UniProtKB - Q5VTA0 (PRA17_HUMAN)
Protein
PRAME family member 17
Gene
PRAMEF17
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- negative regulation of apoptotic process Source: InterPro
- negative regulation of cell differentiation Source: InterPro
- negative regulation of transcription, DNA-templated Source: InterPro
- positive regulation of cell population proliferation Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q5VTA0 |
Names & Taxonomyi
Protein namesi | Recommended name: PRAME family member 17Imported |
Gene namesi | Name:PRAMEF17Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29485, PRAMEF17 |
neXtProti | NX_Q5VTA0 |
VEuPathDBi | HostDB:ENSG00000204479.4 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000204479 |
PharmGKBi | PA145148194 |
Miscellaneous databases
Pharosi | Q5VTA0, Tdark |
Genetic variation databases
BioMutai | PRAMEF17 |
DMDMi | 74746907 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000290162 | 1 – 474 | PRAME family member 17Add BLAST | 474 |
Proteomic databases
MassIVEi | Q5VTA0 |
PaxDbi | Q5VTA0 |
PeptideAtlasi | Q5VTA0 |
PRIDEi | Q5VTA0 |
ProteomicsDBi | 65318 |
PTM databases
iPTMneti | Q5VTA0 |
PhosphoSitePlusi | Q5VTA0 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 133764, 6 interactors |
IntActi | Q5VTA0, 6 interactors |
STRINGi | 9606.ENSP00000365266 |
Miscellaneous databases
RNActi | Q5VTA0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 97 – 124 | LRR 1; degenerateBy similarityAdd BLAST | 28 | |
Repeati | 179 – 203 | LRR 2; degenerateBy similarityAdd BLAST | 25 | |
Repeati | 204 – 230 | LRR 3; degenerateBy similarityAdd BLAST | 27 | |
Repeati | 231 – 265 | LRR 4; degenerateBy similarityAdd BLAST | 35 | |
Repeati | 266 – 291 | LRR 5By similarityAdd BLAST | 26 | |
Repeati | 292 – 323 | LRR 6By similarityAdd BLAST | 32 | |
Repeati | 324 – 342 | LRR 7By similarityAdd BLAST | 19 | |
Repeati | 348 – 375 | LRR 8By similarityAdd BLAST | 28 | |
Repeati | 376 – 400 | LRR 9By similarityAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the PRAME family.Curated
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | ENOG502QWSJ, Eukaryota |
GeneTreei | ENSGT00990000203552 |
HOGENOMi | CLU_039635_2_1_1 |
InParanoidi | Q5VTA0 |
OMAi | TFYFGGN |
OrthoDBi | 631249at2759 |
PhylomeDBi | Q5VTA0 |
TreeFami | TF332708 |
Family and domain databases
InterProi | View protein in InterPro IPR026271, PRAME_family |
PIRSFi | PIRSF038286, PRAME, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5VTA0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLQSPSRLL ELAGQSLLRN QFLTIFILDE LPREVFPLMF MEASSMRHFE
60 70 80 90 100
ALKLMVQAWP FLRLPLGSLM KTPHLETLQA VLKGLDTLLA QKLRPRRWKL
110 120 130 140 150
QVLDLRDVDG NFWTIWSGAR ALSCSPEAMS KRQTVEDYPR TGEHQPLKVF
160 170 180 190 200
IDLCQKESTL DECLSYLCRW IHYRRGLVHL CCNKVQNYSM PTSSFRNLLK
210 220 230 240 250
RVYPDSIQEL EIKRKCSLNK TGKFAPYLSQ MSNLRKLFLA FGYDDELYVS
260 270 280 290 300
GQQQFVPDLD CPFLCLYYPQ MLYIRKISNI KEHLEHLLRC LKNPLGTFIF
310 320 330 340 350
CHAYLADQDM ECLSQYPSLS QLKELHLIHI LMWTTNLEPL GALLEKVAAT
360 370 380 390 400
LEILTLKDCQ IQDSQLRVLL PALSRCSQLT TFYFRGNETS TNALKDLLCH
410 420 430 440 450
TGGLSKLGLE LYPAPLECLD NRGHVNWEIL APIRAELMCT LREVRQPKRI
460 470
FFGPIPCPSC GSWPSEKVDF HLCS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL603749 Genomic DNA No translation available. CH471167 Genomic DNA Translation: EAW51687.1 BC144662 mRNA Translation: AAI44663.1 BC146858 mRNA Translation: AAI46859.1 |
CCDSi | CCDS41264.1 |
RefSeqi | NP_001093321.1, NM_001099851.3 |
Genome annotation databases
Ensembli | ENST00000376098; ENSP00000365266; ENSG00000204479 |
GeneIDi | 391004 |
KEGGi | hsa:391004 |
UCSCi | uc009vnz.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL603749 Genomic DNA No translation available. CH471167 Genomic DNA Translation: EAW51687.1 BC144662 mRNA Translation: AAI44663.1 BC146858 mRNA Translation: AAI46859.1 |
CCDSi | CCDS41264.1 |
RefSeqi | NP_001093321.1, NM_001099851.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 133764, 6 interactors |
IntActi | Q5VTA0, 6 interactors |
STRINGi | 9606.ENSP00000365266 |
PTM databases
iPTMneti | Q5VTA0 |
PhosphoSitePlusi | Q5VTA0 |
Genetic variation databases
BioMutai | PRAMEF17 |
DMDMi | 74746907 |
Proteomic databases
MassIVEi | Q5VTA0 |
PaxDbi | Q5VTA0 |
PeptideAtlasi | Q5VTA0 |
PRIDEi | Q5VTA0 |
ProteomicsDBi | 65318 |
Protocols and materials databases
Antibodypediai | 71974, 62 antibodies |
Genome annotation databases
Ensembli | ENST00000376098; ENSP00000365266; ENSG00000204479 |
GeneIDi | 391004 |
KEGGi | hsa:391004 |
UCSCi | uc009vnz.3, human |
Organism-specific databases
CTDi | 391004 |
GeneCardsi | PRAMEF17 |
HGNCi | HGNC:29485, PRAMEF17 |
HPAi | ENSG00000204479, Not detected |
neXtProti | NX_Q5VTA0 |
OpenTargetsi | ENSG00000204479 |
PharmGKBi | PA145148194 |
VEuPathDBi | HostDB:ENSG00000204479.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWSJ, Eukaryota |
GeneTreei | ENSGT00990000203552 |
HOGENOMi | CLU_039635_2_1_1 |
InParanoidi | Q5VTA0 |
OMAi | TFYFGGN |
OrthoDBi | 631249at2759 |
PhylomeDBi | Q5VTA0 |
TreeFami | TF332708 |
Enzyme and pathway databases
PathwayCommonsi | Q5VTA0 |
Miscellaneous databases
BioGRID-ORCSi | 391004, 102 hits in 551 CRISPR screens |
GenomeRNAii | 391004 |
Pharosi | Q5VTA0, Tdark |
PROi | PR:Q5VTA0 |
RNActi | Q5VTA0, protein |
Family and domain databases
InterProi | View protein in InterPro IPR026271, PRAME_family |
PIRSFi | PIRSF038286, PRAME, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRA17_HUMAN | |
Accessioni | Q5VTA0Primary (citable) accession number: Q5VTA0 Secondary accession number(s): B2RUU4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 12, 2007 |
Last sequence update: | December 7, 2004 | |
Last modified: | April 7, 2021 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families