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Entry version 129 (17 Jun 2020)
Sequence version 2 (08 Mar 2011)
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Protein

Rho GTPase-activating protein SYDE2

Gene

SYDE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

Caution

It is uncertain whether Met-1 or Met-79 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein SYDE2
Alternative name(s):
Synapse defective protein 1 homolog 2
Short name:
Protein syd-1 homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYDE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000097096.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25841 SYDE2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VT97

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000097096

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5VT97 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SYDE2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
325511351

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003121601 – 1194Rho GTPase-activating protein SYDE2Add BLAST1194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei315PhosphoserineCombined sources1
Modified residuei317PhosphoserineCombined sources1
Modified residuei622PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5VT97

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5VT97

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5VT97

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5VT97

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VT97

PeptideAtlas

More...
PeptideAtlasi
Q5VT97

PRoteomics IDEntifications database

More...
PRIDEi
Q5VT97

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65314 [Q5VT97-1]
65315 [Q5VT97-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VT97

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VT97

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000097096 Expressed in heart and 117 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000097096 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123912, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q5VT97, 27 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000340594

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5VT97 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini660 – 779C2PROSITE-ProRule annotationAdd BLAST120
Domaini816 – 1031Rho-GAPPROSITE-ProRule annotationAdd BLAST216

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1452 Eukaryota
ENOG410XYAD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182819

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005764_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VT97

KEGG Orthology (KO)

More...
KOi
K20655

Identification of Orthologs from Complete Genome Data

More...
OMAi
PMSKECT

Database of Orthologous Groups

More...
OrthoDBi
1300981at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VT97

TreeFam database of animal gene trees

More...
TreeFami
TF323458

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035892 C2_domain_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5VT97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHDLPPDSGA RRGGRGLADH SFPAGARAPG QPPSRGAAYR RACPRDGERG
60 70 80 90 100
GGGRPRQQVS PPRSPQREPR GGQLRTPRMR PSCSRSLESL RVGAKPPPFQ
110 120 130 140 150
RWPSDSWIRC GAHRDWDEPP PRGGRMDGWS GDRARAAAPT GLQPPGCKDH
160 170 180 190 200
GCSSGSPFRD PAGSSVIRSG KGDRQEGPSF LRPPAVTVKK LQKWMYKGRL
210 220 230 240 250
LSLGMKGRAR GTAPKVTGTQ AASPNVGALK VRENRVLSVP PDQRITLTDL
260 270 280 290 300
FENAYGSSMK GRELEELKDN IEFRGHKPLN SITVSKKRNW LYQSTLRPLN
310 320 330 340 350
LEEENKKCQD RSHLSISPVS LPKHQLSQSF LKSSKEYCTY VVCNATNSSL
360 370 380 390 400
SKNCALDFNE ENDADDEGEI WYNPIPEDDD LGISSALSFG EADSAVLKLP
410 420 430 440 450
AVNLSMLSGS DLMKAERHTE DSLCSSEHAG DIQTTRSNGM NPIHPAHSTE
460 470 480 490 500
FVQQYKQKLG HKTQEGIMVE DSPMLKSPFA GSGILAATNS TELGIMEPSS
510 520 530 540 550
PNPSPVKKGS SINWSLPDKI KSPRTVRKLS MKMKKLPEFS RKLSVKGTLN
560 570 580 590 600
YINSPDNTPS LSKYNCREVH HTDILPSGNT TTAAKRNVIS RYHLDTSVSS
610 620 630 640 650
QQSYQKKNSM SSKYSCKGGY LSDGDSPELT TKASKHGSEN KFGKGKEIIS
660 670 680 690 700
NSCSKNEIDI DAFRHYSFSD QPKCSQYISG LMSVHFYGAE DLKPPRIDSK
710 720 730 740 750
DVFCAIQVDS VNKARTALLT CRTTFLDMDH TFNIEIENAQ HLKLVVFSWE
760 770 780 790 800
PTPRKNRVCC HGTVVLPTLF RVTKTHQLAV KLEPRGLIYV KVTLMEQWEN
810 820 830 840 850
SLHGLDINQE PIIFGVDIQK VVEKENIGLM VPLLIQKCIM EIEKRGCQVV
860 870 880 890 900
GLYRLCGSAA VKKELREAFE RDSKAVGLCE NQYPDINVIT GVLKDYLREL
910 920 930 940 950
PSPLITKQLY EAVLDAMAKS PLKMSSNGCE NDPGDSKYTV DLLDCLPEIE
960 970 980 990 1000
KATLKMLLDH LKLVASYHEV NKMTCQNLAV CFGPVLLSQR QEPSTHNNRV
1010 1020 1030 1040 1050
FTDSEELASA LDFKKHIEVL HYLLQLWPVQ RLTVKKSTDN LFPEQKSSLN
1060 1070 1080 1090 1100
YLRQKKERPH MLNLSGTDSS GVLRPRQNRL DSPLSNRYAG DWSSCGENYF
1110 1120 1130 1140 1150
LNTKENLNDV DYDDVPSEDR KIGENYSKMD GPEVMIEQPI PMSKECTFQT
1160 1170 1180 1190
YLTMQTVEST VDRKNNLKDL QESIDTLIGN LERELNKNKL NMSF
Length:1,194
Mass (Da):133,230
Last modified:March 8, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i592A8A0D29BC02BE
GO
Isoform 2 (identifier: Q5VT97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     850-863: VGLYRLCGSAAVKK → LSYYGSLLLPLLID
     864-1194: Missing.

Show »
Length:863
Mass (Da):95,471
Checksum:iB7F274BEE137EEFD
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14711 differs from that shown. Probable cloning artifact.Curated
The sequence BAB14711 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti70R → A in BF196265 (Ref. 2) Curated1
Sequence conflicti118E → K in BF196265 (Ref. 2) Curated1
Sequence conflicti175Q → P in BAB14711 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037419484I → M. Corresponds to variant dbSNP:rs12090608Ensembl.1
Natural variantiVAR_037420569V → I2 PublicationsCorresponds to variant dbSNP:rs817443Ensembl.1
Natural variantiVAR_0374211157V → I. Corresponds to variant dbSNP:rs709786Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029718850 – 863VGLYR…AAVKK → LSYYGSLLLPLLID in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_029719864 – 1194Missing in isoform 2. 1 PublicationAdd BLAST331

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL603750 Genomic DNA No translation available.
BF196265 mRNA No translation available.
AK023877 mRNA Translation: BAB14711.1 Sequence problems.
AL834286 mRNA Translation: CAD38960.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44169.1 [Q5VT97-1]

NCBI Reference Sequences

More...
RefSeqi
NP_115560.1, NM_032184.1 [Q5VT97-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000341460; ENSP00000340594; ENSG00000097096 [Q5VT97-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84144

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84144

UCSC genome browser

More...
UCSCi
uc009wcm.4 human [Q5VT97-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL603750 Genomic DNA No translation available.
BF196265 mRNA No translation available.
AK023877 mRNA Translation: BAB14711.1 Sequence problems.
AL834286 mRNA Translation: CAD38960.1
CCDSiCCDS44169.1 [Q5VT97-1]
RefSeqiNP_115560.1, NM_032184.1 [Q5VT97-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123912, 3 interactors
IntActiQ5VT97, 27 interactors
STRINGi9606.ENSP00000340594

PTM databases

iPTMnetiQ5VT97
PhosphoSitePlusiQ5VT97

Polymorphism and mutation databases

BioMutaiSYDE2
DMDMi325511351

Proteomic databases

EPDiQ5VT97
jPOSTiQ5VT97
MassIVEiQ5VT97
MaxQBiQ5VT97
PaxDbiQ5VT97
PeptideAtlasiQ5VT97
PRIDEiQ5VT97
ProteomicsDBi65314 [Q5VT97-1]
65315 [Q5VT97-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
9398 29 antibodies

Genome annotation databases

EnsembliENST00000341460; ENSP00000340594; ENSG00000097096 [Q5VT97-1]
GeneIDi84144
KEGGihsa:84144
UCSCiuc009wcm.4 human [Q5VT97-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84144
EuPathDBiHostDB:ENSG00000097096.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SYDE2
HGNCiHGNC:25841 SYDE2
HPAiENSG00000097096 Low tissue specificity
neXtProtiNX_Q5VT97
OpenTargetsiENSG00000097096

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1452 Eukaryota
ENOG410XYAD LUCA
GeneTreeiENSGT00950000182819
HOGENOMiCLU_005764_1_0_1
InParanoidiQ5VT97
KOiK20655
OMAiPMSKECT
OrthoDBi1300981at2759
PhylomeDBiQ5VT97
TreeFamiTF323458

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84144 1 hit in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SYDE2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84144
PharosiQ5VT97 Tdark

Protein Ontology

More...
PROi
PR:Q5VT97
RNActiQ5VT97 protein

Gene expression databases

BgeeiENSG00000097096 Expressed in heart and 117 other tissues

Family and domain databases

Gene3Di1.10.555.10, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892 C2_domain_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYDE2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VT97
Secondary accession number(s): Q5VT96, Q8NDB8, Q9H8A6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 8, 2011
Last modified: June 17, 2020
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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