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Protein

Rho GTPase-activating protein SYDE2

Gene

SYDE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

Caution

It is uncertain whether Met-1 or Met-79 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein SYDE2
Alternative name(s):
Synapse defective protein 1 homolog 2
Short name:
Protein syd-1 homolog 2
Gene namesi
Name:SYDE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000097096.8
HGNCiHGNC:25841 SYDE2
neXtProtiNX_Q5VT97

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000097096

Polymorphism and mutation databases

BioMutaiSYDE2
DMDMi325511351

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003121601 – 1194Rho GTPase-activating protein SYDE2Add BLAST1194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei315PhosphoserineCombined sources1
Modified residuei317PhosphoserineCombined sources1
Modified residuei622PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5VT97
MaxQBiQ5VT97
PaxDbiQ5VT97
PeptideAtlasiQ5VT97
PRIDEiQ5VT97
ProteomicsDBi65314
65315 [Q5VT97-2]

PTM databases

iPTMnetiQ5VT97
PhosphoSitePlusiQ5VT97

Expressioni

Gene expression databases

BgeeiENSG00000097096 Expressed in 118 organ(s), highest expression level in heart
CleanExiHS_SYDE2

Organism-specific databases

HPAiHPA027138
HPA058378

Interactioni

Protein-protein interaction databases

BioGridi123912, 1 interactor
STRINGi9606.ENSP00000340594

Structurei

3D structure databases

ProteinModelPortaliQ5VT97
SMRiQ5VT97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini681 – 781C2Add BLAST101
Domaini816 – 1031Rho-GAPPROSITE-ProRule annotationAdd BLAST216

Phylogenomic databases

eggNOGiKOG1452 Eukaryota
ENOG410XYAD LUCA
GeneTreeiENSGT00930000150830
HOGENOMiHOG000154470
HOVERGENiHBG094587
InParanoidiQ5VT97
KOiK20655
OMAiEENKKCQ
OrthoDBiEOG091G01HK
PhylomeDBiQ5VT97
TreeFamiTF323458

Family and domain databases

Gene3Di1.10.555.10, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892 C2_domain_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5VT97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHDLPPDSGA RRGGRGLADH SFPAGARAPG QPPSRGAAYR RACPRDGERG
60 70 80 90 100
GGGRPRQQVS PPRSPQREPR GGQLRTPRMR PSCSRSLESL RVGAKPPPFQ
110 120 130 140 150
RWPSDSWIRC GAHRDWDEPP PRGGRMDGWS GDRARAAAPT GLQPPGCKDH
160 170 180 190 200
GCSSGSPFRD PAGSSVIRSG KGDRQEGPSF LRPPAVTVKK LQKWMYKGRL
210 220 230 240 250
LSLGMKGRAR GTAPKVTGTQ AASPNVGALK VRENRVLSVP PDQRITLTDL
260 270 280 290 300
FENAYGSSMK GRELEELKDN IEFRGHKPLN SITVSKKRNW LYQSTLRPLN
310 320 330 340 350
LEEENKKCQD RSHLSISPVS LPKHQLSQSF LKSSKEYCTY VVCNATNSSL
360 370 380 390 400
SKNCALDFNE ENDADDEGEI WYNPIPEDDD LGISSALSFG EADSAVLKLP
410 420 430 440 450
AVNLSMLSGS DLMKAERHTE DSLCSSEHAG DIQTTRSNGM NPIHPAHSTE
460 470 480 490 500
FVQQYKQKLG HKTQEGIMVE DSPMLKSPFA GSGILAATNS TELGIMEPSS
510 520 530 540 550
PNPSPVKKGS SINWSLPDKI KSPRTVRKLS MKMKKLPEFS RKLSVKGTLN
560 570 580 590 600
YINSPDNTPS LSKYNCREVH HTDILPSGNT TTAAKRNVIS RYHLDTSVSS
610 620 630 640 650
QQSYQKKNSM SSKYSCKGGY LSDGDSPELT TKASKHGSEN KFGKGKEIIS
660 670 680 690 700
NSCSKNEIDI DAFRHYSFSD QPKCSQYISG LMSVHFYGAE DLKPPRIDSK
710 720 730 740 750
DVFCAIQVDS VNKARTALLT CRTTFLDMDH TFNIEIENAQ HLKLVVFSWE
760 770 780 790 800
PTPRKNRVCC HGTVVLPTLF RVTKTHQLAV KLEPRGLIYV KVTLMEQWEN
810 820 830 840 850
SLHGLDINQE PIIFGVDIQK VVEKENIGLM VPLLIQKCIM EIEKRGCQVV
860 870 880 890 900
GLYRLCGSAA VKKELREAFE RDSKAVGLCE NQYPDINVIT GVLKDYLREL
910 920 930 940 950
PSPLITKQLY EAVLDAMAKS PLKMSSNGCE NDPGDSKYTV DLLDCLPEIE
960 970 980 990 1000
KATLKMLLDH LKLVASYHEV NKMTCQNLAV CFGPVLLSQR QEPSTHNNRV
1010 1020 1030 1040 1050
FTDSEELASA LDFKKHIEVL HYLLQLWPVQ RLTVKKSTDN LFPEQKSSLN
1060 1070 1080 1090 1100
YLRQKKERPH MLNLSGTDSS GVLRPRQNRL DSPLSNRYAG DWSSCGENYF
1110 1120 1130 1140 1150
LNTKENLNDV DYDDVPSEDR KIGENYSKMD GPEVMIEQPI PMSKECTFQT
1160 1170 1180 1190
YLTMQTVEST VDRKNNLKDL QESIDTLIGN LERELNKNKL NMSF
Length:1,194
Mass (Da):133,230
Last modified:March 8, 2011 - v2
Checksum:i592A8A0D29BC02BE
GO
Isoform 2 (identifier: Q5VT97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     850-863: VGLYRLCGSAAVKK → LSYYGSLLLPLLID
     864-1194: Missing.

Show »
Length:863
Mass (Da):95,471
Checksum:iB7F274BEE137EEFD
GO

Sequence cautioni

The sequence BAB14711 differs from that shown. Probable cloning artifact.Curated
The sequence BAB14711 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70R → A in BF196265 (Ref. 2) Curated1
Sequence conflicti118E → K in BF196265 (Ref. 2) Curated1
Sequence conflicti175Q → P in BAB14711 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037419484I → M. Corresponds to variant dbSNP:rs12090608Ensembl.1
Natural variantiVAR_037420569V → I2 PublicationsCorresponds to variant dbSNP:rs817443Ensembl.1
Natural variantiVAR_0374211157V → I. Corresponds to variant dbSNP:rs709786Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029718850 – 863VGLYR…AAVKK → LSYYGSLLLPLLID in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_029719864 – 1194Missing in isoform 2. 1 PublicationAdd BLAST331

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL603750 Genomic DNA No translation available.
BF196265 mRNA No translation available.
AK023877 mRNA Translation: BAB14711.1 Sequence problems.
AL834286 mRNA Translation: CAD38960.1
CCDSiCCDS44169.1 [Q5VT97-1]
RefSeqiNP_115560.1, NM_032184.1 [Q5VT97-1]
UniGeneiHs.533853
Hs.670497
Hs.729233

Genome annotation databases

EnsembliENST00000341460; ENSP00000340594; ENSG00000097096 [Q5VT97-1]
GeneIDi84144
KEGGihsa:84144
UCSCiuc009wcm.4 human [Q5VT97-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL603750 Genomic DNA No translation available.
BF196265 mRNA No translation available.
AK023877 mRNA Translation: BAB14711.1 Sequence problems.
AL834286 mRNA Translation: CAD38960.1
CCDSiCCDS44169.1 [Q5VT97-1]
RefSeqiNP_115560.1, NM_032184.1 [Q5VT97-1]
UniGeneiHs.533853
Hs.670497
Hs.729233

3D structure databases

ProteinModelPortaliQ5VT97
SMRiQ5VT97
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123912, 1 interactor
STRINGi9606.ENSP00000340594

PTM databases

iPTMnetiQ5VT97
PhosphoSitePlusiQ5VT97

Polymorphism and mutation databases

BioMutaiSYDE2
DMDMi325511351

Proteomic databases

EPDiQ5VT97
MaxQBiQ5VT97
PaxDbiQ5VT97
PeptideAtlasiQ5VT97
PRIDEiQ5VT97
ProteomicsDBi65314
65315 [Q5VT97-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341460; ENSP00000340594; ENSG00000097096 [Q5VT97-1]
GeneIDi84144
KEGGihsa:84144
UCSCiuc009wcm.4 human [Q5VT97-1]

Organism-specific databases

CTDi84144
EuPathDBiHostDB:ENSG00000097096.8
GeneCardsiSYDE2
H-InvDBiHIX0000742
HGNCiHGNC:25841 SYDE2
HPAiHPA027138
HPA058378
neXtProtiNX_Q5VT97
OpenTargetsiENSG00000097096
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1452 Eukaryota
ENOG410XYAD LUCA
GeneTreeiENSGT00930000150830
HOGENOMiHOG000154470
HOVERGENiHBG094587
InParanoidiQ5VT97
KOiK20655
OMAiEENKKCQ
OrthoDBiEOG091G01HK
PhylomeDBiQ5VT97
TreeFamiTF323458

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRSiSYDE2 human
GenomeRNAii84144
PROiPR:Q5VT97

Gene expression databases

BgeeiENSG00000097096 Expressed in 118 organ(s), highest expression level in heart
CleanExiHS_SYDE2

Family and domain databases

Gene3Di1.10.555.10, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892 C2_domain_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYDE2_HUMAN
AccessioniPrimary (citable) accession number: Q5VT97
Secondary accession number(s): Q5VT96, Q8NDB8, Q9H8A6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 8, 2011
Last modified: November 7, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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