

Organism-specific databases

CTDⁱ	126767
EuPathDBⁱ	HostDB:ENSG00000188984.11
GeneCardsⁱ	AADACL3
HGNCⁱ	HGNC:32037 AADACL3
neXtProtⁱ	NX_Q5VUY0
OpenTargetsⁱ	ENSG00000188984
PharmGKBⁱ	PA145147526
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1515 Eukaryota COG0657 LUCA
GeneTreeⁱ	ENSGT00550000074556
HOGENOMⁱ	HOG000231073
HOVERGENⁱ	HBG058974
InParanoidⁱ	Q5VUY0
KOⁱ	K14351
OrthoDBⁱ	EOG091G082E
PhylomeDBⁱ	Q5VUY0
TreeFamⁱ	TF314978

Enzyme and pathway databases

SABIO-RKⁱ	Q5VUY0

SABIO-RKⁱ

Q5VUY0

Miscellaneous databases

GeneWikiⁱ	AADACL3_(gene)
GenomeRNAiⁱ	126767
Protein Ontology More...PROⁱ	PR:Q5VUY0

Gene expression databases

Bgeeⁱ	ENSG00000188984 Expressed in 7 organ(s), highest expression level in placenta
CleanExⁱ	HS_AADACL3

Family and domain databases

InterProⁱ	View protein in InterPro IPR029058 AB_hydrolase IPR013094 AB_hydrolase_3 IPR017157 Arylacetamide_deacetylase
Pfamⁱ	View protein in Pfam PF07859 Abhydrolase_3, 2 hits
PIRSFⁱ	PIRSF037251 Arylacetamide_deacetylase, 1 hit
SUPFAMⁱ	SSF53474 SSF53474, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADCL3_HUMAN
Accessionⁱ	Q5VUY0Primary (citable) accession number: Q5VUY0 Secondary accession number(s): B3KXR9, Q5VUY1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
	Last sequence update:	March 28, 2018
	Last modified:	September 12, 2018
	This is version 107 of the entry and version 5 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q5VUY0 (ADCL3_HUMAN)

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Arylacetamide deacetylase-like 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ