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UniProtKB - Q5VT06 (CE350_HUMAN)

Entry version 158 (02 Dec 2020)
Sequence version 1 (07 Dec 2004)
Previous versions | rss
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Protein

Centrosome-associated protein 350

Gene

CEP350

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5VT06

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q5VT06

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosome-associated protein 350Curated
Short name:
Cep350
Alternative name(s):
Centrosome-associated protein of 350 kDa1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP350Imported
Synonyms:CAP3501 Publication, KIAA0480
ORF Names:GM1331 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000135837.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:24238, CEP350

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617870, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5VT06

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi762 – 763LL → AA: Abolishes recruitment of PPARA to specific nuclear foci. No effect on interaction with PPARA (in vitro). 1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		9857

Open Targets

More...OpenTargetsi		ENSG00000135837

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485434

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5VT06, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CEP350

Domain mapping of disease mutations (DMDM)

More...DMDMi		74746869

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002332911 – 3117Centrosome-associated protein 350Add BLAST3117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei86PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei507PhosphoserineCombined sources1
Modified residuei695PhosphoserineCombined sources1
Modified residuei878PhosphothreonineCombined sources1
Modified residuei939PhosphoserineCombined sources1
Modified residuei1061PhosphoserineCombined sources1
Modified residuei1253PhosphothreonineCombined sources1
Modified residuei1256PhosphoserineCombined sources1
Modified residuei1259PhosphoserineCombined sources1
Modified residuei1613PhosphoserineBy similarity1
Modified residuei1648PhosphoserineCombined sources1
Modified residuei1653PhosphoserineCombined sources1
Modified residuei1818PhosphoserineCombined sources1
Modified residuei1936PhosphoserineBy similarity1
Modified residuei2115PhosphoserineCombined sources1
Modified residuei2204PhosphothreonineCombined sources1
Modified residuei2206PhosphoserineCombined sources1
Modified residuei2431PhosphoserineBy similarity1
Modified residuei2460PhosphoserineCombined sources1
Modified residuei2689PhosphothreonineCombined sources1
Modified residuei2830PhosphoserineBy similarity1
Modified residuei2839PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated during mitosis.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5VT06

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5VT06

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5VT06

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5VT06

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5VT06

PeptideAtlas

More...PeptideAtlasi		Q5VT06

PRoteomics IDEntifications database

More...PRIDEi		Q5VT06

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65290

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5VT06

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5VT06

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in heart, brain, skeletal muscle, testis, placenta, lung, liver, kidney and pancreas.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000135837, Expressed in testis and 256 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5VT06, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5VT06, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000135837, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a ternary complex that contains CEP350, CEP43 and MAPRE1.

Interacts (via C-terminus) directly with CEP43 (via N-terminus) (PubMed:16314388, PubMed:28625565, PubMed:28428259).

Interacts with NR1H3, PPARA, PPARD and PPARG (PubMed:15615782).

Interacts directly with microtubules (PubMed:17878239).

Interacts with the fusion protein CEP43-FGFR1, and by doing so recruits and activates PI3K and PLC-gamma (PubMed:18412956).

Interacts with CYLD (PubMed:25134987).

Interacts with CFAP157 (By similarity).

Interacts with CEP19 (via C-terminus) (PubMed:28659385).

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115191, 76 interactors

Database of interacting proteins

More...DIPi		DIP-49946N

Protein interaction database and analysis system

More...IntActi		Q5VT06, 69 interactors

Molecular INTeraction database

More...MINTi		Q5VT06

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356579

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5VT06, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5VT06

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q5VT06

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2517 – 2559CAP-GlyPROSITE-ProRule annotationAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili598 – 645Sequence analysisAdd BLAST48
Coiled coili1369 – 1411Sequence analysisAdd BLAST43
Coiled coili1707 – 1800Sequence analysisAdd BLAST94
Coiled coili1856 – 1899Sequence analysisAdd BLAST44
Coiled coili2051 – 2110Sequence analysisAdd BLAST60
Coiled coili2719 – 2752Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1112 – 1281Ser-richAdd BLAST170
Compositional biasi1502 – 1556Ser-richAdd BLAST55

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4568, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155130

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000421_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5VT06

Identification of Orthologs from Complete Genome Data

More...OMAi		ADITTSW

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5VT06

TreeFam database of animal gene trees

More...TreeFami		TF329845

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.30.190, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036859, CAP-Gly_dom_sf
IPR000938, CAP-Gly_domain
IPR028750, CEP350
IPR025486, DUF4378

The PANTHER Classification System

More...PANTHERi		PTHR13958, PTHR13958, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01302, CAP_GLY, 1 hit
PF14309, DUF4378, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01052, CAP_GLY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF74924, SSF74924, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00845, CAP_GLY_1, 1 hit
PS50245, CAP_GLY_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q5VT06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSSKSKEVP LPNPRNSQSK DTVQADITTS WDALSQTKAA LRHIENKLEV 
        60         70         80         90        100
APTSTAVCDS VMDTKKSSTS ATRKISRKDG RYLDDSWVNA PISKSTKSRK 
       110        120        130        140        150
EKSRSPLRAT TLESNVKKNN RVEFREPLVS YREIHGAPSN FSSSHLESKH 
       160        170        180        190        200
VYCVDVNEEK TESGNWMIGS REERNIRSCD FESSQSSVIN DTVVRFLNDR 
       210        220        230        240        250
PAIDALQNSE CLIRMGASMR TEEEMPNRTK GSENNLKLSV NNMAHDTDPK 
       260        270        280        290        300
ALRLTDSSPS STSTSNSQRL DILKRRQHDV KLEKLKERIR KQWEHSEETN 
       310        320        330        340        350
GRGQKLGHID HPVMVVNVDN SVTAKVRKVA TAPPAPAYKG FNPSETKIRT 
       360        370        380        390        400
PDGKVWQEAE FQNMSRELYR DLALHFADDI SIKEKPAEKS KEKKVVKPVR 
       410        420        430        440        450
KVQKVAQLSS TECRTGSSHL ISTSSWRDGQ KLVKKILGPA PRMEPKEQRT 
       460        470        480        490        500
ASSDRGGRER TAKSGGHIGR AESDPRLDVL HRHLQRNSER SRSKSRSENN 
       510        520        530        540        550
IKKLASSLPD NKQEENTALN KDFLPIEIRG ILDDLQLDST AHTAKQDTVE 
       560        570        580        590        600
LQNQKSSAPV HAPRSHSPVK RKPDKITANE DPPVISKRRH YDTDEVRQYI 
       610        620        630        640        650
VRQQEERKRK QNEEKKAQKE ATEQKNKRLQ ELYRKQKEAF TKVKNVPPSE 
       660        670        680        690        700
PSATRRLQET YSKLLLEKTL LEEPSHQHVT QETQAKPGYQ PSGESDKENK 
       710        720        730        740        750
VQERPPSASS SSDMSLSEPP QPLARKDLME STWMQPERLS PQVHHSQPQP 
       760        770        780        790        800
FAGTAGSLLS HLLSLEHVGI LHKDFESILP TRKNHNMASR PLTFTPQPYV 
       810        820        830        840        850
TSPAAYTDAL LKPSASQYKS KLDRIEALKA TAASLSSRIE SEAKKLAGAS 
       860        870        880        890        900
INYGSAWNTE YDVQQAPQED GPWTKAVTPP VKDDNEDVFS ARIQKMLGSC 
       910        920        930        940        950
VSHATFDDDL PGVGNLSEFK KLPEMIRPQS AISSFRVRSP GPKPEGLLAQ 
       960        970        980        990       1000
LCKRQTDSSS SDMQACSQDK AKISLGSSID SVSEGPLLSE GSLSEEEGDQ 
      1010       1020       1030       1040       1050
DGQPLLKVAE ILKEKEFCPG ERNSYEPIKE FQKEAEKFLP LFGHIGGTQS 
      1060       1070       1080       1090       1100
KGPWEELAKG SPHSVINIFT KSYQLYGKGF EDKLDRGTST SRPLNATATP 
      1110       1120       1130       1140       1150
LSGVSYEDDF VSSPGTGTST EKKSTLEPHS TLSPQEDHSN RKSAYDPSSV 
      1160       1170       1180       1190       1200
DVTSQHSSGA QSAASSRSST SSKGKKGKKE KTEWLDSFTG NVQNSLLDEE 
      1210       1220       1230       1240       1250
KAERGSHQGK KSGTSSKLSV KDFEQTLDTD STLEDLSGHS VSVSSDKGRS 
      1260       1270       1280       1290       1300
QKTPTSPLSP SSQKSLQFDV AGTSSERSKS SVMPPTITGF KPNAPLTDLN 
      1310       1320       1330       1340       1350
PAASRTTTEN MAPIPGSKRF SPAGLHHRMA AELSYLNAIE ESVRQLSDVE 
      1360       1370       1380       1390       1400
RVRGISLAQQ ESVSLAQIIK AQQQRHERDL ALLKLKAEQE ALESQRQLEE 
      1410       1420       1430       1440       1450
TRNKAAQVHA ESLQQVVQSQ REVTEVLQEA TCKIAAQQSE TARLTTDAAR 
      1460       1470       1480       1490       1500
QICEMAELTR THISDAVVAS GAPLAILYDH QRQHLPDFVK QLRTRTETDR 
      1510       1520       1530       1540       1550
KSPSVSLSQS KEGTLDSKHQ KYSASYDSYS ESSGYKNHDR RSSSGSSRQE 
      1560       1570       1580       1590       1600
SPSVPSCKEN EKKLNGEKIE SSIDEQVQTA ADDSLRSDSV PSLPDEKDST 
      1610       1620       1630       1640       1650
SIATEYSLKF DESMTEDEIE EQSFRSLLPS ESHRRFNMEK RRGHHDDSDE 
      1660       1670       1680       1690       1700
EASPEKTTLS TAKELNMPFS GGQDSFSKFT MEMVRQYMKE EEMRAAHQSS 
      1710       1720       1730       1740       1750
LLRLREKALK EKTKAELAWL EHQKKHLRDK GEDDKMPPLR KKQRGLLLRL 
      1760       1770       1780       1790       1800
QQEKAEIKRL QEANKAARKE RQLILKQQEE IEKIRQTTIK LQEKLKSAGE 
      1810       1820       1830       1840       1850
SKLDSHSDDD TKDNKATSPG PTDLETRSPS PISISSSETS SIMQKLKKMR 
      1860       1870       1880       1890       1900
SRMDEKFLTK REQKLMQRRQ HAEELLEWKR RLDAEEAEIR QMEKQALAAW 
      1910       1920       1930       1940       1950
DKELIKPKTP KKELEDQRTE QKEIASEEES PVPLYSHLNS ESSIPEELGS 
      1960       1970       1980       1990       2000
PAVEYVPSES IGQEQPGSPD HSILTEEMIC SQELESSTSP SKHSLPKSCT 
      2010       2020       2030       2040       2050
SVSKQESSKG SHRTGGQCHL PIKSHQHCYS WSDESLSMTQ SETTSDQSDI 
      2060       2070       2080       2090       2100
EGRIRALKDE LRKRKSVVNQ LKKEQKKRQK ERLKAQEASL IKQLESYDEF 
      2110       2120       2130       2140       2150
IKKTEAELSQ DLETSPTAKP QIKTLSSASE KPKIKPLTPL HRSETAKNWK 
      2160       2170       2180       2190       2200
SLTESERSRG SLESIAEHVD ASLSGSERSV SERSLSAYAK RVNEWDSRTE 
      2210       2220       2230       2240       2250
DFQTPSPVLR SSRKIREESG DSLENVPALH LLKELNATSR ILDMSDGKVG 
      2260       2270       2280       2290       2300
ESSKKSEIKE IEYTKLKKSK IEDAFSKEGK SDVLLKLVLE QGDSSEILSK 
      2310       2320       2330       2340       2350
KDLPLDSENV QKDLVGLAIE NLHKSEEMLK ERQSDQDMNH SPNIQSGKDI 
      2360       2370       2380       2390       2400
HEQKNTKEKD LSWSEHLFAP KEIPYSEDFE VSSFKKEISA ELYKDDFEVS 
      2410       2420       2430       2440       2450
SLLSLRKDSQ SCRDKPQPMR SSTSGATSFG SNEEISECLS EKSLSIHSNV 
      2460       2470       2480       2490       2500
HSDRLLELKS PTELMKSKER SDVEHEQQVT ESPSLASVPT ADELFDFHIG 
      2510       2520       2530       2540       2550
DRVLIGNVQP GILRFKGETS FAKGFWAGVE LDKPEGNNNG TYDGIAYFEC 
      2560       2570       2580       2590       2600
KEKHGIFAPP QKISHIPENF DDYVDINEDE DCYSDERYQC YNQEQNDTEG 
      2610       2620       2630       2640       2650
PKDREKDVSE YFYEKSLPSV NDIEASVNRS RSLKIETDNV QDISGVLEAH 
      2660       2670       2680       2690       2700
VHQQSSVDSQ ISSKENKDLI SDATEKVSIA AEDDTLDNTF SEELEKQQQF 
      2710       2720       2730       2740       2750
TEEEDNLYAE ASEKLCTPLL DLLTREKNQL EAQLKSSLNE EKKSKQQLEK 
      2760       2770       2780       2790       2800
ISLLTDSLLK VFVKDTVNQL QQIKKTRDEK IQLSNQELLG DDQKKVTPQD 
      2810       2820       2830       2840       2850
LSQNVEEQSP SISGCFLSSE LEDEKEEISS PDMCPRPESP VFGASGQEEL 
      2860       2870       2880       2890       2900
AKRLAELELS REFLSALGDD QDWFDEDFGL SSSHKIQKNK AEETIVPLMA 
      2910       2920       2930       2940       2950
EPKRVTQQPC ETLLAVPHTA EEVEILVHNA AEELWKWKEL GHDLHSISIP 
      2960       2970       2980       2990       3000
TKLLGCASKG LDIESTSKRV YKQAVFDLTK EIFEEIFAED PNLNQPVWMK 
      3010       3020       3030       3040       3050
PCRINSSYFR RVKNPNNLDE IKSFIASEVL KLFSLKKEPN HKTDWQKMMK 
      3060       3070       3080       3090       3100
FGRKKRDRVD HILVQELHEE EAQWVNYDED ELCVKMQLAD GIFETLIKDT 
      3110 
IDVLNQISEK QGRMLLV
Length:3,117
Mass (Da):350,930
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD0E03EA96DA319E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y7F7H0Y7F7_HUMAN
Centrosome-associated protein 350
CEP350
1,292Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6Q4H0Y6Q4_HUMAN
Centrosome-associated protein 350
CEP350
331Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIK0E9PIK0_HUMAN
Centrosome-associated protein 350
CEP350
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T2X5Q5T2X5_HUMAN
Centrosome-associated protein 350
CEP350
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T2X4Q5T2X4_HUMAN
Centrosome-associated protein 350
CEP350
581Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A4F6A2A4F6_HUMAN
Centrosome-associated protein 350
CEP350
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YD38H0YD38_HUMAN
Centrosome-associated protein 350
CEP350
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25Missing in AAL91355 (PubMed:11891061).Curated1
Sequence conflicti114S → G in AAL55733 (Ref. 1) Curated1
Sequence conflicti459E → R in AAL55733 (Ref. 1) Curated1
Sequence conflicti2164S → P in AAL55733 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059202892R → T. Corresponds to variant dbSNP:rs6692219Ensembl.1
Natural variantiVAR_026126945E → Q1 PublicationCorresponds to variant dbSNP:rs2477120Ensembl.1
Natural variantiVAR_0592031213G → V. Corresponds to variant dbSNP:rs12125245Ensembl.1
Natural variantiVAR_0486711445T → A. Corresponds to variant dbSNP:rs16855164Ensembl.1
Natural variantiVAR_0592041446T → A. Corresponds to variant dbSNP:rs16855164Ensembl.1
Natural variantiVAR_0592051517S → A. Corresponds to variant dbSNP:rs12124336Ensembl.1
Natural variantiVAR_0610922044T → P. Corresponds to variant dbSNP:rs56173179Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF287356 mRNA Translation: AAL55733.1
AL645487 Genomic DNA No translation available.
AL590632 Genomic DNA No translation available.
AL390718 Genomic DNA No translation available.
AF387614 mRNA Translation: AAL91355.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1336.1

Protein sequence database of the Protein Information Resource

More...PIRi		T00263

NCBI Reference Sequences

More...RefSeqi		NP_055625.4, NM_014810.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000367607; ENSP00000356579; ENSG00000135837

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9857

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9857

UCSC genome browser

More...UCSCi		uc001gnt.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287356 mRNA Translation: AAL55733.1
AL645487 Genomic DNA No translation available.
AL590632 Genomic DNA No translation available.
AL390718 Genomic DNA No translation available.
AF387614 mRNA Translation: AAL91355.1
CCDSiCCDS1336.1
PIRiT00263
RefSeqiNP_055625.4, NM_014810.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2COZNMR-A2473-2581[»]
SMRiQ5VT06
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115191, 76 interactors
DIPiDIP-49946N
IntActiQ5VT06, 69 interactors
MINTiQ5VT06
STRINGi9606.ENSP00000356579

PTM databases

iPTMnetiQ5VT06
PhosphoSitePlusiQ5VT06

Polymorphism and mutation databases

BioMutaiCEP350
DMDMi74746869

Proteomic databases

EPDiQ5VT06
jPOSTiQ5VT06
MassIVEiQ5VT06
MaxQBiQ5VT06
PaxDbiQ5VT06
PeptideAtlasiQ5VT06
PRIDEiQ5VT06
ProteomicsDBi65290

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34424, 68 antibodies

Genome annotation databases

EnsembliENST00000367607; ENSP00000356579; ENSG00000135837
GeneIDi9857
KEGGihsa:9857
UCSCiuc001gnt.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9857
DisGeNETi9857
EuPathDBiHostDB:ENSG00000135837.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		CEP350
HGNCiHGNC:24238, CEP350
HPAiENSG00000135837, Low tissue specificity
MIMi617870, gene
neXtProtiNX_Q5VT06
OpenTargetsiENSG00000135837
PharmGKBiPA143485434

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4568, Eukaryota
GeneTreeiENSGT00940000155130
HOGENOMiCLU_000421_0_0_1
InParanoidiQ5VT06
OMAiADITTSW
PhylomeDBiQ5VT06
TreeFamiTF329845

Enzyme and pathway databases

PathwayCommonsiQ5VT06
SIGNORiQ5VT06

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9857, 62 hits in 849 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CEP350, human
EvolutionaryTraceiQ5VT06

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CEP350

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9857
PharosiQ5VT06, Tbio

Protein Ontology

More...PROi		PR:Q5VT06
RNActiQ5VT06, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000135837, Expressed in testis and 256 other tissues
ExpressionAtlasiQ5VT06, baseline and differential
GenevisibleiQ5VT06, HS

Family and domain databases

Gene3Di2.30.30.190, 1 hit
InterProiView protein in InterPro
IPR036859, CAP-Gly_dom_sf
IPR000938, CAP-Gly_domain
IPR028750, CEP350
IPR025486, DUF4378
PANTHERiPTHR13958, PTHR13958, 1 hit
PfamiView protein in Pfam
PF01302, CAP_GLY, 1 hit
PF14309, DUF4378, 1 hit
SMARTiView protein in SMART
SM01052, CAP_GLY, 1 hit
SUPFAMiSSF74924, SSF74924, 1 hit
PROSITEiView protein in PROSITE
PS00845, CAP_GLY_1, 1 hit
PS50245, CAP_GLY_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCE350_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VT06
Secondary accession number(s): O75068, Q8TDK3, Q8WY20
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 7, 2004
Last modified: December 2, 2020
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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