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UniProtKB - Q5VTH2 (FLTOP_HUMAN)
Protein
Protein Flattop
Gene
CFAP126
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear.
By similarityGO - Biological processi
- cilium organization Source: UniProtKB
Keywordsi
Biological process | Cilium biogenesis/degradation |
Enzyme and pathway databases
PathwayCommonsi | Q5VTH2 |
SignaLinki | Q5VTH2 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein FlattopCuratedAlternative name(s): Cilia- and flagella-associated protein 126Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:32325, CFAP126 |
MIMi | 616119, gene |
neXtProti | NX_Q5VTH2 |
VEuPathDBi | HostDB:ENSG00000188931 |
Subcellular locationi
Plasma membrane
- Apical cell membrane By similarity
Cytoskeleton
- cilium basal body By similarity
Other locations
- cilium By similarity
Note: Localizes to the apical cell membrane, the basal body and the primary cilium in monociliated node cells.By similarity
Cytoskeleton
- ciliary basal body Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: UniProtKB
Other locations
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000188931 |
PharmGKBi | PA142672403 |
Miscellaneous databases
Pharosi | Q5VTH2, Tdark |
Genetic variation databases
BioMutai | CFAP126 |
DMDMi | 74746942 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000316972 | 1 – 177 | Protein FlattopAdd BLAST | 177 |
Proteomic databases
MassIVEi | Q5VTH2 |
PaxDbi | Q5VTH2 |
PeptideAtlasi | Q5VTH2 |
PRIDEi | Q5VTH2 |
ProteomicsDBi | 65328 |
PTM databases
iPTMneti | Q5VTH2 |
PhosphoSitePlusi | Q5VTH2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188931, Expressed in right uterine tube and 112 other tissues |
Genevisiblei | Q5VTH2, HS |
Organism-specific databases
HPAi | ENSG00000188931, Tissue enhanced (fallopian tube, skeletal muscle) |
Interactioni
Subunit structurei
Interacts with DLG3.
By similarityProtein-protein interaction databases
STRINGi | 9606.ENSP00000356951 |
Miscellaneous databases
RNActi | Q5VTH2, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 113 – 177 | DisorderedSequence analysisAdd BLAST | 65 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 133 – 167 | Polar residuesSequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the Flattop family.Curated
Phylogenomic databases
eggNOGi | ENOG502S5M4, Eukaryota |
GeneTreei | ENSGT00390000001092 |
HOGENOMi | CLU_108980_0_0_1 |
InParanoidi | Q5VTH2 |
OMAi | TFMGTWQ |
OrthoDBi | 1487116at2759 |
PhylomeDBi | Q5VTH2 |
TreeFami | TF329474 |
Family and domain databases
InterProi | View protein in InterPro IPR038797, Fltp |
PANTHERi | PTHR34639, PTHR34639, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5VTH2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATNYSANQY EKAFSSKYLQ NWSPTKPTKE SISSHEGYTQ IIANDRGHLL
60 70 80 90 100
PSVPRSKANP WGSFMGTWQM PLKIPPARVT LTSRTTAGAA SLTKWIQKNP
110 120 130 140 150
DLLKASNGLC PEILGKPHDP DSQKKLRKKS ITKTVQQARS PTIIPSSPAA
160 170
NLNSPDELQS SHPSAGHTPG PQRPAKS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | G → A in BU688150 (PubMed:8889548).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL592295 Genomic DNA No translation available. BU688150 mRNA No translation available. |
CCDSi | CCDS30921.1 |
RefSeqi | NP_001013647.2, NM_001013625.3 |
Genome annotation databases
Ensembli | ENST00000367974.2; ENSP00000356951.1; ENSG00000188931.4 |
GeneIDi | 257177 |
KEGGi | hsa:257177 |
MANE-Selecti | ENST00000367974.2; ENSP00000356951.1; NM_001013625.4; NP_001013647.2 |
UCSCi | uc001gal.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL592295 Genomic DNA No translation available. BU688150 mRNA No translation available. |
CCDSi | CCDS30921.1 |
RefSeqi | NP_001013647.2, NM_001013625.3 |
3D structure databases
AlphaFoldDBi | Q5VTH2 |
SMRi | Q5VTH2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000356951 |
PTM databases
iPTMneti | Q5VTH2 |
PhosphoSitePlusi | Q5VTH2 |
Genetic variation databases
BioMutai | CFAP126 |
DMDMi | 74746942 |
Proteomic databases
MassIVEi | Q5VTH2 |
PaxDbi | Q5VTH2 |
PeptideAtlasi | Q5VTH2 |
PRIDEi | Q5VTH2 |
ProteomicsDBi | 65328 |
Protocols and materials databases
Antibodypediai | 50104, 46 antibodies from 11 providers |
DNASUi | 257177 |
Genome annotation databases
Ensembli | ENST00000367974.2; ENSP00000356951.1; ENSG00000188931.4 |
GeneIDi | 257177 |
KEGGi | hsa:257177 |
MANE-Selecti | ENST00000367974.2; ENSP00000356951.1; NM_001013625.4; NP_001013647.2 |
UCSCi | uc001gal.5, human |
Organism-specific databases
CTDi | 257177 |
GeneCardsi | CFAP126 |
HGNCi | HGNC:32325, CFAP126 |
HPAi | ENSG00000188931, Tissue enhanced (fallopian tube, skeletal muscle) |
MIMi | 616119, gene |
neXtProti | NX_Q5VTH2 |
OpenTargetsi | ENSG00000188931 |
PharmGKBi | PA142672403 |
VEuPathDBi | HostDB:ENSG00000188931 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S5M4, Eukaryota |
GeneTreei | ENSGT00390000001092 |
HOGENOMi | CLU_108980_0_0_1 |
InParanoidi | Q5VTH2 |
OMAi | TFMGTWQ |
OrthoDBi | 1487116at2759 |
PhylomeDBi | Q5VTH2 |
TreeFami | TF329474 |
Enzyme and pathway databases
PathwayCommonsi | Q5VTH2 |
SignaLinki | Q5VTH2 |
Miscellaneous databases
BioGRID-ORCSi | 257177, 6 hits in 1055 CRISPR screens |
ChiTaRSi | CFAP126, human |
GenomeRNAii | 257177 |
Pharosi | Q5VTH2, Tdark |
PROi | PR:Q5VTH2 |
RNActi | Q5VTH2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000188931, Expressed in right uterine tube and 112 other tissues |
Genevisiblei | Q5VTH2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR038797, Fltp |
PANTHERi | PTHR34639, PTHR34639, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FLTOP_HUMAN | |
Accessioni | Q5VTH2Primary (citable) accession number: Q5VTH2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | December 7, 2004 | |
Last modified: | May 25, 2022 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families