UniProtKB - Q5VST6 (AB17B_HUMAN)
Protein
Alpha/beta hydrolase domain-containing protein 17B
Gene
ABHD17B
Organism
Homo sapiens (Human)
Status
Functioni
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913).By similarity1 Publication
Catalytic activityi
- H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H+ + hexadecanoate + L-cysteinyl-[protein]1 PublicationEC:3.1.2.221 Publication
Activity regulationi
Inhibited by palmostatin-B.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 170 | Charge relay systemBy similarity | 1 | |
Active sitei | 235 | Charge relay systemBy similarity | 1 | |
Active sitei | 264 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- palmitoyl-(protein) hydrolase activity Source: UniProtKB
GO - Biological processi
- negative regulation of protein localization to microtubule Source: Ensembl
- positive regulation of protein localization to endosome Source: Ensembl
- protein depalmitoylation Source: UniProtKB
- regulation of dendritic spine maintenance Source: Ensembl
- regulation of postsynapse organization Source: GO_Central
- regulation of protein localization to synapse Source: Ensembl
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
PathwayCommonsi | Q5VST6 |
Reactomei | R-HSA-9648002, RAS processing |
Protein family/group databases
ESTHERi | human-ABHD17B, ABHD17-depalmitoylase |
MEROPSi | S09.055 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha/beta hydrolase domain-containing protein 17BCurated (EC:3.1.2.221 Publication)Short name: Abhydrolase domain-containing protein 17BImported |
Gene namesi | ORF Names:CGI-67 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24278, ABHD17B |
MIMi | 617943, gene |
neXtProti | NX_Q5VST6 |
VEuPathDBi | HostDB:ENSG00000107362.13 |
Subcellular locationi
Endosome
- Recycling endosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Plasma membrane
- Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
- postsynaptic density membrane By similarity
Other locations
- dendritic spine By similarity
Endosome
- anchored component of postsynaptic recycling endosome membrane Source: Ensembl
- endosome membrane Source: GO_Central
- recycling endosome membrane Source: UniProtKB-SubCell
Plasma Membrane
- anchored component of postsynaptic density membrane Source: Ensembl
- plasma membrane Source: GO_Central
Other locations
- dendritic spine Source: UniProtKB-SubCell
- glutamatergic synapse Source: Ensembl
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Endosome, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000107362 |
PharmGKBi | PA162385624 |
Miscellaneous databases
Pharosi | Q5VST6, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2189132 |
Genetic variation databases
BioMutai | ABHD17B |
DMDMi | 74746845 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000281111 | 1 – 288 | Alpha/beta hydrolase domain-containing protein 17BAdd BLAST | 288 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 282 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95.By similarity
Keywords - PTMi
Lipoprotein, Palmitate, PhosphoproteinProteomic databases
EPDi | Q5VST6 |
jPOSTi | Q5VST6 |
MassIVEi | Q5VST6 |
MaxQBi | Q5VST6 |
PaxDbi | Q5VST6 |
PeptideAtlasi | Q5VST6 |
PRIDEi | Q5VST6 |
ProteomicsDBi | 65278 [Q5VST6-1] 65279 [Q5VST6-2] |
PTM databases
iPTMneti | Q5VST6 |
PhosphoSitePlusi | Q5VST6 |
SwissPalmi | Q5VST6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000107362, Expressed in endothelial cell and 219 other tissues |
ExpressionAtlasi | Q5VST6, baseline and differential |
Genevisiblei | Q5VST6, HS |
Organism-specific databases
HPAi | ENSG00000107362, Tissue enhanced (lymphoid) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 119293, 31 interactors |
IntActi | Q5VST6, 18 interactors |
STRINGi | 9606.ENSP00000366240 |
Miscellaneous databases
RNActi | Q5VST6, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1552, Eukaryota |
GeneTreei | ENSGT00940000157611 |
HOGENOMi | CLU_029375_5_4_1 |
InParanoidi | Q5VST6 |
OMAi | NVIVYGQ |
OrthoDBi | 691954at2759 |
PhylomeDBi | Q5VST6 |
TreeFami | TF314365 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR022742, Hydrolase_4 |
Pfami | View protein in Pfam PF12146, Hydrolase_4, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q5VST6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNNLSFSELC CLFCCPPCPG KIASKLAFLP PDPTYTLMCD ESGSRWTLHL
60 70 80 90 100
SERADWQYSS REKDAIECFM TRTSKGNRIA CMFVRCSPNA KYTLLFSHGN
110 120 130 140 150
AVDLGQMSSF YIGLGSRINC NIFSYDYSGY GASSGKPTEK NLYADIEAAW
160 170 180 190 200
LALRTRYGIR PENVIIYGQS IGTVPSVDLA ARYESAAVIL HSPLTSGMRV
210 220 230 240 250
AFPDTKKTYC FDAFPNIDKI SKITSPVLII HGTEDEVIDF SHGLALFERC
260 270 280
QRPVEPLWVE GAGHNDVELY GQYLERLKQF VSQELVNL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 18 – 21 | CPGK → LSGE in AAD34062 (PubMed:10810093).Curated | 4 | |
Sequence conflicti | 43 – 44 | GS → RT in AAD34062 (PubMed:10810093).Curated | 2 | |
Sequence conflicti | 207 | K → E in AAD34062 (PubMed:10810093).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054080 | 154 | R → K. Corresponds to variant dbSNP:rs12380380Ensembl. | 1 | |
Natural variantiVAR_031230 | 169 | Q → K1 PublicationCorresponds to variant dbSNP:rs17854317Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023975 | 287 – 288 | NL → QKHKEGK in isoform 2. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151825 mRNA Translation: AAD34062.1 AK293060 mRNA Translation: BAF85749.1 AL138751 Genomic DNA No translation available. AL671309 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62521.1 BC038390 mRNA Translation: AAH38390.2 BC044576 mRNA Translation: AAH44576.1 |
CCDSi | CCDS35042.1 [Q5VST6-2] CCDS35043.1 [Q5VST6-1] |
RefSeqi | NP_001020951.1, NM_001025780.2 [Q5VST6-1] NP_057098.2, NM_016014.3 [Q5VST6-2] XP_006717197.2, XM_006717134.3 [Q5VST6-2] XP_016870276.1, XM_017014787.1 [Q5VST6-2] XP_016870277.1, XM_017014788.1 [Q5VST6-1] XP_016870278.1, XM_017014789.1 [Q5VST6-1] |
Genome annotation databases
Ensembli | ENST00000333421; ENSP00000330222; ENSG00000107362 [Q5VST6-1] ENST00000377041; ENSP00000366240; ENSG00000107362 [Q5VST6-2] |
GeneIDi | 51104 |
KEGGi | hsa:51104 |
UCSCi | uc004ail.4, human [Q5VST6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151825 mRNA Translation: AAD34062.1 AK293060 mRNA Translation: BAF85749.1 AL138751 Genomic DNA No translation available. AL671309 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62521.1 BC038390 mRNA Translation: AAH38390.2 BC044576 mRNA Translation: AAH44576.1 |
CCDSi | CCDS35042.1 [Q5VST6-2] CCDS35043.1 [Q5VST6-1] |
RefSeqi | NP_001020951.1, NM_001025780.2 [Q5VST6-1] NP_057098.2, NM_016014.3 [Q5VST6-2] XP_006717197.2, XM_006717134.3 [Q5VST6-2] XP_016870276.1, XM_017014787.1 [Q5VST6-2] XP_016870277.1, XM_017014788.1 [Q5VST6-1] XP_016870278.1, XM_017014789.1 [Q5VST6-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119293, 31 interactors |
IntActi | Q5VST6, 18 interactors |
STRINGi | 9606.ENSP00000366240 |
Chemistry databases
ChEMBLi | CHEMBL2189132 |
Protein family/group databases
ESTHERi | human-ABHD17B, ABHD17-depalmitoylase |
MEROPSi | S09.055 |
PTM databases
iPTMneti | Q5VST6 |
PhosphoSitePlusi | Q5VST6 |
SwissPalmi | Q5VST6 |
Genetic variation databases
BioMutai | ABHD17B |
DMDMi | 74746845 |
Proteomic databases
EPDi | Q5VST6 |
jPOSTi | Q5VST6 |
MassIVEi | Q5VST6 |
MaxQBi | Q5VST6 |
PaxDbi | Q5VST6 |
PeptideAtlasi | Q5VST6 |
PRIDEi | Q5VST6 |
ProteomicsDBi | 65278 [Q5VST6-1] 65279 [Q5VST6-2] |
Protocols and materials databases
Antibodypediai | 26944, 34 antibodies |
Genome annotation databases
Ensembli | ENST00000333421; ENSP00000330222; ENSG00000107362 [Q5VST6-1] ENST00000377041; ENSP00000366240; ENSG00000107362 [Q5VST6-2] |
GeneIDi | 51104 |
KEGGi | hsa:51104 |
UCSCi | uc004ail.4, human [Q5VST6-1] |
Organism-specific databases
CTDi | 51104 |
GeneCardsi | ABHD17B |
HGNCi | HGNC:24278, ABHD17B |
HPAi | ENSG00000107362, Tissue enhanced (lymphoid) |
MIMi | 617943, gene |
neXtProti | NX_Q5VST6 |
OpenTargetsi | ENSG00000107362 |
PharmGKBi | PA162385624 |
VEuPathDBi | HostDB:ENSG00000107362.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1552, Eukaryota |
GeneTreei | ENSGT00940000157611 |
HOGENOMi | CLU_029375_5_4_1 |
InParanoidi | Q5VST6 |
OMAi | NVIVYGQ |
OrthoDBi | 691954at2759 |
PhylomeDBi | Q5VST6 |
TreeFami | TF314365 |
Enzyme and pathway databases
PathwayCommonsi | Q5VST6 |
Reactomei | R-HSA-9648002, RAS processing |
Miscellaneous databases
BioGRID-ORCSi | 51104, 12 hits in 875 CRISPR screens |
ChiTaRSi | ABHD17B, human |
GenomeRNAii | 51104 |
Pharosi | Q5VST6, Tbio |
PROi | PR:Q5VST6 |
RNActi | Q5VST6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000107362, Expressed in endothelial cell and 219 other tissues |
ExpressionAtlasi | Q5VST6, baseline and differential |
Genevisiblei | Q5VST6, HS |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR022742, Hydrolase_4 |
Pfami | View protein in Pfam PF12146, Hydrolase_4, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AB17B_HUMAN | |
Accessioni | Q5VST6Primary (citable) accession number: Q5VST6 Secondary accession number(s): A8KAJ5 Q9Y377 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | December 7, 2004 | |
Last modified: | February 10, 2021 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families