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UniProtKB - Q5VTW1 (Q5VTW1_HUMAN)
Protein
Submitted name:
A disintegrin and metalloproteinase with thrombospondin motifs 4
Gene
ADAMTS4
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: A disintegrin and metalloproteinase with thrombospondin motifs 4Imported |
Gene namesi | Name:ADAMTS4Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:220, ADAMTS4 |
VEuPathDBi | HostDB:ENSG00000158859 |
Subcellular locationi
Nucleus
- nuclear speck Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 24 – 46 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000158859, Expressed in left coronary artery and 109 other tissues |
ExpressionAtlasi | Q5VTW1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 78 – 176 | Pep_M12B_propepInterPro annotationAdd BLAST | 99 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000160966 |
HOGENOMi | CLU_818763_0_0_1 |
Family and domain databases
Gene3Di | 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR024079, MetalloPept_cat_dom_sf IPR002870, Peptidase_M12B_N |
Pfami | View protein in Pfam PF01562, Pep_M12B_propep, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5VTW1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQTGSHPGR GLAGRWLWGA QPCLLLPIVP LSWLVWLLLL LLASLLPSAR
60 70 80 90 100
LASPLPREEE IVFPEKLNGS VLPGSGAPAR LLCRLQAFGE TLLLELEQDS
110 120 130 140 150
GVQVEGLTVQ YLGQAPELLG GAEPGTYLTG TINGDPESVA SLHWDGGALL
160 170 180 190 200
GVLQYRGAEL HLQPLEGGTP NSAGGPGAHI LRRKSPASGQ GPMCNVKAPL
210 220 230 240 250
GSPSPRPRRA KRFASLSRFV ETLVVADDKM AAFHGAGLKR YLLTVMAAAA
260 270 280 290 300
KAFKHPSIRN PVSLVVTRLV ILGSGEEGPQ VGPSAAQTLR SFCAWQRGLN
310 320 330
TPEDSDPDHF DTAILFTRQV RPQSAPQAMH CTILRSATT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketO75173 | ATS4_HUMAN | A disintegrin and metalloproteinase... | ADAMTS4 KIAA0688, UNQ769/PRO1563 | 837 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL590714 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000367995; ENSP00000356974; ENSG00000158859 |
UCSCi | uc001fyu.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL590714 Genomic DNA No translation available. |
3D structure databases
SMRi | Q5VTW1 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | Q5VTW1 |
PRIDEi | Q5VTW1 |
ProteomicsDBi | 65359 |
Protocols and materials databases
Antibodypediai | 20503, 575 antibodies from 36 providers |
Genome annotation databases
Ensembli | ENST00000367995; ENSP00000356974; ENSG00000158859 |
UCSCi | uc001fyu.3, human |
Organism-specific databases
HGNCi | HGNC:220, ADAMTS4 |
OpenTargetsi | ENSG00000158859 |
VEuPathDBi | HostDB:ENSG00000158859 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160966 |
HOGENOMi | CLU_818763_0_0_1 |
Miscellaneous databases
ChiTaRSi | ADAMTS4, human |
Gene expression databases
Bgeei | ENSG00000158859, Expressed in left coronary artery and 109 other tissues |
ExpressionAtlasi | Q5VTW1, baseline and differential |
Family and domain databases
Gene3Di | 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR024079, MetalloPept_cat_dom_sf IPR002870, Peptidase_M12B_N |
Pfami | View protein in Pfam PF01562, Pep_M12B_propep, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5VTW1_HUMAN | |
Accessioni | Q5VTW1Primary (citable) accession number: Q5VTW1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 16, 2008 |
Last sequence update: | December 16, 2008 | |
Last modified: | January 19, 2022 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |