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Protein

DnaJ homolog subfamily C member 11

Gene

Dnajc11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex.Curated1 Publication

Miscellaneous

Following chemical mutagenesis predicted to give rise to a transcript subject to non-sense mediated deccay, mice exhibit an autosomal recessive neuromuscular disease and abnormal mitochondrial cristae morphology.1 Publication

GO - Biological processi

  • cristae formation Source: UniProtKB

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 11
Gene namesi
Name:Dnajc11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2443386 Dnajc11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002471582 – 559DnaJ homolog subfamily C member 11Add BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei204PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5U458
MaxQBiQ5U458
PaxDbiQ5U458
PeptideAtlasiQ5U458
PRIDEiQ5U458

PTM databases

iPTMnetiQ5U458
PhosphoSitePlusiQ5U458
SwissPalmiQ5U458

Expressioni

Gene expression databases

BgeeiENSMUSG00000039768 Expressed in 268 organ(s), highest expression level in primary oocyte
CleanExiMM_DNAJC11
ExpressionAtlasiQ5U458 baseline and differential
GenevisibleiQ5U458 MM

Interactioni

Subunit structurei

Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex.By similarityCurated

Protein-protein interaction databases

IntActiQ5U458, 2 interactors
MINTiQ5U458
STRINGi10090.ENSMUSP00000051643

Structurei

3D structure databases

ProteinModelPortaliQ5U458
SMRiQ5U458
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 82JPROSITE-ProRule annotationAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili415 – 457Sequence analysisAdd BLAST43

Sequence similaritiesi

Belongs to the DNAJC11 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0718 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00860000133842
HOGENOMiHOG000231113
HOVERGENiHBG080125
InParanoidiQ5U458
KOiK09531
OMAiNYYTFLN
OrthoDBiEOG091G050E
TreeFamiTF105170

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR024586 DnaJ-like_C11_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF11875 DUF3395, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5U458-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATALSEEEL DNEDYYSLLN VRREASSEEL KAAYRRLCML YHPDKHRDPE
60 70 80 90 100
LKSQAERLFN LVHQAYEVLS DPQTRAIYDI YGKRGLEMEG WEVVERKRTP
110 120 130 140 150
AEIREEFERL QREREERRLQ QRTNPKGTIS VGVDATDLFD RYDEEYEDVS
160 170 180 190 200
GSGFPQIEIN KMHISQSIEA PLTATDTAIL SGSLSTQNGN GGGSVNFALR
210 220 230 240 250
RVTSAKGWGE LEFGAGDLQG PLFGLKLFRN LTPRCFVTTN CALQFSSRGI
260 270 280 290 300
RPGLTTVLAR NLDKNTVGYL QWRWGIQSAM NTSIVRDTKT CHFTVALQLG
310 320 330 340 350
IPHSFALISY QHKFQDDDQT RVKGSLKAGF FGTIVEYGAE RKISRHSVLG
360 370 380 390 400
AAVSIGVPQG VSLKVKLNRA SQTYFFPIHL TDQLLPSAVF YATVGPLVVY
410 420 430 440 450
LAVHRLIIRP YLRAQKEKEL EKQRENTASD ILQKKQEAEA AVRLMQESVR
460 470 480 490 500
RIIEAEESRM GLIIVNAWYG KFVNDKSRKN EKVKVIDVTV PLQCLVKDSK
510 520 530 540 550
LILTEASKAG LPGFYDPCVG EEKSLRVLYQ FRGVLHQVMV PDSEALRIPK

QSHRIDTDG
Length:559
Mass (Da):63,233
Last modified:July 27, 2011 - v2
Checksum:iDA6B7590EC7D2561
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q8B3E9Q8B3_MOUSE
DnaJ homolog subfamily C member 11
Dnajc11
402Annotation score:
A2A8D1A2A8D1_MOUSE
DnaJ homolog subfamily C member 11
Dnajc11
127Annotation score:

Sequence cautioni

The sequence BAC41027 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195V → I in BAC41027 (PubMed:16141072).Curated1
Sequence conflicti195V → I in BAE42661 (PubMed:16141072).Curated1
Sequence conflicti195V → I in BAE43060 (PubMed:16141072).Curated1
Sequence conflicti195V → I in AAH85257 (PubMed:15489334).Curated1
Sequence conflicti256T → S in BAC41027 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053156 mRNA Translation: BAC35287.1
AK077544 mRNA Translation: BAC36856.1
AK089983 mRNA Translation: BAC41027.1 Sequence problems.
AK171781 mRNA Translation: BAE42661.1
AK172542 mRNA Translation: BAE43060.1
AL611931 Genomic DNA No translation available.
BC085257 mRNA Translation: AAH85257.1
CCDSiCCDS18981.2
RefSeqiNP_766292.2, NM_172704.3
UniGeneiMm.21353

Genome annotation databases

EnsembliENSMUST00000062904; ENSMUSP00000051643; ENSMUSG00000039768
GeneIDi230935
KEGGimmu:230935
UCSCiuc008vys.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053156 mRNA Translation: BAC35287.1
AK077544 mRNA Translation: BAC36856.1
AK089983 mRNA Translation: BAC41027.1 Sequence problems.
AK171781 mRNA Translation: BAE42661.1
AK172542 mRNA Translation: BAE43060.1
AL611931 Genomic DNA No translation available.
BC085257 mRNA Translation: AAH85257.1
CCDSiCCDS18981.2
RefSeqiNP_766292.2, NM_172704.3
UniGeneiMm.21353

3D structure databases

ProteinModelPortaliQ5U458
SMRiQ5U458
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5U458, 2 interactors
MINTiQ5U458
STRINGi10090.ENSMUSP00000051643

PTM databases

iPTMnetiQ5U458
PhosphoSitePlusiQ5U458
SwissPalmiQ5U458

Proteomic databases

EPDiQ5U458
MaxQBiQ5U458
PaxDbiQ5U458
PeptideAtlasiQ5U458
PRIDEiQ5U458

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062904; ENSMUSP00000051643; ENSMUSG00000039768
GeneIDi230935
KEGGimmu:230935
UCSCiuc008vys.2 mouse

Organism-specific databases

CTDi55735
MGIiMGI:2443386 Dnajc11

Phylogenomic databases

eggNOGiKOG0718 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00860000133842
HOGENOMiHOG000231113
HOVERGENiHBG080125
InParanoidiQ5U458
KOiK09531
OMAiNYYTFLN
OrthoDBiEOG091G050E
TreeFamiTF105170

Miscellaneous databases

PROiPR:Q5U458
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039768 Expressed in 268 organ(s), highest expression level in primary oocyte
CleanExiMM_DNAJC11
ExpressionAtlasiQ5U458 baseline and differential
GenevisibleiQ5U458 MM

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR024586 DnaJ-like_C11_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF11875 DUF3395, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDJC11_MOUSE
AccessioniPrimary (citable) accession number: Q5U458
Secondary accession number(s): A2A8C9
, Q8BP83, Q8C1Z4, Q8C6U5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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