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Protein

Protein FAM171A1

Gene

FAM171A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM171A1
Alternative name(s):
Astroprincin
Gene namesi
Name:FAM171A1
Synonyms:C10orf38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148468.16
HGNCiHGNC:23522 FAM171A1
neXtProtiNX_Q5VUB5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 303ExtracellularSequence analysisAdd BLAST282
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 890CytoplasmicSequence analysisAdd BLAST566

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi221061
OpenTargetsiENSG00000148468
PharmGKBiPA162387176

Polymorphism and mutation databases

BioMutaiFAM171A1
DMDMi74747078

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000027426322 – 890Protein FAM171A1Add BLAST869

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi159N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei358PhosphoserineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei371PhosphoserineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Modified residuei443PhosphoserineCombined sources1
Modified residuei525PhosphoserineCombined sources1
Modified residuei849PhosphoserineCombined sources1
Modified residuei855PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ5VUB5
MaxQBiQ5VUB5
PaxDbiQ5VUB5
PeptideAtlasiQ5VUB5
PRIDEiQ5VUB5
ProteomicsDBi65405

PTM databases

iPTMnetiQ5VUB5
PhosphoSitePlusiQ5VUB5
SwissPalmiQ5VUB5

Expressioni

Gene expression databases

BgeeiENSG00000148468
CleanExiHS_FAM171A1
ExpressionAtlasiQ5VUB5 baseline and differential
GenevisibleiQ5VUB5 HS

Organism-specific databases

HPAiHPA051345

Interactioni

Protein-protein interaction databases

BioGridi128680, 6 interactors
IntActiQ5VUB5, 5 interactors

Structurei

3D structure databases

ProteinModelPortaliQ5VUB5
SMRiQ5VUB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM171 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKM3 Eukaryota
ENOG410ZV9V LUCA
GeneTreeiENSGT00530000063318
HOGENOMiHOG000231925
HOVERGENiHBG057508
InParanoidiQ5VUB5
OMAiVDMNEPK
OrthoDBiEOG091G01Y7
PhylomeDBiQ5VUB5
TreeFamiTF331338

Family and domain databases

InterProiView protein in InterPro
IPR018890 Uncharacterised_FAM171
PANTHERiPTHR31626 PTHR31626, 1 hit
PfamiView protein in Pfam
PF10577 UPF0560, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5VUB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSATLLLC LLGCHVWKAV TKTLREPGAG AQEVTLKVHI SDASTHQPVA
60 70 80 90 100
DALIEIFTNQ ASIASGTSGT DGVAFIKFQY KLGSQLIVTA SKHAYVPNSA
110 120 130 140 150
PWKPIRLPVF SSLSLGLLPE RSATLMVYED VVQIVSGFQG ARPQPRVHFQ
160 170 180 190 200
RRALRLPENT SYSDLTAFLT AASSPSEVDS FPYLRGLDGN GTGNSTRHDL
210 220 230 240 250
TPVTAVSVHL LSSNGTPVLV DGPIYVTVPL ATQSSLRHNA YVAAWRFDQK
260 270 280 290 300
LGTWLKSGLG LVHQEGSQLT WTYIAPQLGY WVAAMSPPIP GPVVTQDITT
310 320 330 340 350
YHTVFLLAIL GGMAFILLVL LCLLLYYCRR KCLKPRQHHR KLQLPAGLES
360 370 380 390 400
SKRDQSTSMS HINLLFSRRA SEFPGPLSVT SHGRPEAPGT KELMSGVHLE
410 420 430 440 450
MMSPGGEGDL HTPMLKLSYS TSQEFSSREE LLSCKEEDKS QISFDNLTPS
460 470 480 490 500
GTLGKDYHKS VEVFPLKARK SMEREGYESS GNDDYRGSYN TVLSQPLFEK
510 520 530 540 550
QDREGPASTG SKLTIQEHLY PAPSSPEKEQ LLDRRPTECM MSRSVDHLER
560 570 580 590 600
PTSFPRPGQL ICCSSVDQVN DSVYRKVLPA LVIPAHYMKL PGDHSYVSQP
610 620 630 640 650
LVVPADQQLE IERLQAELSN PHAGIFPHPS SQIQPQPLSS QAISQQHLQD
660 670 680 690 700
AGTREWSPQN ASMSESLSIP ASLNDAALAQ MNSEVQLLTE KALMELGGGK
710 720 730 740 750
PLPHPRAWFV SLDGRSNAHV RHSYIDLQRA GRNGSNDASL DSGVDMNEPK
760 770 780 790 800
SARKGRGDAL SLQQNYPPVQ EHQQKEPRAP DSTAYTQLVY LDDVEQSGSE
810 820 830 840 850
CGTTVCTPED SALRCLLEGS SRRSGGQLPS LQEETTRRTA DAPSEPAASP
860 870 880 890
HQRRSAHEEE EDDDDDDQGE DKKSPWQKRE ERPLMAFNIK
Length:890
Mass (Da):97,854
Last modified:December 7, 2004 - v1
Checksum:iA0718E29A639FB72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118L → P in AAI09304 (PubMed:15489334).Curated1
Sequence conflicti592G → R in AAH34232 (PubMed:15489334).Curated1
Sequence conflicti670P → Q in AAH34232 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030220465P → S1 PublicationCorresponds to variant dbSNP:rs3814165Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY683003 mRNA Translation: AAV85904.1
AL590365 Genomic DNA No translation available.
AL139338 Genomic DNA No translation available.
AL607028 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86237.1
BC034232 mRNA Translation: AAH34232.1
BC109302 mRNA Translation: AAI09303.1
BC109303 mRNA Translation: AAI09304.1
CCDSiCCDS31154.1
RefSeqiNP_001010924.1, NM_001010924.1
UniGeneiHs.66762

Genome annotation databases

EnsembliENST00000378116; ENSP00000367356; ENSG00000148468
GeneIDi221061
KEGGihsa:221061
UCSCiuc001iob.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF1711_HUMAN
AccessioniPrimary (citable) accession number: Q5VUB5
Secondary accession number(s): D3DRT9, Q32M49, Q8N4I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 7, 2004
Last modified: July 18, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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