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Entry version 112 (08 May 2019)
Sequence version 2 (23 Sep 2008)
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Protein

Cytosolic carboxypeptidase 2

Gene

AGBL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.By similarity1 Publication

Caution

Was originally thought to have detyrosinating activity from C-terminal positions on tubulin.1 Publication

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by RARRES1.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi462ZincBy similarity1
Metal bindingi465ZincBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei512NucleophileBy similarity1
Metal bindingi558ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytosolic carboxypeptidase 2 (EC:3.4.17.-)
Alternative name(s):
ATP/GTP-binding protein-like 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGBL2
Synonyms:CCP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26296 AGBL2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617345 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5U5Z8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79841

Open Targets

More...
OpenTargetsi
ENSG00000165923

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672634

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3886062

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AGBL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
206729855

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002837481 – 902Cytosolic carboxypeptidase 2Add BLAST902

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5U5Z8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5U5Z8

PeptideAtlas

More...
PeptideAtlasi
Q5U5Z8

PRoteomics IDEntifications database

More...
PRIDEi
Q5U5Z8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
65234
65235 [Q5U5Z8-2]
65236 [Q5U5Z8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5U5Z8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5U5Z8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165923 Expressed in 119 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5U5Z8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5U5Z8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007718

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122932, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q5U5Z8, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000435582

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3641 Eukaryota
COG2866 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160201

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111052

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5U5Z8

Database of Orthologous Groups

More...
OrthoDBi
481670at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5U5Z8

TreeFam database of animal gene trees

More...
TreeFami
TF313794

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040626 Pepdidase_M14_N
IPR000834 Peptidase_M14

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18027 Pepdidase_M14_N, 1 hit
PF00246 Peptidase_M14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5U5Z8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFPALETHLK QTIPDPYEDF MYRHLQYYGY FKAQRGSLPN SATHQHVRKN
60 70 80 90 100
NPQCLLNGSL GEKDDLIPDT LQKEKLLWPI SLSSAVHRQI EAINRDFHSC
110 120 130 140 150
LGWMQWRGLS SLQPPPPRFK DSPASAFRVA GITDSHMLSL PHLRSRQLLY
160 170 180 190 200
DELDEVNPRL REPQELFSIL STKRPLQAPR WPIECEVIKE NIHHIEWAPP
210 220 230 240 250
QPEYFYQPKG NEKVPEIVGE KKGTVVYQLD SVPIEGSYFT SSRVGGKRGI
260 270 280 290 300
VKELAVTLQG PEDNTLLFES RFESGNLQKA VRVDTYEYEL TLRTDLYTNK
310 320 330 340 350
HTQWFYFRVQ NTRKDATYRF TIVNLLKPKS LYTVGMKPLL YSQLDANTRN
360 370 380 390 400
IGWRREGNEI KYYKNNTDDG QQPFYCLTWT IQFPYDQDTC FFAHFYPYTY
410 420 430 440 450
TDLQCYLLSV ANNPIQSQFC KLQTLCRSLA GNTVYLLTIT NPSQTPQEAA
460 470 480 490 500
AKKAVVLSAR VHPGESNGSW VMKGFLDFIL SNSPDAQLLR DIFVFKVLPM
510 520 530 540 550
LNPDGVIVGN YRCSLAGRDL NRHYKTILKE SFPCIWYTRN MIKRLLEERE
560 570 580 590 600
VLLYCDFHGH SRKNNIFLYG CNNNNRKYWL HERVFPLMLC KNAPDKFSFH
610 620 630 640 650
SCNFKVQKCK EGTGRVVMWR MGILNSYTME STFGGSTLGN KRDTHFTIED
660 670 680 690 700
LKSLGYHVCD TLLDFCDPDQ MKFTQCLAEL KELLRQEIHK KFHELGQDVD
710 720 730 740 750
LEGSWSDISL SDIESSTSGS DSSLSDGLPV HLANIADELT QKKKMFKKKK
760 770 780 790 800
KKSLQTRKQR NEQYQKKNLM QKLKLTEDTS EKAGFASTLQ KQPTFFKNSE
810 820 830 840 850
NSSFLPMKNE NPRLNETNLN RRDKDTPLDP SMATLILPKN KGRMQNKKPG
860 870 880 890 900
FTVSCSPKRT INSSQEPAPG MKPNWPRSRY PATKRGCAAM AAYPSLHIYT

YP
Length:902
Mass (Da):104,194
Last modified:September 23, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9C5D8260AFBCF65
GO
Isoform 2 (identifier: Q5U5Z8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-471: Missing.

Show »
Length:431
Mass (Da):49,706
Checksum:i24C22924E231027A
GO
Isoform 3 (identifier: Q5U5Z8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-617: Missing.

Show »
Length:285
Mass (Da):32,454
Checksum:iC5D03FEC06B4A594
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KV53H9KV53_HUMAN
Cytosolic carboxypeptidase 2
AGBL2
904Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6U0I4F6U0I4_HUMAN
Cytosolic carboxypeptidase 2
AGBL2
824Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J9JIH1J9JIH1_HUMAN
Cytosolic carboxypeptidase 2
AGBL2
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR59E9PR59_HUMAN
Cytosolic carboxypeptidase 2
AGBL2
331Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRJ1E9PRJ1_HUMAN
Cytosolic carboxypeptidase 2
AGBL2
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI49E9PI49_HUMAN
Cytosolic carboxypeptidase 2
AGBL2
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJH3E9PJH3_HUMAN
Cytosolic carboxypeptidase 2
AGBL2
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PS54E9PS54_HUMAN
Cytosolic carboxypeptidase 2
AGBL2
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15707 differs from that shown. Reason: Erroneous termination at position 797. Translated as Lys.Curated
The sequence BAD96891 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD96896 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04663790I → R. Corresponds to variant dbSNP:rs12795414Ensembl.1
Natural variantiVAR_046638333T → P. Corresponds to variant dbSNP:rs35898124Ensembl.1
Natural variantiVAR_031572349R → H. Corresponds to variant dbSNP:rs7941404Ensembl.1
Natural variantiVAR_046639368D → G. Corresponds to variant dbSNP:rs1870545Ensembl.1
Natural variantiVAR_046640671M → I3 PublicationsCorresponds to variant dbSNP:rs12286721Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0243611 – 617Missing in isoform 3. 1 PublicationAdd BLAST617
Alternative sequenceiVSP_0243601 – 471Missing in isoform 2. 2 PublicationsAdd BLAST471

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK027251 mRNA Translation: BAB15707.1 Sequence problems.
AK223171 mRNA Translation: BAD96891.1 Different initiation.
AK223176 mRNA Translation: BAD96896.1 Different initiation.
AC021443 Genomic DNA No translation available.
BC028200 mRNA Translation: AAH28200.1
BC036234 mRNA Translation: AAH36234.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7944.1 [Q5U5Z8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_079059.2, NM_024783.3 [Q5U5Z8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000525123; ENSP00000435582; ENSG00000165923 [Q5U5Z8-1]
ENST00000645431; ENSP00000494229; ENSG00000285501 [Q5U5Z8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79841

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79841

UCSC genome browser

More...
UCSCi
uc001ngg.4 human [Q5U5Z8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027251 mRNA Translation: BAB15707.1 Sequence problems.
AK223171 mRNA Translation: BAD96891.1 Different initiation.
AK223176 mRNA Translation: BAD96896.1 Different initiation.
AC021443 Genomic DNA No translation available.
BC028200 mRNA Translation: AAH28200.1
BC036234 mRNA Translation: AAH36234.1
CCDSiCCDS7944.1 [Q5U5Z8-1]
RefSeqiNP_079059.2, NM_024783.3 [Q5U5Z8-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi122932, 4 interactors
IntActiQ5U5Z8, 2 interactors
STRINGi9606.ENSP00000435582

Chemistry databases

ChEMBLiCHEMBL3886062

PTM databases

iPTMnetiQ5U5Z8
PhosphoSitePlusiQ5U5Z8

Polymorphism and mutation databases

BioMutaiAGBL2
DMDMi206729855

Proteomic databases

EPDiQ5U5Z8
PaxDbiQ5U5Z8
PeptideAtlasiQ5U5Z8
PRIDEiQ5U5Z8
ProteomicsDBi65234
65235 [Q5U5Z8-2]
65236 [Q5U5Z8-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000525123; ENSP00000435582; ENSG00000165923 [Q5U5Z8-1]
ENST00000645431; ENSP00000494229; ENSG00000285501 [Q5U5Z8-1]
GeneIDi79841
KEGGihsa:79841
UCSCiuc001ngg.4 human [Q5U5Z8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79841
DisGeNETi79841

GeneCards: human genes, protein and diseases

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GeneCardsi
AGBL2
HGNCiHGNC:26296 AGBL2
HPAiHPA007718
MIMi617345 gene
neXtProtiNX_Q5U5Z8
OpenTargetsiENSG00000165923
PharmGKBiPA142672634

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3641 Eukaryota
COG2866 LUCA
GeneTreeiENSGT00940000160201
HOGENOMiHOG000111052
InParanoidiQ5U5Z8
OrthoDBi481670at2759
PhylomeDBiQ5U5Z8
TreeFamiTF313794

Enzyme and pathway databases

ReactomeiR-HSA-8955332 Carboxyterminal post-translational modifications of tubulin

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AGBL2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79841

Protein Ontology

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PROi
PR:Q5U5Z8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000165923 Expressed in 119 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ5U5Z8 baseline and differential
GenevisibleiQ5U5Z8 HS

Family and domain databases

InterProiView protein in InterPro
IPR040626 Pepdidase_M14_N
IPR000834 Peptidase_M14
PfamiView protein in Pfam
PF18027 Pepdidase_M14_N, 1 hit
PF00246 Peptidase_M14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCBPC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5U5Z8
Secondary accession number(s): A8MPX2
, Q53FV5, Q8IV57, Q9H5C0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 23, 2008
Last modified: May 8, 2019
This is version 112 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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