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Protein

Phosphoinositide 3-kinase regulatory subunit 6

Gene

PIK3R6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAngiogenesis

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000174083-MONOMER
ReactomeiR-HSA-114604 GPVI-mediated activation cascade
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-392451 G beta:gamma signalling through PI3Kgamma

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide 3-kinase regulatory subunit 6
Alternative name(s):
Phosphoinositide 3-kinase gamma adapter protein of 87 kDa
p84 PI3K adapter protein
Short name:
p84 PIKAP
p87 PI3K adapter protein
Short name:
p87PIKAP
Gene namesi
Name:PIK3R6
Synonyms:C17orf38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000276231.4
HGNCiHGNC:27101 PIK3R6
MIMi611462 gene
neXtProtiNX_Q5UE93

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000276231
PharmGKBiPA162399570

Polymorphism and mutation databases

BioMutaiPIK3R6
DMDMi74746772

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002343381 – 754Phosphoinositide 3-kinase regulatory subunit 6Add BLAST754

Proteomic databases

EPDiQ5UE93
PeptideAtlasiQ5UE93
PRIDEiQ5UE93
ProteomicsDBi65246

PTM databases

iPTMnetiQ5UE93
PhosphoSitePlusiQ5UE93

Expressioni

Gene expression databases

BgeeiENSG00000276231 Expressed in 91 organ(s), highest expression level in amniotic fluid
CleanExiHS_PIK3R6
ExpressionAtlasiQ5UE93 baseline and differential
GenevisibleiQ5UE93 HS

Organism-specific databases

HPAiHPA023077

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit (PIK3CG) and a regulatory (PIK3R6) subunit. The binding of PIK3R6 to PIK3CG may exclude the binding of PIK3R5 to PIK3CG. Interacts with beta-gamma G protein dimers. Interacts with PDE3B; the interaction allows recruitment of the PI3K gamma complex to a PDE3B:RAPGEF3 complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PDE3BQ133703EBI-6172907,EBI-6172856

Protein-protein interaction databases

IntActiQ5UE93, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ5UE93
SMRiQ5UE93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063753
HOVERGENiHBG080761
InParanoidiQ5UE93
KOiK21290
OMAiIQDSKFP
OrthoDBiEOG091G0339
PhylomeDBiQ5UE93

Family and domain databases

InterProiView protein in InterPro
IPR019522 PIK3R5/6
PANTHERiPTHR15593 PTHR15593, 1 hit
PfamiView protein in Pfam
PF10486 PI3K_1B_p101, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5UE93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESSDVELDL QRSVQAVLRE LSTQAPALQS NQGMWRWSLH KKVERDPGKS
60 70 80 90 100
PVLVRILLRE LEKAESQDLR HVIIPLLHTV MYVLTKATGI TEELYQRIYA
110 120 130 140 150
FCTRLLTLPT PYCTVALDCA IRLKTEMAVP GTLYQRMVIA EQNLTNELYP
160 170 180 190 200
YQERVFLFVD PELVSASVCS ALLLEIEAAQ AQQTPETCMR HVVSHALQAA
210 220 230 240 250
LGEACHAGAL HRKLQASPRR TLEHYFHAVV AALEQMASEA SPSREGHVER
260 270 280 290 300
LEEIYCSLLG PAAGRCGGDL VQERPPSIPL PSPYITFHLW TGEEQLWKEL
310 320 330 340 350
VLFLRPRSQL RLSADLEVLD LQGLRPDREL ARVSVLSTDS GIERDLPTGA
360 370 380 390 400
DELPAPGSPE MERAGLQRKG GIKKRAWPLD FLMPGSWDGP PGLHRRTGRP
410 420 430 440 450
SGDGEMLPGV SRLHTARVLV LGDDRMLGRL AQAYHRLRKR ETQKFCLTPR
460 470 480 490 500
LSLQLYYIPV LAPEKPAASR QPELGELATF LGRVDPWYQS NVNTLCPAIH
510 520 530 540 550
KLAEMPPSLD TSRTVDPFIL DVITYYIRMG TQPIYFQIYT VKIFFSDLSQ
560 570 580 590 600
DPTEDIFLIE LKVKIQDSKF PKDGFSPRRR GVAEGPGAEL SLCYQKALLS
610 620 630 640 650
HRPREVTVSL RATGLILKAI PASDTEVSGS SHCPLPAAPV TDHTCLNVNV
660 670 680 690 700
TEVVKSSNLA GKSFSTVTNT FRTNNIQIQS RDQRLLTLSL DKDDQRTFRD
710 720 730 740 750
VVRFEVAPCP EPCSGAQKSK APWLNLHGQQ EVEAIKAKPK PLLMPINTFS

GIVQ
Length:754
Mass (Da):84,258
Last modified:December 7, 2004 - v1
Checksum:iB7E3F1C2D422E2E6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1F3A0A087X1F3_HUMAN
Phosphoinositide 3-kinase regulator...
PIK3R6
100Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY753192 mRNA Translation: AAV30085.1
AC003695 Genomic DNA No translation available.
AC009451 Genomic DNA No translation available.
AL833037 mRNA Translation: CAH56340.1
CCDSiCCDS73985.1
RefSeqiNP_001010855.1, NM_001010855.3
XP_016879718.1, XM_017024229.1
UniGeneiHs.255809

Genome annotation databases

EnsembliENST00000614407; ENSP00000482341; ENSG00000276231
ENST00000619866; ENSP00000480157; ENSG00000276231
GeneIDi146850
KEGGihsa:146850
UCSCiuc032etf.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY753192 mRNA Translation: AAV30085.1
AC003695 Genomic DNA No translation available.
AC009451 Genomic DNA No translation available.
AL833037 mRNA Translation: CAH56340.1
CCDSiCCDS73985.1
RefSeqiNP_001010855.1, NM_001010855.3
XP_016879718.1, XM_017024229.1
UniGeneiHs.255809

3D structure databases

ProteinModelPortaliQ5UE93
SMRiQ5UE93
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5UE93, 2 interactors

PTM databases

iPTMnetiQ5UE93
PhosphoSitePlusiQ5UE93

Polymorphism and mutation databases

BioMutaiPIK3R6
DMDMi74746772

Proteomic databases

EPDiQ5UE93
PeptideAtlasiQ5UE93
PRIDEiQ5UE93
ProteomicsDBi65246

Protocols and materials databases

DNASUi146850
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614407; ENSP00000482341; ENSG00000276231
ENST00000619866; ENSP00000480157; ENSG00000276231
GeneIDi146850
KEGGihsa:146850
UCSCiuc032etf.1 human

Organism-specific databases

CTDi146850
EuPathDBiHostDB:ENSG00000276231.4
GeneCardsiPIK3R6
HGNCiHGNC:27101 PIK3R6
HPAiHPA023077
MIMi611462 gene
neXtProtiNX_Q5UE93
OpenTargetsiENSG00000276231
PharmGKBiPA162399570
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063753
HOVERGENiHBG080761
InParanoidiQ5UE93
KOiK21290
OMAiIQDSKFP
OrthoDBiEOG091G0339
PhylomeDBiQ5UE93

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000174083-MONOMER
ReactomeiR-HSA-114604 GPVI-mediated activation cascade
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-392451 G beta:gamma signalling through PI3Kgamma

Miscellaneous databases

GenomeRNAii146850
PROiPR:Q5UE93
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000276231 Expressed in 91 organ(s), highest expression level in amniotic fluid
CleanExiHS_PIK3R6
ExpressionAtlasiQ5UE93 baseline and differential
GenevisibleiQ5UE93 HS

Family and domain databases

InterProiView protein in InterPro
IPR019522 PIK3R5/6
PANTHERiPTHR15593 PTHR15593, 1 hit
PfamiView protein in Pfam
PF10486 PI3K_1B_p101, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPI3R6_HUMAN
AccessioniPrimary (citable) accession number: Q5UE93
Secondary accession number(s): Q658R3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 7, 2004
Last modified: September 12, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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