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Protein

Arylacetamide deacetylase-like 3

Gene

AADACL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei193By similarity1
Active sitei347By similarity1
Active sitei377By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

SABIO-RKiQ5VUY0

Protein family/group databases

ESTHERihuman-AADACL3 Arylacetamide_deacetylase

Names & Taxonomyi

Protein namesi
Recommended name:
Arylacetamide deacetylase-like 3 (EC:3.1.1.-)
Gene namesi
Name:AADACL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188984.11
HGNCiHGNC:32037 AADACL3
neXtProtiNX_Q5VUY0

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188984
PharmGKBiPA145147526

Polymorphism and mutation databases

BioMutaiAADACL3
DMDMi317373552

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002659361 – 407Arylacetamide deacetylase-like 3Add BLAST407

Proteomic databases

PaxDbiQ5VUY0
PRIDEiQ5VUY0
ProteomicsDBi65428

PTM databases

iPTMnetiQ5VUY0
PhosphoSitePlusiQ5VUY0

Expressioni

Gene expression databases

BgeeiENSG00000188984 Expressed in 7 organ(s), highest expression level in placenta
CleanExiHS_AADACL3

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352268

Structurei

3D structure databases

ProteinModelPortaliQ5VUY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi119 – 121Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity3

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Phylogenomic databases

eggNOGiKOG1515 Eukaryota
COG0657 LUCA
GeneTreeiENSGT00550000074556
HOGENOMiHOG000231073
HOVERGENiHBG058974
InParanoidiQ5VUY0
KOiK14351
OMAiRICSMPQ
OrthoDBiEOG091G082E
PhylomeDBiQ5VUY0
TreeFamiTF314978

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013094 AB_hydrolase_3
IPR017157 Arylacetamide_deacetylase
PfamiView protein in Pfam
PF07859 Abhydrolase_3, 2 hits
PIRSFiPIRSF037251 Arylacetamide_deacetylase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q5VUY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWDLALIFLA AACVFSLGVT LWVICSHFFT VHIPAAVGHP VKLRVLHCIF
60 70 80 90 100
QLLLTWGMIF EKLRICSMPQ FFCFMQDLPP LKYDPDVVVT DFRFGTIPVK
110 120 130 140 150
LYQPKASTCT LKPGIVYYHG GGGVMGSLKT HHGICSRLCK ESDSVVLAVG
160 170 180 190 200
YRKLPKHKFP VPVRDCLVAT IHFLKSLDAY GVDPARVVVC GDSFGGAIAA
210 220 230 240 250
VVCQQLVDRP DLPRIRAQIL IYAILQALDL QTPSFQQRKN IPLLTWSFIC
260 270 280 290 300
YFFFQNLDFS SSWQEVIMKG AHLPAEVWEK YRKWLGPENI PERFKERGYQ
310 320 330 340 350
LKPHEPMNEA AYLEVSVVLD VMCSPLIAED DIVSQLPETC IVSCEYDALR
360 370 380 390 400
DNSLLYKKRL EDLGVPVTWH HMEDGFHGVL RTIDMSFLHF PCSMRILSAL

VQFVKGL
Length:407
Mass (Da):46,155
Last modified:March 28, 2018 - v5
Checksum:i0BAB3056EEED2B19
GO

Sequence cautioni

The sequence BAG54581 differs from that shown. Aberrant splicing.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060666104P → S. Corresponds to variant dbSNP:rs3010877Ensembl.1
Natural variantiVAR_060667128L → M. Corresponds to variant dbSNP:rs3000859Ensembl.1
Natural variantiVAR_060668186R → W. Corresponds to variant dbSNP:rs17038445Ensembl.1
Natural variantiVAR_060665252F → C. Corresponds to variant dbSNP:rs7513079Ensembl.1
Natural variantiVAR_060670307M → I. Corresponds to variant dbSNP:rs3000931Ensembl.1
Natural variantiVAR_060671337P → L. Corresponds to variant dbSNP:rs11121969Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127828 mRNA Translation: BAG54581.1 Sequence problems.
AC244670 Genomic DNA No translation available.
CCDSiCCDS41253.2
RefSeqiNP_001096640.2, NM_001103170.2
UniGeneiHs.464705

Genome annotation databases

EnsembliENST00000359318; ENSP00000352268; ENSG00000188984
GeneIDi126767
KEGGihsa:126767
UCSCiuc057ckc.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127828 mRNA Translation: BAG54581.1 Sequence problems.
AC244670 Genomic DNA No translation available.
CCDSiCCDS41253.2
RefSeqiNP_001096640.2, NM_001103170.2
UniGeneiHs.464705

3D structure databases

ProteinModelPortaliQ5VUY0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000352268

Protein family/group databases

ESTHERihuman-AADACL3 Arylacetamide_deacetylase

PTM databases

iPTMnetiQ5VUY0
PhosphoSitePlusiQ5VUY0

Polymorphism and mutation databases

BioMutaiAADACL3
DMDMi317373552

Proteomic databases

PaxDbiQ5VUY0
PRIDEiQ5VUY0
ProteomicsDBi65428

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359318; ENSP00000352268; ENSG00000188984
GeneIDi126767
KEGGihsa:126767
UCSCiuc057ckc.1 human

Organism-specific databases

CTDi126767
EuPathDBiHostDB:ENSG00000188984.11
GeneCardsiAADACL3
HGNCiHGNC:32037 AADACL3
neXtProtiNX_Q5VUY0
OpenTargetsiENSG00000188984
PharmGKBiPA145147526
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1515 Eukaryota
COG0657 LUCA
GeneTreeiENSGT00550000074556
HOGENOMiHOG000231073
HOVERGENiHBG058974
InParanoidiQ5VUY0
KOiK14351
OMAiRICSMPQ
OrthoDBiEOG091G082E
PhylomeDBiQ5VUY0
TreeFamiTF314978

Enzyme and pathway databases

SABIO-RKiQ5VUY0

Miscellaneous databases

GeneWikiiAADACL3_(gene)
GenomeRNAii126767
PROiPR:Q5VUY0

Gene expression databases

BgeeiENSG00000188984 Expressed in 7 organ(s), highest expression level in placenta
CleanExiHS_AADACL3

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013094 AB_hydrolase_3
IPR017157 Arylacetamide_deacetylase
PfamiView protein in Pfam
PF07859 Abhydrolase_3, 2 hits
PIRSFiPIRSF037251 Arylacetamide_deacetylase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADCL3_HUMAN
AccessioniPrimary (citable) accession number: Q5VUY0
Secondary accession number(s): B3KXR9, Q5VUY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 108 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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