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Protein

Myomegalin

Gene

PDE4DIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity).By similarity
Isoform 13: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697).4 Publications

Caution

Was initially reported to localize in the cytoplasm and nucleus (PubMed:11374908). However, many reports in different species have shown that it is associated with the Golgi apparatus and the centrosome.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei742 – 743Breakpoint for insertion to form PDE4DIP-PDGFRB fusion protein2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • protein-containing complex scaffold activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

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SIGNORi
Q5VU43

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myomegalin
Alternative name(s):
Cardiomyopathy-associated protein 2
Phosphodiesterase 4D-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDE4DIP
Synonyms:CMYA2, KIAA0454, KIAA0477, MMGL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000178104.19

Human Gene Nomenclature Database

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HGNCi
HGNC:15580 PDE4DIP

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608117 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VU43

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving PDE4DIP may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP-PDGFRB fusion protein.1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
653513
9659

Open Targets

More...
OpenTargetsi
ENSG00000178104

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33131

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PDE4DIP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74747041

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003076901 – 2346MyomegalinAdd BLAST2346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei704PhosphothreonineCombined sources1
Isoform 2 (identifier: Q5VU43-2)
Modified residuei252PhosphoserineCombined sources1
Isoform 13 (identifier: Q5VU43-13)
Modified residuei252PhosphoserineCombined sources3 Publications1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5VU43

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5VU43

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q5VU43

PeptideAtlas

More...
PeptideAtlasi
Q5VU43

PRoteomics IDEntifications database

More...
PRIDEi
Q5VU43

ProteomicsDB human proteome resource

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ProteomicsDBi
65374
65375 [Q5VU43-10]
65376 [Q5VU43-11]
65377 [Q5VU43-12]
65378 [Q5VU43-2]
65379 [Q5VU43-3]
65380 [Q5VU43-4]
65381 [Q5VU43-6]
65382 [Q5VU43-7]
65383 [Q5VU43-8]
65384 [Q5VU43-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VU43

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VU43

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in adult and fetal heart, in skeletal muscle and, to a lower extent, in brain and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000178104 Expressed in 227 organ(s), highest expression level in gastrocnemius

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5VU43 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q5VU43 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA008162
HPA012678

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PDE4D (By similarity). Isoform 13 interacts with MAPRE1 and MAPRE3 (PubMed:25217626, PubMed:28814570, PubMed:29162697). Isoform 13 forms a pericentrosomal complex with AKAP9, CDK5RAP2 and EB1/MAPRE1; within this complex, may mediate MAPRE1-binding to CDK5RAP2 (PubMed:29162697). Interaction of isoform 13 with AKAP9 stabilizes both proteins (PubMed:25217626, PubMed:27666745). Isoform 13 interacts (via N-terminus) with CAMSAP2; this interaction is much stronger in the presence of AKAP9 (PubMed:27666745). In complex with AKAP9, Isoform 13 recruits CAMSAP2 to the Golgi apparatus (PubMed:27666745, PubMed:28814570). Isoform 13 interacts with unglycosylated LGALS3BP; this interaction may connect the pericentrosomal complex to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (PubMed:25217626, PubMed:29162697).By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115017, 144 interactors

Database of interacting proteins

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DIPi
DIP-51263N

Protein interaction database and analysis system

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IntActi
Q5VU43, 113 interactors

Molecular INTeraction database

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MINTi
Q5VU43

STRING: functional protein association networks

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STRINGi
9606.ENSP00000358363

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q5VU43

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5VU43

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1551 – 1642NBPFPROSITE-ProRule annotationAdd BLAST92

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili41 – 132Sequence analysisAdd BLAST92
Coiled coili162 – 205Sequence analysisAdd BLAST44
Coiled coili238 – 318Sequence analysisAdd BLAST81
Coiled coili350 – 684Sequence analysisAdd BLAST335
Coiled coili743 – 936Sequence analysisAdd BLAST194
Coiled coili1002 – 1043Sequence analysisAdd BLAST42
Coiled coili1096 – 1124Sequence analysisAdd BLAST29
Coiled coili1212 – 1240Sequence analysisAdd BLAST29
Coiled coili1346 – 1385Sequence analysisAdd BLAST40
Coiled coili1431 – 1455Sequence analysisAdd BLAST25
Coiled coili1736 – 1760Sequence analysisAdd BLAST25
Coiled coili1840 – 2077Sequence analysisAdd BLAST238
Coiled coili2273 – 2312Sequence analysisAdd BLAST40

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Isoform 13: residues 1-150 are involved in AKAP9-binding.1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J2NR Eukaryota
ENOG411281S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063845

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108166

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5VU43

KEGG Orthology (KO)

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KOi
K16549

Identification of Orthologs from Complete Genome Data

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OMAi
LNTVLQC

Database of Orthologous Groups

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OrthoDBi
15127at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q5VU43

TreeFam database of animal gene trees

More...
TreeFami
TF329233

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012943 Cnn_1N
IPR010630 Olduvai_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07989 Cnn_1N, 1 hit
PF06758 Olduvai, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01148 DUF1220, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51316 NBPF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 12 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 12 described isoforms and 20 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VU43-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNGYRTLSQ HLNDLKKENF SLKLRIYFLE ERMQQKYEAS REDIYKRNIE
60 70 80 90 100
LKVEVESLKR ELQDKKQHLD KTWADVENLN SQNEAELRRQ FEERQQETEH
110 120 130 140 150
VYELLENKIQ LLQEESRLAK NEAARMAALV EAEKECNLEL SEKLKGVTKN
160 170 180 190 200
WEDVPGDQVK PDQYTEALAQ RDKRIEELNQ SLAAQERLVE QLSREKQQLL
210 220 230 240 250
HLLEEPTSME VQPMTEELLK QQKLNSHETT ITQQSVSDSH LAELQEKIQQ
260 270 280 290 300
TEATNKILQE KLNEMSYELK CAQESSQKQD GTIQNLKETL KSRERETEEL
310 320 330 340 350
YQVIEGQNDT MAKLREMLHQ SQLGQLHSSE GTSPAQQQVA LLDLQSALFC
360 370 380 390 400
SQLEIQKLQR VVRQKERQLA DAKQCVQFVE AAAHESEQQK EASWKHNQEL
410 420 430 440 450
RKALQQLQEE LQNKSQQLRA WEAEKYNEIR TQEQNIQHLN HSLSHKEQLL
460 470 480 490 500
QEFRELLQYR DNSDKTLEAN EMLLEKLRQR IHDKAVALER AIDEKFSALE
510 520 530 540 550
EKEKELRQLR LAVRERDHDL ERLRDVLSSN EATMQSMESL LRAKGLEVEQ
560 570 580 590 600
LSTTCQNLQW LKEEMETKFS RWQKEQESII QQLQTSLHDR NKEVEDLSAT
610 620 630 640 650
LLCKLGPGQS EIAEELCQRL QRKERMLQDL LSDRNKQVLE HEMEIQGLLQ
660 670 680 690 700
SVSTREQESQ AAAEKLVQAL MERNSELQAL RQYLGGRDSL MSQAPISNQQ
710 720 730 740 750
AEVTPTGRLG KQTDQGSMQI PSRDDSTSLT AKEDVSIPRS TLGDLDTVAG
760 770 780 790 800
LEKELSNAKE ELELMAKKER ESQMELSALQ SMMAVQEEEL QVQAADMESL
810 820 830 840 850
TRNIQIKEDL IKDLQMQLVD PEDIPAMERL TQEVLLLREK VASVESQGQE
860 870 880 890 900
ISGNRRQQLL LMLEGLVDER SRLNEALQAE RQLYSSLVKF HAHPESSERD
910 920 930 940 950
RTLQVELEGA QVLRSRLEEV LGRSLERLNR LETLAAIGGA AAGDDTEDTS
960 970 980 990 1000
TEFTDSIEEE AAHHSHQQLV KVALEKSLAT VETQNPSFSP PSPMGGDSNR
1010 1020 1030 1040 1050
CLQEEMLHLR AEFHQHLEEK RKAEEELKEL KAQIEEAGFS SVSHIRNTML
1060 1070 1080 1090 1100
SLCLENAELK EQMGEAMSDG WEIEEDKEKG EVMVETVVTK EGLSESSLQA
1110 1120 1130 1140 1150
EFRKLQGKLK NAHNIINLLK EQLVLSSKEG NSKLTPELLV HLTSTIERIN
1160 1170 1180 1190 1200
TELVGSPGKH QHQEEGNVTV RPFPRPQSLD LGATFTVDAH QLDNQSQPRD
1210 1220 1230 1240 1250
PGPQSAFSLP GSTQHLRSQL SQCKQRYQDL QEKLLLSEAT VFAQANELEK
1260 1270 1280 1290 1300
YRVMLTGESL VKQDSKQIQV DLQDLGYETC GRSENEAERE ETTSPECEEH
1310 1320 1330 1340 1350
NSLKEMVLME GLCSEQGRRG STLASSSERK PLENQLGKQE EFRVYGKSEN
1360 1370 1380 1390 1400
ILVLRKDIKD LKAQLQNANK VIQNLKSRVR SLSVTSDYSS SLERPRKLRA
1410 1420 1430 1440 1450
VGTLEGSSPH SVPDEDEGWL SDGTGAFYSP GLQAKKDLES LIQRVSQLEA
1460 1470 1480 1490 1500
QLPKNGLEEK LAEELRSASW PGKYDSLIQD QARELSYLRQ KIREGRGICY
1510 1520 1530 1540 1550
LITRHAKDTV KSFEDLLRSN DIDYYLGQSF REQLAQGSQL TERLTSKLST
1560 1570 1580 1590 1600
KDHKSEKDQA GLEPLALRLS RELQEKEKVI EVLQAKLDAR SLTPSSSHAL
1610 1620 1630 1640 1650
SDSHRSPSST SFLSDELEAC SDMDIVSEYT HYEEKKASPS HSDSIHHSSH
1660 1670 1680 1690 1700
SAVLSSKPSS TSASQGAKAE SNSNPISLPT PQNTPKEANQ AHSGFHFHSI
1710 1720 1730 1740 1750
PKLASLPQAP LPSAPSSFLP FSPTGPLLLG CCETPVVSLA EAQQELQMLQ
1760 1770 1780 1790 1800
KQLGESASTV PPASTATLLS NDLEADSSYY LNSAQPHSPP RGTIELGRIL
1810 1820 1830 1840 1850
EPGYLGSSGK WDVMRPQKGS VSGDLSSGSS VYQLNSKPTG ADLLEEHLGE
1860 1870 1880 1890 1900
IRNLRQRLEE SICINDRLRE QLEHRLTSTA RGRGSTSNFY SQGLESIPQL
1910 1920 1930 1940 1950
CNENRVLRED NRRLQAQLSH VSREHSQETE SLREALLSSR SHLQELEKEL
1960 1970 1980 1990 2000
EHQKVERQQL LEDLREKQQE VLHFREERLS LQENDSRLQH KLVLLQQQCE
2010 2020 2030 2040 2050
EKQQLFESLQ SELQIYEALY GNSKKGLKAY SLDACHQIPL SSDLSHLVAE
2060 2070 2080 2090 2100
VRALRGQLEQ SIQGNNCLRL QLQQQLESGA GKASLSPSSI NQNFPASTDP
2110 2120 2130 2140 2150
GNKQLLLQDS AVSPPVRDVG MNSPALVFPS SASSTPGSET PIINRANGLG
2160 2170 2180 2190 2200
LDTSPVMKTP PKLEGDATDG SFANKHGRHV IGHIDDYSAL RQQIAEGKLL
2210 2220 2230 2240 2250
VKKIVSLVRS ACSFPGLEAQ GTEVLGSKGI HELRSSTSAL HHALEESASL
2260 2270 2280 2290 2300
LTMFWRAALP STHIPVLPGK VGESTERELL ELRTKVSKQE RLLQSTTEHL
2310 2320 2330 2340
KNANQQKESM EQFIVSQLTR THDVLKKART NLEVKSLRAL PCTPAL
Length:2,346
Mass (Da):265,103
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A29AA1514759B0C
GO
Isoform 2 (identifier: Q5VU43-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-210: MSNGYRTLSQ...HLLEEPTSME → MKEICRICAR...DLCEDYLPLR
     970-2346: Missing.

Show »
Length:1,132
Mass (Da):128,518
Checksum:i40C7CC8FCA2D77C4
GO
Isoform 3 (identifier: Q5VU43-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MSNGYRTLSQ → MEQTWTRDYF...QTQALRDFEK
     1082-1191: Missing.
     1695-1756: Missing.

Note: No experimental confirmation available.
Show »
Length:2,240
Mass (Da):254,069
Checksum:i91F0BA4B645E89DD
GO
Isoform 4 (identifier: Q5VU43-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2334-2346: VKSLRALPCTPAL → EPCKKRSHQKSLKQQERWACPPFVQLPIC

Show »
Length:2,362
Mass (Da):267,200
Checksum:iC47E0094FB787B0D
GO
Isoform 6 (identifier: Q5VU43-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     970-2346: Missing.

Show »
Length:969
Mass (Da):112,285
Checksum:iFCFA6AC1FF598B7A
GO
Isoform 7 (identifier: Q5VU43-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     968-988: QLVKVALEKSLATVETQNPSF → QVSQCQGLGLPGWTAHSPSEV
     989-2346: Missing.

Show »
Length:988
Mass (Da):114,207
Checksum:i53A63137BFF77658
GO
Isoform 8 (identifier: Q5VU43-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MSNGYRTLSQ → MKGTDSGSCC...QTQALRDFEK
     174-2346: Missing.

Show »
Length:310
Mass (Da):36,121
Checksum:i0E2AF02001FE1AD7
GO
Isoform 9 (identifier: Q5VU43-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MSNGYRTLSQ → MKGTDSGSCC...QTQALRDFEK
     174-174: R → I
     175-2346: Missing.

Show »
Length:311
Mass (Da):36,234
Checksum:iCB2E2AF02001FE1A
GO
Isoform 10 (identifier: Q5VU43-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-174: R → I
     175-2346: Missing.

Show »
Length:174
Mass (Da):20,798
Checksum:i1A5F8C9A64D2F3F7
GO
Isoform 11 (identifier: Q5VU43-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-2346: Missing.

Show »
Length:173
Mass (Da):20,685
Checksum:iEF8C9A64D2F3F758
GO
Isoform 12 (identifier: Q5VU43-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MSNGYRTLSQ → MEQTWTRDYF...QTQALRDFEK
     174-174: R → I
     175-2346: Missing.

Show »
Length:240
Mass (Da):28,507
Checksum:iF145659765664C06
GO
Isoform 13 (identifier: Q5VU43-13) [UniParc]FASTAAdd to basket
Also known as: Myomegalin variant 81 Publication, MMG2 Publications, MMG81 Publication, Short myomegalin-like EB1 binding protein1 Publication, SMYLE1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-210: MSNGYRTLSQ...HLLEEPTSME → MKEICRICAR...DLCEDYLPLR
     940-953: AAAGDDTEDTSTEF → GELESVRIHHKHAY
     954-2346: Missing.

Note: Mutagenesis at position 311-312:LP->AA (loss of MAPRE1- and MAPRE3-binding and loss of association with microtubule ends, no effect on AKAP9- and CDK5RAP2-binding, relocalizes from EB1/MAPRE1 microtubule ends to centrosomal area).Combined sources3 Publications
Show »
Length:1,116
Mass (Da):126,950
Checksum:i38947C0DFF2C49AD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVF8A0A087WVF8_HUMAN
Myomegalin
PDE4DIP
2,240Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRM1A0A0A0MRM1_HUMAN
Myomegalin
PDE4DIP
2,362Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A075B749A0A075B749_HUMAN
Myomegalin
PDE4DIP
2,482Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYE4A0A087WYE4_HUMAN
Myomegalin
PDE4DIP
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WX83A0A087WX83_HUMAN
Myomegalin
PDE4DIP
2,431Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PS60E9PS60_HUMAN
Myomegalin
PDE4DIP
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVQ4A0A087WVQ4_HUMAN
Myomegalin
PDE4DIP
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWY1A0A087WWY1_HUMAN
Myomegalin
PDE4DIP
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWI2A0A087WWI2_HUMAN
Myomegalin
PDE4DIP
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0I1A0A087X0I1_HUMAN
Myomegalin
PDE4DIP
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH04860 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA32299 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA32322 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAD91152 differs from that shown. Reason: Frameshift at position 1507.Curated
The sequence CAH18128 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33M → T in CAD89923 (PubMed:17974005).Curated1
Sequence conflicti98T → M in BAB17761 (PubMed:11374908).Curated1
Sequence conflicti98T → M in BAB17762 (PubMed:11374908).Curated1
Sequence conflicti109I → M in BAB17759 (PubMed:11374908).Curated1
Sequence conflicti109I → M in BAB17760 (PubMed:11374908).Curated1
Sequence conflicti109I → M in BAB17761 (PubMed:11374908).Curated1
Sequence conflicti109I → M in BAB17762 (PubMed:11374908).Curated1
Sequence conflicti109I → M in AAH25406 (PubMed:15489334).Curated1
Sequence conflicti109I → M in AAI10295 (PubMed:15489334).Curated1
Sequence conflicti401R → Q in CAD91152 (PubMed:17974005).Curated1
Sequence conflicti643M → V in CAD91152 (PubMed:17974005).Curated1
Sequence conflicti776L → P in CAD91152 (PubMed:17974005).Curated1
Sequence conflicti783M → I in CAD38529 (PubMed:17974005).Curated1
Sequence conflicti783M → I in AAI32718 (PubMed:15489334).Curated1
Sequence conflicti830L → P in CAD91152 (PubMed:17974005).Curated1
Sequence conflicti863L → P in CAD38529 (PubMed:17974005).Curated1
Sequence conflicti1266K → E in CAH18128 (PubMed:17974005).Curated1
Sequence conflicti1286E → G in CAD91152 (PubMed:17974005).Curated1
Sequence conflicti1356K → R in CAD91152 (PubMed:17974005).Curated1
Sequence conflicti1397K → E in CAD91152 (PubMed:17974005).Curated1
Sequence conflicti1454K → E in CAH18128 (PubMed:17974005).Curated1
Sequence conflicti1504R → Q in CAH18128 (PubMed:17974005).Curated1
Sequence conflicti1598H → R in CAH18128 (PubMed:17974005).Curated1
Sequence conflicti1610T → P in CAH18128 (PubMed:17974005).Curated1
Sequence conflicti1727L → P in CAH18128 (PubMed:17974005).Curated1
Sequence conflicti1757A → T in CAH18128 (PubMed:17974005).Curated1
Sequence conflicti1867R → C in CAH18128 (PubMed:17974005).Curated1
Sequence conflicti1910D → E in CAH18128 (PubMed:17974005).Curated1
Sequence conflicti2001E → G in CAH18128 (PubMed:17974005).Curated1
Sequence conflicti2088Missing in CAH18128 (PubMed:17974005).Curated1
Sequence conflicti2291R → Q in CAH18128 (PubMed:17974005).Curated1
Sequence conflicti2317Q → R in CAH18128 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03662713N → S. Corresponds to variant dbSNP:rs3010980Ensembl.1
Natural variantiVAR_03662825R → L. Corresponds to variant dbSNP:rs1664022Ensembl.1
Natural variantiVAR_03662949I → T2 PublicationsCorresponds to variant dbSNP:rs573724Ensembl.1
Natural variantiVAR_056951143K → E. Corresponds to variant dbSNP:rs1747958Ensembl.1
Natural variantiVAR_056952150N → S. Corresponds to variant dbSNP:rs3010980Ensembl.1
Natural variantiVAR_036630167A → T. Corresponds to variant dbSNP:rs2590120Ensembl.1
Natural variantiVAR_051204171R → K. Corresponds to variant dbSNP:rs3121544Ensembl.1
Natural variantiVAR_051205391E → A. Corresponds to variant dbSNP:rs1324366Ensembl.1
Natural variantiVAR_051206410E → V. Corresponds to variant dbSNP:rs1061308Ensembl.1
Natural variantiVAR_051207482H → R. Corresponds to variant dbSNP:rs1698681Ensembl.1
Natural variantiVAR_051208681R → H. Corresponds to variant dbSNP:rs1629011Ensembl.1
Natural variantiVAR_051209708R → C2 PublicationsCorresponds to variant dbSNP:rs1628172Ensembl.1
Natural variantiVAR_0512101013F → I1 PublicationCorresponds to variant dbSNP:rs1698624Ensembl.1
Natural variantiVAR_0512111066A → T1 PublicationCorresponds to variant dbSNP:rs1698647Ensembl.1
Natural variantiVAR_0512121359K → E1 PublicationCorresponds to variant dbSNP:rs1747958Ensembl.1
Natural variantiVAR_0802321396R → W. Corresponds to variant dbSNP:rs2798901Ensembl.1
Natural variantiVAR_0512131736V → E1 PublicationCorresponds to variant dbSNP:rs1778159Ensembl.1
Natural variantiVAR_0512141742A → S1 PublicationCorresponds to variant dbSNP:rs1698605Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0287721 – 210MSNGY…PTSME → MKEICRICARELCGNQRRWI FHTASKLNLQVLLSHVLGKD VPRDGKAEFACSKCAFMLDR IYRFDTVIARIEALSIERLQ KLLLEKDRLKFCIASMYRKN NDDSGAEIKAGNGTVDMSVL PDARYSALLQEDFAYSGFEC WVENEDQIQEPHSCHGSEGP GNRPRRCRGCAALRVADSDY EAICKVPRKVARSISCGPSS RWSTSICTEEPALSEVGPPD LASTKVPPDGESMEEETPGS SVESLDASVQASPPQQKDEE TERSAKELGKCDCCSDDQAP QHGCNHKLELALSMIKGLDY KPIQSPRGSRLPIPVKSSLP GAKPGPSMTDGVSSGFLNRS LKPLYKTPVSYPLELSDLQE LWDDLCEDYLPLR in isoform 2 and isoform 13. 2 PublicationsAdd BLAST210
Alternative sequenceiVSP_0287731 – 10MSNGYRTLSQ → MEQTWTRDYFAEDDGEMVPR TSHTAAFLSDTKDRGPPVQS QIWRSGEKVPFVQTYSLRAF EKPPQVQTQALRDFEK in isoform 3 and isoform 12. 2 Publications10
Alternative sequenceiVSP_0287741 – 10MSNGYRTLSQ → MKGTDSGSCCRRRCDFGCCC RASRRAHYTPYRSGDATRTP QSPRQTPSRERRRPEPAGSW AAAAEEEEAAAAATPWMRDY FAEDDGEMVPRTSHTAAFLS DTKDRGPPVQSQIWRSGEKV PFVQTYSLRAFEKPPQVQTQ ALRDFEK in isoform 8 and isoform 9. 1 Publication10
Alternative sequenceiVSP_028775174 – 2346Missing in isoform 8 and isoform 11. 2 PublicationsAdd BLAST2173
Alternative sequenceiVSP_028776174R → I in isoform 9, isoform 10 and isoform 12. 2 Publications1
Alternative sequenceiVSP_028777175 – 2346Missing in isoform 9, isoform 10 and isoform 12. 2 PublicationsAdd BLAST2172
Alternative sequenceiVSP_059333940 – 953AAAGD…TSTEF → GELESVRIHHKHAY in isoform 13. Add BLAST14
Alternative sequenceiVSP_059334954 – 2346Missing in isoform 13. Add BLAST1393
Alternative sequenceiVSP_028778968 – 988QLVKV…QNPSF → QVSQCQGLGLPGWTAHSPSE V in isoform 7. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_028779970 – 2346Missing in isoform 2 and isoform 6. 3 PublicationsAdd BLAST1377
Alternative sequenceiVSP_028780989 – 2346Missing in isoform 7. 1 PublicationAdd BLAST1358
Alternative sequenceiVSP_0287811082 – 1191Missing in isoform 3. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_0287821695 – 1756Missing in isoform 3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_0287832334 – 2346VKSLR…CTPAL → EPCKKRSHQKSLKQQERWAC PPFVQLPIC in isoform 4. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB042555 mRNA Translation: BAB17759.1
AB042556 mRNA Translation: BAB17760.1
AB042557 mRNA Translation: BAB17761.1
AB042558 mRNA Translation: BAB17762.1
AB007923 mRNA Translation: BAA32299.2 Different initiation.
AB007946 mRNA Translation: BAA32322.2 Different initiation.
HQ333476 mRNA Translation: ADO32613.1
AL831815 mRNA Translation: CAD38529.1
AL832024 mRNA Translation: CAD89923.1
AL833273 mRNA Translation: CAD91152.1 Frameshift.
CR749273 mRNA Translation: CAH18128.1 Sequence problems.
AL590452, AL138791 Genomic DNA Translation: CAH72521.1
AL590452, AL138796 Genomic DNA Translation: CAH72522.1
AL590452, AL138796 Genomic DNA Translation: CAH72523.1
AL590452, AL138796 Genomic DNA Translation: CAH72524.1
AL590452 Genomic DNA Translation: CAH72525.1
AL590452, AL138796 Genomic DNA Translation: CAH72526.1
AL590452, AL138796 Genomic DNA Translation: CAH72527.1
AL590452, AL138796 Genomic DNA Translation: CAH72528.1
AL138791, AL590452 Genomic DNA Translation: CAI22527.1
AL138796, AL590452 Genomic DNA Translation: CAI22822.1
AL138796, AL590452 Genomic DNA Translation: CAI22823.1
AL138796, AL590452 Genomic DNA Translation: CAI22824.1
AL138796, AL590452 Genomic DNA Translation: CAI22825.1
AL138796, AL590452 Genomic DNA Translation: CAI22826.1
AL138796, AL590452 Genomic DNA Translation: CAI22827.1
AC239802 Genomic DNA No translation available.
AC245389 Genomic DNA No translation available.
AC239804 Genomic DNA No translation available.
BC004860 mRNA Translation: AAH04860.1 Sequence problems.
BC025406 mRNA Translation: AAH25406.1
BC078660 mRNA Translation: AAH78660.1
BC110294 mRNA Translation: AAI10295.1
BC132717 mRNA Translation: AAI32718.1
BC152439 mRNA Translation: AAI52440.1
DA900724 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS72887.1 [Q5VU43-8]
CCDS72888.1 [Q5VU43-3]
CCDS72890.1 [Q5VU43-6]
CCDS72891.1 [Q5VU43-1]
CCDS72892.1 [Q5VU43-4]
CCDS72893.1 [Q5VU43-11]
CCDS72894.1 [Q5VU43-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00069
T00259

NCBI Reference Sequences

More...
RefSeqi
NP_001002810.1, NM_001002810.3 [Q5VU43-11]
NP_001002811.2, NM_001002811.2 [Q5VU43-2]
NP_001002812.2, NM_001002812.2 [Q5VU43-6]
NP_001182189.1, NM_001195260.1
NP_001182190.1, NM_001195261.1
NP_001185761.2, NM_001198832.2 [Q5VU43-3]
NP_001185763.3, NM_001198834.3 [Q5VU43-4]
NP_055459.5, NM_014644.5 [Q5VU43-1]
NP_071754.3, NM_022359.5 [Q5VU43-8]
XP_016855361.1, XM_016999872.1
XP_016855362.1, XM_016999873.1
XP_016858514.1, XM_017003025.1
XP_016858515.1, XM_017003026.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.584841
Hs.632434
Hs.657490
Hs.682380
Hs.721759
Hs.731111

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000313431; ENSP00000316434; ENSG00000178104 [Q5VU43-2]
ENST00000369347; ENSP00000358353; ENSG00000178104 [Q5VU43-11]
ENST00000369349; ENSP00000358355; ENSG00000178104 [Q5VU43-6]
ENST00000369351; ENSP00000358357; ENSG00000178104 [Q5VU43-7]
ENST00000369354; ENSP00000358360; ENSG00000178104 [Q5VU43-1]
ENST00000369356; ENSP00000358363; ENSG00000178104 [Q5VU43-4]
ENST00000529945; ENSP00000433392; ENSG00000178104 [Q5VU43-13]
ENST00000530472; ENSP00000482121; ENSG00000178104 [Q5VU43-8]
ENST00000618462; ENSP00000479409; ENSG00000178104 [Q5VU43-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
653513
9659

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9659

UCSC genome browser

More...
UCSCi
uc001emb.3 human [Q5VU43-1]
uc057kja.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042555 mRNA Translation: BAB17759.1
AB042556 mRNA Translation: BAB17760.1
AB042557 mRNA Translation: BAB17761.1
AB042558 mRNA Translation: BAB17762.1
AB007923 mRNA Translation: BAA32299.2 Different initiation.
AB007946 mRNA Translation: BAA32322.2 Different initiation.
HQ333476 mRNA Translation: ADO32613.1
AL831815 mRNA Translation: CAD38529.1
AL832024 mRNA Translation: CAD89923.1
AL833273 mRNA Translation: CAD91152.1 Frameshift.
CR749273 mRNA Translation: CAH18128.1 Sequence problems.
AL590452, AL138791 Genomic DNA Translation: CAH72521.1
AL590452, AL138796 Genomic DNA Translation: CAH72522.1
AL590452, AL138796 Genomic DNA Translation: CAH72523.1
AL590452, AL138796 Genomic DNA Translation: CAH72524.1
AL590452 Genomic DNA Translation: CAH72525.1
AL590452, AL138796 Genomic DNA Translation: CAH72526.1
AL590452, AL138796 Genomic DNA Translation: CAH72527.1
AL590452, AL138796 Genomic DNA Translation: CAH72528.1
AL138791, AL590452 Genomic DNA Translation: CAI22527.1
AL138796, AL590452 Genomic DNA Translation: CAI22822.1
AL138796, AL590452 Genomic DNA Translation: CAI22823.1
AL138796, AL590452 Genomic DNA Translation: CAI22824.1
AL138796, AL590452 Genomic DNA Translation: CAI22825.1
AL138796, AL590452 Genomic DNA Translation: CAI22826.1
AL138796, AL590452 Genomic DNA Translation: CAI22827.1
AC239802 Genomic DNA No translation available.
AC245389 Genomic DNA No translation available.
AC239804 Genomic DNA No translation available.
BC004860 mRNA Translation: AAH04860.1 Sequence problems.
BC025406 mRNA Translation: AAH25406.1
BC078660 mRNA Translation: AAH78660.1
BC110294 mRNA Translation: AAI10295.1
BC132717 mRNA Translation: AAI32718.1
BC152439 mRNA Translation: AAI52440.1
DA900724 mRNA No translation available.
CCDSiCCDS72887.1 [Q5VU43-8]
CCDS72888.1 [Q5VU43-3]
CCDS72890.1 [Q5VU43-6]
CCDS72891.1 [Q5VU43-1]
CCDS72892.1 [Q5VU43-4]
CCDS72893.1 [Q5VU43-11]
CCDS72894.1 [Q5VU43-2]
PIRiT00069
T00259
RefSeqiNP_001002810.1, NM_001002810.3 [Q5VU43-11]
NP_001002811.2, NM_001002811.2 [Q5VU43-2]
NP_001002812.2, NM_001002812.2 [Q5VU43-6]
NP_001182189.1, NM_001195260.1
NP_001182190.1, NM_001195261.1
NP_001185761.2, NM_001198832.2 [Q5VU43-3]
NP_001185763.3, NM_001198834.3 [Q5VU43-4]
NP_055459.5, NM_014644.5 [Q5VU43-1]
NP_071754.3, NM_022359.5 [Q5VU43-8]
XP_016855361.1, XM_016999872.1
XP_016855362.1, XM_016999873.1
XP_016858514.1, XM_017003025.1
XP_016858515.1, XM_017003026.1
UniGeneiHs.584841
Hs.632434
Hs.657490
Hs.682380
Hs.721759
Hs.731111

3D structure databases

ProteinModelPortaliQ5VU43
SMRiQ5VU43
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115017, 144 interactors
DIPiDIP-51263N
IntActiQ5VU43, 113 interactors
MINTiQ5VU43
STRINGi9606.ENSP00000358363

PTM databases

iPTMnetiQ5VU43
PhosphoSitePlusiQ5VU43

Polymorphism and mutation databases

BioMutaiPDE4DIP
DMDMi74747041

Proteomic databases

EPDiQ5VU43
jPOSTiQ5VU43
PaxDbiQ5VU43
PeptideAtlasiQ5VU43
PRIDEiQ5VU43
ProteomicsDBi65374
65375 [Q5VU43-10]
65376 [Q5VU43-11]
65377 [Q5VU43-12]
65378 [Q5VU43-2]
65379 [Q5VU43-3]
65380 [Q5VU43-4]
65381 [Q5VU43-6]
65382 [Q5VU43-7]
65383 [Q5VU43-8]
65384 [Q5VU43-9]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9659
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313431; ENSP00000316434; ENSG00000178104 [Q5VU43-2]
ENST00000369347; ENSP00000358353; ENSG00000178104 [Q5VU43-11]
ENST00000369349; ENSP00000358355; ENSG00000178104 [Q5VU43-6]
ENST00000369351; ENSP00000358357; ENSG00000178104 [Q5VU43-7]
ENST00000369354; ENSP00000358360; ENSG00000178104 [Q5VU43-1]
ENST00000369356; ENSP00000358363; ENSG00000178104 [Q5VU43-4]
ENST00000529945; ENSP00000433392; ENSG00000178104 [Q5VU43-13]
ENST00000530472; ENSP00000482121; ENSG00000178104 [Q5VU43-8]
ENST00000618462; ENSP00000479409; ENSG00000178104 [Q5VU43-3]
GeneIDi653513
9659
KEGGihsa:9659
UCSCiuc001emb.3 human [Q5VU43-1]
uc057kja.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9659
DisGeNETi653513
9659
EuPathDBiHostDB:ENSG00000178104.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PDE4DIP

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0178151
HGNCiHGNC:15580 PDE4DIP
HPAiHPA008162
HPA012678
MIMi608117 gene
neXtProtiNX_Q5VU43
OpenTargetsiENSG00000178104
PharmGKBiPA33131

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J2NR Eukaryota
ENOG411281S LUCA
GeneTreeiENSGT00530000063845
HOVERGENiHBG108166
InParanoidiQ5VU43
KOiK16549
OMAiLNTVLQC
OrthoDBi15127at2759
PhylomeDBiQ5VU43
TreeFamiTF329233

Enzyme and pathway databases

SIGNORiQ5VU43

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PDE4DIP human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Myomegalin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9659

Protein Ontology

More...
PROi
PR:Q5VU43

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000178104 Expressed in 227 organ(s), highest expression level in gastrocnemius
ExpressionAtlasiQ5VU43 baseline and differential
GenevisibleiQ5VU43 HS

Family and domain databases

InterProiView protein in InterPro
IPR012943 Cnn_1N
IPR010630 Olduvai_dom
PfamiView protein in Pfam
PF07989 Cnn_1N, 1 hit
PF06758 Olduvai, 1 hit
SMARTiView protein in SMART
SM01148 DUF1220, 1 hit
PROSITEiView protein in PROSITE
PS51316 NBPF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYOME_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VU43
Secondary accession number(s): A0A0A0MRM0
, A0A0C4DFQ0, A2RU15, E9PL24, O75042, O75065, Q2YDC1, Q5VU42, Q5VU44, Q5VU45, Q5VU46, Q5VU47, Q5VU48, Q5VU49, Q68DU2, Q6AZ93, Q6PK88, Q86T40, Q86TB2, Q8N3W0, Q8TAY9, Q9HCP2, Q9HCP3, Q9HCP4, Q9HCP5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 28, 2018
Last modified: January 16, 2019
This is version 138 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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