UniProtKB - Q5VTH9 (DNAI4_HUMAN)
Protein
Dynein intermediate chain 4, axonemal
Gene
DNAI4
Organism
Homo sapiens (Human)
Status
Functioni
Plays a critical role in the assembly of axonemal dynein complex, thereby playing a role in ciliary motility.By similarity
GO - Molecular functioni
- dynein heavy chain binding Source: GO_Central
- dynein light chain binding Source: GO_Central
GO - Biological processi
- axonemal dynein complex assembly Source: UniProtKB
- cilium movement Source: UniProtKB
- hematopoietic progenitor cell differentiation Source: Ensembl
- microtubule-based movement Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q5VTH9 |
SignaLinki | Q5VTH9 |
Names & Taxonomyi
Protein namesi | Recommended name: Dynein intermediate chain 4, axonemalCuratedAlternative name(s): Dynein axonemal intermediate chain 4 WD repeat-containing protein 78 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26252, DNAI4 |
neXtProti | NX_Q5VTH9 |
VEuPathDBi | HostDB:ENSG00000152763.16 |
Subcellular locationi
Cytoskeleton
- flagellum axoneme By similarity
- cilium axoneme By similarity
Cytoskeleton
- axonemal dynein complex Source: UniProtKB
- axoneme Source: UniProtKB
Other locations
- motile cilium Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, Cytoskeleton, FlagellumPathology & Biotechi
Organism-specific databases
DisGeNETi | 79819 |
OpenTargetsi | ENSG00000152763 |
PharmGKBi | PA142670582 |
Miscellaneous databases
Pharosi | Q5VTH9, Tdark |
Genetic variation databases
BioMutai | WDR78 |
DMDMi | 74756797 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000262773 | 1 – 848 | Dynein intermediate chain 4, axonemalAdd BLAST | 848 |
Proteomic databases
EPDi | Q5VTH9 |
MassIVEi | Q5VTH9 |
PaxDbi | Q5VTH9 |
PeptideAtlasi | Q5VTH9 |
PRIDEi | Q5VTH9 |
ProteomicsDBi | 43534 65329 [Q5VTH9-1] 65330 [Q5VTH9-2] 65331 [Q5VTH9-3] |
PTM databases
iPTMneti | Q5VTH9 |
PhosphoSitePlusi | Q5VTH9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000152763, Expressed in bronchial epithelial cell and 153 other tissues |
ExpressionAtlasi | Q5VTH9, baseline and differential |
Genevisiblei | Q5VTH9, HS |
Organism-specific databases
HPAi | ENSG00000152763, Tissue enhanced (fallopian tube, testis) |
Interactioni
Subunit structurei
Part of the multisubunit axonemal dynein complex formed at least of two heavy chains and a number of intermediate and light chains. Associated with axonemal dynein subunits such as, DNAH2, DNAI3, and DYNLT1.
Interacts with DYNLT1.
By similarityGO - Molecular functioni
- dynein heavy chain binding Source: GO_Central
- dynein light chain binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 122914, 1 interactor |
IntActi | Q5VTH9, 1 interactor |
STRINGi | 9606.ENSP00000360065 |
Miscellaneous databases
RNActi | Q5VTH9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 534 – 574 | WD 1Sequence analysisAdd BLAST | 41 | |
Repeati | 583 – 631 | WD 2Sequence analysisAdd BLAST | 49 | |
Repeati | 658 – 698 | WD 3Sequence analysisAdd BLAST | 41 | |
Repeati | 702 – 742 | WD 4Sequence analysisAdd BLAST | 41 | |
Repeati | 745 – 784 | WD 5Sequence analysisAdd BLAST | 40 | |
Repeati | 790 – 829 | WD 6Sequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 431 – 465 | Glu-richAdd BLAST | 35 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0263, Eukaryota |
GeneTreei | ENSGT00940000156209 |
HOGENOMi | CLU_015820_3_0_1 |
InParanoidi | Q5VTH9 |
OMAi | KGLDCYD |
PhylomeDBi | Q5VTH9 |
TreeFami | TF300553 |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5VTH9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTPGKHSGAS ARAANGGAWG YRDFRGGQKK GWCTTPQLVA TMPVSPAGSH
60 70 80 90 100
KQQNFGLNNA TQPKKSISFF ATMKATSVKG YTGANQSRMA VSKTVLIPPE
110 120 130 140 150
LKTVEKPNPN IKTTQVFDIN GTDVTPRPLY HPDPLTGTAK PSKLLTSQEG
160 170 180 190 200
SLGSEFISSY SLYQNTINPS TLGQFTRSVL GSSTVSKSSV SASESIAEDL
210 220 230 240 250
EEPSYKRERL TSFTDLQVIR AAPEKIVTKE DLEKNIEIIL TETETLRFFD
260 270 280 290 300
LPTVMVSVES EEAEKVTQRN KNYEVLCRNR LGNDLYVERM MQTFNGAPKN
310 320 330 340 350
KDVQCDKIIM EDKGIMSTAW DLYDSYNAME LVSLSVKQSV VESSSKANVL
360 370 380 390 400
PKDQDQRLPG STTEKNSETS SLMDIENVIL AKIHEDEEDH SDAILKSDKF
410 420 430 440 450
HQDLFFMERV LMENIFQPKL AAYRQLPVLK EPEPEEPEDV LESAKHEEVE
460 470 480 490 500
EESKKEEEEE IHAEESTIPA NLERLWSFSC DLTKGLNVSS LAWNKTNPDL
510 520 530 540 550
LAVGYGHFGF KEQKRGLACC WSIKNPMWPE RIYQSPYGVT AVDFSIGAPN
560 570 580 590 600
LLAVGYHNGT IAIYNVRSNS NVPVLDSSES PQKHLGPVWQ LQWIEQDRGT
610 620 630 640 650
TGDGKREILV SISADGRISK WVIRKGLDCY DLMRLKRTTA ASNKKGGEKE
660 670 680 690 700
KKDEALISRQ APGMCFAFHP KDTNIYLAGT EEGHIHKCSC SYNEQYLDTY
710 720 730 740 750
RGHKGPVYKV TWNPFCHDVF LSCSADWGVI IWQQENVKPS LSFYPATSVV
760 770 780 790 800
YDVAWSPKSS YIFAAANENR VEIWDLHIST LDPLIVNTAN PGIKFTTILF
810 820 830 840
AKQTDCLLVG DSDGQVSVYE LRNMPTVLET GRGDIMDTLL GSKSNQSA
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YDI6 | H0YDI6_HUMAN | Dynein intermediate chain 4, axonem... | DNAI4 | 581 | Annotation score: | ||
H0YD58 | H0YD58_HUMAN | Dynein intermediate chain 4, axonem... | DNAI4 | 167 | Annotation score: | ||
E9PQT5 | E9PQT5_HUMAN | Dynein intermediate chain 4, axonem... | DNAI4 | 49 | Annotation score: | ||
H0YD49 | H0YD49_HUMAN | Dynein intermediate chain 4, axonem... | DNAI4 | 122 | Annotation score: | ||
Q5TAD8 | Q5TAD8_HUMAN | Dynein intermediate chain 4, axonem... | DNAI4 | 320 | Annotation score: | ||
H0YEH4 | H0YEH4_HUMAN | Dynein intermediate chain 4, axonem... | DNAI4 | 159 | Annotation score: | ||
H0YES1 | H0YES1_HUMAN | Dynein intermediate chain 4, axonem... | DNAI4 | 62 | Annotation score: | ||
H0YCX1 | H0YCX1_HUMAN | Dynein intermediate chain 4, axonem... | DNAI4 | 55 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057635 | 16 | G → A1 PublicationCorresponds to variant dbSNP:rs1886686Ensembl. | 1 | |
Natural variantiVAR_057636 | 33 | C → W. Corresponds to variant dbSNP:rs3008858Ensembl. | 1 | |
Natural variantiVAR_057637 | 832 | R → Q1 PublicationCorresponds to variant dbSNP:rs482082Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021812 | 1 – 254 | Missing in isoform 3. 1 PublicationAdd BLAST | 254 | |
Alternative sequenceiVSP_021816 | 528 – 545 | WPERI…AVDFS → VTQTRIRSIFIWLLTKFS in isoform 2. 1 PublicationAdd BLAST | 18 | |
Alternative sequenceiVSP_021817 | 546 – 848 | Missing in isoform 2. 1 PublicationAdd BLAST | 303 | |
Alternative sequenceiVSP_021815 | 672 – 704 | Missing in isoform 3. 1 PublicationAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026782 mRNA Translation: BAB15551.1 Frameshift. AK292830 mRNA Translation: BAF85519.1 AL139216 Genomic DNA No translation available. AL354978 Genomic DNA No translation available. AL592161 Genomic DNA No translation available. BC032406 mRNA Translation: AAH32406.2 AL133617 mRNA Translation: CAB63744.3 |
CCDSi | CCDS44157.1 [Q5VTH9-2] CCDS635.1 [Q5VTH9-1] |
PIRi | T43473 |
RefSeqi | NP_079039.4, NM_024763.4 [Q5VTH9-1] NP_996897.2, NM_207014.2 [Q5VTH9-2] |
Genome annotation databases
Ensembli | ENST00000371023; ENSP00000360062; ENSG00000152763 [Q5VTH9-2] ENST00000371026; ENSP00000360065; ENSG00000152763 [Q5VTH9-1] |
GeneIDi | 79819 |
KEGGi | hsa:79819 |
UCSCi | uc001dcx.5, human [Q5VTH9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026782 mRNA Translation: BAB15551.1 Frameshift. AK292830 mRNA Translation: BAF85519.1 AL139216 Genomic DNA No translation available. AL354978 Genomic DNA No translation available. AL592161 Genomic DNA No translation available. BC032406 mRNA Translation: AAH32406.2 AL133617 mRNA Translation: CAB63744.3 |
CCDSi | CCDS44157.1 [Q5VTH9-2] CCDS635.1 [Q5VTH9-1] |
PIRi | T43473 |
RefSeqi | NP_079039.4, NM_024763.4 [Q5VTH9-1] NP_996897.2, NM_207014.2 [Q5VTH9-2] |
3D structure databases
SMRi | Q5VTH9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122914, 1 interactor |
IntActi | Q5VTH9, 1 interactor |
STRINGi | 9606.ENSP00000360065 |
PTM databases
iPTMneti | Q5VTH9 |
PhosphoSitePlusi | Q5VTH9 |
Genetic variation databases
BioMutai | WDR78 |
DMDMi | 74756797 |
Proteomic databases
EPDi | Q5VTH9 |
MassIVEi | Q5VTH9 |
PaxDbi | Q5VTH9 |
PeptideAtlasi | Q5VTH9 |
PRIDEi | Q5VTH9 |
ProteomicsDBi | 43534 65329 [Q5VTH9-1] 65330 [Q5VTH9-2] 65331 [Q5VTH9-3] |
Protocols and materials databases
Antibodypediai | 51698, 17 antibodies |
DNASUi | 79819 |
Genome annotation databases
Ensembli | ENST00000371023; ENSP00000360062; ENSG00000152763 [Q5VTH9-2] ENST00000371026; ENSP00000360065; ENSG00000152763 [Q5VTH9-1] |
GeneIDi | 79819 |
KEGGi | hsa:79819 |
UCSCi | uc001dcx.5, human [Q5VTH9-1] |
Organism-specific databases
CTDi | 79819 |
DisGeNETi | 79819 |
GeneCardsi | DNAI4 |
HGNCi | HGNC:26252, DNAI4 |
HPAi | ENSG00000152763, Tissue enhanced (fallopian tube, testis) |
neXtProti | NX_Q5VTH9 |
OpenTargetsi | ENSG00000152763 |
PharmGKBi | PA142670582 |
VEuPathDBi | HostDB:ENSG00000152763.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0263, Eukaryota |
GeneTreei | ENSGT00940000156209 |
HOGENOMi | CLU_015820_3_0_1 |
InParanoidi | Q5VTH9 |
OMAi | KGLDCYD |
PhylomeDBi | Q5VTH9 |
TreeFami | TF300553 |
Enzyme and pathway databases
PathwayCommonsi | Q5VTH9 |
SignaLinki | Q5VTH9 |
Miscellaneous databases
BioGRID-ORCSi | 79819, 10 hits in 875 CRISPR screens |
ChiTaRSi | WDR78, human |
GenomeRNAii | 79819 |
Pharosi | Q5VTH9, Tdark |
PROi | PR:Q5VTH9 |
RNActi | Q5VTH9, protein |
Gene expression databases
Bgeei | ENSG00000152763, Expressed in bronchial epithelial cell and 153 other tissues |
ExpressionAtlasi | Q5VTH9, baseline and differential |
Genevisiblei | Q5VTH9, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DNAI4_HUMAN | |
Accessioni | Q5VTH9Primary (citable) accession number: Q5VTH9 Secondary accession number(s): A8K9W5 Q9UF44 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | December 7, 2004 | |
Last modified: | February 10, 2021 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports