CFAP126

Functionⁱ

Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear.By similarity

GO - Biological processⁱ

cilium organization Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cilium biogenesis/degradation

Biological process

Cilium biogenesis/degradation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein FlattopCurated Alternative name(s): Cilia- and flagella-associated protein 126Imported
Gene namesⁱ	Name:CFAP126Imported Synonyms:C1orf192Imported, FLTPBy similarity
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000188931.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:32325 CFAP126
MIMⁱ	616119 gene
neXtProtⁱ	NX_Q5VTH2

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000188931
PharmGKBⁱ	PA142672403

Polymorphism and mutation databases

DMDMⁱ	74746942

DMDMⁱ

74746942

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000316972	1 – 177	Protein FlattopAdd BLAST		177

Proteomic databases

PaxDbⁱ	Q5VTH2
PeptideAtlas More...PeptideAtlasⁱ	Q5VTH2
PRIDEⁱ	Q5VTH2
ProteomicsDBⁱ	65328

PTM databases

iPTMnetⁱ	Q5VTH2
PhosphoSitePlusⁱ	Q5VTH2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000188931
CleanExⁱ	HS_C1orf192
Genevisibleⁱ	Q5VTH2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045904

HPAⁱ

HPA045904

Interactionⁱ

Subunit structureⁱ

Interacts with DLG3.By similarity

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000356951

STRINGⁱ

9606.ENSP00000356951

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5VTH2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Flattop family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410J0RM Eukaryota ENOG41129F8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001092
HOGENOMⁱ	HOG000111270
HOVERGENⁱ	HBG059083
InParanoidⁱ	Q5VTH2
OMAⁱ	QARSPTI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0SJX
PhylomeDBⁱ	Q5VTH2
TreeFamⁱ	TF329474

Family and domain databases

InterProⁱ	View protein in InterPro IPR038797 Fltp
PANTHERⁱ	PTHR34639 PTHR34639, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5VTH2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATNYSANQY EKAFSSKYLQ NWSPTKPTKE SISSHEGYTQ IIANDRGHLL 
        60         70         80         90        100
PSVPRSKANP WGSFMGTWQM PLKIPPARVT LTSRTTAGAA SLTKWIQKNP 
       110        120        130        140        150
DLLKASNGLC PEILGKPHDP DSQKKLRKKS ITKTVQQARS PTIIPSSPAA 
       160        170 
NLNSPDELQS SHPSAGHTPG PQRPAKS

Length:177

Mass (Da):19,293

Last modified:December 7, 2004 - v1

Checksum:ⁱ3D50FC792F5A8AF9

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	37	G → A in BU688150 (PubMed:8889548).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL592295 Genomic DNA No translation available. BU688150 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30921.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001013647.2, NM_001013625.3
UniGeneⁱ	Hs.534593

Genome annotation databases

Ensemblⁱ	ENST00000367974; ENSP00000356951; ENSG00000188931
GeneIDⁱ	257177
KEGGⁱ	hsa:257177
UCSC genome browser More...UCSCⁱ	uc001gal.5 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q5VTH2	UPI000642F44E		MICMU		197
CFAP126 isoform 1		PANTR		177
Cilia and flagella associated protein 126		PANPA		177
Cilia and flagella associated protein 126		SAIBB		177
Cilia and flagella associated protein 126		COLAP		177
+6

Protein	Similar proteins		Species	Score	Length
Q5VTH2	UPI000642F44E		MICMU		197
Uncharacterized protein		MACFA		177
Cilia and flagella associated protein 126		MACNE		177
Cilia and flagella associated protein 126		COLAP		177
Cilia and flagella associated protein 126		RHIRO		177
+15

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL592295 Genomic DNA No translation available. BU688150 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30921.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001013647.2, NM_001013625.3
UniGeneⁱ	Hs.534593

3D structure databases

ProteinModelPortalⁱ	Q5VTH2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000356951

STRINGⁱ

9606.ENSP00000356951

PTM databases

iPTMnetⁱ	Q5VTH2
PhosphoSitePlusⁱ	Q5VTH2

Polymorphism and mutation databases

DMDMⁱ	74746942

DMDMⁱ

74746942

Proteomic databases

PaxDbⁱ	Q5VTH2
PeptideAtlas More...PeptideAtlasⁱ	Q5VTH2
PRIDEⁱ	Q5VTH2
ProteomicsDBⁱ	65328

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000367974; ENSP00000356951; ENSG00000188931
GeneIDⁱ	257177
KEGGⁱ	hsa:257177
UCSC genome browser More...UCSCⁱ	uc001gal.5 human

Organism-specific databases

CTDⁱ	257177
EuPathDBⁱ	HostDB:ENSG00000188931.3
GeneCardsⁱ	CFAP126
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:32325 CFAP126
Human Protein Atlas More...HPAⁱ	HPA045904
MIMⁱ	616119 gene
neXtProtⁱ	NX_Q5VTH2
Open Targets More...OpenTargetsⁱ	ENSG00000188931
PharmGKBⁱ	PA142672403
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J0RM Eukaryota ENOG41129F8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001092
HOGENOMⁱ	HOG000111270
HOVERGENⁱ	HBG059083
InParanoidⁱ	Q5VTH2
OMAⁱ	QARSPTI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0SJX
PhylomeDBⁱ	Q5VTH2
TreeFamⁱ	TF329474

Miscellaneous databases

ChiTaRSⁱ	CFAP126 human
GenomeRNAiⁱ	257177
Protein Ontology More...PROⁱ	PR:Q5VTH2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000188931
CleanExⁱ	HS_C1orf192
Genevisibleⁱ	Q5VTH2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR038797 Fltp
PANTHERⁱ	PTHR34639 PTHR34639, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FLTOP_HUMAN
Accessionⁱ	Q5VTH2Primary (citable) accession number: Q5VTH2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
	Last sequence update:	December 7, 2004
	Last modified:	June 20, 2018
	This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q5VTH2 (FLTOP_HUMAN)

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Protein Flattop

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytoskeleton

Other locations

Cytoskeleton

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ