Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q5VUA4 (ZN318_HUMAN)

Protein

Zinc finger protein 318

Gene

ZNF318

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 2: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.By similarity
Isoform 1: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1063 – 1097Matrin-type 1Add BLAST35
Zinc fingeri1136 – 1166Matrin-type 2Add BLAST31

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, Repressor
Biological processMeiosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 318
Alternative name(s):
Endocrine regulatory protein
Gene namesi
Name:ZNF318
ORF Names:HRIHFB2436
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000171467.15
HGNCiHGNC:13578 ZNF318
MIMi617512 gene
neXtProtiNX_Q5VUA4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi24149
OpenTargetsiENSG00000171467
PharmGKBiPA134923137

Polymorphism and mutation databases

BioMutaiZNF318
DMDMi166215018

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001918071 – 2279Zinc finger protein 318Add BLAST2279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1
Modified residuei205PhosphotyrosineBy similarity1
Modified residuei207PhosphoserineCombined sources1
Modified residuei214PhosphoserineCombined sources1
Modified residuei464PhosphoserineCombined sources1
Modified residuei472PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Cross-linki547Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki553Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki566Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki578Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei842PhosphothreonineCombined sources1
Modified residuei1010PhosphoserineCombined sources1
Modified residuei1037PhosphoserineCombined sources1
Modified residuei1243PhosphoserineCombined sources1
Modified residuei1267PhosphoserineCombined sources1
Modified residuei1420PhosphoserineCombined sources1
Modified residuei1713PhosphoserineCombined sources1
Modified residuei1856PhosphoserineCombined sources1
Modified residuei1896PhosphoserineCombined sources1
Modified residuei1971PhosphoserineCombined sources1
Modified residuei2030PhosphoserineCombined sources1
Modified residuei2035PhosphoserineCombined sources1
Modified residuei2091PhosphoserineCombined sources1
Modified residuei2101PhosphoserineCombined sources1
Modified residuei2189PhosphoserineCombined sources1
Modified residuei2192PhosphoserineCombined sources1
Modified residuei2243PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5VUA4
MaxQBiQ5VUA4
PaxDbiQ5VUA4
PeptideAtlasiQ5VUA4
PRIDEiQ5VUA4
ProteomicsDBi65403
65404 [Q5VUA4-2]

PTM databases

iPTMnetiQ5VUA4
PhosphoSitePlusiQ5VUA4

Expressioni

Tissue specificityi

Expressed in endocrine tissue.1 Publication

Gene expression databases

BgeeiENSG00000171467 Expressed in 214 organ(s), highest expression level in testis
CleanExiHS_ZNF318
ExpressionAtlasiQ5VUA4 baseline and differential
GenevisibleiQ5VUA4 HS

Organism-specific databases

HPAiHPA027022
HPA027031

Interactioni

Subunit structurei

Homodimer. Heterodimer of isoform 1 and isoform 2. Isoform 1 and isoform 2 interact with AR.By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi117299, 43 interactors
IntActiQ5VUA4, 11 interactors
STRINGi9606.ENSP00000354964

Structurei

3D structure databases

ProteinModelPortaliQ5VUA4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 1092Interaction with ARBy similarityAdd BLAST1092

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili315 – 343Sequence analysisAdd BLAST29
Coiled coili876 – 980Sequence analysisAdd BLAST105
Coiled coili1768 – 1792Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 103Pro-richAdd BLAST63
Compositional biasi1201 – 1327Lys-richAdd BLAST127
Compositional biasi1433 – 1541Pro-richAdd BLAST109

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1063 – 1097Matrin-type 1Add BLAST35
Zinc fingeri1136 – 1166Matrin-type 2Add BLAST31

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHGT Eukaryota
ENOG4111IJJ LUCA
GeneTreeiENSGT00390000000614
HOGENOMiHOG000043103
HOVERGENiHBG107139
InParanoidiQ5VUA4
OMAiQHNEKYK
OrthoDBiEOG091G00B9
PhylomeDBiQ5VUA4
TreeFamiTF350583

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
SMARTiView protein in SMART
SM00451 ZnF_U1, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VUA4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYRSSARSSV SSHRPKDDGG GGPRSGRSSG SSSGPARRSS PPPPPSGSSS 
        60         70         80         90        100
RTPARRPRSP SGHRGRRASP SPPRGRRVSP SPPRARRGSP SPPRGRRLFP 
       110        120        130        140        150
PGPAGFRGSS RGESRADYAR DGRGDHPGDS GSRRRSPGLC SDSLEKSLRI 
       160        170        180        190        200
TVGNDHFCVS TPERRRLSDR LGSPVDNLED MDRDDLTDDS VFTRSSQCSR 
       210        220        230        240        250
GLERYISQEE GPLSPFLGQL DEDYRTKETF LHRSDYSPHI SCHDELLRGT 
       260        270        280        290        300
ERNREKLKGY SIRSEERSRE AKRPRYDDTV KINSMGGDHP SFTSGTRNYR 
       310        320        330        340        350
QRRRSPSPRF LDPEFRELDL ARRKREEEEE RSRSLSQELV GVDGGGTGCS 
       360        370        380        390        400
IPGLSGVLTA SEPGYSLHRP EEVSVMPKKS ILKKRIEVDI MEPSMQLESF 
       410        420        430        440        450
SSSTSSSQDH PLYSGHPSLP LSGAIAAFAS EIENKGTMVE TALKEPQGNL 
       460        470        480        490        500
YQWGPLPGIP KDNSPLREKF GSFLCHKDNL DLKAEGPERH TDFLLPHERA 
       510        520        530        540        550
SQDGSGFSRI LSMLADSTST QEKRRRSFPD IEDEEKFLYG DEEEDLKAES 
       560        570        580        590        600
VPKPLGSSES EVMRQKASSL PSSAPAVKLE SLEETNPEYA KIHDLLKTIG 
       610        620        630        640        650
LDIGVAEISQ LAARTQERLH GKKPSLRSSA DRRSSVDRYF SADHCSSVDH 
       660        670        680        690        700
RFSADRCSSV DHCFSADRRS SDPHRLESRE AHHSNTHSPE VSHPHPPSPV 
       710        720        730        740        750
DPYLLTKNSP PFLKSDHPVG HISGPEVVGS GFQSSVAVRC MLPSAPSAPI 
       760        770        780        790        800
RLPHTAALSQ FHMPRASQFA AARIPPNYQG PAIPPASFDA YRHYMAYAAS 
       810        820        830        840        850
RWPMYPTSQP SNHPVPEPHR IMPITKQATR SRPNLRVIPT VTPDKPKQKE 
       860        870        880        890        900
SLRGSIPAAQ VPVQVSIPSL IRYNPEKISD EKNRASQKQK VIEEREKLKN 
       910        920        930        940        950
DREARQKKMY YLRTELERLH KQQGEMLRKK RREKDGHKDP LLVEVSRLQD 
       960        970        980        990       1000
NIMKDIAELR QEAEEAEKKQ SELDKVAQIL GINIFDKSQK SLSDSREPTE 
      1010       1020       1030       1040       1050
KPGKAEKSKS PEKVSSFSNS SSNKESKVNN EKFRTKSPKP AESPQSATKQ 
      1060       1070       1080       1090       1100
LDQPTAAYEY YDAGNHWCKD CNTICGTMFD FFTHMHNKKH TQTLDPYNRP 
      1110       1120       1130       1140       1150
WASKTQSEAK QDAIKRTDKI TVPAKGSEFL VPISGFYCQL CEEFLGDPIS 
      1160       1170       1180       1190       1200
GEQHVKGHQH NEKYKKYVDE NPLYEERRNL DRQAGLAVVL ETERRRQSEL 
      1210       1220       1230       1240       1250
KRKLSEKPKE EKKEKKAKAV KEVKEDDKVS EKLEDQLSEG RNSPEKAENK 
      1260       1270       1280       1290       1300
RNTGIKLQLK EEVKKESPTS SSFGKFSWKK PEKEEEKSSL VTPSISKEEI 
      1310       1320       1330       1340       1350
LESSKDKEDG KTEAGKAKPI KIKLSGKTVV AHTSPWMPVV TTSTQTKIRP 
      1360       1370       1380       1390       1400
NLPIPSTVLR KSCSATMSKP APLNTFLSIK SSGTTAKPLP VVKESSADLL 
      1410       1420       1430       1440       1450
LPPDIISKAF GGEEVILKGS PEEKVVLAEK SEPSHLPEQI LPPPPPPPPP 
      1460       1470       1480       1490       1500
PPPPPPVIPH PAAPSAAQAN AILAPVKSNP VVSQTLSPGF VGPNILNPVL 
      1510       1520       1530       1540       1550
PVAIMASAQP AAIPSDETAP GVSESDRDQT LFSVLVRPPP PLSSVFSEQA 
      1560       1570       1580       1590       1600
KKLEKRNSCL ATANAKDLYD IFYSSGGKGA PETKGAPETK LSGGPLANGE 
      1610       1620       1630       1640       1650
NSNLSRTKSS DTSSTSPLNS SASQEELHQD EGLVAAPIVS NSEKPIAKTL 
      1660       1670       1680       1690       1700
VALGKWSVVE HVGPKSTGST YGFLQPLTRL CQSRPYETIT PKTDTLAIWT 
      1710       1720       1730       1740       1750
SSSFQSDTSR DISPEKSELD LGEPGPPGVE PPPQLLDIQC KESQKLVEIH 
      1760       1770       1780       1790       1800
LRESVNQDKE SQELRKSEDC RESEIETNTE LKERVKELSE GIVDEGVSTS 
      1810       1820       1830       1840       1850
IGPHSIDDSN LNHGNRYMWE GEVKQPNLLM IDKEAEQSNK LMTGSETPSK 
      1860       1870       1880       1890       1900
VVIKLSPQAC SFTKAKLDSF LSEARSLLNP QDTPVKISAP ELLLHSPARS 
      1910       1920       1930       1940       1950
AMCLTGSPQE QGVSVVSEEG LENSAPESAS RTSRYRSLKL KRERSKDFQV 
      1960       1970       1980       1990       2000
KKIYELAVWD ENKKRPETWE SPEKPKTEAL ELQDVHPELT VTIESKALED 
      2010       2020       2030       2040       2050
FEATDLKVEE LTALGNLGDM PVDFCTTRVS PAHRSPTVLC QKVCEENSVS 
      2060       2070       2080       2090       2100
PIGCNSSDPA DFEPIPSFSG FPLDSPKTLV LDFETEGERN SPNPRSVRIP 
      2110       2120       2130       2140       2150
SPNILKTGLT ENVDRGLGGL EGTHQALDLL AGGMMPEEVK ESSQLDKQES 
      2160       2170       2180       2190       2200
LGLELKTINS AGLGPSPCLP DLVDFVTRTS GVQKDKLCSP LSEPGDPSKC 
      2210       2220       2230       2240       2250
SSLELGPLQL EISNASTTEV AILQVDDDSG DPLNLVKAPV SRSPPREQVI 
      2260       2270 
EDNMVPQGMP EQETTVGAIQ DHTESSVHN
Length:2,279
Mass (Da):251,112
Last modified:January 15, 2008 - v2
Checksum:iCC8F7D54710E2450
GO
Isoform 2 (identifier: Q5VUA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1093-1117: TLDPYNRPWASKTQSEAKQDAIKRT → GQFQKSSDFQKEGLQQTFLPPERQG
     1118-2279: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:1,117
Mass (Da):124,880
Checksum:i65866465A953CF07
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQ37U3KQ37_HUMAN
Zinc finger protein 318
ZNF318
79Annotation score:

Sequence cautioni

The sequence AAD17298 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAD47387 differs from that shown. Reason: Frameshift at positions 4 and 44.Curated
The sequence AAH98434 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 1214.Curated
The sequence AAH98434 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62G → R in AAD47387 (Ref. 1) Curated1
Sequence conflicti75G → V in AAD47387 (Ref. 1) Curated1
Sequence conflicti75G → V in AAD17298 (Ref. 1) Curated1
Sequence conflicti1034 – 1035RT → CI in AAD47387 (Ref. 1) Curated2
Sequence conflicti1034 – 1035RT → CI in AAD17298 (Ref. 1) Curated2
Sequence conflicti1259L → F in AAD47387 (Ref. 1) Curated1
Sequence conflicti1259L → F in AAD17298 (Ref. 1) Curated1
Sequence conflicti1349R → G in AAD47387 (Ref. 1) Curated1
Sequence conflicti1349R → G in AAD17298 (Ref. 1) Curated1
Sequence conflicti2160S → F in AAD47387 (Ref. 1) Curated1
Sequence conflicti2160S → F in AAD17298 (Ref. 1) Curated1
Sequence conflicti2173V → D in BAA34799 (PubMed:9853615).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053759407S → I. Corresponds to variant dbSNP:rs34541323Ensembl.1
Natural variantiVAR_036056812N → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs141660717Ensembl.1
Natural variantiVAR_053760870L → V. Corresponds to variant dbSNP:rs9357410Ensembl.1
Natural variantiVAR_0360571274G → R in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0537611292T → I. Corresponds to variant dbSNP:rs10948072Ensembl.1
Natural variantiVAR_0537621580A → T. Corresponds to variant dbSNP:rs3734684Ensembl.1
Natural variantiVAR_0537631583T → I. Corresponds to variant dbSNP:rs36107018Ensembl.1
Natural variantiVAR_0537641797V → A1 PublicationCorresponds to variant dbSNP:rs1459675Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0165921093 – 1117TLDPY…AIKRT → GQFQKSSDFQKEGLQQTFLP PERQG in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0165931118 – 2279Missing in isoform 2. 1 PublicationAdd BLAST1162

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090114 mRNA Translation: AAD47387.1 Frameshift.
AF121141 mRNA Translation: AAD17298.1 Different initiation.
AL590383 Genomic DNA No translation available.
AL583834 Genomic DNA No translation available.
BC030687 mRNA No translation available.
BC098434 mRNA Translation: AAH98434.1 Sequence problems.
AB015342 mRNA Translation: BAA34799.1
CCDSiCCDS4895.2 [Q5VUA4-1]
RefSeqiNP_055160.2, NM_014345.2 [Q5VUA4-1]
XP_011512754.1, XM_011514452.2
UniGeneiHs.509718

Genome annotation databases

EnsembliENST00000361428; ENSP00000354964; ENSG00000171467 [Q5VUA4-1]
ENST00000605935; ENSP00000475748; ENSG00000171467 [Q5VUA4-2]
GeneIDi24149
KEGGihsa:24149
UCSCiuc003ouw.4 human [Q5VUA4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090114 mRNA Translation: AAD47387.1 Frameshift.
AF121141 mRNA Translation: AAD17298.1 Different initiation.
AL590383 Genomic DNA No translation available.
AL583834 Genomic DNA No translation available.
BC030687 mRNA No translation available.
BC098434 mRNA Translation: AAH98434.1 Sequence problems.
AB015342 mRNA Translation: BAA34799.1
CCDSiCCDS4895.2 [Q5VUA4-1]
RefSeqiNP_055160.2, NM_014345.2 [Q5VUA4-1]
XP_011512754.1, XM_011514452.2
UniGeneiHs.509718

3D structure databases

ProteinModelPortaliQ5VUA4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117299, 43 interactors
IntActiQ5VUA4, 11 interactors
STRINGi9606.ENSP00000354964

PTM databases

iPTMnetiQ5VUA4
PhosphoSitePlusiQ5VUA4

Polymorphism and mutation databases

BioMutaiZNF318
DMDMi166215018

Proteomic databases

EPDiQ5VUA4
MaxQBiQ5VUA4
PaxDbiQ5VUA4
PeptideAtlasiQ5VUA4
PRIDEiQ5VUA4
ProteomicsDBi65403
65404 [Q5VUA4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361428; ENSP00000354964; ENSG00000171467 [Q5VUA4-1]
ENST00000605935; ENSP00000475748; ENSG00000171467 [Q5VUA4-2]
GeneIDi24149
KEGGihsa:24149
UCSCiuc003ouw.4 human [Q5VUA4-1]

Organism-specific databases

CTDi24149
DisGeNETi24149
EuPathDBiHostDB:ENSG00000171467.15
GeneCardsiZNF318
HGNCiHGNC:13578 ZNF318
HPAiHPA027022
HPA027031
MIMi617512 gene
neXtProtiNX_Q5VUA4
OpenTargetsiENSG00000171467
PharmGKBiPA134923137
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHGT Eukaryota
ENOG4111IJJ LUCA
GeneTreeiENSGT00390000000614
HOGENOMiHOG000043103
HOVERGENiHBG107139
InParanoidiQ5VUA4
OMAiQHNEKYK
OrthoDBiEOG091G00B9
PhylomeDBiQ5VUA4
TreeFamiTF350583

Miscellaneous databases

ChiTaRSiZNF318 human
GeneWikiiZNF318
GenomeRNAii24149
PROiPR:Q5VUA4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171467 Expressed in 214 organ(s), highest expression level in testis
CleanExiHS_ZNF318
ExpressionAtlasiQ5VUA4 baseline and differential
GenevisibleiQ5VUA4 HS

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
SMARTiView protein in SMART
SM00451 ZnF_U1, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN318_HUMAN
AccessioniPrimary (citable) accession number: Q5VUA4
Secondary accession number(s): O94796
, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again