We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q5VUG0 (SMBT2_HUMAN)
Protein
Scm-like with four MBT domains protein 2
Gene
SFMBT2
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional repressor of HOXB13 gene.
1 PublicationGO - Molecular functioni
- chromatin binding Source: GO_Central
- histone binding Source: UniProtKB
- transcription corepressor activity Source: InterPro
GO - Biological processi
- negative regulation of gene expression Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Repressor |
Enzyme and pathway databases
PathwayCommonsi | Q5VUG0 |
SignaLinki | Q5VUG0 |
Names & Taxonomyi
Protein namesi | Recommended name: Scm-like with four MBT domains protein 2Short name: Scm-like with 4 MBT domains protein 2 |
Gene namesi | Name:SFMBT2 Synonyms:KIAA1617 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20256, SFMBT2 |
MIMi | 615392, gene |
neXtProti | NX_Q5VUG0 |
VEuPathDBi | HostDB:ENSG00000198879 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear body Source: HPA
- nuclear speck Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- aggresome Source: HPA
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 57713 |
OpenTargetsi | ENSG00000198879 |
PharmGKBi | PA134866013 |
Miscellaneous databases
Pharosi | Q5VUG0, Tdark |
Genetic variation databases
BioMutai | SFMBT2 |
DMDMi | 67461560 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071969 | 1 – 894 | Scm-like with four MBT domains protein 2Add BLAST | 894 |
Proteomic databases
MassIVEi | Q5VUG0 |
MaxQBi | Q5VUG0 |
PaxDbi | Q5VUG0 |
PeptideAtlasi | Q5VUG0 |
PRIDEi | Q5VUG0 |
ProteomicsDBi | 65417 |
PTM databases
iPTMneti | Q5VUG0 |
PhosphoSitePlusi | Q5VUG0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198879, Expressed in corpus callosum and 192 other tissues |
ExpressionAtlasi | Q5VUG0, baseline and differential |
Genevisiblei | Q5VUG0, HS |
Organism-specific databases
HPAi | ENSG00000198879, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with YY1.
Interacts with methylated histones H3K9me2 and H4K20me2, but not with H3K4me2, nor H3K9Ac.
1 PublicationBinary interactionsi
Q5VUG0
GO - Molecular functioni
- histone binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 121736, 20 interactors |
IntActi | Q5VUG0, 16 interactors |
MINTi | Q5VUG0 |
STRINGi | 9606.ENSP00000380353 |
Miscellaneous databases
RNActi | Q5VUG0, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q5VUG0 |
SMRi | Q5VUG0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q5VUG0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 44 – 144 | MBT 1Add BLAST | 101 | |
Repeati | 152 – 256 | MBT 2Add BLAST | 105 | |
Repeati | 266 – 372 | MBT 3Add BLAST | 107 | |
Repeati | 380 – 477 | MBT 4Add BLAST | 98 | |
Domaini | 824 – 887 | SAMAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 39 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 672 – 813 | DisorderedSequence analysisAdd BLAST | 142 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 22 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 687 – 702 | Basic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 715 – 736 | Acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 795 – 813 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3766, Eukaryota |
GeneTreei | ENSGT00940000158123 |
HOGENOMi | CLU_005352_0_0_1 |
InParanoidi | Q5VUG0 |
OMAi | KMTSEWK |
OrthoDBi | 237430at2759 |
PhylomeDBi | Q5VUG0 |
TreeFami | TF316498 |
Family and domain databases
CDDi | cd09581, SAM_Scm-like-4MBT1_2, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 3.90.1150.190, 1 hit |
InterProi | View protein in InterPro IPR004092, Mbt IPR001660, SAM IPR013761, SAM/pointed_sf IPR037604, Scm-like-4MBT1/2_SAM IPR021987, SLED IPR038348, SLED_sf |
Pfami | View protein in Pfam PF02820, MBT, 4 hits PF00536, SAM_1, 1 hit PF12140, SLED, 1 hit |
SMARTi | View protein in SMART SM00561, MBT, 4 hits SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS51079, MBT, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
Q5VUG0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESTLSASNM QDPSSSPLEK CLGSANGNGD LDSEEGSSLE ETGFNWGEYL
60 70 80 90 100
EETGASAAPH TSFKHVEISI QSNFQPGMKL EVANKNNPDT YWVATIITTC
110 120 130 140 150
GQLLLLRYCG YGEDRRADFW CDVVIADLHP VGWCTQNNKV LMPPDAIKEK
160 170 180 190 200
YTDWTEFLIR DLTGSRTAPA NLLEGPLRGK GPIDLITVGS LIELQDSQNP
210 220 230 240 250
FQYWIVSVIE NVGGRLRLRY VGLEDTESYD QWLFYLDYRL RPVGWCQENK
260 270 280 290 300
YRMDPPSEIY PLKMASEWKC TLEKSLIDAA KFPLPMEVFK DHADLRSHFF
310 320 330 340 350
TVGMKLETVN MCEPFYISPA SVTKVFNNHF FQVTIDDLRP EPSKLSMLCH
360 370 380 390 400
ADSLGILPVQ WCLKNGVSLT PPKGYSGQDF DWADYHKQHG AQEAPPFCFR
410 420 430 440 450
NTSFSRGFTK NMKLEAVNPR NPGELCVASV VSVKGRLMWL HLEGLQTPVP
460 470 480 490 500
EVIVDVESMD IFPVGWCEAN SYPLTAPHKT VSQKKRKIAV VQPEKQLPPT
510 520 530 540 550
VPVKKIPHDL CLFPHLDTTG TVNGKYCCPQ LFINHRCFSG PYLNKGRIAE
560 570 580 590 600
LPQSVGPGKC VLVLKEVLSM IINAAYKPGR VLRELQLVED PHWNFQEETL
610 620 630 640 650
KAKYRGKTYR AVVKIVRTSD QVANFCRRVC AKLECCPNLF SPVLISENCP
660 670 680 690 700
ENCSIHTKTK YTYYYGKRKK ISKPPIGESN PDSGHPKPAR RRKRRKSIFV
710 720 730 740 750
QKKRRSSAVD FTAGSGEESE EEDADAMDDD TASEETGSEL RDDQTDTSSA
760 770 780 790 800
EVPSARPRRA VTLRSGSEPV RRPPPERTRR GRGAPAASSA EEGEKCPPTK
810 820 830 840 850
PEGTEDTKQE EEERLVLESN PLEWTVTDVV RFIKLTDCAP LAKIFQEQDI
860 870 880 890
DGQALLLLTL PTVQECMELK LGPAIKLCHQ IERVKVAFYA QYAN
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A669KBL2 | A0A669KBL2_HUMAN | Scm-like with four MBT domains prot... | SFMBT2 | 893 | Annotation score: | ||
A0A804HK46 | A0A804HK46_HUMAN | Scm-like with four MBT domains prot... | SFMBT2 | 729 | Annotation score: | ||
A0A804HLD5 | A0A804HLD5_HUMAN | Scm-like with four MBT domains prot... | SFMBT2 | 782 | Annotation score: | ||
Q5T980 | Q5T980_HUMAN | Scm-like with four MBT domains prot... | SFMBT2 | 160 | Annotation score: | ||
Q5T981 | Q5T981_HUMAN | Scm-like with four MBT domains prot... | SFMBT2 | 186 | Annotation score: | ||
A0A804HJD5 | A0A804HJD5_HUMAN | Scm-like with four MBT domains prot... | SFMBT2 | 123 | Annotation score: | ||
A0A804HJE9 | A0A804HJE9_HUMAN | Scm-like with four MBT domains prot... | SFMBT2 | 161 | Annotation score: | ||
A0A804HKS4 | A0A804HKS4_HUMAN | Scm-like with four MBT domains prot... | SFMBT2 | 185 | Annotation score: |
Sequence cautioni
The sequence BAB13443 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051362 | 675 | P → R. Corresponds to variant dbSNP:rs3740212Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB046837 mRNA Translation: BAB13443.1 Different initiation. AL590095 Genomic DNA No translation available. AL158046 Genomic DNA No translation available. AL139125 Genomic DNA No translation available. AL138771 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86385.1 BC152430 mRNA Translation: AAI52431.1 |
CCDSi | CCDS31138.1 |
RefSeqi | NP_001018049.1, NM_001018039.1 NP_001025051.1, NM_001029880.2 XP_011517913.1, XM_011519611.1 XP_016871955.1, XM_017016466.1 |
Genome annotation databases
Ensembli | ENST00000361972.8; ENSP00000355109.4; ENSG00000198879.13 ENST00000397167.6; ENSP00000380353.1; ENSG00000198879.13 |
GeneIDi | 57713 |
KEGGi | hsa:57713 |
MANE-Selecti | ENST00000397167.6; ENSP00000380353.1; NM_001387889.1; NP_001374818.1 |
UCSCi | uc001ijn.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB046837 mRNA Translation: BAB13443.1 Different initiation. AL590095 Genomic DNA No translation available. AL158046 Genomic DNA No translation available. AL139125 Genomic DNA No translation available. AL138771 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86385.1 BC152430 mRNA Translation: AAI52431.1 |
CCDSi | CCDS31138.1 |
RefSeqi | NP_001018049.1, NM_001018039.1 NP_001025051.1, NM_001029880.2 XP_011517913.1, XM_011519611.1 XP_016871955.1, XM_017016466.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WJR | NMR | - | A | 182-295 | [»] | |
AlphaFoldDBi | Q5VUG0 | |||||
SMRi | Q5VUG0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121736, 20 interactors |
IntActi | Q5VUG0, 16 interactors |
MINTi | Q5VUG0 |
STRINGi | 9606.ENSP00000380353 |
PTM databases
iPTMneti | Q5VUG0 |
PhosphoSitePlusi | Q5VUG0 |
Genetic variation databases
BioMutai | SFMBT2 |
DMDMi | 67461560 |
Proteomic databases
MassIVEi | Q5VUG0 |
MaxQBi | Q5VUG0 |
PaxDbi | Q5VUG0 |
PeptideAtlasi | Q5VUG0 |
PRIDEi | Q5VUG0 |
ProteomicsDBi | 65417 |
Protocols and materials databases
ABCDi | Q5VUG0, 1 sequenced antibody |
Antibodypediai | 52040, 43 antibodies from 14 providers |
DNASUi | 57713 |
Genome annotation databases
Ensembli | ENST00000361972.8; ENSP00000355109.4; ENSG00000198879.13 ENST00000397167.6; ENSP00000380353.1; ENSG00000198879.13 |
GeneIDi | 57713 |
KEGGi | hsa:57713 |
MANE-Selecti | ENST00000397167.6; ENSP00000380353.1; NM_001387889.1; NP_001374818.1 |
UCSCi | uc001ijn.2, human |
Organism-specific databases
CTDi | 57713 |
DisGeNETi | 57713 |
GeneCardsi | SFMBT2 |
HGNCi | HGNC:20256, SFMBT2 |
HPAi | ENSG00000198879, Tissue enhanced (brain) |
MIMi | 615392, gene |
neXtProti | NX_Q5VUG0 |
OpenTargetsi | ENSG00000198879 |
PharmGKBi | PA134866013 |
VEuPathDBi | HostDB:ENSG00000198879 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3766, Eukaryota |
GeneTreei | ENSGT00940000158123 |
HOGENOMi | CLU_005352_0_0_1 |
InParanoidi | Q5VUG0 |
OMAi | KMTSEWK |
OrthoDBi | 237430at2759 |
PhylomeDBi | Q5VUG0 |
TreeFami | TF316498 |
Enzyme and pathway databases
PathwayCommonsi | Q5VUG0 |
SignaLinki | Q5VUG0 |
Miscellaneous databases
BioGRID-ORCSi | 57713, 6 hits in 1081 CRISPR screens |
ChiTaRSi | SFMBT2, human |
EvolutionaryTracei | Q5VUG0 |
GenomeRNAii | 57713 |
Pharosi | Q5VUG0, Tdark |
PROi | PR:Q5VUG0 |
RNActi | Q5VUG0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198879, Expressed in corpus callosum and 192 other tissues |
ExpressionAtlasi | Q5VUG0, baseline and differential |
Genevisiblei | Q5VUG0, HS |
Family and domain databases
CDDi | cd09581, SAM_Scm-like-4MBT1_2, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 3.90.1150.190, 1 hit |
InterProi | View protein in InterPro IPR004092, Mbt IPR001660, SAM IPR013761, SAM/pointed_sf IPR037604, Scm-like-4MBT1/2_SAM IPR021987, SLED IPR038348, SLED_sf |
Pfami | View protein in Pfam PF02820, MBT, 4 hits PF00536, SAM_1, 1 hit PF12140, SLED, 1 hit |
SMARTi | View protein in SMART SM00561, MBT, 4 hits SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS51079, MBT, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SMBT2_HUMAN | |
Accessioni | Q5VUG0Primary (citable) accession number: Q5VUG0 Secondary accession number(s): A7MD09, Q9HCF5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | December 7, 2004 | |
Last modified: | May 25, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references