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Entry version 124 (26 Feb 2020)
Sequence version 1 (07 Dec 2004)
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Protein

Ras-interacting protein 1

Gene

RASIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAngiogenesis

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q5U651

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras-interacting protein 1
Short name:
Rain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RASIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24716 RASIP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609623 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5U651

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54922

Open Targets

More...
OpenTargetsi
ENSG00000105538

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134875519

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5U651 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RASIP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74736209

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000971631 – 963Ras-interacting protein 1Add BLAST963

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei94Omega-N-methylarginineBy similarity1
Modified residuei188PhosphoserineCombined sources1
Modified residuei280PhosphoserineBy similarity1
Modified residuei292PhosphoserineBy similarity1
Modified residuei326PhosphoserineBy similarity1
Modified residuei328PhosphoserineBy similarity1
Modified residuei331PhosphoserineBy similarity1
Modified residuei419PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5U651

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5U651

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5U651

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5U651

PeptideAtlas

More...
PeptideAtlasi
Q5U651

PRoteomics IDEntifications database

More...
PRIDEi
Q5U651

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65240

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5U651

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5U651

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart. Detected at lower levels in placenta and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105538 Expressed in right lung and 168 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5U651 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5U651 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA077251

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Ras family members that have been activated by GTP binding.

Interacts with HRAS, RAP1A, RAP2, RRAS, RAF1 and RRAS2.

Interacts with MYH9 and ARHGAP29 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120263, 17 interactors

Database of interacting proteins

More...
DIPi
DIP-29457N

Protein interaction database and analysis system

More...
IntActi
Q5U651, 19 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000222145

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5U651 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1963
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5U651

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini144 – 259Ras-associatingPROSITE-ProRule annotationAdd BLAST116
Domaini600 – 897DilutePROSITE-ProRule annotationAdd BLAST298

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi59 – 65Poly-Pro7

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0160 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160072

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010386_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5U651

Identification of Orthologs from Complete Genome Data

More...
OMAi
WETECRR

Database of Orthologous Groups

More...
OrthoDBi
447883at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5U651

TreeFam database of animal gene trees

More...
TreeFami
TF315987

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15472 Myo5p-like_CBD_Rasip1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037983 CBD_Rasip1/Radil
IPR002710 Dilute_dom
IPR000159 RA_dom
IPR008984 SMAD_FHA_dom_sf
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843 DIL, 1 hit
PF00788 RA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01132 DIL, 1 hit
SM00314 RA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879 SSF49879, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126 DILUTE, 1 hit
PS50200 RA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5U651-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSGERKEGG SPRFGKLHLP VGLWINSPRK QLAKLGRRWP SAASVKSSSS
60 70 80 90 100
DTGSRSSEPL PPPPPHVELR RVGAVKAAGG ASGSRAKRIS QLFRGSGTGT
110 120 130 140 150
TGSSGAGGPG TPGGAQRWAS EKKLPELAAG VAPEPPLATR ATAPPGVLKI
160 170 180 190 200
FGAGLASGAN YKSVLATARS TARELVAEAL ERYGLAGSPG GGPGESSCVD
210 220 230 240 250
AFALCDALGR PAAAGVGSGE WRAEHLRVLG DSERPLLVQE LWRARPGWAR
260 270 280 290 300
RFELRGREEA RRLEQEAFGA ADSEGTGAPS WRPQKNRSRA ASGGAALASP
310 320 330 340 350
GPGTGSGAPA GSGGKERSEN LSLRRSVSEL SLQGRRRRQQ ERRQQALSMA
360 370 380 390 400
PGAADAQIGT ADPGDFDQLT QCLIQAPSNR PYFLLLQGYQ DAQDFVVYVM
410 420 430 440 450
TREQHVFGRG GNSSGRGGSP APYVDTFLNA PDILPRHCTV RAGPEHPAMV
460 470 480 490 500
RPSRGAPVTH NGCLLLREAE LHPGDLLGLG EHFLFMYKDP RTGGSGPARP
510 520 530 540 550
PWLPARPGAT PPGPGWAFSC RLCGRGLQER GEALAAYLDG REPVLRFRPR
560 570 580 590 600
EEEALLGEIV RAAAAGSGDL PPLGPATLLA LCVQHSAREL ELGHLPRLLG
610 620 630 640 650
RLARLIKEAV WEKIKEIGDR QPENHPEGVP EVPLTPEAVS VELRPLMLWM
660 670 680 690 700
ANTTELLSFV QEKVLEMEKE ADQEDPQLCN DLELCDEAMA LLDEVIMCTF
710 720 730 740 750
QQSVYYLTKT LYSTLPALLD SNPFTAGAEL PGPGAELGAM PPGLRPTLGV
760 770 780 790 800
FQAALELTSQ CELHPDLVSQ TFGYLFFFSN ASLLNSLMER GQGRPFYQWS
810 820 830 840 850
RAVQIRTNLD LVLDWLQGAG LGDIATEFFR KLSMAVNLLC VPRTSLLKAS
860 870 880 890 900
WSSLRTDHPT LTPAQLHHLL SHYQLGPGRG PPAAWDPPPA EREAVDTGDI
910 920 930 940 950
FESFSSHPPL ILPLGSSRLR LTGPVTDDAL HRELRRLRRL LWDLEQQELP
960
ANYRHGPPVA TSP
Length:963
Mass (Da):103,457
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i470021F91B59EC52
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R148M0R148_HUMAN
Ras-interacting protein 1
RASIP1
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti500P → R in AAR24580 (PubMed:15031288).Curated1
Sequence conflicti511 – 517PPGPGWA → RQPWLG in AAR24580 (PubMed:15031288).Curated7
Sequence conflicti736 – 737EL → DW in AAR24580 (PubMed:15031288).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051302601R → C1 PublicationCorresponds to variant dbSNP:rs2287922Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY378097 mRNA Translation: AAR24580.1
BC028614 mRNA Translation: AAH28614.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12731.1

NCBI Reference Sequences

More...
RefSeqi
NP_060275.2, NM_017805.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000222145; ENSP00000222145; ENSG00000105538

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54922

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54922

UCSC genome browser

More...
UCSCi
uc002pki.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY378097 mRNA Translation: AAR24580.1
BC028614 mRNA Translation: AAH28614.1
CCDSiCCDS12731.1
RefSeqiNP_060275.2, NM_017805.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KHOX-ray2.78A/B134-285[»]
5KHQX-ray2.80A/B134-285[»]
SMRiQ5U651
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi120263, 17 interactors
DIPiDIP-29457N
IntActiQ5U651, 19 interactors
STRINGi9606.ENSP00000222145

PTM databases

iPTMnetiQ5U651
PhosphoSitePlusiQ5U651

Polymorphism and mutation databases

BioMutaiRASIP1
DMDMi74736209

Proteomic databases

EPDiQ5U651
jPOSTiQ5U651
MassIVEiQ5U651
PaxDbiQ5U651
PeptideAtlasiQ5U651
PRIDEiQ5U651
ProteomicsDBi65240

Genome annotation databases

EnsembliENST00000222145; ENSP00000222145; ENSG00000105538
GeneIDi54922
KEGGihsa:54922
UCSCiuc002pki.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54922
DisGeNETi54922

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RASIP1
HGNCiHGNC:24716 RASIP1
HPAiHPA077251
MIMi609623 gene
neXtProtiNX_Q5U651
OpenTargetsiENSG00000105538
PharmGKBiPA134875519

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0160 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000160072
HOGENOMiCLU_010386_1_0_1
InParanoidiQ5U651
OMAiWETECRR
OrthoDBi447883at2759
PhylomeDBiQ5U651
TreeFamiTF315987

Enzyme and pathway databases

SignaLinkiQ5U651

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RASIP1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54922
PharosiQ5U651 Tbio

Protein Ontology

More...
PROi
PR:Q5U651
RNActiQ5U651 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105538 Expressed in right lung and 168 other tissues
ExpressionAtlasiQ5U651 baseline and differential
GenevisibleiQ5U651 HS

Family and domain databases

CDDicd15472 Myo5p-like_CBD_Rasip1, 1 hit
InterProiView protein in InterPro
IPR037983 CBD_Rasip1/Radil
IPR002710 Dilute_dom
IPR000159 RA_dom
IPR008984 SMAD_FHA_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50200 RA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAIN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5U651
Secondary accession number(s): Q6U676
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 7, 2004
Last modified: February 26, 2020
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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