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UniProtKB - Q5VTA0 (PRA17_HUMAN)

Entry version 105 (12 Aug 2020)
Sequence version 1 (07 Dec 2004)
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Protein

PRAME family member 17

Gene

PRAMEF17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5VTA0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PRAME family member 17Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRAMEF17Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000204479.4

Human Gene Nomenclature Database

More...HGNCi		HGNC:29485, PRAMEF17

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5VTA0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000204479

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA145148194

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5VTA0, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRAMEF17

Domain mapping of disease mutations (DMDM)

More...DMDMi		74746907

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002901621 – 474PRAME family member 17Add BLAST474

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5VTA0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5VTA0

PeptideAtlas

More...PeptideAtlasi		Q5VTA0

PRoteomics IDEntifications database

More...PRIDEi		Q5VTA0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65318

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5VTA0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5VTA0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000204479, Not detected

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		133764, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q5VTA0, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365266

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5VTA0, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati97 – 124LRR 1; degenerateBy similarityAdd BLAST28
Repeati179 – 203LRR 2; degenerateBy similarityAdd BLAST25
Repeati204 – 230LRR 3; degenerateBy similarityAdd BLAST27
Repeati231 – 265LRR 4; degenerateBy similarityAdd BLAST35
Repeati266 – 291LRR 5By similarityAdd BLAST26
Repeati292 – 323LRR 6By similarityAdd BLAST32
Repeati324 – 342LRR 7By similarityAdd BLAST19
Repeati348 – 375LRR 8By similarityAdd BLAST28
Repeati376 – 400LRR 9By similarityAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PRAME family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QWSJ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00990000203552

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_039635_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5VTA0

Identification of Orthologs from Complete Genome Data

More...OMAi		TFYFGGN

Database of Orthologous Groups

More...OrthoDBi		631249at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5VTA0

TreeFam database of animal gene trees

More...TreeFami		TF332708

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026271, PRAME_family

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038286, PRAME, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5VTA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLQSPSRLL ELAGQSLLRN QFLTIFILDE LPREVFPLMF MEASSMRHFE 
        60         70         80         90        100
ALKLMVQAWP FLRLPLGSLM KTPHLETLQA VLKGLDTLLA QKLRPRRWKL 
       110        120        130        140        150
QVLDLRDVDG NFWTIWSGAR ALSCSPEAMS KRQTVEDYPR TGEHQPLKVF 
       160        170        180        190        200
IDLCQKESTL DECLSYLCRW IHYRRGLVHL CCNKVQNYSM PTSSFRNLLK 
       210        220        230        240        250
RVYPDSIQEL EIKRKCSLNK TGKFAPYLSQ MSNLRKLFLA FGYDDELYVS 
       260        270        280        290        300
GQQQFVPDLD CPFLCLYYPQ MLYIRKISNI KEHLEHLLRC LKNPLGTFIF 
       310        320        330        340        350
CHAYLADQDM ECLSQYPSLS QLKELHLIHI LMWTTNLEPL GALLEKVAAT 
       360        370        380        390        400
LEILTLKDCQ IQDSQLRVLL PALSRCSQLT TFYFRGNETS TNALKDLLCH 
       410        420        430        440        450
TGGLSKLGLE LYPAPLECLD NRGHVNWEIL APIRAELMCT LREVRQPKRI 
       460        470 
FFGPIPCPSC GSWPSEKVDF HLCS
Length:474
Mass (Da):54,769
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D21A88813D471C5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL603749 Genomic DNA No translation available.
CH471167 Genomic DNA Translation: EAW51687.1
BC144662 mRNA Translation: AAI44663.1
BC146858 mRNA Translation: AAI46859.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41264.1

NCBI Reference Sequences

More...RefSeqi		NP_001093321.1, NM_001099851.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000376098; ENSP00000365266; ENSG00000204479

Database of genes from NCBI RefSeq genomes

More...GeneIDi		391004

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:391004

UCSC genome browser

More...UCSCi		uc009vnz.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL603749 Genomic DNA No translation available.
CH471167 Genomic DNA Translation: EAW51687.1
BC144662 mRNA Translation: AAI44663.1
BC146858 mRNA Translation: AAI46859.1
CCDSiCCDS41264.1
RefSeqiNP_001093321.1, NM_001099851.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi133764, 6 interactors
IntActiQ5VTA0, 6 interactors
STRINGi9606.ENSP00000365266

PTM databases

iPTMnetiQ5VTA0
PhosphoSitePlusiQ5VTA0

Polymorphism and mutation databases

BioMutaiPRAMEF17
DMDMi74746907

Proteomic databases

MassIVEiQ5VTA0
PaxDbiQ5VTA0
PeptideAtlasiQ5VTA0
PRIDEiQ5VTA0
ProteomicsDBi65318

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		71974, 62 antibodies

Genome annotation databases

EnsembliENST00000376098; ENSP00000365266; ENSG00000204479
GeneIDi391004
KEGGihsa:391004
UCSCiuc009vnz.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		391004
EuPathDBiHostDB:ENSG00000204479.4

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRAMEF17
HGNCiHGNC:29485, PRAMEF17
HPAiENSG00000204479, Not detected
neXtProtiNX_Q5VTA0
OpenTargetsiENSG00000204479
PharmGKBiPA145148194

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QWSJ, Eukaryota
GeneTreeiENSGT00990000203552
HOGENOMiCLU_039635_2_1_1
InParanoidiQ5VTA0
OMAiTFYFGGN
OrthoDBi631249at2759
PhylomeDBiQ5VTA0
TreeFamiTF332708

Enzyme and pathway databases

PathwayCommonsiQ5VTA0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		391004, 102 hits in 500 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		391004
PharosiQ5VTA0, Tdark

Protein Ontology

More...PROi		PR:Q5VTA0
RNActiQ5VTA0, protein

Family and domain databases

InterProiView protein in InterPro
IPR026271, PRAME_family
PIRSFiPIRSF038286, PRAME, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRA17_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VTA0
Secondary accession number(s): B2RUU4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: December 7, 2004
Last modified: August 12, 2020
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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