UniProtKB - Q5VUY0 (ADCL3_HUMAN)
Protein
Arylacetamide deacetylase-like 3
Gene
AADACL3
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 193 | By similarity | 1 | |
Active sitei | 347 | By similarity | 1 | |
Active sitei | 377 | By similarity | 1 |
GO - Molecular functioni
- carboxylic ester hydrolase activity Source: InterPro
- hydrolase activity Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
PathwayCommonsi | Q5VUY0 |
SABIO-RKi | Q5VUY0 |
Protein family/group databases
ESTHERi | human-AADACL3, Arylacetamide_deacetylase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:AADACL3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:32037, AADACL3 |
neXtProti | NX_Q5VUY0 |
VEuPathDBi | HostDB:ENSG00000188984.11 |
Subcellular locationi
Other locations
- integral component of membrane Source: InterPro
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000188984 |
PharmGKBi | PA145147526 |
Miscellaneous databases
Pharosi | Q5VUY0, Tdark |
Genetic variation databases
BioMutai | AADACL3 |
DMDMi | 317373552 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000265936 | 1 – 407 | Arylacetamide deacetylase-like 3Add BLAST | 407 |
Proteomic databases
PaxDbi | Q5VUY0 |
PRIDEi | Q5VUY0 |
PTM databases
iPTMneti | Q5VUY0 |
PhosphoSitePlusi | Q5VUY0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188984, Expressed in placenta and 9 other tissues |
Organism-specific databases
HPAi | ENSG00000188984, Group enriched (placenta, skin) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000352268 |
Miscellaneous databases
RNActi | Q5VUY0, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 119 – 121 | Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity | 3 |
Sequence similaritiesi
Belongs to the 'GDXG' lipolytic enzyme family.Curated
Phylogenomic databases
eggNOGi | KOG1515, Eukaryota |
GeneTreei | ENSGT00940000162160 |
HOGENOMi | CLU_012494_12_2_1 |
InParanoidi | Q5VUY0 |
OMAi | RDCLVAT |
OrthoDBi | 1263520at2759 |
PhylomeDBi | Q5VUY0 |
TreeFami | TF314978 |
Family and domain databases
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR013094, AB_hydrolase_3 IPR017157, Arylacetamide_deacetylase |
Pfami | View protein in Pfam PF07859, Abhydrolase_3, 2 hits |
PIRSFi | PIRSF037251, Arylacetamide_deacetylase, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5VUY0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWDLALIFLA AACVFSLGVT LWVICSHFFT VHIPAAVGHP VKLRVLHCIF
60 70 80 90 100
QLLLTWGMIF EKLRICSMPQ FFCFMQDLPP LKYDPDVVVT DFRFGTIPVK
110 120 130 140 150
LYQPKASTCT LKPGIVYYHG GGGVMGSLKT HHGICSRLCK ESDSVVLAVG
160 170 180 190 200
YRKLPKHKFP VPVRDCLVAT IHFLKSLDAY GVDPARVVVC GDSFGGAIAA
210 220 230 240 250
VVCQQLVDRP DLPRIRAQIL IYAILQALDL QTPSFQQRKN IPLLTWSFIC
260 270 280 290 300
YFFFQNLDFS SSWQEVIMKG AHLPAEVWEK YRKWLGPENI PERFKERGYQ
310 320 330 340 350
LKPHEPMNEA AYLEVSVVLD VMCSPLIAED DIVSQLPETC IVSCEYDALR
360 370 380 390 400
DNSLLYKKRL EDLGVPVTWH HMEDGFHGVL RTIDMSFLHF PCSMRILSAL
VQFVKGL
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060666 | 104 | P → S. Corresponds to variant dbSNP:rs3010877Ensembl. | 1 | |
Natural variantiVAR_060667 | 128 | L → M. Corresponds to variant dbSNP:rs3000859Ensembl. | 1 | |
Natural variantiVAR_060668 | 186 | R → W. Corresponds to variant dbSNP:rs17038445Ensembl. | 1 | |
Natural variantiVAR_060665 | 252 | F → C. Corresponds to variant dbSNP:rs7513079Ensembl. | 1 | |
Natural variantiVAR_060670 | 307 | M → I. Corresponds to variant dbSNP:rs3000931Ensembl. | 1 | |
Natural variantiVAR_060671 | 337 | P → L. Corresponds to variant dbSNP:rs11121969Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK127828 mRNA Translation: BAG54581.1 Sequence problems. AC244670 Genomic DNA No translation available. |
CCDSi | CCDS41253.2 |
RefSeqi | NP_001096640.2, NM_001103170.2 |
Genome annotation databases
Ensembli | ENST00000359318; ENSP00000352268; ENSG00000188984 |
GeneIDi | 126767 |
KEGGi | hsa:126767 |
UCSCi | uc057ckc.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK127828 mRNA Translation: BAG54581.1 Sequence problems. AC244670 Genomic DNA No translation available. |
CCDSi | CCDS41253.2 |
RefSeqi | NP_001096640.2, NM_001103170.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000352268 |
Protein family/group databases
ESTHERi | human-AADACL3, Arylacetamide_deacetylase |
PTM databases
iPTMneti | Q5VUY0 |
PhosphoSitePlusi | Q5VUY0 |
Genetic variation databases
BioMutai | AADACL3 |
DMDMi | 317373552 |
Proteomic databases
PaxDbi | Q5VUY0 |
PRIDEi | Q5VUY0 |
Protocols and materials databases
Antibodypediai | 57582, 48 antibodies |
Genome annotation databases
Ensembli | ENST00000359318; ENSP00000352268; ENSG00000188984 |
GeneIDi | 126767 |
KEGGi | hsa:126767 |
UCSCi | uc057ckc.1, human |
Organism-specific databases
CTDi | 126767 |
GeneCardsi | AADACL3 |
HGNCi | HGNC:32037, AADACL3 |
HPAi | ENSG00000188984, Group enriched (placenta, skin) |
neXtProti | NX_Q5VUY0 |
OpenTargetsi | ENSG00000188984 |
PharmGKBi | PA145147526 |
VEuPathDBi | HostDB:ENSG00000188984.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1515, Eukaryota |
GeneTreei | ENSGT00940000162160 |
HOGENOMi | CLU_012494_12_2_1 |
InParanoidi | Q5VUY0 |
OMAi | RDCLVAT |
OrthoDBi | 1263520at2759 |
PhylomeDBi | Q5VUY0 |
TreeFami | TF314978 |
Enzyme and pathway databases
PathwayCommonsi | Q5VUY0 |
SABIO-RKi | Q5VUY0 |
Miscellaneous databases
BioGRID-ORCSi | 126767, 2 hits in 867 CRISPR screens |
GeneWikii | AADACL3_(gene) |
GenomeRNAii | 126767 |
Pharosi | Q5VUY0, Tdark |
PROi | PR:Q5VUY0 |
RNActi | Q5VUY0, protein |
Gene expression databases
Bgeei | ENSG00000188984, Expressed in placenta and 9 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR013094, AB_hydrolase_3 IPR017157, Arylacetamide_deacetylase |
Pfami | View protein in Pfam PF07859, Abhydrolase_3, 2 hits |
PIRSFi | PIRSF037251, Arylacetamide_deacetylase, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADCL3_HUMAN | |
Accessioni | Q5VUY0Primary (citable) accession number: Q5VUY0 Secondary accession number(s): B3KXR9, Q5VUY1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | March 28, 2018 | |
Last modified: | February 10, 2021 | |
This is version 123 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families