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Protein

Cholesteryl ester transfer protein

Gene

cetp

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCholesterol metabolismUniRule annotation, Lipid metabolism, Lipid transportUniRule annotation, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

ReactomeiR-DRE-8964041 LDL remodeling
R-DRE-8964058 HDL remodeling

Names & Taxonomyi

Protein namesi
Recommended name:
Cholesteryl ester transfer proteinUniRule annotation
Gene namesi
Name:cetpImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-041114-54 cetp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21UniRule annotationAdd BLAST21
ChainiPRO_501509805022 – 493Cholesteryl ester transfer proteinUniRule annotationAdd BLAST472

Expressioni

Gene expression databases

BgeeiENSDARG00000030872 Expressed in 16 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000046890

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 260BPI1InterPro annotationAdd BLAST226
Domaini274 – 475BPI2InterPro annotationAdd BLAST202

Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00390000008226
HOGENOMiHOG000111553
HOVERGENiHBG005310
KOiK16835
OMAiFWFSEQV
OrthoDBiEOG091G08KX
TreeFamiTF333484

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR017130 Cholesteryl_ester_transfer
IPR001124 Lipid-bd_serum_glycop_C
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PTHR10504:SF12 PTHR10504:SF12, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
PIRSFiPIRSF037185 Cholesteryl_ester_transf, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits

Sequencei

Sequence statusi: Complete.

Q5U3E2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERRAVLFLV VALVKISCCC LDPPAAYRFT GAVCRLTYPA AVVLNEKTTE
60 70 80 90 100
VIQAAFQHAK YPSVQGERSI GFGTVKYGFH NLEIHNLSIG KSEFELKENV
110 120 130 140 150
GIGIAISNVY AVFKGTINYG YGSWLLSLNQ SMDFEVESQI DLVINPKLYC
160 170 180 190 200
GKGKVAADTS DCYLTFHKLK LLLQGDREPG WMKKMFTDIV TFTVKLVVKS
210 220 230 240 250
QICKEINSVA NILADFIQEQ AEQFLSEGGI GVDISVTSSP VIKSNYIESY
260 270 280 290 300
HKGLVTFNNE TSDLSNSVFH PSQLSEGRML YFWFSDGLLD PLLGAIHNDG
310 320 330 340 350
RFVRSISGTE LTDLFQTELS TARPELLSKW LSSEGPVLKA RSVSIPHLWT
360 370 380 390 400
TTQGTSVRVM AGVQLLLDGQ ETPVLYFETD VTVVVNASYA EKKLILKATA
410 420 430 440 450
QRISITNVSS SEGAIEMEES LRAYLQEAVE KMGIPKVVSY LEVELTSLMD
460 470 480 490
EHGLNLFDIF NPEVVPQDGY VMVQLDFGFP QHLLVEFLKR TLD
Length:493
Mass (Da):54,798
Last modified:December 7, 2004 - v1
Checksum:iA28D60D6ECF87C16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX470170 Genomic DNA No translation available.
BC085584 mRNA Translation: AAH85584.1
RefSeqiNP_001007361.1, NM_001007360.1
UniGeneiDr.91675

Genome annotation databases

EnsembliENSDART00000046891; ENSDARP00000046890; ENSDARG00000030872
GeneIDi492488
KEGGidre:492488

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX470170 Genomic DNA No translation available.
BC085584 mRNA Translation: AAH85584.1
RefSeqiNP_001007361.1, NM_001007360.1
UniGeneiDr.91675

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000046890

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000046891; ENSDARP00000046890; ENSDARG00000030872
GeneIDi492488
KEGGidre:492488

Organism-specific databases

CTDi1071
ZFINiZDB-GENE-041114-54 cetp

Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00390000008226
HOGENOMiHOG000111553
HOVERGENiHBG005310
KOiK16835
OMAiFWFSEQV
OrthoDBiEOG091G08KX
TreeFamiTF333484

Enzyme and pathway databases

ReactomeiR-DRE-8964041 LDL remodeling
R-DRE-8964058 HDL remodeling

Gene expression databases

BgeeiENSDARG00000030872 Expressed in 16 organ(s), highest expression level in liver

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR017130 Cholesteryl_ester_transfer
IPR001124 Lipid-bd_serum_glycop_C
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PTHR10504:SF12 PTHR10504:SF12, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
PIRSFiPIRSF037185 Cholesteryl_ester_transf, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ5U3E2_DANRE
AccessioniPrimary (citable) accession number: Q5U3E2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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