UniProtKB - Q5VUJ5 (AGAP7_HUMAN)
Protein
Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7
Gene
AGAP7P
Organism
Homo sapiens (Human)
Status
Functioni
Putative GTPase-activating protein.Curated
Miscellaneous
Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.
Caution
Could be the product of a pseudogene.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 456 – 479 | C4-typePROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | GTPase activation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q5VUJ5 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7Short name: AGAP-7 Alternative name(s): Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7 pseudogene Centaurin-gamma-like family member 4 |
Gene namesi | Name:AGAP7P Synonyms:AGAP7, CTGLF4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23465, AGAP7P |
neXtProti | NX_Q5VUJ5 |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Pathology & Biotechi
Miscellaneous databases
Pharosi | Q5VUJ5, Tdark |
Polymorphism and mutation databases
BioMutai | HGNC:23465 |
DMDMi | 74756856 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284675 | 1 – 663 | Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7Add BLAST | 663 |
Proteomic databases
jPOSTi | Q5VUJ5 |
MassIVEi | Q5VUJ5 |
PaxDbi | Q5VUJ5 |
PRIDEi | Q5VUJ5 |
ProteomicsDBi | 65419 |
PTM databases
iPTMneti | Q5VUJ5 |
PhosphoSitePlusi | Q5VUJ5 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 575652, 1 interactor |
IntActi | Q5VUJ5, 2 interactors |
MINTi | Q5VUJ5 |
Miscellaneous databases
RNActi | Q5VUJ5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 259 – 420 | PHPROSITE-ProRule annotationAdd BLAST | 162 | |
Domaini | 441 – 561 | Arf-GAPPROSITE-ProRule annotationAdd BLAST | 121 | |
Repeati | 600 – 629 | ANK 1Add BLAST | 30 | |
Repeati | 633 – 662 | ANK 2Add BLAST | 30 |
Sequence similaritiesi
Belongs to the centaurin gamma-like family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 456 – 479 | C4-typePROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
ANK repeat, Repeat, Zinc-fingerPhylogenomic databases
InParanoidi | Q5VUJ5 |
PhylomeDBi | Q5VUJ5 |
TreeFami | TF317762 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 3.30.40.160, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF01412, ArfGap, 1 hit |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00248, ANK, 2 hits SM00105, ArfGap, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS50115, ARFGAP, 1 hit PS50003, PH_DOMAIN, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5VUJ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGNILTCRVH PSVSLEFDQQ QGSVCPSESE IYEAGAEDRM AGAPMAAAVQ
60 70 80 90 100
PAEVTVEVGE DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE
110 120 130 140 150
IRRSNCTNHV STVHFSQQYS LCSTIFLDDS TAIQHYLTMT IISVTLEIPH
160 170 180 190 200
HITQRDADRS LSIPDEQLHS FAVSTVHITK NRNGGGSLNN YSSSIPSTPS
210 220 230 240 250
TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD KERKAPENHA
260 270 280 290 300
DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGVL TYYSSLGDYM
310 320 330 340 350
KYIHKKEIDL QTSTIKVPGK WPSLATLACT PISSSKSDGL SKDMDTGLGD
360 370 380 390 400
SICFSPSISS TTIPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF
410 420 430 440 450
EATTYEERDA WVQAIQSQIL ASLQSCESSK SKSQLTSQSE AMALQSIQNM
460 470 480 490 500
RGNAHCVDCE TQNPKWASLN LGVLMCIECS GIHRSLGTRL SRVRSLELDD
510 520 530 540 550
WPVELRKVMS SIGNDLANSI WEGSSQGRTK PTEKSTREEK ERWIRSKYEE
560 570 580 590 600
KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSRE EVNETCGEGD
610 620 630 640 650
GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI
660
NVLLQYGCPD ECV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL589822 Genomic DNA No translation available. |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL589822 Genomic DNA No translation available. |
3D structure databases
SMRi | Q5VUJ5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 575652, 1 interactor |
IntActi | Q5VUJ5, 2 interactors |
MINTi | Q5VUJ5 |
PTM databases
iPTMneti | Q5VUJ5 |
PhosphoSitePlusi | Q5VUJ5 |
Polymorphism and mutation databases
BioMutai | HGNC:23465 |
DMDMi | 74756856 |
Proteomic databases
jPOSTi | Q5VUJ5 |
MassIVEi | Q5VUJ5 |
PaxDbi | Q5VUJ5 |
PRIDEi | Q5VUJ5 |
ProteomicsDBi | 65419 |
Organism-specific databases
GeneCardsi | AGAP7P |
HGNCi | HGNC:23465, AGAP7P |
neXtProti | NX_Q5VUJ5 |
GenAtlasi | Search... |
Phylogenomic databases
InParanoidi | Q5VUJ5 |
PhylomeDBi | Q5VUJ5 |
TreeFami | TF317762 |
Enzyme and pathway databases
PathwayCommonsi | Q5VUJ5 |
Miscellaneous databases
Pharosi | Q5VUJ5, Tdark |
PROi | PR:Q5VUJ5 |
RNActi | Q5VUJ5, protein |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 3.30.40.160, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf IPR001849, PH_domain |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF01412, ArfGap, 1 hit |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00248, ANK, 2 hits SM00105, ArfGap, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS50115, ARFGAP, 1 hit PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AGAP7_HUMAN | |
Accessioni | Q5VUJ5Primary (citable) accession number: Q5VUJ5 Secondary accession number(s): A6NGH4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | December 7, 2004 | |
Last modified: | August 12, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM