Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 124 (02 Jun 2021)
Sequence version 2 (21 Dec 2004)
Previous versions | rss
Add a publicationFeedback
Protein

Autoprotease p20

Gene
N/A
Organism
Classical swine fever virus
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a cofactor for the NS3 protease activity.

ARBA annotation

Leader cysteine autoprotease that cleaves itself from the nascent polyprotein during translation of the viral mRNA. Once released, plays a role in the inhibition of host innate immune response by interacting with host IRF3 and inducing its proteasomal degradation.

ARBA annotation

Packages viral RNA to form a viral nucleocapsid and thereby protects viral RNA. Plays also a role in transcription regulation. Protects the incoming virus against IFN-induced effectors.

ARBA annotation

Plays a role in the regulation of viral RNA replication.

ARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites.ARBA annotation EC:3.4.21.113

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei49For N-terminal protease activityPROSITE-ProRule annotation1
Active sitei69For N-terminal protease activityPROSITE-ProRule annotation1
Active sitei1658Charge relay system; for serine protease NS3 activityPROSITE-ProRule annotation1
Active sitei1695Charge relay system; for serine protease NS3 activityPROSITE-ProRule annotation1
Active sitei1752Charge relay system; for serine protease NS3 activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicaseARBA annotation, Hydrolase, Ion channel, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseARBA annotation, Serine proteasePROSITE-ProRule annotationARBA annotation, Thiol proteasePROSITE-ProRule annotationARBA annotation, Transferase, Viral ion channelARBA annotation
Biological processActivation of host autophagy by virusARBA annotation, Fusion of virus membrane with host endosomal membraneARBA annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virusPROSITE-ProRule annotationARBA annotation, Inhibition of host RLR pathway by virus, Ion transport, Transport, Viral attachment to host cellARBA annotation, Viral immunoevasion, Viral penetration into host cytoplasm, Viral RNA replicationARBA annotation, Virus entry into host cell
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.21.113, 1439

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S31.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Autoprotease p20ARBA annotation (EC:2.7.7.48ARBA annotation, EC:3.4.21.113ARBA annotation, EC:3.6.1.15ARBA annotation, EC:3.6.4.13ARBA annotation)
Alternative name(s):
Capsid protein CARBA annotation
Cysteine protease NS2ARBA annotation
E(rns) glycoproteinARBA annotation
Envelope glycoprotein E1ARBA annotation
Envelope glycoprotein E2ARBA annotation
Genome polyproteinARBA annotation
N-terminal proteaseARBA annotation
NS5BARBA annotation
Non-structural protein 2ARBA annotation
Non-structural protein 2-3ARBA annotation
Non-structural protein 3ARBA annotation
Non-structural protein 4AARBA annotation
Non-structural protein 4BARBA annotation
Non-structural protein 5AARBA annotation
RNA-directed RNA polymeraseARBA annotation
Serine protease NS3ARBA annotation
Viroporin p7ARBA annotation
gp33ARBA annotation
gp44/48ARBA annotation
gp55ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiClassical swine fever virusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11096 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeKitrinoviricotaFlasuviricetesAmarilloviralesFlaviviridaePestivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000137954 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1031 – 1055HelicalSequence analysisAdd BLAST25
Transmembranei1076 – 1095HelicalSequence analysisAdd BLAST20
Transmembranei1115 – 1133HelicalSequence analysisAdd BLAST19
Transmembranei1145 – 1164HelicalSequence analysisAdd BLAST20
Transmembranei1189 – 1208HelicalSequence analysisAdd BLAST20
Transmembranei1220 – 1238HelicalSequence analysisAdd BLAST19
Transmembranei1250 – 1271HelicalSequence analysisAdd BLAST22
Transmembranei1283 – 1304HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Host cytoplasmARBA annotation, Host membraneARBA annotation, Membrane, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei168 – 169Cleavage; by autolysisPROSITE-ProRule annotation2

Keywords - PTMi

Disulfide bondARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q5U8X5, 36 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5U8X5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 168Peptidase C53InterPro annotationAdd BLAST168
Domaini1441 – 1589Peptidase C74InterPro annotationAdd BLAST149
Domaini1590 – 1763Peptidase S31InterPro annotationAdd BLAST174
Domaini1802 – 1960Helicase ATP-bindingInterPro annotationAdd BLAST159
Domaini1978 – 2179Helicase C-terminalInterPro annotationAdd BLAST202
Domaini3519 – 3642RdRp catalyticInterPro annotationAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni170 – 206DisorderedSequence analysisAdd BLAST37
Regioni221 – 242DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi173 – 205Basic and acidic residuesSequence analysisAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pestivirus polyprotein family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.140.40, 1 hit
2.60.320.20, 1 hit
2.60.40.3000, 1 hit
3.30.1360.280, 1 hit
3.30.70.270, 2 hits
3.90.730.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021824, Capsid-C_pestivirus
IPR011492, DEAD_Flavivir
IPR043502, DNA/RNA_pol_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR022120, NS2
IPR030399, NS2_C74
IPR027417, P-loop_NTPase
IPR008751, Peptidase_C53
IPR042542, Peptidase_C53_interaction
IPR032521, Pestivirus_E2
IPR042309, Pestivirus_E2_A
IPR042310, Pestivirus_E2_B
IPR042311, Pestivirus_E2_D
IPR000280, Pestivirus_NS3_S31
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR007094, RNA-dir_pol_PSvirus
IPR002166, RNA_pol_HCV
IPR036430, RNase_T2-like_sf
IPR033130, RNase_T2_His_AS_2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11889, DUF3409, 1 hit
PF07652, Flavi_DEAD, 1 hit
PF00271, Helicase_C, 1 hit
PF05550, Peptidase_C53, 1 hit
PF12387, Peptidase_C74, 1 hit
PF05578, Peptidase_S31, 1 hit
PF16329, Pestivirus_E2, 1 hit
PF00998, RdRP_3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00729, CDVENDOPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF55895, SSF55895, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51692, PESTIVIRUS_NS2_PRO, 1 hit
PS51535, PESTIVIRUS_NS3PRO, 1 hit
PS51876, PV_NPRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS00531, RNASE_T2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5U8X5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELNHFELLY KTNKQKPMGV EEPVYDVTGR PLFGDPSEVH PQSTLKLPHD
60 70 80 90 100
RGRGNIKTTL NNLPRKGDCR SGNHLGPVSG IYVKPGPVFY QDYMGPVYHR
110 120 130 140 150
APLEFFNEAQ FCEVTKRIGR VTGSDGKLYH IYVCIDGCIL LKLAKRGEPR
160 170 180 190 200
TLKWIRNFTD CPLWVTSCSD DGASGSKEKK PDRINKGKLK IAPKEHEKDS
210 220 230 240 250
RTKPPDATIV VEGVKYQVKK KGKVKGKNTQ DGLYHNKNKP PESRKKLEKA
260 270 280 290 300
LLAWAVITIM LYQPVEAENI TQWNLSDNGT NGIQHAMYLR GVSRSLHGIW
310 320 330 340 350
PEKICKGVPT YLATDTELKE IQGMMDASEG TNYTCCKLQR HEWNKHGWCN
360 370 380 390 400
WYNIDPWIQL MNRTQANLAE GPPAKECAVT CRYDKDADIN VVTQARNRPT
410 420 430 440 450
TLTGCKKGKN FSFAGTIIEG PCNFNVSVED ILYGDHECGS LLQDTALYLV
460 470 480 490 500
DGMTNTIENA RQGAARVTSW LGRQLSTAGK RLEGRSKTWF GAYALSPYCN
510 520 530 540 550
VTSKIGYIWY TNNCTPACLP KNTKIIGPGK FDTNAEDGKI LHEMGGHLSE
560 570 580 590 600
FLLLSLVVLS DFAPETASAL YLILHYVIPQ SYEEPEGCDT NQLNLTVELR
610 620 630 640 650
TEDVIPSSVW NVGKYVCVRP DWWPYETKVA LLFEEAGQVV KLALRALRDL
660 670 680 690 700
TRVWNSASTT AFLICLIKVL RGQIVQGVIW LLLVTGAQGR LACKEDYRYA
710 720 730 740 750
LSSTNEIGLL GAGGLTTTWE EYSHDLQLND GTVKAICVAG SFKVTALNVV
760 770 780 790 800
SRRYLASLHK GALLTSVTFE LLFDGTNPST EEMGDDFGFG LCPFDTSPVV
810 820 830 840 850
KGKYNTTLLN GSAFYLVCPI GWTGVIECTA VSPTTLRTEV VKTFRREKPF
860 870 880 890 900
PHRMDCVTTT VENEDLFYCK LGGNWTCVKG EPVVYTGGQV KQCKWCGFDF
910 920 930 940 950
NEPDGLPHYP IGKCILANET GYRIVDSTDC NRDGVVISAE GSHECLIGNT
960 970 980 990 1000
TVKVHASDER LGPMPCRPKE IVSSAGPVRK TSCTFNYAKT LKNKYYEPRD
1010 1020 1030 1040 1050
SYFQQYMLKG EYQYWFDLDV TDRHSDYFAE FVVLVVVALL GGRYVLWLIV
1060 1070 1080 1090 1100
TYIVLTEQLA AGLPLGQGEV VLIGNLITHT DIEVVVYFLL LYLVMRDEPI
1110 1120 1130 1140 1150
KKWILLLFHA MTNNPVKTIT VALLMVSGVA KGGKIDGGWQ RLPETSFDIQ
1160 1170 1180 1190 1200
LALTVIVVAV MLLAKRDPTT VPLVITVATL RTAKMTNGLS TDIAIATVST
1210 1220 1230 1240 1250
ALLTWTYISD YYRYKTWLQY LISTVTGIFL IRVLKGIGEL DLHTPTLPSY
1260 1270 1280 1290 1300
RPLFFILVYL ISTAVVTRWN LDIAGLLLQC VPTLLMVFTM WADILTLILI
1310 1320 1330 1340 1350
LPTYELTKLY YLKEVKIGAE RGWLWKTNFK RVNDIYEVDQ AGEGVYLFPS
1360 1370 1380 1390 1400
KQKTSSITGT MLPLIKAILI SCISNKWQFI YLLYLIFEVS YYLHKKIIDE
1410 1420 1430 1440 1450
IAGGTNFISR LVAALIEANW AFDNEEVRGL KKFFLLSSRV KELIIKHKVR
1460 1470 1480 1490 1500
NEVMVHWFGD EEVYGMPKLV GLVKAATLSK NKHCILCTVC EDREWKGETC
1510 1520 1530 1540 1550
PKCGRFGPPM TCGMTLADFE EKHYKRIFFR EDQSEGPVRE EYAGYLQYRA
1560 1570 1580 1590 1600
RGQLFLRNLP VLATKVKMLL VGNLGTEVGD LEHLGWVLRG PAVCKKVTEH
1610 1620 1630 1640 1650
EKCTTSIMDK LTAFFGVMPR GTTPRAPVRF PTSLLKIRRG LETGWAYTHQ
1660 1670 1680 1690 1700
GGISSVDHVT CGKDLLVCDT MGRTRVVCQS NNKMTDESEY GVKTDSGCPE
1710 1720 1730 1740 1750
GARCYVFNPE AVNISGTKGA MVHLQKTGGE FTCVTASGTP AFFDLKNLKG
1760 1770 1780 1790 1800
WSGLPIFEAS SGRVVGRVKV GKNEDSKPTK LMSGIQTVSK STTDLTEMVK
1810 1820 1830 1840 1850
KITTMNRGEF RQITLATGAG KTTELPRSVI EEIGRHKRVL VLIPLRAAAE
1860 1870 1880 1890 1900
SVYQYMRQKH PSIAFNLRIG EMKEGDMATG ITYASYGYFC QMPQPKLRAA
1910 1920 1930 1940 1950
MVEYSFIFLD EYHCATPEQL AIMGKIHRFS ENLRVVAMTA TPAGTVTTTG
1960 1970 1980 1990 2000
QKHPIEEFIA PEVMKGEDLG SEYLDIAGLK IPVEEMKSNM LVFVPTRNMA
2010 2020 2030 2040 2050
VETAKKLKAK GYNSGYYYSG EDPSNLRVVT SQSPYVVVAT NAIESGVTLP
2060 2070 2080 2090 2100
DLDVVVDTGL KCEKRIRLSS KMPFIVTGLK RMAVTIGEQA QRRGRVGRVK
2110 2120 2130 2140 2150
PGRYYRSQET PVGSKDYHYD LLQAQRYGIE DGINITKSFR EMNYDWSLYE
2160 2170 2180 2190 2200
EDSLMITQLE ILNNLLISEE LPMAVKNIMA RTDHPEPIQL AYNSYETQVP
2210 2220 2230 2240 2250
VLFPKIRNGE VTDSYDNYTF LNARKLGDDV PPYVYATEDE DLAVELLGLD
2260 2270 2280 2290 2300
WPDPGNQGTV EAGRALKQVV GLSTAENALL VALFGYVGYQ ALSKRHIPVV
2310 2320 2330 2340 2350
TDIYSIEDHR LEDTTHLQYA PNAIKTEGKE TELKELAQGD VQRCVEAMTN
2360 2370 2380 2390 2400
YAREGIQFMK SQALKVKETP TYKETMDTVT DYVKKFMEAL KDSKEDIMKY
2410 2420 2430 2440 2450
GLWGTHTALY KSISARLGSE TAFATLVVKW LAFGGESIAD HVKQAATDLV
2460 2470 2480 2490 2500
VYYIINRPQF PGDTETQQEG RKFVASLLVS ALATYTYKSW NYNNLSKIVE
2510 2520 2530 2540 2550
PALATLPYAA TALKLFAPTR LESVVILSTA IYKTYLSIRR GKSDGLLGTG
2560 2570 2580 2590 2600
VSAAMEIMSQ NPVSVGIAVM LGVGAVAAHN AIEASEQKRT LLMKVFVKNF
2610 2620 2630 2640 2650
LDQAATDELV KESPEKIIMA LFEAVQTVGN PLRLVYHLYG VFYKGWEAKE
2660 2670 2680 2690 2700
LAQRTAGRNL FTLIMFEAVE LLGVDSEGKI RQLSSNYILE LLYKFRDSIK
2710 2720 2730 2740 2750
SSVREMAISW APAPFSCDWT PTDDRIGLPQ DNFLQVETKC PCGYKMKAVK
2760 2770 2780 2790 2800
NCAGELRLLE EEGSFLCRNK FGRGSRNYKV TKYYDDNLSE IKPVIKMEGH
2810 2820 2830 2840 2850
VELYYKGATI KLDFNNSKTI LATDKWEVDH STLVRVLKRH TGAGYNGAYL
2860 2870 2880 2890 2900
GEKPNHKHLI ERDCATITKD KVCFLKMKRG CAFTYDLSLH NLTRLIELVH
2910 2920 2930 2940 2950
KNNLEDKEIP AVTVTTWLAY TFVNEDIGTI RPAFGEKVTP EMQEEITLQP
2960 2970 2980 2990 3000
AVVVDTTDVT VTVVGEAPTM TTGETPTAFT SSGSDPKGQQ VLKLGVGEGQ
3010 3020 3030 3040 3050
YPGTNPQRAS LHEAIQGADE RPSVLILGSD KATSNRVKTA KNVKVYRGRD
3060 3070 3080 3090 3100
PLEVRDMMRR GKILVIALSR VDNALLKFVD YKGTFLTRET LEALSLGRPK
3110 3120 3130 3140 3150
KKDITKAEAQ WLLCLEDQME ELPDWFAAGE PIFLEANIKH DRYHLVGDIA
3160 3170 3180 3190 3200
TIKEKAKQLG ATDSTKISKE VGAKVYSMKL SNWVMQEENK QGNLTPLFEE
3210 3220 3230 3240 3250
LLQQCPPGGQ NKTAHMVSAY QLAQGNWMPT SCHVFMGTIS ARRTKTHPYE
3260 3270 3280 3290 3300
AYVKLRELVE EHKMKTLCPG SSLGKHNDWI IGKIKYQGNL RTKHMLNPGK
3310 3320 3330 3340 3350
VAEQLCREGH RHNVYNKTIG SVMTATGIRL EKLPVVRAQT DTTNFHQAIR
3360 3370 3380 3390 3400
DKIDKEENLQ TPGLHKKLME VFNALKRPEL ESSYDAVEWE ELERGINRKG
3410 3420 3430 3440 3450
AAGFFERKNI GEILDSEKNK VEEIIDNLKK GRNIKYYETA IPKNEKRDVN
3460 3470 3480 3490 3500
DDWTAGDFVD EKKPRVIQYP EAKTRLAITK VMYKWVKQKP VVIPGYEGKT
3510 3520 3530 3540 3550
PLFQIFDKVK KEWDQFQNPV AVSFDTKAWD TQVTTKDLEL IKDIQKYYFK
3560 3570 3580 3590 3600
KKWHKFIDTL TMHMTEVPVI CADGEVYIRK GQRGSGQPDT SAGNSMLNVL
3610 3620 3630 3640 3650
TMVYAFCEAT GVPYKSFDRV AKIHVCGDDG FLITERALGE KFASKGVQIL
3660 3670 3680 3690 3700
YEAGKPQKIT EGDKMKVAYQ FDDIEFCSHT PIQVRWSDNT SSYMPGRNTT
3710 3720 3730 3740 3750
TILAKMATRL DSSGERGTIA YEKAVAFSFL LMYSWNPLIR RICLLVLSTE
3760 3770 3780 3790 3800
LQVKPGKSTT YYYEGDPISA YKEVIGHNLF DLKRTSFEKL AKLNLSMSVL
3810 3820 3830 3840 3850
GAWTRHTSKR LLQDCVNMGV KEGNWLVNAD RLVSSKTGNR YIPGEGHTLQ
3860 3870 3880 3890
GRHYEELVLA RKQINNFQGT DRYNLGPIVN MVLRRLRVMM MTLIGRGV
Length:3,898
Mass (Da):437,835
Last modified:December 21, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i221D3B27E69E8E44
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY775178 mRNA Translation: AAV40685.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY775178 mRNA Translation: AAV40685.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WX1X-ray2.35A1590-2272[»]
5YF5X-ray2.49A3181-3874[»]
5YF6X-ray2.10A3181-3862[»]
5YF7X-ray2.27A3181-3852[»]
5YF8X-ray3.40A3181-3852[»]
6AE4X-ray2.95A3181-3874[»]
6AE5X-ray2.75A3181-3852[»]
6AE6X-ray3.86A/B3181-3852[»]
6AE7X-ray3.80A3181-3852[»]
SMRiQ5U8X5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ5U8X5, 36 interactors

Protein family/group databases

MEROPSiS31.001

Enzyme and pathway databases

BRENDAi3.4.21.113, 1439

Family and domain databases

Gene3Di2.30.140.40, 1 hit
2.60.320.20, 1 hit
2.60.40.3000, 1 hit
3.30.1360.280, 1 hit
3.30.70.270, 2 hits
3.90.730.10, 1 hit
InterProiView protein in InterPro
IPR021824, Capsid-C_pestivirus
IPR011492, DEAD_Flavivir
IPR043502, DNA/RNA_pol_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR022120, NS2
IPR030399, NS2_C74
IPR027417, P-loop_NTPase
IPR008751, Peptidase_C53
IPR042542, Peptidase_C53_interaction
IPR032521, Pestivirus_E2
IPR042309, Pestivirus_E2_A
IPR042310, Pestivirus_E2_B
IPR042311, Pestivirus_E2_D
IPR000280, Pestivirus_NS3_S31
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR007094, RNA-dir_pol_PSvirus
IPR002166, RNA_pol_HCV
IPR036430, RNase_T2-like_sf
IPR033130, RNase_T2_His_AS_2
PfamiView protein in Pfam
PF11889, DUF3409, 1 hit
PF07652, Flavi_DEAD, 1 hit
PF00271, Helicase_C, 1 hit
PF05550, Peptidase_C53, 1 hit
PF12387, Peptidase_C74, 1 hit
PF05578, Peptidase_S31, 1 hit
PF16329, Pestivirus_E2, 1 hit
PF00998, RdRP_3, 1 hit
PRINTSiPR00729, CDVENDOPTASE
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF55895, SSF55895, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51692, PESTIVIRUS_NS2_PRO, 1 hit
PS51535, PESTIVIRUS_NS3PRO, 1 hit
PS51876, PV_NPRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS00531, RNASE_T2_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5U8X5_9FLAV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5U8X5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 21, 2004
Last modified: June 2, 2021
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again