Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q5VTH9 (DNAI4_HUMAN)

Entry version 148 (10 Feb 2021)
Sequence version 1 (07 Dec 2004)
Previous versions | rss
Add a publicationFeedback
Protein

Dynein intermediate chain 4, axonemal

Gene

DNAI4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a critical role in the assembly of axonemal dynein complex, thereby playing a role in ciliary motility.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5VTH9

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q5VTH9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein intermediate chain 4, axonemalCurated
Alternative name(s):
Dynein axonemal intermediate chain 4
WD repeat-containing protein 78
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAI4Imported
Synonyms:WDR78
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26252, DNAI4

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5VTH9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000152763.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		79819

Open Targets

More...OpenTargetsi		ENSG00000152763

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670582

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5VTH9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		WDR78

Domain mapping of disease mutations (DMDM)

More...DMDMi		74756797

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002627731 – 848Dynein intermediate chain 4, axonemalAdd BLAST848

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5VTH9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5VTH9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5VTH9

PeptideAtlas

More...PeptideAtlasi		Q5VTH9

PRoteomics IDEntifications database

More...PRIDEi		Q5VTH9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		43534
65329 [Q5VTH9-1]
65330 [Q5VTH9-2]
65331 [Q5VTH9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5VTH9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5VTH9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000152763, Expressed in bronchial epithelial cell and 153 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5VTH9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5VTH9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000152763, Tissue enhanced (fallopian tube, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the multisubunit axonemal dynein complex formed at least of two heavy chains and a number of intermediate and light chains. Associated with axonemal dynein subunits such as, DNAH2, DNAI3, and DYNLT1.

Interacts with DYNLT1.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122914, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q5VTH9, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360065

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5VTH9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5VTH9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati534 – 574WD 1Sequence analysisAdd BLAST41
Repeati583 – 631WD 2Sequence analysisAdd BLAST49
Repeati658 – 698WD 3Sequence analysisAdd BLAST41
Repeati702 – 742WD 4Sequence analysisAdd BLAST41
Repeati745 – 784WD 5Sequence analysisAdd BLAST40
Repeati790 – 829WD 6Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi431 – 465Glu-richAdd BLAST35

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0263, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156209

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015820_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5VTH9

Identification of Orthologs from Complete Genome Data

More...OMAi		KGLDCYD

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5VTH9

TreeFam database of animal gene trees

More...TreeFami		TF300553

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00400, WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00320, WD40, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50082, WD_REPEATS_2, 2 hits
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VTH9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPGKHSGAS ARAANGGAWG YRDFRGGQKK GWCTTPQLVA TMPVSPAGSH 
        60         70         80         90        100
KQQNFGLNNA TQPKKSISFF ATMKATSVKG YTGANQSRMA VSKTVLIPPE 
       110        120        130        140        150
LKTVEKPNPN IKTTQVFDIN GTDVTPRPLY HPDPLTGTAK PSKLLTSQEG 
       160        170        180        190        200
SLGSEFISSY SLYQNTINPS TLGQFTRSVL GSSTVSKSSV SASESIAEDL 
       210        220        230        240        250
EEPSYKRERL TSFTDLQVIR AAPEKIVTKE DLEKNIEIIL TETETLRFFD 
       260        270        280        290        300
LPTVMVSVES EEAEKVTQRN KNYEVLCRNR LGNDLYVERM MQTFNGAPKN 
       310        320        330        340        350
KDVQCDKIIM EDKGIMSTAW DLYDSYNAME LVSLSVKQSV VESSSKANVL 
       360        370        380        390        400
PKDQDQRLPG STTEKNSETS SLMDIENVIL AKIHEDEEDH SDAILKSDKF 
       410        420        430        440        450
HQDLFFMERV LMENIFQPKL AAYRQLPVLK EPEPEEPEDV LESAKHEEVE 
       460        470        480        490        500
EESKKEEEEE IHAEESTIPA NLERLWSFSC DLTKGLNVSS LAWNKTNPDL 
       510        520        530        540        550
LAVGYGHFGF KEQKRGLACC WSIKNPMWPE RIYQSPYGVT AVDFSIGAPN 
       560        570        580        590        600
LLAVGYHNGT IAIYNVRSNS NVPVLDSSES PQKHLGPVWQ LQWIEQDRGT 
       610        620        630        640        650
TGDGKREILV SISADGRISK WVIRKGLDCY DLMRLKRTTA ASNKKGGEKE 
       660        670        680        690        700
KKDEALISRQ APGMCFAFHP KDTNIYLAGT EEGHIHKCSC SYNEQYLDTY 
       710        720        730        740        750
RGHKGPVYKV TWNPFCHDVF LSCSADWGVI IWQQENVKPS LSFYPATSVV 
       760        770        780        790        800
YDVAWSPKSS YIFAAANENR VEIWDLHIST LDPLIVNTAN PGIKFTTILF 
       810        820        830        840 
AKQTDCLLVG DSDGQVSVYE LRNMPTVLET GRGDIMDTLL GSKSNQSA
Length:848
Mass (Da):94,573
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED3E0BA7272E67AE
GO
Isoform 2 (identifier: Q5VTH9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     528-545: WPERIYQSPYGVTAVDFS → VTQTRIRSIFIWLLTKFS
     546-848: Missing.

Show »
Length:545
Mass (Da):60,992
Checksum:iFB9ABEE1EA73DFEC
GO
Isoform 3 (identifier: Q5VTH9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-254: Missing.
     672-704: Missing.

Show »
Length:561
Mass (Da):63,213
Checksum:iBBBD30590E7295AD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YDI6H0YDI6_HUMAN
Dynein intermediate chain 4, axonem...
DNAI4
581Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YD58H0YD58_HUMAN
Dynein intermediate chain 4, axonem...
DNAI4
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQT5E9PQT5_HUMAN
Dynein intermediate chain 4, axonem...
DNAI4
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YD49H0YD49_HUMAN
Dynein intermediate chain 4, axonem...
DNAI4
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TAD8Q5TAD8_HUMAN
Dynein intermediate chain 4, axonem...
DNAI4
320Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEH4H0YEH4_HUMAN
Dynein intermediate chain 4, axonem...
DNAI4
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YES1H0YES1_HUMAN
Dynein intermediate chain 4, axonem...
DNAI4
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCX1H0YCX1_HUMAN
Dynein intermediate chain 4, axonem...
DNAI4
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15551 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05763516G → A1 PublicationCorresponds to variant dbSNP:rs1886686Ensembl.1
Natural variantiVAR_05763633C → W. Corresponds to variant dbSNP:rs3008858Ensembl.1
Natural variantiVAR_057637832R → Q1 PublicationCorresponds to variant dbSNP:rs482082Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0218121 – 254Missing in isoform 3. 1 PublicationAdd BLAST254
Alternative sequenceiVSP_021816528 – 545WPERI…AVDFS → VTQTRIRSIFIWLLTKFS in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_021817546 – 848Missing in isoform 2. 1 PublicationAdd BLAST303
Alternative sequenceiVSP_021815672 – 704Missing in isoform 3. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK026782 mRNA Translation: BAB15551.1 Frameshift.
AK292830 mRNA Translation: BAF85519.1
AL139216 Genomic DNA No translation available.
AL354978 Genomic DNA No translation available.
AL592161 Genomic DNA No translation available.
BC032406 mRNA Translation: AAH32406.2
AL133617 mRNA Translation: CAB63744.3

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44157.1 [Q5VTH9-2]
CCDS635.1 [Q5VTH9-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T43473

NCBI Reference Sequences

More...RefSeqi		NP_079039.4, NM_024763.4 [Q5VTH9-1]
NP_996897.2, NM_207014.2 [Q5VTH9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000371023; ENSP00000360062; ENSG00000152763 [Q5VTH9-2]
ENST00000371026; ENSP00000360065; ENSG00000152763 [Q5VTH9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79819

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79819

UCSC genome browser

More...UCSCi		uc001dcx.5, human [Q5VTH9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026782 mRNA Translation: BAB15551.1 Frameshift.
AK292830 mRNA Translation: BAF85519.1
AL139216 Genomic DNA No translation available.
AL354978 Genomic DNA No translation available.
AL592161 Genomic DNA No translation available.
BC032406 mRNA Translation: AAH32406.2
AL133617 mRNA Translation: CAB63744.3
CCDSiCCDS44157.1 [Q5VTH9-2]
CCDS635.1 [Q5VTH9-1]
PIRiT43473
RefSeqiNP_079039.4, NM_024763.4 [Q5VTH9-1]
NP_996897.2, NM_207014.2 [Q5VTH9-2]

3D structure databases

SMRiQ5VTH9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122914, 1 interactor
IntActiQ5VTH9, 1 interactor
STRINGi9606.ENSP00000360065

PTM databases

iPTMnetiQ5VTH9
PhosphoSitePlusiQ5VTH9

Genetic variation databases

BioMutaiWDR78
DMDMi74756797

Proteomic databases

EPDiQ5VTH9
MassIVEiQ5VTH9
PaxDbiQ5VTH9
PeptideAtlasiQ5VTH9
PRIDEiQ5VTH9
ProteomicsDBi43534
65329 [Q5VTH9-1]
65330 [Q5VTH9-2]
65331 [Q5VTH9-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		51698, 17 antibodies

The DNASU plasmid repository

More...DNASUi		79819

Genome annotation databases

EnsembliENST00000371023; ENSP00000360062; ENSG00000152763 [Q5VTH9-2]
ENST00000371026; ENSP00000360065; ENSG00000152763 [Q5VTH9-1]
GeneIDi79819
KEGGihsa:79819
UCSCiuc001dcx.5, human [Q5VTH9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79819
DisGeNETi79819

GeneCards: human genes, protein and diseases

More...GeneCardsi		DNAI4
HGNCiHGNC:26252, DNAI4
HPAiENSG00000152763, Tissue enhanced (fallopian tube, testis)
neXtProtiNX_Q5VTH9
OpenTargetsiENSG00000152763
PharmGKBiPA142670582
VEuPathDBiHostDB:ENSG00000152763.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0263, Eukaryota
GeneTreeiENSGT00940000156209
HOGENOMiCLU_015820_3_0_1
InParanoidiQ5VTH9
OMAiKGLDCYD
PhylomeDBiQ5VTH9
TreeFamiTF300553

Enzyme and pathway databases

PathwayCommonsiQ5VTH9
SignaLinkiQ5VTH9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79819, 10 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		WDR78, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79819
PharosiQ5VTH9, Tdark

Protein Ontology

More...PROi		PR:Q5VTH9
RNActiQ5VTH9, protein

Gene expression databases

BgeeiENSG00000152763, Expressed in bronchial epithelial cell and 153 other tissues
ExpressionAtlasiQ5VTH9, baseline and differential
GenevisibleiQ5VTH9, HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400, WD40, 2 hits
SMARTiView protein in SMART
SM00320, WD40, 5 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082, WD_REPEATS_2, 2 hits
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNAI4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VTH9
Secondary accession number(s): A8K9W5
, B5MDT3, H7BY80, Q5VTI0, Q8N5G5, Q9H5R9, Q9UF44
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 7, 2004
Last modified: February 10, 2021
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again