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Entry version 144 (17 Jun 2020)
Sequence version 2 (15 Jan 2008)
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Protein

Zinc finger protein 318

Gene

ZNF318

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.By similarity
Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1063 – 1097Matrin-type 1Add BLAST35
Zinc fingeri1136 – 1166Matrin-type 2Add BLAST31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processMeiosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 318
Alternative name(s):
Endocrine regulatory protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF318
ORF Names:HRIHFB2436
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000171467.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13578 ZNF318

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617512 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VUA4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
24149

Open Targets

More...
OpenTargetsi
ENSG00000171467

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134923137

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5VUA4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF318

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166215018

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001918071 – 2279Zinc finger protein 318Add BLAST2279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1
Modified residuei205PhosphotyrosineBy similarity1
Modified residuei207PhosphoserineCombined sources1
Modified residuei214PhosphoserineCombined sources1
Modified residuei464PhosphoserineCombined sources1
Modified residuei472PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki547Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki553Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki566Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki578Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei842PhosphothreonineCombined sources1
Modified residuei1010PhosphoserineCombined sources1
Modified residuei1037PhosphoserineCombined sources1
Modified residuei1243PhosphoserineCombined sources1
Modified residuei1267PhosphoserineCombined sources1
Modified residuei1420PhosphoserineCombined sources1
Modified residuei1713PhosphoserineCombined sources1
Modified residuei1856PhosphoserineCombined sources1
Modified residuei1896PhosphoserineCombined sources1
Modified residuei1971PhosphoserineCombined sources1
Modified residuei2030PhosphoserineCombined sources1
Modified residuei2035PhosphoserineCombined sources1
Modified residuei2091PhosphoserineCombined sources1
Modified residuei2101PhosphoserineCombined sources1
Modified residuei2189PhosphoserineCombined sources1
Modified residuei2192PhosphoserineCombined sources1
Modified residuei2243PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5VUA4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5VUA4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5VUA4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5VUA4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VUA4

PeptideAtlas

More...
PeptideAtlasi
Q5VUA4

PRoteomics IDEntifications database

More...
PRIDEi
Q5VUA4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65403 [Q5VUA4-1]
65404 [Q5VUA4-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2091

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VUA4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VUA4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in endocrine tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171467 Expressed in testis and 213 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5VUA4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5VUA4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000171467 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Heterodimer of isoform 1 and isoform 2. Isoform 1 and isoform 2 interact with AR.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
117299, 53 interactors

Protein interaction database and analysis system

More...
IntActi
Q5VUA4, 30 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354964

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5VUA4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1092Interaction with ARBy similarityAdd BLAST1092

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili315 – 343Sequence analysisAdd BLAST29
Coiled coili876 – 980Sequence analysisAdd BLAST105
Coiled coili1768 – 1792Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi41 – 103Pro-richAdd BLAST63
Compositional biasi1201 – 1327Lys-richAdd BLAST127
Compositional biasi1433 – 1541Pro-richAdd BLAST109

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1063 – 1097Matrin-type 1Add BLAST35
Zinc fingeri1136 – 1166Matrin-type 2Add BLAST31

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHGT Eukaryota
ENOG4111IJJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000614

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_306659_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VUA4

Identification of Orthologs from Complete Genome Data

More...
OMAi
CQSRPYE

Database of Orthologous Groups

More...
OrthoDBi
44718at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VUA4

TreeFam database of animal gene trees

More...
TreeFami
TF350583

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00451 ZnF_U1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VUA4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYRSSARSSV SSHRPKDDGG GGPRSGRSSG SSSGPARRSS PPPPPSGSSS
60 70 80 90 100
RTPARRPRSP SGHRGRRASP SPPRGRRVSP SPPRARRGSP SPPRGRRLFP
110 120 130 140 150
PGPAGFRGSS RGESRADYAR DGRGDHPGDS GSRRRSPGLC SDSLEKSLRI
160 170 180 190 200
TVGNDHFCVS TPERRRLSDR LGSPVDNLED MDRDDLTDDS VFTRSSQCSR
210 220 230 240 250
GLERYISQEE GPLSPFLGQL DEDYRTKETF LHRSDYSPHI SCHDELLRGT
260 270 280 290 300
ERNREKLKGY SIRSEERSRE AKRPRYDDTV KINSMGGDHP SFTSGTRNYR
310 320 330 340 350
QRRRSPSPRF LDPEFRELDL ARRKREEEEE RSRSLSQELV GVDGGGTGCS
360 370 380 390 400
IPGLSGVLTA SEPGYSLHRP EEVSVMPKKS ILKKRIEVDI MEPSMQLESF
410 420 430 440 450
SSSTSSSQDH PLYSGHPSLP LSGAIAAFAS EIENKGTMVE TALKEPQGNL
460 470 480 490 500
YQWGPLPGIP KDNSPLREKF GSFLCHKDNL DLKAEGPERH TDFLLPHERA
510 520 530 540 550
SQDGSGFSRI LSMLADSTST QEKRRRSFPD IEDEEKFLYG DEEEDLKAES
560 570 580 590 600
VPKPLGSSES EVMRQKASSL PSSAPAVKLE SLEETNPEYA KIHDLLKTIG
610 620 630 640 650
LDIGVAEISQ LAARTQERLH GKKPSLRSSA DRRSSVDRYF SADHCSSVDH
660 670 680 690 700
RFSADRCSSV DHCFSADRRS SDPHRLESRE AHHSNTHSPE VSHPHPPSPV
710 720 730 740 750
DPYLLTKNSP PFLKSDHPVG HISGPEVVGS GFQSSVAVRC MLPSAPSAPI
760 770 780 790 800
RLPHTAALSQ FHMPRASQFA AARIPPNYQG PAIPPASFDA YRHYMAYAAS
810 820 830 840 850
RWPMYPTSQP SNHPVPEPHR IMPITKQATR SRPNLRVIPT VTPDKPKQKE
860 870 880 890 900
SLRGSIPAAQ VPVQVSIPSL IRYNPEKISD EKNRASQKQK VIEEREKLKN
910 920 930 940 950
DREARQKKMY YLRTELERLH KQQGEMLRKK RREKDGHKDP LLVEVSRLQD
960 970 980 990 1000
NIMKDIAELR QEAEEAEKKQ SELDKVAQIL GINIFDKSQK SLSDSREPTE
1010 1020 1030 1040 1050
KPGKAEKSKS PEKVSSFSNS SSNKESKVNN EKFRTKSPKP AESPQSATKQ
1060 1070 1080 1090 1100
LDQPTAAYEY YDAGNHWCKD CNTICGTMFD FFTHMHNKKH TQTLDPYNRP
1110 1120 1130 1140 1150
WASKTQSEAK QDAIKRTDKI TVPAKGSEFL VPISGFYCQL CEEFLGDPIS
1160 1170 1180 1190 1200
GEQHVKGHQH NEKYKKYVDE NPLYEERRNL DRQAGLAVVL ETERRRQSEL
1210 1220 1230 1240 1250
KRKLSEKPKE EKKEKKAKAV KEVKEDDKVS EKLEDQLSEG RNSPEKAENK
1260 1270 1280 1290 1300
RNTGIKLQLK EEVKKESPTS SSFGKFSWKK PEKEEEKSSL VTPSISKEEI
1310 1320 1330 1340 1350
LESSKDKEDG KTEAGKAKPI KIKLSGKTVV AHTSPWMPVV TTSTQTKIRP
1360 1370 1380 1390 1400
NLPIPSTVLR KSCSATMSKP APLNTFLSIK SSGTTAKPLP VVKESSADLL
1410 1420 1430 1440 1450
LPPDIISKAF GGEEVILKGS PEEKVVLAEK SEPSHLPEQI LPPPPPPPPP
1460 1470 1480 1490 1500
PPPPPPVIPH PAAPSAAQAN AILAPVKSNP VVSQTLSPGF VGPNILNPVL
1510 1520 1530 1540 1550
PVAIMASAQP AAIPSDETAP GVSESDRDQT LFSVLVRPPP PLSSVFSEQA
1560 1570 1580 1590 1600
KKLEKRNSCL ATANAKDLYD IFYSSGGKGA PETKGAPETK LSGGPLANGE
1610 1620 1630 1640 1650
NSNLSRTKSS DTSSTSPLNS SASQEELHQD EGLVAAPIVS NSEKPIAKTL
1660 1670 1680 1690 1700
VALGKWSVVE HVGPKSTGST YGFLQPLTRL CQSRPYETIT PKTDTLAIWT
1710 1720 1730 1740 1750
SSSFQSDTSR DISPEKSELD LGEPGPPGVE PPPQLLDIQC KESQKLVEIH
1760 1770 1780 1790 1800
LRESVNQDKE SQELRKSEDC RESEIETNTE LKERVKELSE GIVDEGVSTS
1810 1820 1830 1840 1850
IGPHSIDDSN LNHGNRYMWE GEVKQPNLLM IDKEAEQSNK LMTGSETPSK
1860 1870 1880 1890 1900
VVIKLSPQAC SFTKAKLDSF LSEARSLLNP QDTPVKISAP ELLLHSPARS
1910 1920 1930 1940 1950
AMCLTGSPQE QGVSVVSEEG LENSAPESAS RTSRYRSLKL KRERSKDFQV
1960 1970 1980 1990 2000
KKIYELAVWD ENKKRPETWE SPEKPKTEAL ELQDVHPELT VTIESKALED
2010 2020 2030 2040 2050
FEATDLKVEE LTALGNLGDM PVDFCTTRVS PAHRSPTVLC QKVCEENSVS
2060 2070 2080 2090 2100
PIGCNSSDPA DFEPIPSFSG FPLDSPKTLV LDFETEGERN SPNPRSVRIP
2110 2120 2130 2140 2150
SPNILKTGLT ENVDRGLGGL EGTHQALDLL AGGMMPEEVK ESSQLDKQES
2160 2170 2180 2190 2200
LGLELKTINS AGLGPSPCLP DLVDFVTRTS GVQKDKLCSP LSEPGDPSKC
2210 2220 2230 2240 2250
SSLELGPLQL EISNASTTEV AILQVDDDSG DPLNLVKAPV SRSPPREQVI
2260 2270
EDNMVPQGMP EQETTVGAIQ DHTESSVHN
Length:2,279
Mass (Da):251,112
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC8F7D54710E2450
GO
Isoform 2 (identifier: Q5VUA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1093-1117: TLDPYNRPWASKTQSEAKQDAIKRT → GQFQKSSDFQKEGLQQTFLPPERQG
     1118-2279: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:1,117
Mass (Da):124,880
Checksum:i65866465A953CF07
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQ37U3KQ37_HUMAN
Zinc finger protein 318
ZNF318
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD17298 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAD47387 differs from that shown. Reason: Frameshift.Curated
The sequence AAH98434 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 1214.Curated
The sequence AAH98434 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti62G → R in AAD47387 (Ref. 1) Curated1
Sequence conflicti75G → V in AAD47387 (Ref. 1) Curated1
Sequence conflicti75G → V in AAD17298 (Ref. 1) Curated1
Sequence conflicti1034 – 1035RT → CI in AAD47387 (Ref. 1) Curated2
Sequence conflicti1034 – 1035RT → CI in AAD17298 (Ref. 1) Curated2
Sequence conflicti1259L → F in AAD47387 (Ref. 1) Curated1
Sequence conflicti1259L → F in AAD17298 (Ref. 1) Curated1
Sequence conflicti1349R → G in AAD47387 (Ref. 1) Curated1
Sequence conflicti1349R → G in AAD17298 (Ref. 1) Curated1
Sequence conflicti2160S → F in AAD47387 (Ref. 1) Curated1
Sequence conflicti2160S → F in AAD17298 (Ref. 1) Curated1
Sequence conflicti2173V → D in BAA34799 (PubMed:9853615).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053759407S → I. Corresponds to variant dbSNP:rs34541323Ensembl.1
Natural variantiVAR_036056812N → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs141660717Ensembl.1
Natural variantiVAR_053760870L → V. Corresponds to variant dbSNP:rs9357410Ensembl.1
Natural variantiVAR_0360571274G → R in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0537611292T → I. Corresponds to variant dbSNP:rs10948072Ensembl.1
Natural variantiVAR_0537621580A → T. Corresponds to variant dbSNP:rs3734684Ensembl.1
Natural variantiVAR_0537631583T → I. Corresponds to variant dbSNP:rs36107018Ensembl.1
Natural variantiVAR_0537641797V → A1 PublicationCorresponds to variant dbSNP:rs1459675Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0165921093 – 1117TLDPY…AIKRT → GQFQKSSDFQKEGLQQTFLP PERQG in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0165931118 – 2279Missing in isoform 2. 1 PublicationAdd BLAST1162

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF090114 mRNA Translation: AAD47387.1 Frameshift.
AF121141 mRNA Translation: AAD17298.1 Different initiation.
AL590383 Genomic DNA No translation available.
AL583834 Genomic DNA No translation available.
BC030687 mRNA No translation available.
BC098434 mRNA Translation: AAH98434.1 Sequence problems.
AB015342 mRNA Translation: BAA34799.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4895.2 [Q5VUA4-1]

NCBI Reference Sequences

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RefSeqi
NP_055160.2, NM_014345.2 [Q5VUA4-1]
XP_011512754.1, XM_011514452.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361428; ENSP00000354964; ENSG00000171467 [Q5VUA4-1]
ENST00000605935; ENSP00000475748; ENSG00000171467 [Q5VUA4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
24149

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:24149

UCSC genome browser

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UCSCi
uc003ouw.4 human [Q5VUA4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090114 mRNA Translation: AAD47387.1 Frameshift.
AF121141 mRNA Translation: AAD17298.1 Different initiation.
AL590383 Genomic DNA No translation available.
AL583834 Genomic DNA No translation available.
BC030687 mRNA No translation available.
BC098434 mRNA Translation: AAH98434.1 Sequence problems.
AB015342 mRNA Translation: BAA34799.1
CCDSiCCDS4895.2 [Q5VUA4-1]
RefSeqiNP_055160.2, NM_014345.2 [Q5VUA4-1]
XP_011512754.1, XM_011514452.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117299, 53 interactors
IntActiQ5VUA4, 30 interactors
STRINGi9606.ENSP00000354964

PTM databases

GlyConnecti2091
iPTMnetiQ5VUA4
PhosphoSitePlusiQ5VUA4

Polymorphism and mutation databases

BioMutaiZNF318
DMDMi166215018

Proteomic databases

EPDiQ5VUA4
jPOSTiQ5VUA4
MassIVEiQ5VUA4
MaxQBiQ5VUA4
PaxDbiQ5VUA4
PeptideAtlasiQ5VUA4
PRIDEiQ5VUA4
ProteomicsDBi65403 [Q5VUA4-1]
65404 [Q5VUA4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
16456 86 antibodies

Genome annotation databases

EnsembliENST00000361428; ENSP00000354964; ENSG00000171467 [Q5VUA4-1]
ENST00000605935; ENSP00000475748; ENSG00000171467 [Q5VUA4-2]
GeneIDi24149
KEGGihsa:24149
UCSCiuc003ouw.4 human [Q5VUA4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
24149
DisGeNETi24149
EuPathDBiHostDB:ENSG00000171467.15

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF318
HGNCiHGNC:13578 ZNF318
HPAiENSG00000171467 Low tissue specificity
MIMi617512 gene
neXtProtiNX_Q5VUA4
OpenTargetsiENSG00000171467
PharmGKBiPA134923137

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHGT Eukaryota
ENOG4111IJJ LUCA
GeneTreeiENSGT00390000000614
HOGENOMiCLU_306659_0_0_1
InParanoidiQ5VUA4
OMAiCQSRPYE
OrthoDBi44718at2759
PhylomeDBiQ5VUA4
TreeFamiTF350583

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
24149 4 hits in 810 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF318 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZNF318

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
24149
PharosiQ5VUA4 Tbio

Protein Ontology

More...
PROi
PR:Q5VUA4
RNActiQ5VUA4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171467 Expressed in testis and 213 other tissues
ExpressionAtlasiQ5VUA4 baseline and differential
GenevisibleiQ5VUA4 HS

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
SMARTiView protein in SMART
SM00451 ZnF_U1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN318_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VUA4
Secondary accession number(s): O94796
, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 15, 2008
Last modified: June 17, 2020
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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