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UniProtKB - Q5U5X8 (F222A_HUMAN)

Entry version 103 (17 Jun 2020)
Sequence version 1 (07 Dec 2004)
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Protein

Protein FAM222A

Gene

FAM222A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM222A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM222A
Synonyms:C12orf34
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000139438.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:25915 FAM222A

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5U5X8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		84915

Open Targets

More...OpenTargetsi		ENSG00000139438

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485364

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5U5X8 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FAM222A

Domain mapping of disease mutations (DMDM)

More...DMDMi		74736192

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002742391 – 452Protein FAM222AAdd BLAST452

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5U5X8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5U5X8

PeptideAtlas

More...PeptideAtlasi		Q5U5X8

PRoteomics IDEntifications database

More...PRIDEi		Q5U5X8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65233

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5U5X8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5U5X8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000139438 Expressed in islet of Langerhans and 139 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5U5X8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5U5X8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000139438 Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124352, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q5U5X8, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000443292

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5U5X8 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi147 – 299Pro-richAdd BLAST153

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM222 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IFEB Eukaryota
ENOG410XR49 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063811

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027495_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5U5X8

Identification of Orthologs from Complete Genome Data

More...OMAi		PYPQHAA

Database of Orthologous Groups

More...OrthoDBi		507523at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5U5X8

TreeFam database of animal gene trees

More...TreeFami		TF331508

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029340 FAM222

The PANTHER Classification System

More...PANTHERi		PTHR16070 PTHR16070, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15258 FAM222A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5U5X8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLACLQRTQN APGQHLACPS KSLELRKCEA VASAMHSSRY PSPAELDAYA 
        60         70         80         90        100
EKVANSPLSI KIFPTNIRVP QHKHLSRTVN GYDTSGQRYS PYPQHTAGYQ 
       110        120        130        140        150
GLLAIVKAAV SSSSTAAPAG PAKSVLKSAE GKRTKLSPAA VQVGIAPYPV 
       160        170        180        190        200
PSTLGPLAYP KPPEAPAPPP GLPAAATAAS VIPLPGRGLP LPPSNLPSIH 
       210        220        230        240        250
SLLYQLNQQC QAPGAAPPAC QGMAIPHPSP AKHGPVPSFP SMAYSAAAGL 
       260        270        280        290        300
PDCRKGTELG QGATQALTLA GAAKPAGYAD SGLDYLLWPQ KPPPPPPQPL 
       310        320        330        340        350
RAYSGSTVAS KSPEACGGRA YERASGSPLN CGVGLPTSFT VGQYFAAPWN 
       360        370        380        390        400
SVLVTPTSDC YNPAAAVVVT ELGPGAAREL AGPPADALSG LPSKSVCNTS 
       410        420        430        440        450
VLSSSLQSLE YLINDIRPPC IKEQMLGKGY ETVAVPRLLD HQHAHIRLPV 

YR
Length:452
Mass (Da):46,792
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2CD0D013C638E3D5
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11219 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti85S → G in BAB55244 (PubMed:14702039).Curated1
Sequence conflicti347A → V in BAC11219 (PubMed:14702039).Curated1
Sequence conflicti360C → Y in BAB55244 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK027627 mRNA Translation: BAB55244.1
AK074806 mRNA Translation: BAC11219.1 Different initiation.
AC007834 Genomic DNA No translation available.
BC037221 mRNA Translation: AAH37221.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9133.1

NCBI Reference Sequences

More...RefSeqi		NP_116218.2, NM_032829.2
XP_006719717.1, XM_006719654.2
XP_016875544.1, XM_017020055.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000358906; ENSP00000351783; ENSG00000139438
ENST00000538780; ENSP00000443292; ENSG00000139438

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84915

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84915

UCSC genome browser

More...UCSCi		uc001tpd.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027627 mRNA Translation: BAB55244.1
AK074806 mRNA Translation: BAC11219.1 Different initiation.
AC007834 Genomic DNA No translation available.
BC037221 mRNA Translation: AAH37221.1
CCDSiCCDS9133.1
RefSeqiNP_116218.2, NM_032829.2
XP_006719717.1, XM_006719654.2
XP_016875544.1, XM_017020055.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi124352, 7 interactors
IntActiQ5U5X8, 7 interactors
STRINGi9606.ENSP00000443292

PTM databases

iPTMnetiQ5U5X8
PhosphoSitePlusiQ5U5X8

Polymorphism and mutation databases

BioMutaiFAM222A
DMDMi74736192

Proteomic databases

MassIVEiQ5U5X8
PaxDbiQ5U5X8
PeptideAtlasiQ5U5X8
PRIDEiQ5U5X8
ProteomicsDBi65233

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		48247 30 antibodies

Genome annotation databases

EnsembliENST00000358906; ENSP00000351783; ENSG00000139438
ENST00000538780; ENSP00000443292; ENSG00000139438
GeneIDi84915
KEGGihsa:84915
UCSCiuc001tpd.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84915
DisGeNETi84915
EuPathDBiHostDB:ENSG00000139438.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		FAM222A
HGNCiHGNC:25915 FAM222A
HPAiENSG00000139438 Tissue enhanced (brain)
neXtProtiNX_Q5U5X8
OpenTargetsiENSG00000139438
PharmGKBiPA143485364

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IFEB Eukaryota
ENOG410XR49 LUCA
GeneTreeiENSGT00530000063811
HOGENOMiCLU_027495_1_0_1
InParanoidiQ5U5X8
OMAiPYPQHAA
OrthoDBi507523at2759
PhylomeDBiQ5U5X8
TreeFamiTF331508

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84915 1 hit in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FAM222A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84915
PharosiQ5U5X8 Tdark

Protein Ontology

More...PROi		PR:Q5U5X8
RNActiQ5U5X8 protein

Gene expression databases

BgeeiENSG00000139438 Expressed in islet of Langerhans and 139 other tissues
ExpressionAtlasiQ5U5X8 baseline and differential
GenevisibleiQ5U5X8 HS

Family and domain databases

InterProiView protein in InterPro
IPR029340 FAM222
PANTHERiPTHR16070 PTHR16070, 1 hit
PfamiView protein in Pfam
PF15258 FAM222A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF222A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5U5X8
Secondary accession number(s): Q8NCD5, Q96SP6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 7, 2004
Last modified: June 17, 2020
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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