AGAP7P

Functionⁱ

Putative GTPase-activating protein.Curated

Miscellaneous

Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

Caution

Could be the product of a pseudogene.Curated

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	456 – 479	C4-typePROSITE-ProRule annotationAdd BLAST		24

GO - Molecular functionⁱ

GTPase activator activity Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7 Short name: AGAP-7 Alternative name(s): Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7 pseudogene Centaurin-gamma-like family member 4
Gene namesⁱ	Name:AGAP7P Synonyms:AGAP7, CTGLF4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Unplaced

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23465 AGAP7P
neXtProtⁱ	NX_Q5VUJ5

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA164715167

PharmGKBⁱ

PA164715167

Polymorphism and mutation databases

DMDMⁱ	74756856

DMDMⁱ

74756856

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000284675	1 – 663	Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7Add BLAST		663

Proteomic databases

PaxDbⁱ	Q5VUJ5
PeptideAtlas More...PeptideAtlasⁱ	Q5VUJ5
PRIDEⁱ	Q5VUJ5
ProteomicsDBⁱ	65419

PTM databases

iPTMnetⁱ	Q5VUJ5
PhosphoSitePlusⁱ	Q5VUJ5

Expressionⁱ

Gene expression databases

CleanExⁱ	HS_AGAP7

CleanExⁱ

HS_AGAP7

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042490

HPAⁱ

HPA042490

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	575652, 1 interactor
IntActⁱ	Q5VUJ5, 1 interactor
STRINGⁱ	9606.ENSP00000363208

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5VUJ5
SMRⁱ	Q5VUJ5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	259 – 420	PHPROSITE-ProRule annotationAdd BLAST	162
Domainⁱ	441 – 561	Arf-GAPPROSITE-ProRule annotationAdd BLAST	121
Repeatⁱ	600 – 629	ANK 1Add BLAST	30
Repeatⁱ	633 – 662	ANK 2Add BLAST	30

Sequence similaritiesⁱ

Belongs to the centaurin gamma-like family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	456 – 479	C4-typePROSITE-ProRule annotationAdd BLAST		24

Keywords - Domainⁱ

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0705 Eukaryota COG5347 LUCA
HOGENOMⁱ	HOG000007233
HOVERGENⁱ	HBG054045
InParanoidⁱ	Q5VUJ5
PhylomeDBⁱ	Q5VUJ5
TreeFamⁱ	TF317762

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit 3.30.40.160, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR037278 ARFGAP/RecO IPR001164 ArfGAP_dom IPR038508 ArfGAP_dom_sf IPR001849 PH_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF01412 ArfGap, 1 hit
PRINTSⁱ	PR00405 REVINTRACTNG
SMARTⁱ	View protein in SMART SM00248 ANK, 2 hits SM00105 ArfGap, 1 hit SM00233 PH, 1 hit
SUPFAMⁱ	SSF48403 SSF48403, 1 hit SSF57863 SSF57863, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 1 hit PS50115 ARFGAP, 1 hit PS50003 PH_DOMAIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5VUJ5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGNILTCRVH PSVSLEFDQQ QGSVCPSESE IYEAGAEDRM AGAPMAAAVQ 
        60         70         80         90        100
PAEVTVEVGE DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE 
       110        120        130        140        150
IRRSNCTNHV STVHFSQQYS LCSTIFLDDS TAIQHYLTMT IISVTLEIPH 
       160        170        180        190        200
HITQRDADRS LSIPDEQLHS FAVSTVHITK NRNGGGSLNN YSSSIPSTPS 
       210        220        230        240        250
TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD KERKAPENHA 
       260        270        280        290        300
DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGVL TYYSSLGDYM 
       310        320        330        340        350
KYIHKKEIDL QTSTIKVPGK WPSLATLACT PISSSKSDGL SKDMDTGLGD 
       360        370        380        390        400
SICFSPSISS TTIPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF 
       410        420        430        440        450
EATTYEERDA WVQAIQSQIL ASLQSCESSK SKSQLTSQSE AMALQSIQNM 
       460        470        480        490        500
RGNAHCVDCE TQNPKWASLN LGVLMCIECS GIHRSLGTRL SRVRSLELDD 
       510        520        530        540        550
WPVELRKVMS SIGNDLANSI WEGSSQGRTK PTEKSTREEK ERWIRSKYEE 
       560        570        580        590        600
KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSRE EVNETCGEGD 
       610        620        630        640        650
GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI 
       660 
NVLLQYGCPD ECV

Length:663

Mass (Da):73,211

Last modified:December 7, 2004 - v1

Checksum:ⁱ036912A99532FAE0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL589822 Genomic DNA No translation available.
UniGeneⁱ	Hs.447454 Hs.528346

Protein	Similar proteins		Species	Score	Length
Q5VUJ5	UPI0005D02868		HUMAN		716
UPI000D0A16BB		PANTR		663
UPI00001F8CCF		HUMAN		485
UPI0005D034A5		HUMAN		716
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6		HUMAN		663
+6

Protein	Similar proteins		Species	Score	Length
Q5VUJ5	UPI0005D034A5		HUMAN		716
UPI000D0A16BB		PANTR		663
Uncharacterized protein		MACFA		620
Uncharacterized protein		MACNE		646
Uncharacterized protein		CERAT		646
+54

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL589822 Genomic DNA No translation available.
UniGeneⁱ	Hs.447454 Hs.528346

3D structure databases

ProteinModelPortalⁱ	Q5VUJ5
SMRⁱ	Q5VUJ5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	575652, 1 interactor
IntActⁱ	Q5VUJ5, 1 interactor
STRINGⁱ	9606.ENSP00000363208

PTM databases

iPTMnetⁱ	Q5VUJ5
PhosphoSitePlusⁱ	Q5VUJ5

Polymorphism and mutation databases

DMDMⁱ	74756856

DMDMⁱ

74756856

Proteomic databases

PaxDbⁱ	Q5VUJ5
PeptideAtlas More...PeptideAtlasⁱ	Q5VUJ5
PRIDEⁱ	Q5VUJ5
ProteomicsDBⁱ	65419

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Organism-specific databases

GeneCardsⁱ	AGAP7P
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23465 AGAP7P
Human Protein Atlas More...HPAⁱ	HPA042490
neXtProtⁱ	NX_Q5VUJ5
PharmGKBⁱ	PA164715167
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0705 Eukaryota COG5347 LUCA
HOGENOMⁱ	HOG000007233
HOVERGENⁱ	HBG054045
InParanoidⁱ	Q5VUJ5
PhylomeDBⁱ	Q5VUJ5
TreeFamⁱ	TF317762

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q5VUJ5

PROⁱ

PR:Q5VUJ5

Gene expression databases

CleanExⁱ	HS_AGAP7

CleanExⁱ

HS_AGAP7

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit 3.30.40.160, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR037278 ARFGAP/RecO IPR001164 ArfGAP_dom IPR038508 ArfGAP_dom_sf IPR001849 PH_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF01412 ArfGap, 1 hit
PRINTSⁱ	PR00405 REVINTRACTNG
SMARTⁱ	View protein in SMART SM00248 ANK, 2 hits SM00105 ArfGap, 1 hit SM00233 PH, 1 hit
SUPFAMⁱ	SSF48403 SSF48403, 1 hit SSF57863 SSF57863, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 1 hit PS50115 ARFGAP, 1 hit PS50003 PH_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AGAP7_HUMAN
Accessionⁱ	Q5VUJ5Primary (citable) accession number: Q5VUJ5 Secondary accession number(s): A6NGH4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
	Last sequence update:	December 7, 2004
	Last modified:	June 20, 2018
	This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5VUJ5 (AGAP7_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ