Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium-dependent multivitamin transporter

Gene

Slc5a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports pantothenate, biotin and lipoate in the presence of sodium.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandBiotin, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-196780 Biotin transport and metabolism
R-MMU-199220 Vitamin B5 (pantothenate) metabolism
R-MMU-425397 Transport of vitamins, nucleosides, and related molecules

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent multivitamin transporter
Short name:
Na(+)-dependent multivitamin transporter
Alternative name(s):
Solute carrier family 5 member 6
Gene namesi
Name:Slc5a6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2660847 Slc5a6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Transmembranei526 – 546HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053871 – 634Sodium-dependent multivitamin transporterAdd BLAST634

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi488N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi497N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5U4D8
PRIDEiQ5U4D8

PTM databases

iPTMnetiQ5U4D8
PhosphoSitePlusiQ5U4D8
SwissPalmiQ5U4D8

Expressioni

Gene expression databases

BgeeiENSMUSG00000006641 Expressed in 153 organ(s), highest expression level in embryo
ExpressionAtlasiQ5U4D8 baseline and differential
GenevisibleiQ5U4D8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006817

Structurei

3D structure databases

ProteinModelPortaliQ5U4D8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2349 Eukaryota
COG0591 LUCA
GeneTreeiENSGT00760000118955
HOGENOMiHOG000261662
HOVERGENiHBG057280
InParanoidiQ5U4D8
KOiK14386
OMAiQAVFLWP
OrthoDBiEOG091G07OC
TreeFamiTF316728

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5U4D8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVASTAAPF HTTSGSSGAI STFSVVDYVV FGLLLVLSLV IGLYHACRGW
60 70 80 90 100
GHHTVGELLM ADRKMGCLPV ALSLLATFQS AVAILGAPAE IFRFGTQYWF
110 120 130 140 150
LGCSYFLGLL IPAHIFIPVF YRLHLTSAYE YLELRFNKAV RICGTVTFIF
160 170 180 190 200
QMVIYMGVAL YAPSLALNAV TGFDLWLSVL ALGIVCNIYT ALGGLKAVIW
210 220 230 240 250
TDVFQTLVMF LGQLVVIIVG AARVGGLGHV WNVTSQHGLI SGINLDPDPF
260 270 280 290 300
VRHTFWTLAF GGVFMMLSLY GVNQAQVQRY LSSHSERAAV LSCYAVFPCQ
310 320 330 340 350
QVALCMSCLI GLVMFAYYNM YSMSPELKQA APDQLVLYFV MDLLKDMPGL
360 370 380 390 400
PGLFVACLFS GSLSTISSAF NSLATVTMED LIQPWFPQLT ETRAIMLSRG
410 420 430 440 450
LAFAYGLVCL GMAYISSHLG SVLQAALSIF GMVGGPLLGL FCLGLFFPCA
460 470 480 490 500
NPLGAIVGLL TGLTMAFWIG IGSIVSRMSS AVAPPPLNGS SSFLPANVTV
510 520 530 540 550
AAVTTVMPST LSKPTGLQHF YSLSYLWYSA HNSTTVIVVG LIVSLLTGGM
560 570 580 590 600
RGRSLNPGTI YPVLPKLLAL LPLSCQKRLC WRSHSQDIPV IPNLFPEKMR
610 620 630
NGVLQDSTDK ERMAEDGLVH QPCSPTYVVQ ETSL
Length:634
Mass (Da):68,511
Last modified:July 27, 2011 - v2
Checksum:i5C43F53C19F3F38E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6WHY1F6WHY1_MOUSE
Sodium-dependent multivitamin trans...
Slc5a6
195Annotation score:
A0A0J9YVH7A0A0J9YVH7_MOUSE
Sodium-dependent multivitamin trans...
Slc5a6
81Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25V → D in AAH85132 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY572835 mRNA Translation: AAS79366.1
AK088682 mRNA Translation: BAC40502.1
AK161633 mRNA Translation: BAE36503.1
CH466524 Genomic DNA Translation: EDL37322.1
BC085132 mRNA Translation: AAH85132.1
BC117852 mRNA Translation: AAI17853.1
BC117853 mRNA Translation: AAI17854.1
CCDSiCCDS19169.1
RefSeqiNP_001171092.1, NM_001177621.1
NP_001171093.1, NM_001177622.1
NP_808538.1, NM_177870.5
XP_011239053.1, XM_011240751.1
UniGeneiMm.205463

Genome annotation databases

EnsembliENSMUST00000080431; ENSMUSP00000079291; ENSMUSG00000006641
ENSMUST00000114668; ENSMUSP00000110316; ENSMUSG00000006641
ENSMUST00000202520; ENSMUSP00000143938; ENSMUSG00000006641
ENSMUST00000202556; ENSMUSP00000143993; ENSMUSG00000006641
GeneIDi330064
KEGGimmu:330064
UCSCiuc008wwt.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY572835 mRNA Translation: AAS79366.1
AK088682 mRNA Translation: BAC40502.1
AK161633 mRNA Translation: BAE36503.1
CH466524 Genomic DNA Translation: EDL37322.1
BC085132 mRNA Translation: AAH85132.1
BC117852 mRNA Translation: AAI17853.1
BC117853 mRNA Translation: AAI17854.1
CCDSiCCDS19169.1
RefSeqiNP_001171092.1, NM_001177621.1
NP_001171093.1, NM_001177622.1
NP_808538.1, NM_177870.5
XP_011239053.1, XM_011240751.1
UniGeneiMm.205463

3D structure databases

ProteinModelPortaliQ5U4D8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006817

PTM databases

iPTMnetiQ5U4D8
PhosphoSitePlusiQ5U4D8
SwissPalmiQ5U4D8

Proteomic databases

PaxDbiQ5U4D8
PRIDEiQ5U4D8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080431; ENSMUSP00000079291; ENSMUSG00000006641
ENSMUST00000114668; ENSMUSP00000110316; ENSMUSG00000006641
ENSMUST00000202520; ENSMUSP00000143938; ENSMUSG00000006641
ENSMUST00000202556; ENSMUSP00000143993; ENSMUSG00000006641
GeneIDi330064
KEGGimmu:330064
UCSCiuc008wwt.2 mouse

Organism-specific databases

CTDi8884
MGIiMGI:2660847 Slc5a6

Phylogenomic databases

eggNOGiKOG2349 Eukaryota
COG0591 LUCA
GeneTreeiENSGT00760000118955
HOGENOMiHOG000261662
HOVERGENiHBG057280
InParanoidiQ5U4D8
KOiK14386
OMAiQAVFLWP
OrthoDBiEOG091G07OC
TreeFamiTF316728

Enzyme and pathway databases

ReactomeiR-MMU-196780 Biotin transport and metabolism
R-MMU-199220 Vitamin B5 (pantothenate) metabolism
R-MMU-425397 Transport of vitamins, nucleosides, and related molecules

Miscellaneous databases

ChiTaRSiSlc5a6 mouse
PROiPR:Q5U4D8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006641 Expressed in 153 organ(s), highest expression level in embryo
ExpressionAtlasiQ5U4D8 baseline and differential
GenevisibleiQ5U4D8 MM

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC5A6_MOUSE
AccessioniPrimary (citable) accession number: Q5U4D8
Secondary accession number(s): Q8BTU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again