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Entry version 126 (13 Feb 2019)
Sequence version 1 (07 Dec 2004)
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Protein

DDB1- and CUL4-associated factor 12-like protein 1

Gene

DCAF12L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q5VU92

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 12-like protein 1
Alternative name(s):
WD repeat-containing protein 40B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCAF12L1
Synonyms:WDR40B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198889.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29395 DCAF12L1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VU92

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000198889

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165756488

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
DCAF12L1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762259

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003068481 – 463DDB1- and CUL4-associated factor 12-like protein 1Add BLAST463

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5VU92

MaxQB - The MaxQuant DataBase

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MaxQBi
Q5VU92

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VU92

PeptideAtlas

More...
PeptideAtlasi
Q5VU92

PRoteomics IDEntifications database

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PRIDEi
Q5VU92

ProteomicsDB human proteome resource

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ProteomicsDBi
65400

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VU92

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VU92

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198889 Expressed in 45 organ(s), highest expression level in caput epididymis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5VU92 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044737
HPA048981
HPA053138

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SH2D2AQ9NP313EBI-10694873,EBI-490630

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
126547, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q5VU92, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360167

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5VU92

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati87 – 137WD 1Add BLAST51
Repeati138 – 184WD 2Add BLAST47
Repeati185 – 252WD 3Add BLAST68
Repeati253 – 297WD 4Add BLAST45
Repeati298 – 341WD 5Add BLAST44
Repeati342 – 376WD 6Add BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat DCAF12 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KCCW Eukaryota
ENOG410XTH6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000165384

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000047356

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG055605

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VU92

Identification of Orthologs from Complete Genome Data

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OMAi
FDMCWLD

Database of Orthologous Groups

More...
OrthoDBi
885170at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VU92

TreeFam database of animal gene trees

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TreeFami
TF323731

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5VU92-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQQQTGSRK RKAPAVEADA ESSPSQGLAA ADGEGPLLLK RQRRPATYRS
60 70 80 90 100
MAHYLKVREV GGWGPARLQG FDGELRGYAV QRLPELLTER QLELGTVNKV
110 120 130 140 150
FASQWLNSRQ VVCGTKCNTL FVVDVESGHI ARIPLLRDSE ARLAQDQQGC
160 170 180 190 200
GIHAIELNPS KTLLATGGEN PNSLAIYQLP SLDPLCLGDR HGHKDWIFAV
210 220 230 240 250
AWLSDTVAVS GSRDGTVALW RMDPDKFDDT VAWHSEVGLP VYAHIRPRDV
260 270 280 290 300
EAIPRAIINP SNRKVRALAC GGKNQELGAV SLDGYFHLWK AGSALSRLLS
310 320 330 340 350
IRLPYFRDNV CLTYCDDMSV YAVGSHSHVS FLDLRQDQQN IRPLCSREGG
360 370 380 390 400
TGVRSLSFYR HIITVGTGQG SLLFYDVRAQ KFLEERASAT LESSSGPARR
410 420 430 440 450
KLRLACGRGW LNHNDFWVNY FGGMEVFPNA LYTHCYNWPE MKLFVAGGPL
460
PAGLHGNYAG LWS
Length:463
Mass (Da):51,201
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD499893FBE4D4E49
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03532319D → G1 PublicationCorresponds to variant dbSNP:rs11095722Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL590425 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11841.1
BC035674 mRNA Translation: AAH35674.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14610.1

NCBI Reference Sequences

More...
RefSeqi
NP_848565.2, NM_178470.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.120403

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371126; ENSP00000360167; ENSG00000198889

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
139170

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:139170

UCSC genome browser

More...
UCSCi
uc004eul.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590425 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11841.1
BC035674 mRNA Translation: AAH35674.1
CCDSiCCDS14610.1
RefSeqiNP_848565.2, NM_178470.4
UniGeneiHs.120403

3D structure databases

ProteinModelPortaliQ5VU92
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126547, 2 interactors
IntActiQ5VU92, 1 interactor
STRINGi9606.ENSP00000360167

PTM databases

iPTMnetiQ5VU92
PhosphoSitePlusiQ5VU92

Polymorphism and mutation databases

BioMutaiDCAF12L1
DMDMi74762259

Proteomic databases

EPDiQ5VU92
MaxQBiQ5VU92
PaxDbiQ5VU92
PeptideAtlasiQ5VU92
PRIDEiQ5VU92
ProteomicsDBi65400

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
139170
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371126; ENSP00000360167; ENSG00000198889
GeneIDi139170
KEGGihsa:139170
UCSCiuc004eul.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
139170
EuPathDBiHostDB:ENSG00000198889.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DCAF12L1
HGNCiHGNC:29395 DCAF12L1
HPAiHPA044737
HPA048981
HPA053138
neXtProtiNX_Q5VU92
OpenTargetsiENSG00000198889
PharmGKBiPA165756488

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KCCW Eukaryota
ENOG410XTH6 LUCA
GeneTreeiENSGT00940000165384
HOGENOMiHOG000047356
HOVERGENiHBG055605
InParanoidiQ5VU92
OMAiFDMCWLD
OrthoDBi885170at2759
PhylomeDBiQ5VU92
TreeFamiTF323731

Enzyme and pathway databases

SignaLinkiQ5VU92

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
139170

Protein Ontology

More...
PROi
PR:Q5VU92

Gene expression databases

BgeeiENSG00000198889 Expressed in 45 organ(s), highest expression level in caput epididymis
GenevisibleiQ5VU92 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDC121_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VU92
Secondary accession number(s): Q8IYK3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 7, 2004
Last modified: February 13, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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