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Entry version 85 (13 Feb 2019)
Sequence version 1 (07 Dec 2004)
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Protein

Uncharacterized protein C1orf189

Gene

C1orf189

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C1orf189
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000163263.6

Human Gene Nomenclature Database

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HGNCi
HGNC:32305 C1orf189

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VU69

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672400

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C1orf189

Domain mapping of disease mutations (DMDM)

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DMDMi
74747059

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002709661 – 101Uncharacterized protein C1orf189Add BLAST101

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q5VU69

PeptideAtlas

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PeptideAtlasi
Q5VU69

PRoteomics IDEntifications database

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PRIDEi
Q5VU69

ProteomicsDB human proteome resource

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ProteomicsDBi
65393

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000163263 Expressed in 79 organ(s), highest expression level in right uterine tube

Organism-specific databases

Human Protein Atlas

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HPAi
HPA045779

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
132817, 2 interactors

Protein interaction database and analysis system

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IntActi
Q5VU69, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000357511

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q5VU69

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5VU69

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J0HY Eukaryota
ENOG4111DUP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000048901

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000111268

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG079899

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5VU69

Identification of Orthologs from Complete Genome Data

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OMAi
YAILRMQ

Database of Orthologous Groups

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OrthoDBi
1553237at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q5VU69

TreeFam database of animal gene trees

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TreeFami
TF341125

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029375 DUF4558

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15104 DUF4558, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5VU69-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVEKMTKVE ESFQKAMGLK KTVDRWRNSH THCLWQMALG QRRNPYATLR
60 70 80 90 100
MQDTMVQELA LAKKQLLMVR QAALHQLFEK EHQQYQQELN QMGKAFYVER

F
Length:101
Mass (Da):12,131
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FA55630DCDEC78B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL590431 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53228.1
BC127710 mRNA Translation: AAI27711.1
BC130509 mRNA Translation: AAI30510.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS30876.1

NCBI Reference Sequences

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RefSeqi
NP_001010979.1, NM_001010979.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.104967

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368525; ENSP00000357511; ENSG00000163263

Database of genes from NCBI RefSeq genomes

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GeneIDi
388701

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:388701

UCSC genome browser

More...
UCSCi
uc001fee.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590431 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53228.1
BC127710 mRNA Translation: AAI27711.1
BC130509 mRNA Translation: AAI30510.1
CCDSiCCDS30876.1
RefSeqiNP_001010979.1, NM_001010979.2
UniGeneiHs.104967

3D structure databases

ProteinModelPortaliQ5VU69
SMRiQ5VU69
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132817, 2 interactors
IntActiQ5VU69, 2 interactors
STRINGi9606.ENSP00000357511

Polymorphism and mutation databases

BioMutaiC1orf189
DMDMi74747059

Proteomic databases

PaxDbiQ5VU69
PeptideAtlasiQ5VU69
PRIDEiQ5VU69
ProteomicsDBi65393

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
388701
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368525; ENSP00000357511; ENSG00000163263
GeneIDi388701
KEGGihsa:388701
UCSCiuc001fee.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
388701
EuPathDBiHostDB:ENSG00000163263.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C1orf189
HGNCiHGNC:32305 C1orf189
HPAiHPA045779
neXtProtiNX_Q5VU69
PharmGKBiPA142672400

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J0HY Eukaryota
ENOG4111DUP LUCA
GeneTreeiENSGT00510000048901
HOGENOMiHOG000111268
HOVERGENiHBG079899
InParanoidiQ5VU69
OMAiYAILRMQ
OrthoDBi1553237at2759
PhylomeDBiQ5VU69
TreeFamiTF341125

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
388701

Protein Ontology

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PROi
PR:Q5VU69

Gene expression databases

BgeeiENSG00000163263 Expressed in 79 organ(s), highest expression level in right uterine tube

Family and domain databases

InterProiView protein in InterPro
IPR029375 DUF4558
PfamiView protein in Pfam
PF15104 DUF4558, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCA189_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VU69
Secondary accession number(s): A1L4E3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 7, 2004
Last modified: February 13, 2019
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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