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UniProtKB - Q5U421 (Q5U421_MOUSE)
Protein
Mitogen-activated protein kinase 14
Gene
Mapk14
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
Cofactori
Mg2+ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 54 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- MAP kinase activity Source: UniProtKB
- mitogen-activated protein kinase p38 binding Source: Ensembl
- protein phosphatase binding Source: Ensembl
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine kinase activity Source: RHEA
GO - Biological processi
- cellular response to ionizing radiation Source: Ensembl
- cellular response to lipopolysaccharide Source: Ensembl
- cellular response to lipoteichoic acid Source: Ensembl
- cellular response to vascular endothelial growth factor stimulus Source: Ensembl
- cellular response to virus Source: Ensembl
- intracellular signal transduction Source: UniProtKB
- negative regulation of hippo signaling Source: Ensembl
- p38MAPK cascade Source: InterPro
- positive regulation of cyclase activity Source: Ensembl
- positive regulation of erythrocyte differentiation Source: Ensembl
- positive regulation of interleukin-12 production Source: Ensembl
- positive regulation of reactive oxygen species metabolic process Source: Ensembl
- regulation of cytokine production involved in inflammatory response Source: Ensembl
- signal transduction in response to DNA damage Source: Ensembl
- stress-induced premature senescence Source: Ensembl
- vascular endothelial growth factor receptor signaling pathway Source: Ensembl
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseARBA annotation, Transferase |
Biological process | Stress responseARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Mitogen-activated protein kinase 14ARBA annotation (EC:2.7.11.24ARBA annotation)Alternative name(s): Mitogen-activated protein kinase p38 alphaARBA annotation |
Gene namesi | Name:Mapk14Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:1346865, Mapk14 |
VEuPathDBi | HostDB:ENSMUSG00000053436 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000053436, Expressed in granulocyte and 319 other tissues |
ExpressionAtlasi | Q5U421, baseline and differential |
Interactioni
GO - Molecular functioni
- mitogen-activated protein kinase p38 binding Source: Ensembl
- protein phosphatase binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 308 | Protein kinaseInterPro annotationAdd BLAST | 285 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.ARBA annotation
Phylogenomic databases
PhylomeDBi | Q5U421 |
Family and domain databases
CDDi | cd07877, STKc_p38alpha, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR008352, MAPK_p38-like IPR038784, p38alpha IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PRINTSi | PR01773, P38MAPKINASE |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5U421-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGHRV
60 70 80 90 100
AVKKLSRPFQ SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN
110 120 130 140 150
DVYLVTHLMG ADLNNIVKCQ KLTDDHVQFL IYQILRGLKY IHSADIIHRD
160 170 180 190 200
LKPSNLAVNE DCELKILDFG LARHTDDEMT GYVATRWYRA PEIMLNWMHY
210 220 230 240 250
NQTVDIWSVG CIMAELLTGR TLFPGTDHIN QLQQIMRLTG TPPAYLINRM
260 270 280 290 300
PSHEARNYIQ SLAQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA
310 320 330 340 350
QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP
360
PPLDQEEMES
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC085303 mRNA Translation: AAH85303.1 |
RefSeqi | NP_001161980.1, NM_001168508.1 |
Genome annotation databases
GeneIDi | 26416 |
KEGGi | mmu:26416 |
UCSCi | uc008brm.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC085303 mRNA Translation: AAH85303.1 |
RefSeqi | NP_001161980.1, NM_001168508.1 |
3D structure databases
SMRi | Q5U421 |
ModBasei | Search... |
Proteomic databases
EPDi | Q5U421 |
MaxQBi | Q5U421 |
Protocols and materials databases
Antibodypediai | 4142, 2283 antibodies from 53 providers |
DNASUi | 26416 |
Genome annotation databases
GeneIDi | 26416 |
KEGGi | mmu:26416 |
UCSCi | uc008brm.2, mouse |
Organism-specific databases
CTDi | 1432 |
MGIi | MGI:1346865, Mapk14 |
VEuPathDBi | HostDB:ENSMUSG00000053436 |
Phylogenomic databases
PhylomeDBi | Q5U421 |
Miscellaneous databases
BioGRID-ORCSi | 26416, 8 hits in 66 CRISPR screens |
ChiTaRSi | Mapk14, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000053436, Expressed in granulocyte and 319 other tissues |
ExpressionAtlasi | Q5U421, baseline and differential |
Family and domain databases
CDDi | cd07877, STKc_p38alpha, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR008352, MAPK_p38-like IPR038784, p38alpha IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PRINTSi | PR01773, P38MAPKINASE |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5U421_MOUSE | |
Accessioni | Q5U421Primary (citable) accession number: Q5U421 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 7, 2004 |
Last sequence update: | December 7, 2004 | |
Last modified: | January 19, 2022 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |