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UniProtKB - Q5VUA4 (ZN318_HUMAN)

Entry version 144 (17 Jun 2020)
Sequence version 2 (15 Jan 2008)
Previous versions | rss
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Protein

Zinc finger protein 318

Gene

ZNF318

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.By similarity
Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1063 – 1097Matrin-type 1Add BLAST35
Zinc fingeri1136 – 1166Matrin-type 2Add BLAST31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processMeiosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 318
Alternative name(s):
Endocrine regulatory protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF318
ORF Names:HRIHFB2436
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000171467.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:13578 ZNF318

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617512 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5VUA4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		24149

Open Targets

More...OpenTargetsi		ENSG00000171467

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134923137

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5VUA4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF318

Domain mapping of disease mutations (DMDM)

More...DMDMi		166215018

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001918071 – 2279Zinc finger protein 318Add BLAST2279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1
Modified residuei205PhosphotyrosineBy similarity1
Modified residuei207PhosphoserineCombined sources1
Modified residuei214PhosphoserineCombined sources1
Modified residuei464PhosphoserineCombined sources1
Modified residuei472PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki547Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki553Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki566Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki578Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei842PhosphothreonineCombined sources1
Modified residuei1010PhosphoserineCombined sources1
Modified residuei1037PhosphoserineCombined sources1
Modified residuei1243PhosphoserineCombined sources1
Modified residuei1267PhosphoserineCombined sources1
Modified residuei1420PhosphoserineCombined sources1
Modified residuei1713PhosphoserineCombined sources1
Modified residuei1856PhosphoserineCombined sources1
Modified residuei1896PhosphoserineCombined sources1
Modified residuei1971PhosphoserineCombined sources1
Modified residuei2030PhosphoserineCombined sources1
Modified residuei2035PhosphoserineCombined sources1
Modified residuei2091PhosphoserineCombined sources1
Modified residuei2101PhosphoserineCombined sources1
Modified residuei2189PhosphoserineCombined sources1
Modified residuei2192PhosphoserineCombined sources1
Modified residuei2243PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5VUA4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5VUA4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5VUA4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5VUA4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5VUA4

PeptideAtlas

More...PeptideAtlasi		Q5VUA4

PRoteomics IDEntifications database

More...PRIDEi		Q5VUA4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65403 [Q5VUA4-1]
65404 [Q5VUA4-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2091

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5VUA4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5VUA4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in endocrine tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171467 Expressed in testis and 213 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5VUA4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5VUA4 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000171467 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Heterodimer of isoform 1 and isoform 2. Isoform 1 and isoform 2 interact with AR.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117299, 53 interactors

Protein interaction database and analysis system

More...IntActi		Q5VUA4, 30 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000354964

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5VUA4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1092Interaction with ARBy similarityAdd BLAST1092

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili315 – 343Sequence analysisAdd BLAST29
Coiled coili876 – 980Sequence analysisAdd BLAST105
Coiled coili1768 – 1792Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi41 – 103Pro-richAdd BLAST63
Compositional biasi1201 – 1327Lys-richAdd BLAST127
Compositional biasi1433 – 1541Pro-richAdd BLAST109

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1063 – 1097Matrin-type 1Add BLAST35
Zinc fingeri1136 – 1166Matrin-type 2Add BLAST31

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IHGT Eukaryota
ENOG4111IJJ LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000614

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_306659_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5VUA4

Identification of Orthologs from Complete Genome Data

More...OMAi		CQSRPYE

Database of Orthologous Groups

More...OrthoDBi		44718at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5VUA4

TreeFam database of animal gene trees

More...TreeFami		TF350583

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00451 ZnF_U1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VUA4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYRSSARSSV SSHRPKDDGG GGPRSGRSSG SSSGPARRSS PPPPPSGSSS 
        60         70         80         90        100
RTPARRPRSP SGHRGRRASP SPPRGRRVSP SPPRARRGSP SPPRGRRLFP 
       110        120        130        140        150
PGPAGFRGSS RGESRADYAR DGRGDHPGDS GSRRRSPGLC SDSLEKSLRI 
       160        170        180        190        200
TVGNDHFCVS TPERRRLSDR LGSPVDNLED MDRDDLTDDS VFTRSSQCSR 
       210        220        230        240        250
GLERYISQEE GPLSPFLGQL DEDYRTKETF LHRSDYSPHI SCHDELLRGT 
       260        270        280        290        300
ERNREKLKGY SIRSEERSRE AKRPRYDDTV KINSMGGDHP SFTSGTRNYR 
       310        320        330        340        350
QRRRSPSPRF LDPEFRELDL ARRKREEEEE RSRSLSQELV GVDGGGTGCS 
       360        370        380        390        400
IPGLSGVLTA SEPGYSLHRP EEVSVMPKKS ILKKRIEVDI MEPSMQLESF 
       410        420        430        440        450
SSSTSSSQDH PLYSGHPSLP LSGAIAAFAS EIENKGTMVE TALKEPQGNL 
       460        470        480        490        500
YQWGPLPGIP KDNSPLREKF GSFLCHKDNL DLKAEGPERH TDFLLPHERA 
       510        520        530        540        550
SQDGSGFSRI LSMLADSTST QEKRRRSFPD IEDEEKFLYG DEEEDLKAES 
       560        570        580        590        600
VPKPLGSSES EVMRQKASSL PSSAPAVKLE SLEETNPEYA KIHDLLKTIG 
       610        620        630        640        650
LDIGVAEISQ LAARTQERLH GKKPSLRSSA DRRSSVDRYF SADHCSSVDH 
       660        670        680        690        700
RFSADRCSSV DHCFSADRRS SDPHRLESRE AHHSNTHSPE VSHPHPPSPV 
       710        720        730        740        750
DPYLLTKNSP PFLKSDHPVG HISGPEVVGS GFQSSVAVRC MLPSAPSAPI 
       760        770        780        790        800
RLPHTAALSQ FHMPRASQFA AARIPPNYQG PAIPPASFDA YRHYMAYAAS 
       810        820        830        840        850
RWPMYPTSQP SNHPVPEPHR IMPITKQATR SRPNLRVIPT VTPDKPKQKE 
       860        870        880        890        900
SLRGSIPAAQ VPVQVSIPSL IRYNPEKISD EKNRASQKQK VIEEREKLKN 
       910        920        930        940        950
DREARQKKMY YLRTELERLH KQQGEMLRKK RREKDGHKDP LLVEVSRLQD 
       960        970        980        990       1000
NIMKDIAELR QEAEEAEKKQ SELDKVAQIL GINIFDKSQK SLSDSREPTE 
      1010       1020       1030       1040       1050
KPGKAEKSKS PEKVSSFSNS SSNKESKVNN EKFRTKSPKP AESPQSATKQ 
      1060       1070       1080       1090       1100
LDQPTAAYEY YDAGNHWCKD CNTICGTMFD FFTHMHNKKH TQTLDPYNRP 
      1110       1120       1130       1140       1150
WASKTQSEAK QDAIKRTDKI TVPAKGSEFL VPISGFYCQL CEEFLGDPIS 
      1160       1170       1180       1190       1200
GEQHVKGHQH NEKYKKYVDE NPLYEERRNL DRQAGLAVVL ETERRRQSEL 
      1210       1220       1230       1240       1250
KRKLSEKPKE EKKEKKAKAV KEVKEDDKVS EKLEDQLSEG RNSPEKAENK 
      1260       1270       1280       1290       1300
RNTGIKLQLK EEVKKESPTS SSFGKFSWKK PEKEEEKSSL VTPSISKEEI 
      1310       1320       1330       1340       1350
LESSKDKEDG KTEAGKAKPI KIKLSGKTVV AHTSPWMPVV TTSTQTKIRP 
      1360       1370       1380       1390       1400
NLPIPSTVLR KSCSATMSKP APLNTFLSIK SSGTTAKPLP VVKESSADLL 
      1410       1420       1430       1440       1450
LPPDIISKAF GGEEVILKGS PEEKVVLAEK SEPSHLPEQI LPPPPPPPPP 
      1460       1470       1480       1490       1500
PPPPPPVIPH PAAPSAAQAN AILAPVKSNP VVSQTLSPGF VGPNILNPVL 
      1510       1520       1530       1540       1550
PVAIMASAQP AAIPSDETAP GVSESDRDQT LFSVLVRPPP PLSSVFSEQA 
      1560       1570       1580       1590       1600
KKLEKRNSCL ATANAKDLYD IFYSSGGKGA PETKGAPETK LSGGPLANGE 
      1610       1620       1630       1640       1650
NSNLSRTKSS DTSSTSPLNS SASQEELHQD EGLVAAPIVS NSEKPIAKTL 
      1660       1670       1680       1690       1700
VALGKWSVVE HVGPKSTGST YGFLQPLTRL CQSRPYETIT PKTDTLAIWT 
      1710       1720       1730       1740       1750
SSSFQSDTSR DISPEKSELD LGEPGPPGVE PPPQLLDIQC KESQKLVEIH 
      1760       1770       1780       1790       1800
LRESVNQDKE SQELRKSEDC RESEIETNTE LKERVKELSE GIVDEGVSTS 
      1810       1820       1830       1840       1850
IGPHSIDDSN LNHGNRYMWE GEVKQPNLLM IDKEAEQSNK LMTGSETPSK 
      1860       1870       1880       1890       1900
VVIKLSPQAC SFTKAKLDSF LSEARSLLNP QDTPVKISAP ELLLHSPARS 
      1910       1920       1930       1940       1950
AMCLTGSPQE QGVSVVSEEG LENSAPESAS RTSRYRSLKL KRERSKDFQV 
      1960       1970       1980       1990       2000
KKIYELAVWD ENKKRPETWE SPEKPKTEAL ELQDVHPELT VTIESKALED 
      2010       2020       2030       2040       2050
FEATDLKVEE LTALGNLGDM PVDFCTTRVS PAHRSPTVLC QKVCEENSVS 
      2060       2070       2080       2090       2100
PIGCNSSDPA DFEPIPSFSG FPLDSPKTLV LDFETEGERN SPNPRSVRIP 
      2110       2120       2130       2140       2150
SPNILKTGLT ENVDRGLGGL EGTHQALDLL AGGMMPEEVK ESSQLDKQES 
      2160       2170       2180       2190       2200
LGLELKTINS AGLGPSPCLP DLVDFVTRTS GVQKDKLCSP LSEPGDPSKC 
      2210       2220       2230       2240       2250
SSLELGPLQL EISNASTTEV AILQVDDDSG DPLNLVKAPV SRSPPREQVI 
      2260       2270 
EDNMVPQGMP EQETTVGAIQ DHTESSVHN
Length:2,279
Mass (Da):251,112
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC8F7D54710E2450
GO
Isoform 2 (identifier: Q5VUA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1093-1117: TLDPYNRPWASKTQSEAKQDAIKRT → GQFQKSSDFQKEGLQQTFLPPERQG
     1118-2279: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:1,117
Mass (Da):124,880
Checksum:i65866465A953CF07
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQ37U3KQ37_HUMAN
Zinc finger protein 318
ZNF318
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD17298 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAD47387 differs from that shown. Reason: Frameshift.Curated
The sequence AAH98434 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 1214.Curated
The sequence AAH98434 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti62G → R in AAD47387 (Ref. 1) Curated1
Sequence conflicti75G → V in AAD47387 (Ref. 1) Curated1
Sequence conflicti75G → V in AAD17298 (Ref. 1) Curated1
Sequence conflicti1034 – 1035RT → CI in AAD47387 (Ref. 1) Curated2
Sequence conflicti1034 – 1035RT → CI in AAD17298 (Ref. 1) Curated2
Sequence conflicti1259L → F in AAD47387 (Ref. 1) Curated1
Sequence conflicti1259L → F in AAD17298 (Ref. 1) Curated1
Sequence conflicti1349R → G in AAD47387 (Ref. 1) Curated1
Sequence conflicti1349R → G in AAD17298 (Ref. 1) Curated1
Sequence conflicti2160S → F in AAD47387 (Ref. 1) Curated1
Sequence conflicti2160S → F in AAD17298 (Ref. 1) Curated1
Sequence conflicti2173V → D in BAA34799 (PubMed:9853615).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053759407S → I. Corresponds to variant dbSNP:rs34541323Ensembl.1
Natural variantiVAR_036056812N → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs141660717Ensembl.1
Natural variantiVAR_053760870L → V. Corresponds to variant dbSNP:rs9357410Ensembl.1
Natural variantiVAR_0360571274G → R in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0537611292T → I. Corresponds to variant dbSNP:rs10948072Ensembl.1
Natural variantiVAR_0537621580A → T. Corresponds to variant dbSNP:rs3734684Ensembl.1
Natural variantiVAR_0537631583T → I. Corresponds to variant dbSNP:rs36107018Ensembl.1
Natural variantiVAR_0537641797V → A1 PublicationCorresponds to variant dbSNP:rs1459675Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0165921093 – 1117TLDPY…AIKRT → GQFQKSSDFQKEGLQQTFLP PERQG in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0165931118 – 2279Missing in isoform 2. 1 PublicationAdd BLAST1162

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF090114 mRNA Translation: AAD47387.1 Frameshift.
AF121141 mRNA Translation: AAD17298.1 Different initiation.
AL590383 Genomic DNA No translation available.
AL583834 Genomic DNA No translation available.
BC030687 mRNA No translation available.
BC098434 mRNA Translation: AAH98434.1 Sequence problems.
AB015342 mRNA Translation: BAA34799.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4895.2 [Q5VUA4-1]

NCBI Reference Sequences

More...RefSeqi		NP_055160.2, NM_014345.2 [Q5VUA4-1]
XP_011512754.1, XM_011514452.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361428; ENSP00000354964; ENSG00000171467 [Q5VUA4-1]
ENST00000605935; ENSP00000475748; ENSG00000171467 [Q5VUA4-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		24149

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:24149

UCSC genome browser

More...UCSCi		uc003ouw.4 human [Q5VUA4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090114 mRNA Translation: AAD47387.1 Frameshift.
AF121141 mRNA Translation: AAD17298.1 Different initiation.
AL590383 Genomic DNA No translation available.
AL583834 Genomic DNA No translation available.
BC030687 mRNA No translation available.
BC098434 mRNA Translation: AAH98434.1 Sequence problems.
AB015342 mRNA Translation: BAA34799.1
CCDSiCCDS4895.2 [Q5VUA4-1]
RefSeqiNP_055160.2, NM_014345.2 [Q5VUA4-1]
XP_011512754.1, XM_011514452.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117299, 53 interactors
IntActiQ5VUA4, 30 interactors
STRINGi9606.ENSP00000354964

PTM databases

GlyConnecti2091
iPTMnetiQ5VUA4
PhosphoSitePlusiQ5VUA4

Polymorphism and mutation databases

BioMutaiZNF318
DMDMi166215018

Proteomic databases

EPDiQ5VUA4
jPOSTiQ5VUA4
MassIVEiQ5VUA4
MaxQBiQ5VUA4
PaxDbiQ5VUA4
PeptideAtlasiQ5VUA4
PRIDEiQ5VUA4
ProteomicsDBi65403 [Q5VUA4-1]
65404 [Q5VUA4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16456 86 antibodies

Genome annotation databases

EnsembliENST00000361428; ENSP00000354964; ENSG00000171467 [Q5VUA4-1]
ENST00000605935; ENSP00000475748; ENSG00000171467 [Q5VUA4-2]
GeneIDi24149
KEGGihsa:24149
UCSCiuc003ouw.4 human [Q5VUA4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		24149
DisGeNETi24149
EuPathDBiHostDB:ENSG00000171467.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF318
HGNCiHGNC:13578 ZNF318
HPAiENSG00000171467 Low tissue specificity
MIMi617512 gene
neXtProtiNX_Q5VUA4
OpenTargetsiENSG00000171467
PharmGKBiPA134923137

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IHGT Eukaryota
ENOG4111IJJ LUCA
GeneTreeiENSGT00390000000614
HOGENOMiCLU_306659_0_0_1
InParanoidiQ5VUA4
OMAiCQSRPYE
OrthoDBi44718at2759
PhylomeDBiQ5VUA4
TreeFamiTF350583

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		24149 4 hits in 810 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF318 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZNF318

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		24149
PharosiQ5VUA4 Tbio

Protein Ontology

More...PROi		PR:Q5VUA4
RNActiQ5VUA4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171467 Expressed in testis and 213 other tissues
ExpressionAtlasiQ5VUA4 baseline and differential
GenevisibleiQ5VUA4 HS

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
SMARTiView protein in SMART
SM00451 ZnF_U1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN318_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VUA4
Secondary accession number(s): O94796
, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 15, 2008
Last modified: June 17, 2020
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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