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Entry version 65 (02 Jun 2021)
Sequence version 1 (07 Dec 2004)
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Protein

Myotubularin-related protein 10-A

Gene

mtmr10-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 391 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity.Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myotubularin-related protein 10-A
Alternative name(s):
Inactive phosphatidylinositol 3-phosphatase 10-ACurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mtmr10-a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-1002521, mtmr10.S

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002843631 – 765Myotubularin-related protein 10-AAdd BLAST765

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5U581

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini209 – 650Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST442

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Database of Orthologous Groups

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OrthoDBi
620702at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13346, PH-GRAM_MTMR10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030573, MTMR10
IPR036004, MTMR10_PH-GRAM
IPR022587, MTMR12-like_C
IPR010569, Myotubularin-like_Pase_dom
IPR030564, Myotubularin_fam
IPR029021, Prot-tyrosine_phosphatase-like

The PANTHER Classification System

More...
PANTHERi
PTHR10807, PTHR10807, 1 hit
PTHR10807:SF39, PTHR10807:SF39, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12578, 3-PAP, 1 hit
PF06602, Myotub-related, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799, SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51339, PPASE_MYOTUBULARIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5U581-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSLKQPKPS FRSYLLPPQQ EDKLNPETKI KKLKAVLLPG EIVVNEVNFV
60 70 80 90 100
RKCIASDTSQ YDLWGKLICT NFKISFITEN SVPFQRFHYK NLLLGEHDVP
110 120 130 140 150
LTCIEQIVVV NDTKRKQKIL SHNQKLKFNP TELIIYCKDF RILRFRFDEA
160 170 180 190 200
GPESAKKVCL ALAHYSQPTD LQLLFAFEYV AQMYHKPEYK VNGIDPGGGG
210 220 230 240 250
DFCQRTPLFE TYSDWDREIK RTGASDWRVC SVNEGYMIST CLPEYFVVPS
260 270 280 290 300
SLADQDLKQY SHAFVGRRMP LWCWNHSNGS ALVRMASIKD LLQQRKIGQR
310 320 330 340 350
VCSGITRSHP LRSDVYKCDL DHNVPSIQDI QAAFSKLRQL CVNEPFDETE
360 370 380 390 400
EKWLSSLENA QWLEFVRTFL KQAAELAYVL DFSRRSVVLQ EEEGRDVSCL
410 420 430 440 450
VASLVQLMLD PYFRTIVGFQ SLIQKEWVMS AYPFLDRCNH LKRSEKESPL
460 470 480 490 500
FVLFLDCVWQ LLQQYPAAFQ FTETYLTVLH DSTRISLFGT FLFNSPHQRV
510 520 530 540 550
QQSTEFAIAR NIQLGEEKGL KFPSVWDWSL QFSAKDRALF NNPLYIGKSV
560 570 580 590 600
PCVQNGAVKS FKRTKNYSST MRGMPPSVKN GMAIQQDFMP RRNSLILKLK
610 620 630 640 650
PEILQQVPVI IPSSGFEQYL RDWFTKPADL HGVILPCLHG THIKLWKLCY
660 670 680 690 700
LRWTPEAQIN HGGFITAFHK ISLLASEIEL LQSRLRQYRA YPLSTVTSPV
710 720 730 740 750
GEQNRMFFRP DELHSSNGSL DILTSSFPFS PIGNLCRRSI LGTPLSKFIN
760
GAKIWLSTET LANED
Length:765
Mass (Da):88,113
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89E4B64712513599
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC084803 mRNA Translation: AAH84803.1

NCBI Reference Sequences

More...
RefSeqi
NP_001088476.1, NM_001095007.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
495341

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:495341

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC084803 mRNA Translation: AAH84803.1
RefSeqiNP_001088476.1, NM_001095007.1

3D structure databases

SMRiQ5U581
ModBaseiSearch...

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
495341

Genome annotation databases

GeneIDi495341
KEGGixla:495341

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
495341
XenbaseiXB-GENE-1002521, mtmr10.S

Phylogenomic databases

OrthoDBi620702at2759

Family and domain databases

CDDicd13346, PH-GRAM_MTMR10, 1 hit
InterProiView protein in InterPro
IPR030573, MTMR10
IPR036004, MTMR10_PH-GRAM
IPR022587, MTMR12-like_C
IPR010569, Myotubularin-like_Pase_dom
IPR030564, Myotubularin_fam
IPR029021, Prot-tyrosine_phosphatase-like
PANTHERiPTHR10807, PTHR10807, 1 hit
PTHR10807:SF39, PTHR10807:SF39, 1 hit
PfamiView protein in Pfam
PF12578, 3-PAP, 1 hit
PF06602, Myotub-related, 2 hits
SUPFAMiSSF52799, SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51339, PPASE_MYOTUBULARIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTRAA_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5U581
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 7, 2004
Last modified: June 2, 2021
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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