UniProtKB - Q5U5X8 (F222A_HUMAN)
Protein
Protein FAM222A
Gene
FAM222A
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM222A |
Gene namesi | Name:FAM222A Synonyms:C12orf34 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25915, FAM222A |
neXtProti | NX_Q5U5X8 |
VEuPathDBi | HostDB:ENSG00000139438.5 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 84915 |
OpenTargetsi | ENSG00000139438 |
PharmGKBi | PA143485364 |
Miscellaneous databases
Pharosi | Q5U5X8, Tdark |
Genetic variation databases
BioMutai | FAM222A |
DMDMi | 74736192 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274239 | 1 – 452 | Protein FAM222AAdd BLAST | 452 |
Proteomic databases
MassIVEi | Q5U5X8 |
PaxDbi | Q5U5X8 |
PeptideAtlasi | Q5U5X8 |
PRIDEi | Q5U5X8 |
ProteomicsDBi | 65233 |
PTM databases
iPTMneti | Q5U5X8 |
PhosphoSitePlusi | Q5U5X8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000139438, Expressed in C1 segment of cervical spinal cord and 154 other tissues |
ExpressionAtlasi | Q5U5X8, baseline and differential |
Genevisiblei | Q5U5X8, HS |
Organism-specific databases
HPAi | ENSG00000139438, Tissue enhanced (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124352, 11 interactors |
IntActi | Q5U5X8, 7 interactors |
STRINGi | 9606.ENSP00000443292 |
Miscellaneous databases
RNActi | Q5U5X8, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 147 – 299 | Pro-richAdd BLAST | 153 |
Sequence similaritiesi
Belongs to the FAM222 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QPV4, Eukaryota |
GeneTreei | ENSGT00530000063811 |
HOGENOMi | CLU_027495_1_0_1 |
InParanoidi | Q5U5X8 |
OMAi | PYPQHAA |
OrthoDBi | 507523at2759 |
PhylomeDBi | Q5U5X8 |
TreeFami | TF331508 |
Family and domain databases
InterProi | View protein in InterPro IPR029340, FAM222 |
PANTHERi | PTHR16070, PTHR16070, 1 hit |
Pfami | View protein in Pfam PF15258, FAM222A, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5U5X8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLACLQRTQN APGQHLACPS KSLELRKCEA VASAMHSSRY PSPAELDAYA
60 70 80 90 100
EKVANSPLSI KIFPTNIRVP QHKHLSRTVN GYDTSGQRYS PYPQHTAGYQ
110 120 130 140 150
GLLAIVKAAV SSSSTAAPAG PAKSVLKSAE GKRTKLSPAA VQVGIAPYPV
160 170 180 190 200
PSTLGPLAYP KPPEAPAPPP GLPAAATAAS VIPLPGRGLP LPPSNLPSIH
210 220 230 240 250
SLLYQLNQQC QAPGAAPPAC QGMAIPHPSP AKHGPVPSFP SMAYSAAAGL
260 270 280 290 300
PDCRKGTELG QGATQALTLA GAAKPAGYAD SGLDYLLWPQ KPPPPPPQPL
310 320 330 340 350
RAYSGSTVAS KSPEACGGRA YERASGSPLN CGVGLPTSFT VGQYFAAPWN
360 370 380 390 400
SVLVTPTSDC YNPAAAVVVT ELGPGAAREL AGPPADALSG LPSKSVCNTS
410 420 430 440 450
VLSSSLQSLE YLINDIRPPC IKEQMLGKGY ETVAVPRLLD HQHAHIRLPV
YR
Sequence cautioni
The sequence BAC11219 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 85 | S → G in BAB55244 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 347 | A → V in BAC11219 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 360 | C → Y in BAB55244 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027627 mRNA Translation: BAB55244.1 AK074806 mRNA Translation: BAC11219.1 Different initiation. AC007834 Genomic DNA No translation available. BC037221 mRNA Translation: AAH37221.1 |
CCDSi | CCDS9133.1 |
RefSeqi | NP_116218.2, NM_032829.2 XP_006719717.1, XM_006719654.2 XP_016875544.1, XM_017020055.1 |
Genome annotation databases
Ensembli | ENST00000358906; ENSP00000351783; ENSG00000139438 ENST00000538780; ENSP00000443292; ENSG00000139438 |
GeneIDi | 84915 |
KEGGi | hsa:84915 |
UCSCi | uc001tpd.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027627 mRNA Translation: BAB55244.1 AK074806 mRNA Translation: BAC11219.1 Different initiation. AC007834 Genomic DNA No translation available. BC037221 mRNA Translation: AAH37221.1 |
CCDSi | CCDS9133.1 |
RefSeqi | NP_116218.2, NM_032829.2 XP_006719717.1, XM_006719654.2 XP_016875544.1, XM_017020055.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 124352, 11 interactors |
IntActi | Q5U5X8, 7 interactors |
STRINGi | 9606.ENSP00000443292 |
PTM databases
iPTMneti | Q5U5X8 |
PhosphoSitePlusi | Q5U5X8 |
Genetic variation databases
BioMutai | FAM222A |
DMDMi | 74736192 |
Proteomic databases
MassIVEi | Q5U5X8 |
PaxDbi | Q5U5X8 |
PeptideAtlasi | Q5U5X8 |
PRIDEi | Q5U5X8 |
ProteomicsDBi | 65233 |
Protocols and materials databases
Antibodypediai | 48247, 33 antibodies |
Genome annotation databases
Ensembli | ENST00000358906; ENSP00000351783; ENSG00000139438 ENST00000538780; ENSP00000443292; ENSG00000139438 |
GeneIDi | 84915 |
KEGGi | hsa:84915 |
UCSCi | uc001tpd.3, human |
Organism-specific databases
CTDi | 84915 |
DisGeNETi | 84915 |
GeneCardsi | FAM222A |
HGNCi | HGNC:25915, FAM222A |
HPAi | ENSG00000139438, Tissue enhanced (brain) |
neXtProti | NX_Q5U5X8 |
OpenTargetsi | ENSG00000139438 |
PharmGKBi | PA143485364 |
VEuPathDBi | HostDB:ENSG00000139438.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPV4, Eukaryota |
GeneTreei | ENSGT00530000063811 |
HOGENOMi | CLU_027495_1_0_1 |
InParanoidi | Q5U5X8 |
OMAi | PYPQHAA |
OrthoDBi | 507523at2759 |
PhylomeDBi | Q5U5X8 |
TreeFami | TF331508 |
Enzyme and pathway databases
PathwayCommonsi | Q5U5X8 |
Miscellaneous databases
BioGRID-ORCSi | 84915, 2 hits in 992 CRISPR screens |
ChiTaRSi | FAM222A, human |
GenomeRNAii | 84915 |
Pharosi | Q5U5X8, Tdark |
PROi | PR:Q5U5X8 |
RNActi | Q5U5X8, protein |
Gene expression databases
Bgeei | ENSG00000139438, Expressed in C1 segment of cervical spinal cord and 154 other tissues |
ExpressionAtlasi | Q5U5X8, baseline and differential |
Genevisiblei | Q5U5X8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029340, FAM222 |
PANTHERi | PTHR16070, PTHR16070, 1 hit |
Pfami | View protein in Pfam PF15258, FAM222A, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F222A_HUMAN | |
Accessioni | Q5U5X8Primary (citable) accession number: Q5U5X8 Secondary accession number(s): Q8NCD5, Q96SP6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | December 7, 2004 | |
Last modified: | April 7, 2021 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families