Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycoprotein endo-alpha-1,2-mannosidase-like protein

Gene

MANEAL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Protein family/group databases

CAZyiGH99 Glycoside Hydrolase Family 99

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein endo-alpha-1,2-mannosidase-like protein (EC:3.2.1.-)
Gene namesi
Name:MANEAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000185090.14
HGNCiHGNC:26452 MANEAL
neXtProtiNX_Q5VSG8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini30 – 457LumenalSequence analysisAdd BLAST428

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185090
PharmGKBiPA142671481

Polymorphism and mutation databases

BioMutaiMANEAL
DMDMi74746792

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002823201 – 457Glycoprotein endo-alpha-1,2-mannosidase-like proteinAdd BLAST457

Proteomic databases

MaxQBiQ5VSG8
PaxDbiQ5VSG8
PeptideAtlasiQ5VSG8
PRIDEiQ5VSG8
ProteomicsDBi65261
65262 [Q5VSG8-2]
65263 [Q5VSG8-3]

PTM databases

iPTMnetiQ5VSG8
PhosphoSitePlusiQ5VSG8

Expressioni

Gene expression databases

BgeeiENSG00000185090
CleanExiHS_MANEAL
ExpressionAtlasiQ5VSG8 baseline and differential
GenevisibleiQ5VSG8 HS

Organism-specific databases

HPAiHPA063423

Interactioni

Protein-protein interaction databases

BioGridi127196, 20 interactors
STRINGi9606.ENSP00000362136

Structurei

3D structure databases

ProteinModelPortaliQ5VSG8
SMRiQ5VSG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 7Poly-Arg5
Compositional biasi32 – 95Pro-richAdd BLAST64

Sequence similaritiesi

Belongs to the glycosyl hydrolase 99 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMQ9 Eukaryota
ENOG4111PYT LUCA
GeneTreeiENSGT00390000016054
HOGENOMiHOG000223388
HOVERGENiHBG103563
InParanoidiQ5VSG8
OMAiYGSHGAF
OrthoDBiEOG091G0CUF
PhylomeDBiQ5VSG8
TreeFamiTF324051

Family and domain databases

CDDicd11574 GH99, 1 hit
InterProiView protein in InterPro
IPR026071 Glyco_Hydrolase_99
PANTHERiPTHR13572 PTHR13572, 1 hit
PfamiView protein in Pfam
PF16317 Glyco_hydro_99, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VSG8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARRRRRACI ALFLVLLFAF GTLMGLRTLK APDGLPALGP GLELAPFERR
60 70 80 90 100
PEGAPAPAAR APAAPAAPPP PPPPPRTADP GGSPGPAPAE AEPAPVQSLR
110 120 130 140 150
VYSDLHAFYY SWYGSPRREG HYIHWDHVMV PHWDPKISAS YPRGRHSPPD
160 170 180 190 200
DLGSSFYPEL GPYSSRDPEV LREHMTQLKE AAIGVLVLSW YPPGMADDNG
210 220 230 240 250
EPSDDLVPAI LDTAHQYSIQ VAFHIQPYKG RDDITVHDNI KYIIDTYGSH
260 270 280 290 300
GAFYRYKNSM GKSLPLFYIY DSYLTSPEAW AHLLTPNGPH SIRNTPYDGV
310 320 330 340 350
FIALLVEEGH THDILAAGFD GMYTYFASNG FSFGSSHQNW KAVKNFCDAN
360 370 380 390 400
NLMFIPSVGP GYIDTSIRPW NNHNTRNRVN GKYYETALQA ALTVRPEIVS
410 420 430 440 450
ITSFNEWHEG TQIEKAIPKK TPTRLYLDYL PHQPSLYLEL TRRWAEHFIK

EKEQWLM
Length:457
Mass (Da):51,317
Last modified:December 7, 2004 - v1
Checksum:i1C7AA38C32FE1A5A
GO
Isoform 2 (identifier: Q5VSG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.
     223-246: FHIQPYKGRDDITVHDNIKYIIDT → MITGSPQMTWCPPFWTPPISTASR

Show »
Length:235
Mass (Da):27,024
Checksum:i09057B0D65BD5D3C
GO
Isoform 3 (identifier: Q5VSG8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-250: YGSH → TGKL
     251-457: Missing.

Show »
Length:250
Mass (Da):27,386
Checksum:i40F26AFB6F18509B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0241161 – 222Missing in isoform 2. 1 PublicationAdd BLAST222
Alternative sequenceiVSP_024117223 – 246FHIQP…YIIDT → MITGSPQMTWCPPFWTPPIS TASR in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_024118247 – 250YGSH → TGKL in isoform 3. 1 Publication4
Alternative sequenceiVSP_024119251 – 457Missing in isoform 3. 1 PublicationAdd BLAST207

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055996 mRNA Translation: BAB71068.1
AL929472 Genomic DNA No translation available.
BC009952 mRNA Translation: AAH09952.2
BC031903 mRNA Translation: AAH31903.1
BC063587 mRNA Translation: AAH63587.1
BC077730 mRNA Translation: AAH77730.1
CCDSiCCDS426.1 [Q5VSG8-2]
CCDS44110.1 [Q5VSG8-1]
CCDS44111.1 [Q5VSG8-3]
RefSeqiNP_001026910.1, NM_001031740.2 [Q5VSG8-3]
NP_001106954.1, NM_001113482.1 [Q5VSG8-1]
NP_689709.1, NM_152496.2 [Q5VSG8-2]
XP_011539090.1, XM_011540788.1 [Q5VSG8-2]
UniGeneiHs.534562
Hs.706404

Genome annotation databases

EnsembliENST00000329006; ENSP00000328770; ENSG00000185090 [Q5VSG8-2]
ENST00000373045; ENSP00000362136; ENSG00000185090 [Q5VSG8-1]
ENST00000397631; ENSP00000380755; ENSG00000185090 [Q5VSG8-3]
GeneIDi149175
KEGGihsa:149175
UCSCiuc001cbx.3 human [Q5VSG8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMANEL_HUMAN
AccessioniPrimary (citable) accession number: Q5VSG8
Secondary accession number(s): Q6DD86
, Q6P497, Q8N5P8, Q96G55, Q96N42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 7, 2004
Last modified: June 20, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health