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UniProtKB - Q5VST6 (AB17B_HUMAN)

Entry version 143 (07 Apr 2021)
Sequence version 1 (07 Dec 2004)
Previous versions | rss
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Protein

Alpha/beta hydrolase domain-containing protein 17B

Gene

ABHD17B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by palmostatin-B.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei170Charge relay systemBy similarity1
Active sitei235Charge relay systemBy similarity1
Active sitei264Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • palmitoyl-(protein) hydrolase activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5VST6

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9648002, RAS processing

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...ESTHERi		human-ABHD17B, ABHD17-depalmitoylase

MEROPS protease database

More...MEROPSi		S09.055

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha/beta hydrolase domain-containing protein 17BCurated (EC:3.1.2.221 Publication)
Short name:
Abhydrolase domain-containing protein 17BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABHD17BImported
Synonyms:C9orf77, FAM108B1
ORF Names:CGI-67
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24278, ABHD17B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617943, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5VST6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000107362.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Endosome, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000107362

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162385624

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5VST6, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2189132

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ABHD17B

Domain mapping of disease mutations (DMDM)

More...DMDMi		74746845

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002811111 – 288Alpha/beta hydrolase domain-containing protein 17BAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei282PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5VST6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5VST6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5VST6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5VST6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5VST6

PeptideAtlas

More...PeptideAtlasi		Q5VST6

PRoteomics IDEntifications database

More...PRIDEi		Q5VST6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65278 [Q5VST6-1]
65279 [Q5VST6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5VST6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5VST6

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q5VST6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000107362, Expressed in endothelial cell and 219 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5VST6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5VST6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000107362, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119293, 32 interactors

Protein interaction database and analysis system

More...IntActi		Q5VST6, 18 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000366240

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5VST6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AB hydrolase superfamily. ABHD17 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1552, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157611

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_029375_5_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5VST6

Identification of Orthologs from Complete Genome Data

More...OMAi		NVIVYGQ

Database of Orthologous Groups

More...OrthoDBi		691954at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5VST6

TreeFam database of animal gene trees

More...TreeFami		TF314365

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029058, AB_hydrolase
IPR022742, Hydrolase_4

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12146, Hydrolase_4, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53474, SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5VST6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNNLSFSELC CLFCCPPCPG KIASKLAFLP PDPTYTLMCD ESGSRWTLHL 
        60         70         80         90        100
SERADWQYSS REKDAIECFM TRTSKGNRIA CMFVRCSPNA KYTLLFSHGN 
       110        120        130        140        150
AVDLGQMSSF YIGLGSRINC NIFSYDYSGY GASSGKPTEK NLYADIEAAW 
       160        170        180        190        200
LALRTRYGIR PENVIIYGQS IGTVPSVDLA ARYESAAVIL HSPLTSGMRV 
       210        220        230        240        250
AFPDTKKTYC FDAFPNIDKI SKITSPVLII HGTEDEVIDF SHGLALFERC 
       260        270        280 
QRPVEPLWVE GAGHNDVELY GQYLERLKQF VSQELVNL
Length:288
Mass (Da):32,215
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF315AF711AF532BD
GO
Isoform 2 (identifier: Q5VST6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-288: NL → QKHKEGK

Show »
Length:293
Mass (Da):32,823
Checksum:i239D054DAE87173F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18 – 21CPGK → LSGE in AAD34062 (PubMed:10810093).Curated4
Sequence conflicti43 – 44GS → RT in AAD34062 (PubMed:10810093).Curated2
Sequence conflicti207K → E in AAD34062 (PubMed:10810093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054080154R → K. Corresponds to variant dbSNP:rs12380380Ensembl.1
Natural variantiVAR_031230169Q → K1 PublicationCorresponds to variant dbSNP:rs17854317Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023975287 – 288NL → QKHKEGK in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF151825 mRNA Translation: AAD34062.1
AK293060 mRNA Translation: BAF85749.1
AL138751 Genomic DNA No translation available.
AL671309 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62521.1
BC038390 mRNA Translation: AAH38390.2
BC044576 mRNA Translation: AAH44576.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35042.1 [Q5VST6-2]
CCDS35043.1 [Q5VST6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001020951.1, NM_001025780.2 [Q5VST6-1]
NP_057098.2, NM_016014.3 [Q5VST6-2]
XP_006717197.2, XM_006717134.3 [Q5VST6-2]
XP_016870276.1, XM_017014787.1 [Q5VST6-2]
XP_016870277.1, XM_017014788.1 [Q5VST6-1]
XP_016870278.1, XM_017014789.1 [Q5VST6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000333421; ENSP00000330222; ENSG00000107362 [Q5VST6-1]
ENST00000377041; ENSP00000366240; ENSG00000107362 [Q5VST6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51104

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51104

UCSC genome browser

More...UCSCi		uc004ail.4, human [Q5VST6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151825 mRNA Translation: AAD34062.1
AK293060 mRNA Translation: BAF85749.1
AL138751 Genomic DNA No translation available.
AL671309 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62521.1
BC038390 mRNA Translation: AAH38390.2
BC044576 mRNA Translation: AAH44576.1
CCDSiCCDS35042.1 [Q5VST6-2]
CCDS35043.1 [Q5VST6-1]
RefSeqiNP_001020951.1, NM_001025780.2 [Q5VST6-1]
NP_057098.2, NM_016014.3 [Q5VST6-2]
XP_006717197.2, XM_006717134.3 [Q5VST6-2]
XP_016870276.1, XM_017014787.1 [Q5VST6-2]
XP_016870277.1, XM_017014788.1 [Q5VST6-1]
XP_016870278.1, XM_017014789.1 [Q5VST6-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119293, 32 interactors
IntActiQ5VST6, 18 interactors
STRINGi9606.ENSP00000366240

Chemistry databases

ChEMBLiCHEMBL2189132

Protein family/group databases

ESTHERihuman-ABHD17B, ABHD17-depalmitoylase
MEROPSiS09.055

PTM databases

iPTMnetiQ5VST6
PhosphoSitePlusiQ5VST6
SwissPalmiQ5VST6

Genetic variation databases

BioMutaiABHD17B
DMDMi74746845

Proteomic databases

EPDiQ5VST6
jPOSTiQ5VST6
MassIVEiQ5VST6
MaxQBiQ5VST6
PaxDbiQ5VST6
PeptideAtlasiQ5VST6
PRIDEiQ5VST6
ProteomicsDBi65278 [Q5VST6-1]
65279 [Q5VST6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26944, 34 antibodies

Genome annotation databases

EnsembliENST00000333421; ENSP00000330222; ENSG00000107362 [Q5VST6-1]
ENST00000377041; ENSP00000366240; ENSG00000107362 [Q5VST6-2]
GeneIDi51104
KEGGihsa:51104
UCSCiuc004ail.4, human [Q5VST6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51104

GeneCards: human genes, protein and diseases

More...GeneCardsi		ABHD17B
HGNCiHGNC:24278, ABHD17B
HPAiENSG00000107362, Tissue enhanced (lymphoid)
MIMi617943, gene
neXtProtiNX_Q5VST6
OpenTargetsiENSG00000107362
PharmGKBiPA162385624
VEuPathDBiHostDB:ENSG00000107362.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1552, Eukaryota
GeneTreeiENSGT00940000157611
HOGENOMiCLU_029375_5_4_1
InParanoidiQ5VST6
OMAiNVIVYGQ
OrthoDBi691954at2759
PhylomeDBiQ5VST6
TreeFamiTF314365

Enzyme and pathway databases

PathwayCommonsiQ5VST6
ReactomeiR-HSA-9648002, RAS processing

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51104, 13 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ABHD17B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51104
PharosiQ5VST6, Tbio

Protein Ontology

More...PROi		PR:Q5VST6
RNActiQ5VST6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000107362, Expressed in endothelial cell and 219 other tissues
ExpressionAtlasiQ5VST6, baseline and differential
GenevisibleiQ5VST6, HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR022742, Hydrolase_4
PfamiView protein in Pfam
PF12146, Hydrolase_4, 1 hit
SUPFAMiSSF53474, SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAB17B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VST6
Secondary accession number(s): A8KAJ5
, Q5VST7, Q86YB6, Q8IY03, Q9Y377
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 7, 2004
Last modified: April 7, 2021
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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