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Protein

Cyclic AMP-responsive element-binding protein 3-like protein 4

Gene

Creb3l4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. Increases the binding of CREM isoform Delta with CRE. The CREM isoform Delta-CREB3L4 heterodimer functions through CRE but not through UPRE and may recruit HIRA to CRE to regulate histone exchange (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Unfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 3-like protein 4
Short name:
cAMP-responsive element-binding protein 3-like protein 4
Alternative name(s):
Androgen-induced basic leucine zipper protein
Short name:
AIbZIP
Cleaved into the following chain:
Gene namesi
Name:Creb3l4
Synonyms:Aibzip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1359278 Creb3l4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 267CytoplasmicSequence analysisAdd BLAST267
Transmembranei268 – 288Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini289 – 367LumenalSequence analysisAdd BLAST79

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002880821 – 367Cyclic AMP-responsive element-binding protein 3-like protein 4Add BLAST367
ChainiPRO_00002962221 – ?Processed cyclic AMP-responsive element-binding protein 3-like protein 4

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei310 – 311Cleavage; by PS1By similarity2

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5UEM7
PRIDEiQ5UEM7

PTM databases

iPTMnetiQ5UEM7
PhosphoSitePlusiQ5UEM7

Expressioni

Gene expression databases

BgeeiENSRNOG00000023493
GenevisibleiQ5UEM7 RN

Interactioni

Subunit structurei

Binds DNA as a dimer. Forms a heterodimer with CREM isoform Delta (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033353

Structurei

3D structure databases

ProteinModelPortaliQ5UEM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini189 – 252bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 52Required for transcriptional activationBy similarityAdd BLAST52
Regioni191 – 230Basic motifPROSITE-ProRule annotationAdd BLAST40
Regioni231 – 252Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0709 Eukaryota
ENOG410ZZQM LUCA
GeneTreeiENSGT00520000055538
HOGENOMiHOG000059566
HOVERGENiHBG058316
InParanoidiQ5UEM7
KOiK09048
OMAiEDYQPHG
OrthoDBiEOG091G0GTJ
PhylomeDBiQ5UEM7

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR029807 CREB4
PANTHERiPTHR22952:SF105 PTHR22952:SF105, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5UEM7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELGCPELLE PPEDIFSTGS FLELGFNGPP SKVPGLQKSE SDDFLNLFID
60 70 80 90 100
PNMIRCSETS PGSDSGVSED PGSPAPQAPS SPALYEVVYE AGALQGTQRE
110 120 130 140 150
AGPTFGLISI QIDQWSPAFM VPGACTVSDL PSEAHRHILP RVSTIAPPPP
160 170 180 190 200
AALLSCQRLF LTDEEKHLLG QEGVTLPSHL PLTKAEERIL KKIRRKIRNK
210 220 230 240 250
QSAQDSRRRK KEYIDGLESR VAACSEQNQK LQRKVQELER QNISLVAQVH
260 270 280 290 300
QLQKFTAQTS SRAAQTSTCV LILLFSLALI ILPSFSPFQS QPEARSEGYQ
310 320 330 340 350
LHGVISRNIL THEDMTESPE SPVLKANLEE LPQVPATNGS TKMAHLKMRV
360
KARPTGPIRG MVHADEM
Length:367
Mass (Da):40,281
Last modified:December 7, 2004 - v1
Checksum:i5670035EC3F9C37E
GO
Isoform 2 (identifier: Q5UEM7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-34: Missing.

Show »
Length:365
Mass (Da):40,085
Checksum:iE3632145EEB5BA81
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02564033 – 34Missing in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY750875 mRNA Translation: AAV29942.1
AY750876 mRNA Translation: AAV29943.1
RefSeqiNP_001007094.1, NM_001007093.1 [Q5UEM7-1]
XP_006232689.1, XM_006232627.2 [Q5UEM7-1]
XP_008759369.1, XM_008761147.1 [Q5UEM7-2]
XP_017446367.1, XM_017590878.1 [Q5UEM7-1]
UniGeneiRn.19624

Genome annotation databases

EnsembliENSRNOT00000032062; ENSRNOP00000033353; ENSRNOG00000023493 [Q5UEM7-2]
GeneIDi310616
KEGGirno:310616
UCSCiRGD:1359278 rat [Q5UEM7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCR3L4_RAT
AccessioniPrimary (citable) accession number: Q5UEM7
Secondary accession number(s): Q5UEM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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