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UniProtKB - Q5U5Z8 (CBPC2_HUMAN)

Entry version 124 (07 Apr 2021)
Sequence version 2 (23 Sep 2008)
Previous versions | rss
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Protein

Cytosolic carboxypeptidase 2

Gene

AGBL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.By similarity1 Publication

Caution

Was originally thought to have detyrosinating activity from C-terminal positions on tubulin.1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by RARRES1.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi462ZincBy similarity1
Metal bindingi465ZincBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei512NucleophileBy similarity1
Metal bindingi558ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5U5Z8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8955332, Carboxyterminal post-translational modifications of tubulin

Protein family/group databases

MEROPS protease database

More...MEROPSi		M14.029

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytosolic carboxypeptidase 2 (EC:3.4.17.-)
Alternative name(s):
ATP/GTP-binding protein-like 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGBL2
Synonyms:CCP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26296, AGBL2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617345, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5U5Z8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000165923.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		79841

Open Targets

More...OpenTargetsi		ENSG00000165923

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672634

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5U5Z8, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3886062

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AGBL2

Domain mapping of disease mutations (DMDM)

More...DMDMi		206729855

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002837481 – 902Cytosolic carboxypeptidase 2Add BLAST902

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5U5Z8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5U5Z8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5U5Z8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5U5Z8

PeptideAtlas

More...PeptideAtlasi		Q5U5Z8

PRoteomics IDEntifications database

More...PRIDEi		Q5U5Z8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65234 [Q5U5Z8-1]
65235 [Q5U5Z8-2]
65236 [Q5U5Z8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5U5Z8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5U5Z8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165923, Expressed in right uterine tube and 140 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5U5Z8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5U5Z8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000165923, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122932, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q5U5Z8, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000435582

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5U5Z8, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3641, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160201

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007523_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5U5Z8

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5U5Z8

TreeFam database of animal gene trees

More...TreeFami		TF313794

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040626, Pepdidase_M14_N
IPR000834, Peptidase_M14

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18027, Pepdidase_M14_N, 1 hit
PF00246, Peptidase_M14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5U5Z8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFPALETHLK QTIPDPYEDF MYRHLQYYGY FKAQRGSLPN SATHQHVRKN 
        60         70         80         90        100
NPQCLLNGSL GEKDDLIPDT LQKEKLLWPI SLSSAVHRQI EAINRDFHSC 
       110        120        130        140        150
LGWMQWRGLS SLQPPPPRFK DSPASAFRVA GITDSHMLSL PHLRSRQLLY 
       160        170        180        190        200
DELDEVNPRL REPQELFSIL STKRPLQAPR WPIECEVIKE NIHHIEWAPP 
       210        220        230        240        250
QPEYFYQPKG NEKVPEIVGE KKGTVVYQLD SVPIEGSYFT SSRVGGKRGI 
       260        270        280        290        300
VKELAVTLQG PEDNTLLFES RFESGNLQKA VRVDTYEYEL TLRTDLYTNK 
       310        320        330        340        350
HTQWFYFRVQ NTRKDATYRF TIVNLLKPKS LYTVGMKPLL YSQLDANTRN 
       360        370        380        390        400
IGWRREGNEI KYYKNNTDDG QQPFYCLTWT IQFPYDQDTC FFAHFYPYTY 
       410        420        430        440        450
TDLQCYLLSV ANNPIQSQFC KLQTLCRSLA GNTVYLLTIT NPSQTPQEAA 
       460        470        480        490        500
AKKAVVLSAR VHPGESNGSW VMKGFLDFIL SNSPDAQLLR DIFVFKVLPM 
       510        520        530        540        550
LNPDGVIVGN YRCSLAGRDL NRHYKTILKE SFPCIWYTRN MIKRLLEERE 
       560        570        580        590        600
VLLYCDFHGH SRKNNIFLYG CNNNNRKYWL HERVFPLMLC KNAPDKFSFH 
       610        620        630        640        650
SCNFKVQKCK EGTGRVVMWR MGILNSYTME STFGGSTLGN KRDTHFTIED 
       660        670        680        690        700
LKSLGYHVCD TLLDFCDPDQ MKFTQCLAEL KELLRQEIHK KFHELGQDVD 
       710        720        730        740        750
LEGSWSDISL SDIESSTSGS DSSLSDGLPV HLANIADELT QKKKMFKKKK 
       760        770        780        790        800
KKSLQTRKQR NEQYQKKNLM QKLKLTEDTS EKAGFASTLQ KQPTFFKNSE 
       810        820        830        840        850
NSSFLPMKNE NPRLNETNLN RRDKDTPLDP SMATLILPKN KGRMQNKKPG 
       860        870        880        890        900
FTVSCSPKRT INSSQEPAPG MKPNWPRSRY PATKRGCAAM AAYPSLHIYT 

YP
Length:902
Mass (Da):104,194
Last modified:September 23, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9C5D8260AFBCF65
GO
Isoform 2 (identifier: Q5U5Z8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-471: Missing.

Show »
Length:431
Mass (Da):49,706
Checksum:i24C22924E231027A
GO
Isoform 3 (identifier: Q5U5Z8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-617: Missing.

Show »
Length:285
Mass (Da):32,454
Checksum:iC5D03FEC06B4A594
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KV53H9KV53_HUMAN
Cytosolic carboxypeptidase 2
AGBL2
904Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6U0I4F6U0I4_HUMAN
Cytosolic carboxypeptidase 2
AGBL2
824Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J9JIH1J9JIH1_HUMAN
Cytosolic carboxypeptidase 2
AGBL2
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR59E9PR59_HUMAN
Cytosolic carboxypeptidase 2
AGBL2
331Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRJ1E9PRJ1_HUMAN
Cytosolic carboxypeptidase 2
AGBL2
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI49E9PI49_HUMAN
Cytosolic carboxypeptidase 2
AGBL2
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJH3E9PJH3_HUMAN
Cytosolic carboxypeptidase 2
AGBL2
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PS54E9PS54_HUMAN
Cytosolic carboxypeptidase 2
AGBL2
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15707 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAD96891 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD96896 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04663790I → R. Corresponds to variant dbSNP:rs12795414Ensembl.1
Natural variantiVAR_046638333T → P. Corresponds to variant dbSNP:rs35898124Ensembl.1
Natural variantiVAR_031572349R → H. Corresponds to variant dbSNP:rs7941404Ensembl.1
Natural variantiVAR_046639368D → G. Corresponds to variant dbSNP:rs1870545Ensembl.1
Natural variantiVAR_046640671M → I3 PublicationsCorresponds to variant dbSNP:rs12286721Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0243611 – 617Missing in isoform 3. 1 PublicationAdd BLAST617
Alternative sequenceiVSP_0243601 – 471Missing in isoform 2. 2 PublicationsAdd BLAST471

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK027251 mRNA Translation: BAB15707.1 Sequence problems.
AK223171 mRNA Translation: BAD96891.1 Different initiation.
AK223176 mRNA Translation: BAD96896.1 Different initiation.
AC021443 Genomic DNA No translation available.
BC028200 mRNA Translation: AAH28200.1
BC036234 mRNA Translation: AAH36234.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7944.1 [Q5U5Z8-1]

NCBI Reference Sequences

More...RefSeqi		NP_079059.2, NM_024783.3 [Q5U5Z8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000525123; ENSP00000435582; ENSG00000165923 [Q5U5Z8-1]
ENST00000645431; ENSP00000494229; ENSG00000285501 [Q5U5Z8-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79841

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79841

UCSC genome browser

More...UCSCi		uc001ngg.4, human [Q5U5Z8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027251 mRNA Translation: BAB15707.1 Sequence problems.
AK223171 mRNA Translation: BAD96891.1 Different initiation.
AK223176 mRNA Translation: BAD96896.1 Different initiation.
AC021443 Genomic DNA No translation available.
BC028200 mRNA Translation: AAH28200.1
BC036234 mRNA Translation: AAH36234.1
CCDSiCCDS7944.1 [Q5U5Z8-1]
RefSeqiNP_079059.2, NM_024783.3 [Q5U5Z8-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi122932, 6 interactors
IntActiQ5U5Z8, 3 interactors
STRINGi9606.ENSP00000435582

Chemistry databases

ChEMBLiCHEMBL3886062

Protein family/group databases

MEROPSiM14.029

PTM databases

iPTMnetiQ5U5Z8
PhosphoSitePlusiQ5U5Z8

Genetic variation databases

BioMutaiAGBL2
DMDMi206729855

Proteomic databases

EPDiQ5U5Z8
jPOSTiQ5U5Z8
MassIVEiQ5U5Z8
PaxDbiQ5U5Z8
PeptideAtlasiQ5U5Z8
PRIDEiQ5U5Z8
ProteomicsDBi65234 [Q5U5Z8-1]
65235 [Q5U5Z8-2]
65236 [Q5U5Z8-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1166, 116 antibodies

Genome annotation databases

EnsembliENST00000525123; ENSP00000435582; ENSG00000165923 [Q5U5Z8-1]
ENST00000645431; ENSP00000494229; ENSG00000285501 [Q5U5Z8-1]
GeneIDi79841
KEGGihsa:79841
UCSCiuc001ngg.4, human [Q5U5Z8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79841
DisGeNETi79841

GeneCards: human genes, protein and diseases

More...GeneCardsi		AGBL2
HGNCiHGNC:26296, AGBL2
HPAiENSG00000165923, Tissue enhanced (testis)
MIMi617345, gene
neXtProtiNX_Q5U5Z8
OpenTargetsiENSG00000165923
PharmGKBiPA142672634
VEuPathDBiHostDB:ENSG00000165923.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3641, Eukaryota
GeneTreeiENSGT00940000160201
HOGENOMiCLU_007523_5_0_1
InParanoidiQ5U5Z8
PhylomeDBiQ5U5Z8
TreeFamiTF313794

Enzyme and pathway databases

PathwayCommonsiQ5U5Z8
ReactomeiR-HSA-8955332, Carboxyterminal post-translational modifications of tubulin

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79841, 7 hits in 986 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AGBL2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79841
PharosiQ5U5Z8, Tbio

Protein Ontology

More...PROi		PR:Q5U5Z8
RNActiQ5U5Z8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000165923, Expressed in right uterine tube and 140 other tissues
ExpressionAtlasiQ5U5Z8, baseline and differential
GenevisibleiQ5U5Z8, HS

Family and domain databases

InterProiView protein in InterPro
IPR040626, Pepdidase_M14_N
IPR000834, Peptidase_M14
PfamiView protein in Pfam
PF18027, Pepdidase_M14_N, 1 hit
PF00246, Peptidase_M14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCBPC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5U5Z8
Secondary accession number(s): A8MPX2
, Q53FV5, Q8IV57, Q9H5C0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 23, 2008
Last modified: April 7, 2021
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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