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UniProtKB - Q5U4E2 (REPI1_MOUSE)
Protein
Replication initiator 1
Gene
Repin1
Organism
Mus musculus (Mouse)
Status
Functioni
Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 52 – 74 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 80 – 102 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 111 – 133 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 140 – 162 | C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 172 – 194 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 229 – 251 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 257 – 279 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 285 – 307 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 353 – 375 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 381 – 403 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 409 – 431 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 437 – 459 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 465 – 487 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 493 – 515 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 521 – 543 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- chromatin insulator sequence binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- DNA replication Source: UniProtKB-KW
- positive regulation of glucose import Source: MGI
- regulation of fatty acid transport Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | DNA replication |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Replication initiator 1Alternative name(s): Zinc finger protein 464 Short name: Zfp-464 |
Gene namesi | Name:Repin1 Synonyms:Zfp464 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1889817, Repin1 |
VEuPathDBi | HostDB:ENSMUSG00000052751 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: MGI
- cytosolic ribosome Source: MGI
Nucleus
- nuclear membrane Source: MGI
- nucleoplasm Source: MGI
Other locations
- chromosome Source: GO_Central
- lipid droplet Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274913 | 1 – 545 | Replication initiator 1Add BLAST | 545 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 27 | PhosphoserineBy similarity | 1 | |
Modified residuei | 39 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 269 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q5U4E2 |
MaxQBi | Q5U4E2 |
PaxDbi | Q5U4E2 |
PeptideAtlasi | Q5U4E2 |
PRIDEi | Q5U4E2 |
ProteomicsDBi | 253211 |
PTM databases
iPTMneti | Q5U4E2 |
PhosphoSitePlusi | Q5U4E2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000052751, Expressed in cumulus cell and 310 other tissues |
ExpressionAtlasi | Q5U4E2, baseline and differential |
Genevisiblei | Q5U4E2, MM |
Interactioni
Subunit structurei
Homodimers and homomultimers.
Found in a complex with RIP60 and RIP100 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000113548 |
Miscellaneous databases
RNActi | Q5U4E2, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 50 | DisorderedSequence analysisAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 20 – 44 | Polar residuesSequence analysisAdd BLAST | 25 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 52 – 74 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 80 – 102 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 111 – 133 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 140 – 162 | C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 172 – 194 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 229 – 251 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 257 – 279 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 285 – 307 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 353 – 375 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 381 – 403 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 409 – 431 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 437 – 459 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 465 – 487 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 493 – 515 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 521 – 543 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162588 |
HOGENOMi | CLU_002678_36_0_1 |
InParanoidi | Q5U4E2 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q5U4E2 |
TreeFami | TF326846 |
Family and domain databases
InterProi | View protein in InterPro IPR039705, REPIN1 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR24406:SF10, PTHR24406:SF10, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 14 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q5U4E2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLEQRCRGPT AMGPAQPWLF SGPSQESSQP DRGLRYQGKS AQPRGQTPGK
60 70 80 90 100
VHRCAHCRKR FPGWVALWLH ARRCQARLPL PCHECNQRFR HAPFLALHLQ
110 120 130 140 150
VHASAVPDLG FICHLCGHSF RGWVALVLHL RAHSASKRPI TCPECDRRFW
160 170 180 190 200
RQKQLRAHLR RCQPPVPEAR PFICGNCGRS FAQWDQLVVH KRVHVAEALE
210 220 230 240 250
EAAAKALGPR PRGRPAAPRP GGDAVDRPFQ CACCGKRFRH KPNLIAHRRV
260 270 280 290 300
HTGERPHQCP ECGKRFTNKP YLTSHRRIHT GEKPYPCTEC GRRFRHKPNL
310 320 330 340 350
LSHSKIHKRL EVSAQAAPHP ESHQIAAEPM AQPALGVPLG SPRTPAEAPA
360 370 380 390 400
LLHSCSDCGR SFRLERFLRL HQRQHTGERP FACTECGKNF GKKTHLVAHS
410 420 430 440 450
RVHSGERPFA CEECGRRFSQ GSHLAAHRRD HAPERPFVCP DCGKAFRHKP
460 470 480 490 500
YLAAHRRIHT GEKPYVCPDC GKAFSQKSNL VSHRRIHTGE RPYACPDCDR
510 520 530 540
SFSQKSNLIT HRKSHIRDGA FCCAICGQTF DDEDRLLMHQ KKHDA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YY67 | D3YY67_MOUSE | Replication initiator 1 | Repin1 | 601 | Annotation score: | ||
A0A0R3P9D3 | A0A0R3P9D3_MOUSE | Replication initiator 1 | Repin1 | 598 | Annotation score: | ||
E9Q8A0 | E9Q8A0_MOUSE | Replication initiator 1 | Repin1 | 360 | Annotation score: |
Sequence cautioni
The sequence BAC40716 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 33 | G → R in BAC40716 (PubMed:12466851).Curated | 1 | |
Sequence conflicti | 339 | L → Q in BAC40716 (PubMed:12466851).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK089041 mRNA Translation: BAC40716.1 Frameshift. BC085128 mRNA Translation: AAH85128.1 |
CCDSi | CCDS39480.1 |
RefSeqi | NP_001073370.2, NM_001079901.1 NP_001073371.2, NM_001079902.1 NP_001073372.2, NM_001079903.1 NP_001073373.2, NM_001079904.1 NP_001073374.1, NM_001079905.1 NP_780308.2, NM_175099.3 |
Genome annotation databases
Ensembli | ENSMUST00000009420; ENSMUSP00000009420; ENSMUSG00000052751 ENSMUST00000163452; ENSMUSP00000132365; ENSMUSG00000052751 |
GeneIDi | 58887 |
KEGGi | mmu:58887 |
UCSCi | uc009buv.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK089041 mRNA Translation: BAC40716.1 Frameshift. BC085128 mRNA Translation: AAH85128.1 |
CCDSi | CCDS39480.1 |
RefSeqi | NP_001073370.2, NM_001079901.1 NP_001073371.2, NM_001079902.1 NP_001073372.2, NM_001079903.1 NP_001073373.2, NM_001079904.1 NP_001073374.1, NM_001079905.1 NP_780308.2, NM_175099.3 |
3D structure databases
SMRi | Q5U4E2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000113548 |
PTM databases
iPTMneti | Q5U4E2 |
PhosphoSitePlusi | Q5U4E2 |
Proteomic databases
EPDi | Q5U4E2 |
MaxQBi | Q5U4E2 |
PaxDbi | Q5U4E2 |
PeptideAtlasi | Q5U4E2 |
PRIDEi | Q5U4E2 |
ProteomicsDBi | 253211 |
Protocols and materials databases
Antibodypediai | 32865, 66 antibodies from 16 providers |
DNASUi | 58887 |
Genome annotation databases
Ensembli | ENSMUST00000009420; ENSMUSP00000009420; ENSMUSG00000052751 ENSMUST00000163452; ENSMUSP00000132365; ENSMUSG00000052751 |
GeneIDi | 58887 |
KEGGi | mmu:58887 |
UCSCi | uc009buv.1, mouse |
Organism-specific databases
CTDi | 29803 |
MGIi | MGI:1889817, Repin1 |
VEuPathDBi | HostDB:ENSMUSG00000052751 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162588 |
HOGENOMi | CLU_002678_36_0_1 |
InParanoidi | Q5U4E2 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q5U4E2 |
TreeFami | TF326846 |
Miscellaneous databases
BioGRID-ORCSi | 58887, 4 hits in 64 CRISPR screens |
ChiTaRSi | Repin1, mouse |
PROi | PR:Q5U4E2 |
RNActi | Q5U4E2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000052751, Expressed in cumulus cell and 310 other tissues |
ExpressionAtlasi | Q5U4E2, baseline and differential |
Genevisiblei | Q5U4E2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR039705, REPIN1 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR24406:SF10, PTHR24406:SF10, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 14 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | REPI1_MOUSE | |
Accessioni | Q5U4E2Primary (citable) accession number: Q5U4E2 Secondary accession number(s): Q8BTQ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | December 7, 2004 | |
Last modified: | February 23, 2022 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot