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Protein

Leucine-rich repeat and calponin homology domain-containing protein 2

Gene

LRCH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and calponin homology domain-containing protein 2
Gene namesi
Name:LRCH2
Synonyms:KIAA1495
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000130224.14
HGNCiHGNC:29292 LRCH2
neXtProtiNX_Q5VUJ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130224
PharmGKBiPA134890613

Polymorphism and mutation databases

BioMutaiLRCH2
DMDMi116248529

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002534821 – 765Leucine-rich repeat and calponin homology domain-containing protein 2Add BLAST765

Proteomic databases

EPDiQ5VUJ6
MaxQBiQ5VUJ6
PaxDbiQ5VUJ6
PeptideAtlasiQ5VUJ6
PRIDEiQ5VUJ6
ProteomicsDBi65420

PTM databases

iPTMnetiQ5VUJ6
PhosphoSitePlusiQ5VUJ6

Expressioni

Gene expression databases

BgeeiENSG00000130224 Expressed in 163 organ(s), highest expression level in prostate gland
CleanExiHS_LRCH2
GenevisibleiQ5VUJ6 HS

Organism-specific databases

HPAiHPA003233

Interactioni

Protein-protein interaction databases

BioGridi121674, 24 interactors
IntActiQ5VUJ6, 12 interactors
STRINGi9606.ENSP00000325091

Structurei

3D structure databases

ProteinModelPortaliQ5VUJ6
SMRiQ5VUJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati89 – 110LRR 1Add BLAST22
Repeati112 – 133LRR 2Add BLAST22
Repeati135 – 156LRR 3Add BLAST22
Repeati158 – 179LRR 4Add BLAST22
Repeati180 – 201LRR 5Add BLAST22
Repeati203 – 224LRR 6Add BLAST22
Repeati226 – 248LRR 7Add BLAST23
Repeati249 – 269LRR 8Add BLAST21
Repeati271 – 292LRR 9Add BLAST22
Domaini642 – 755Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili438 – 472Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 44Gly-richAdd BLAST39

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0532 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148937
HOGENOMiHOG000049055
HOVERGENiHBG052350
InParanoidiQ5VUJ6
OMAiIWQSEER
OrthoDBiEOG091G05CB
PhylomeDBiQ5VUJ6
TreeFamiTF318428

Family and domain databases

Gene3Di1.10.418.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00369 LRR_TYP, 5 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS51450 LRR, 8 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5VUJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASQGGGGN SGGGGCGGGG SSGGCGTAGG GGGGAGGGGG GGGGTLVVPI
60 70 80 90 100
PVPTLFGQPF PNGPPWNPGS LQPQHTVRSL DRALEEAGSS GILSLSGRKL
110 120 130 140 150
RDFPGSGYDL TDTTQADLSR NRFTEIPSDV WLFAPLETLN LYHNCIKTIP
160 170 180 190 200
EAIKNLQMLT YLNISRNLLS TLPKYLFDLP LKVLVVSNNK LVSIPEEIGK
210 220 230 240 250
LKDLMELDIS CNEIQVLPQQ MGKLHSLREL NIRRNNLHVL PDELGDLPLV
260 270 280 290 300
KLDFSCNKVT EIPVCYRKLH HLQVIILDNN PLQVPPAQIC LKGKVHIFKY
310 320 330 340 350
LNIQACCRMD KKPDSLDLPS LSKRMPSQPL TDSMEDFYPN KNHGPDSGIG
360 370 380 390 400
SDNGEKRLST TEPSDDDTVS LHSQVSESNR EQTSRNDSHI IGSKTDSQKD
410 420 430 440 450
QEVYDFVDPN TEDVAVPEQG NAHIGSFVSF FKGKEKCSEK SRKNEELGDE
460 470 480 490 500
KRLEKEQLLA EEEDDDLKEV TDLRKIAAQL LQQEQKNRIL NHSTSVMRNK
510 520 530 540 550
PKQTVECEKS VSADEVNSPL SPLTWQPLEN QKDQIDEQPW PESHPIIWQS
560 570 580 590 600
EERRRSKQIR KEYFKYKSMR KSSSGNENDE QDSDNANMST QSPVSSEEYD
610 620 630 640 650
RTDGFSHSPF GLKPRSAFSR SSRQEYGAAD PGFTMRRKME HLREEREQIR
660 670 680 690 700
QLRNNLESRL KVILPDDIGA ALMDGVVLCH LANHIRPRSV ASIHVPSPAV
710 720 730 740 750
PKLSMAKCRR NVENFLDACK KLGVSQERLC LPHHILEERG LVKVGVTVQA
760
LLELPTTKAS QLSVA
Length:765
Mass (Da):84,588
Last modified:October 17, 2006 - v2
Checksum:i89A56712621F52F9
GO
Isoform 2 (identifier: Q5VUJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     580-596: Missing.

Note: No experimental confirmation available.
Show »
Length:748
Mass (Da):82,810
Checksum:iC0E80AA77CD20C0C
GO

Sequence cautioni

The sequence BAA96019 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti710R → K in AAI25225 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044969580 – 596Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121878 Genomic DNA No translation available.
AL445164 Genomic DNA No translation available.
AL589786 Genomic DNA No translation available.
BC125224 mRNA Translation: AAI25225.1
AK022128 mRNA Translation: BAB13966.1
AB040928 mRNA Translation: BAA96019.1 Different initiation.
CCDSiCCDS48155.1 [Q5VUJ6-1]
CCDS59175.1 [Q5VUJ6-2]
RefSeqiNP_001230892.1, NM_001243963.1 [Q5VUJ6-2]
NP_065922.3, NM_020871.3 [Q5VUJ6-1]
UniGeneiHs.65366

Genome annotation databases

EnsembliENST00000317135; ENSP00000325091; ENSG00000130224 [Q5VUJ6-1]
ENST00000538422; ENSP00000439366; ENSG00000130224 [Q5VUJ6-2]
GeneIDi57631
KEGGihsa:57631
UCSCiuc004epz.4 human [Q5VUJ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121878 Genomic DNA No translation available.
AL445164 Genomic DNA No translation available.
AL589786 Genomic DNA No translation available.
BC125224 mRNA Translation: AAI25225.1
AK022128 mRNA Translation: BAB13966.1
AB040928 mRNA Translation: BAA96019.1 Different initiation.
CCDSiCCDS48155.1 [Q5VUJ6-1]
CCDS59175.1 [Q5VUJ6-2]
RefSeqiNP_001230892.1, NM_001243963.1 [Q5VUJ6-2]
NP_065922.3, NM_020871.3 [Q5VUJ6-1]
UniGeneiHs.65366

3D structure databases

ProteinModelPortaliQ5VUJ6
SMRiQ5VUJ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121674, 24 interactors
IntActiQ5VUJ6, 12 interactors
STRINGi9606.ENSP00000325091

PTM databases

iPTMnetiQ5VUJ6
PhosphoSitePlusiQ5VUJ6

Polymorphism and mutation databases

BioMutaiLRCH2
DMDMi116248529

Proteomic databases

EPDiQ5VUJ6
MaxQBiQ5VUJ6
PaxDbiQ5VUJ6
PeptideAtlasiQ5VUJ6
PRIDEiQ5VUJ6
ProteomicsDBi65420

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317135; ENSP00000325091; ENSG00000130224 [Q5VUJ6-1]
ENST00000538422; ENSP00000439366; ENSG00000130224 [Q5VUJ6-2]
GeneIDi57631
KEGGihsa:57631
UCSCiuc004epz.4 human [Q5VUJ6-1]

Organism-specific databases

CTDi57631
EuPathDBiHostDB:ENSG00000130224.14
GeneCardsiLRCH2
H-InvDBiHIX0017001
HGNCiHGNC:29292 LRCH2
HPAiHPA003233
neXtProtiNX_Q5VUJ6
OpenTargetsiENSG00000130224
PharmGKBiPA134890613
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0532 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148937
HOGENOMiHOG000049055
HOVERGENiHBG052350
InParanoidiQ5VUJ6
OMAiIWQSEER
OrthoDBiEOG091G05CB
PhylomeDBiQ5VUJ6
TreeFamiTF318428

Miscellaneous databases

ChiTaRSiLRCH2 human
GenomeRNAii57631
PROiPR:Q5VUJ6

Gene expression databases

BgeeiENSG00000130224 Expressed in 163 organ(s), highest expression level in prostate gland
CleanExiHS_LRCH2
GenevisibleiQ5VUJ6 HS

Family and domain databases

Gene3Di1.10.418.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00369 LRR_TYP, 5 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS51450 LRR, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRCH2_HUMAN
AccessioniPrimary (citable) accession number: Q5VUJ6
Secondary accession number(s): F5H2T1
, Q08AD5, Q9HA88, Q9P233
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: September 12, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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