Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dihydrofolate reductase 1

Gene

folA1

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).By similarity

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.PROSITE-ProRule annotation

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate.
Proteins known to be involved in this subpathway in this organism are:
  1. Dihydrofolate reductase 2 (folA2), Dihydrofolate reductase 1 (folA1)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processOne-carbon metabolism
LigandNADP

Enzyme and pathway databases

UniPathwayi
UPA00077;UER00158

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrofolate reductase 1 (EC:1.5.1.3)
Gene namesi
Name:folA1
Ordered Locus Names:rrnAC0859
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupHalobacteriaHalobacterialesHaloarculaceaeHaloarcula
Proteomesi
  • UP000001169 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001864311 – 185Dihydrofolate reductase 1Add BLAST185

Interactioni

Protein-protein interaction databases

STRINGi272569.rrnAC0859

Structurei

3D structure databases

ProteinModelPortaliQ5V3R2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 185DHFRPROSITE-ProRule annotationAdd BLAST178

Sequence similaritiesi

Belongs to the dihydrofolate reductase family.Curated

Phylogenomic databases

eggNOGiarCOG01490 Archaea
COG0262 LUCA
HOGENOMiHOG000040233
KOiK00287
OrthoDBiPOG093Z0BT1

Family and domain databases

CDDicd00209 DHFR, 1 hit
Gene3Di3.40.430.10, 1 hit
InterProiView protein in InterPro
IPR012259 DHFR
IPR024072 DHFR-like_dom_sf
IPR017925 DHFR_CS
IPR001796 DHFR_dom
PANTHERiPTHR22778:SF16 PTHR22778:SF16, 1 hit
PfamiView protein in Pfam
PF00186 DHFR_1, 1 hit
PIRSFiPIRSF000194 DHFR, 1 hit
SUPFAMiSSF53597 SSF53597, 1 hit
PROSITEiView protein in PROSITE
PS00075 DHFR_1, 1 hit
PS51330 DHFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5V3R2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMIPDTELV LVVAADENNV IGLDGGVPWH YPEDVRQYKN RIAGHPIILG
60 70 80 90 100
RRTFESMKPI PDCYTVVLTS DDRRSADSET VEYATTPQIA VEAAARAGAS
110 120 130 140 150
GAFAGDSAGA DSSPPVTYVI GGEAVYDLFL PFAGRVFLSR IHEHNEGDRY
160 170 180
FPDLGAEWTE LSREPHDGFD VIEYEQASPR PLDDL
Length:185
Mass (Da):20,284
Last modified:December 7, 2004 - v1
Checksum:i943E45089F069380
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA Translation: AAV45840.1
RefSeqiWP_011223281.1, NC_006396.1

Genome annotation databases

EnsemblBacteriaiAAV45840; AAV45840; rrnAC0859
GeneIDi3130204
KEGGihma:rrnAC0859
PATRICifig|272569.17.peg.1598

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA Translation: AAV45840.1
RefSeqiWP_011223281.1, NC_006396.1

3D structure databases

ProteinModelPortaliQ5V3R2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272569.rrnAC0859

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV45840; AAV45840; rrnAC0859
GeneIDi3130204
KEGGihma:rrnAC0859
PATRICifig|272569.17.peg.1598

Phylogenomic databases

eggNOGiarCOG01490 Archaea
COG0262 LUCA
HOGENOMiHOG000040233
KOiK00287
OrthoDBiPOG093Z0BT1

Enzyme and pathway databases

UniPathwayi
UPA00077;UER00158

Family and domain databases

CDDicd00209 DHFR, 1 hit
Gene3Di3.40.430.10, 1 hit
InterProiView protein in InterPro
IPR012259 DHFR
IPR024072 DHFR-like_dom_sf
IPR017925 DHFR_CS
IPR001796 DHFR_dom
PANTHERiPTHR22778:SF16 PTHR22778:SF16, 1 hit
PfamiView protein in Pfam
PF00186 DHFR_1, 1 hit
PIRSFiPIRSF000194 DHFR, 1 hit
SUPFAMiSSF53597 SSF53597, 1 hit
PROSITEiView protein in PROSITE
PS00075 DHFR_1, 1 hit
PS51330 DHFR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDYR1_HALMA
AccessioniPrimary (citable) accession number: Q5V3R2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 7, 2004
Last modified: October 10, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again