WD repeat-containing protein 78

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• dynein heavy chain binding Source: GO_Central
• dynein light chain binding Source: GO_Central

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• cilium movement Source: GO_Central
• hematopoietic progenitor cell differentiation Source: Ensembl

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• dynein heavy chain binding Source: GO_Central
• dynein light chain binding Source: GO_Central

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

Compositional bias

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MTPGKHSGAS ARAANGGAWG YRDFRGGQKK GWCTTPQLVA TMPVSPAGSH 
        60         70         80         90        100
KQQNFGLNNA TQPKKSISFF ATMKATSVKG YTGANQSRMA VSKTVLIPPE 
       110        120        130        140        150
LKTVEKPNPN IKTTQVFDIN GTDVTPRPLY HPDPLTGTAK PSKLLTSQEG 
       160        170        180        190        200
SLGSEFISSY SLYQNTINPS TLGQFTRSVL GSSTVSKSSV SASESIAEDL 
       210        220        230        240        250
EEPSYKRERL TSFTDLQVIR AAPEKIVTKE DLEKNIEIIL TETETLRFFD 
       260        270        280        290        300
LPTVMVSVES EEAEKVTQRN KNYEVLCRNR LGNDLYVERM MQTFNGAPKN 
       310        320        330        340        350
KDVQCDKIIM EDKGIMSTAW DLYDSYNAME LVSLSVKQSV VESSSKANVL 
       360        370        380        390        400
PKDQDQRLPG STTEKNSETS SLMDIENVIL AKIHEDEEDH SDAILKSDKF 
       410        420        430        440        450
HQDLFFMERV LMENIFQPKL AAYRQLPVLK EPEPEEPEDV LESAKHEEVE 
       460        470        480        490        500
EESKKEEEEE IHAEESTIPA NLERLWSFSC DLTKGLNVSS LAWNKTNPDL 
       510        520        530        540        550
LAVGYGHFGF KEQKRGLACC WSIKNPMWPE RIYQSPYGVT AVDFSIGAPN 
       560        570        580        590        600
LLAVGYHNGT IAIYNVRSNS NVPVLDSSES PQKHLGPVWQ LQWIEQDRGT 
       610        620        630        640        650
TGDGKREILV SISADGRISK WVIRKGLDCY DLMRLKRTTA ASNKKGGEKE 
       660        670        680        690        700
KKDEALISRQ APGMCFAFHP KDTNIYLAGT EEGHIHKCSC SYNEQYLDTY 
       710        720        730        740        750
RGHKGPVYKV TWNPFCHDVF LSCSADWGVI IWQQENVKPS LSFYPATSVV 
       760        770        780        790        800
YDVAWSPKSS YIFAAANENR VEIWDLHIST LDPLIVNTAN PGIKFTTILF 
       810        820        830        840 
AKQTDCLLVG DSDGQVSVYE LRNMPTVLET GRGDIMDTLL GSKSNQSA   

        10         20         30         40         50
MTPGKHSGAS ARAANGGAWG YRDFRGGQKK GWCTTPQLVA TMPVSPAGSH 
        60         70         80         90        100
KQQNFGLNNA TQPKKSISFF ATMKATSVKG YTGANQSRMA VSKTVLIPPE 
       110        120        130        140        150
LKTVEKPNPN IKTTQVFDIN GTDVTPRPLY HPDPLTGTAK PSKLLTSQEG 
       160        170        180        190        200
SLGSEFISSY SLYQNTINPS TLGQFTRSVL GSSTVSKSSV SASESIAEDL 
       210        220        230        240        250
EEPSYKRERL TSFTDLQVIR AAPEKIVTKE DLEKNIEIIL TETETLRFFD 
       260        270        280        290        300
LPTVMVSVES EEAEKVTQRN KNYEVLCRNR LGNDLYVERM MQTFNGAPKN 
       310        320        330        340        350
KDVQCDKIIM EDKGIMSTAW DLYDSYNAME LVSLSVKQSV VESSSKANVL 
       360        370        380        390        400
PKDQDQRLPG STTEKNSETS SLMDIENVIL AKIHEDEEDH SDAILKSDKF 
       410        420        430        440        450
HQDLFFMERV LMENIFQPKL AAYRQLPVLK EPEPEEPEDV LESAKHEEVE 
       460        470        480        490        500
EESKKEEEEE IHAEESTIPA NLERLWSFSC DLTKGLNVSS LAWNKTNPDL 
       510        520        530        540 
LAVGYGHFGF KEQKRGLACC WSIKNPMVTQ TRIRSIFIWL LTKFS      

        10         20         30         40         50
MVSVESEEAE KVTQRNKNYE VLCRNRLGND LYVERMMQTF NGAPKNKDVQ 
        60         70         80         90        100
CDKIIMEDKG IMSTAWDLYD SYNAMELVSL SVKQSVVESS SKANVLPKDQ 
       110        120        130        140        150
DQRLPGSTTE KNSETSSLMD IENVILAKIH EDEEDHSDAI LKSDKFHQDL 
       160        170        180        190        200
FFMERVLMEN IFQPKLAAYR QLPVLKEPEP EEPEDVLESA KHEEVEEESK 
       210        220        230        240        250
KEEEEEIHAE ESTIPANLER LWSFSCDLTK GLNVSSLAWN KTNPDLLAVG 
       260        270        280        290        300
YGHFGFKEQK RGLACCWSIK NPMWPERIYQ SPYGVTAVDF SIGAPNLLAV 
       310        320        330        340        350
GYHNGTIAIY NVRSNSNVPV LDSSESPQKH LGPVWQLQWI EQDRGTTGDG 
       360        370        380        390        400
KREILVSISA DGRISKWVIR KGLDCYDLMR LKRTTAASNK KGGEKEKKDE 
       410        420        430        440        450
ALISRQAPGM CFAFHPKGPV YKVTWNPFCH DVFLSCSADW GVIIWQQENV 
       460        470        480        490        500
KPSLSFYPAT SVVYDVAWSP KSSYIFAAAN ENRVEIWDLH ISTLDPLIVN 
       510        520        530        540        550
TANPGIKFTT ILFAKQTDCL LVGDSDGQVS VYELRNMPTV LETGRGDIMD 
       560 
TLLGSKSNQS A                                           

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations