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Entry version 122 (02 Dec 2020)
Sequence version 1 (07 Dec 2004)
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Protein

E3 ubiquitin-protein ligase CBL

Gene

cbl

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.UniRule annotationARBA annotation EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.UniRule annotationARBA annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processUbl conjugation pathwayUniRule annotation
LigandCalciumUniRule annotationARBA annotation, Metal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase CBLUniRule annotation (EC:2.3.2.7UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cblImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-041114-207, cbl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 335Cbl-PTBInterPro annotationAdd BLAST305
Domaini365 – 404RING-typeInterPro annotationAdd BLAST40
Domaini863 – 902UBAInterPro annotationAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni464 – 653DisorderedSequence analysisAdd BLAST190
Regioni669 – 726DisorderedSequence analysisAdd BLAST58
Regioni742 – 789DisorderedSequence analysisAdd BLAST48
Regioni824 – 865DisorderedSequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi474 – 501Pro-richSequence analysisAdd BLAST28
Compositional biasi524 – 542Pro-richSequence analysisAdd BLAST19
Compositional biasi553 – 588Pro-richSequence analysisAdd BLAST36
Compositional biasi591 – 646PolarSequence analysisAdd BLAST56

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.UniRule annotation

Keywords - Domaini

RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
540689at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5U376

Family and domain databases

Conserved Domains Database

More...
CDDi
cd16709, RING-HC_Cbl-b, 1 hit
cd09920, SH2_Cbl-b_TKB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.930.20, 1 hit
3.30.40.10, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024162, Adaptor_Cbl
IPR014741, Adaptor_Cbl_EF_hand-like
IPR036537, Adaptor_Cbl_N_dom_sf
IPR003153, Adaptor_Cbl_N_hlx
IPR014742, Adaptor_Cbl_SH2-like
IPR039520, CBL-B_RING-HC
IPR024159, Cbl_PTB
IPR011992, EF-hand-dom_pair
IPR036860, SH2_dom_sf
IPR015940, UBA
IPR009060, UBA-like_sf
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

The PANTHER Classification System

More...
PANTHERi
PTHR23007, PTHR23007, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02262, Cbl_N, 1 hit
PF02761, Cbl_N2, 1 hit
PF02762, Cbl_N3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00184, RING, 1 hit
SM00165, UBA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934, SSF46934, 1 hit
SSF47473, SSF47473, 1 hit
SSF47668, SSF47668, 1 hit
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51506, CBL_PTB, 1 hit
PS50030, UBA, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5U376-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGNLKKGGG LIGMMKDAFQ PHHHLHHSHH QPGAVDKKTV EKCWKFMDKV
60 70 80 90 100
VRLCQNPKLA LKNSPPYILD LLPDTYQHLR TILSRYEGKM ETLGDNEYFR
110 120 130 140 150
VFMENLTKKT KQTISLFKDG KERMFEENSQ PRRNLTKLSL IFSHMLAELK
160 170 180 190 200
AIFPNGLFQG DNFRITKADA AEFWRRSFGD KTIVPWKVFR QALHEFHPIS
210 220 230 240 250
SGLEAMALKS TIDLTCNDYI SVFEFDIFTR LFQPWSSLLR NWNSLAVTHP
260 270 280 290 300
GYMAFLTYDE VKARLQKFIH KPGSYIFRLS CTRLGQWAIG YVTADGNILQ
310 320 330 340 350
TIPHNKPLFQ AHIDGFREGF YLFPDGRTQN PDLTGLCEPS PQDHIKVTQE
360 370 380 390 400
QYELYCEMGS TFQLCKICAE NDKDVKIEPC GHLMCTSCLT AWQESEGQGC
410 420 430 440 450
PFCRCEIKGT EPIVVDPFDP KDPNSAASYG CRGMFGAEGA PSPSYDDDDD
460 470 480 490 500
DRLEETPFMI SKLVGSKVER PPSPMSISPQ PVVPPVPPRL DLLPLRPTNP
510 520 530 540 550
PGASSPGATS KAPSHHKDKP LPLPPALRDL PPPPPPDRPH PAGADNRLPR
560 570 580 590 600
RPLPSTPGDP SRDKLPPAPP NRNMPDWNSR PVPKAPSQPP ASGDTRGSRE
610 620 630 640 650
LSNRHSLPLQ LPSTLDSRTE APRNNGPPSL DHQLSFGSSN PASDYDSPKV
660 670 680 690 700
KPSASANAIY SLAIRPVAAA RTQTGEETNE NDEESEYMTP SSRPVLPSAA
710 720 730 740 750
GEAVPRPPPP LSLSPRSMLN ELESESPQMY EAMYNIQAQA LTASAPQARD
760 770 780 790 800
SDYSELPPLT CSNGPRDPVG AYAEEEEEEE NSYDYPKPHL SAALARRTLS
810 820 830 840 850
DANSPSSSAF SRLSFDSDLG AAATVLDPSE APERPPKPLP RRINSDRRPS
860 870 880 890 900
PVPPGASPGP SQQISSEIEH LLSQGYSHQD IQKALMIAQN NIEMAKNVLR
910
EFVSIPSTAH ILT
Length:913
Mass (Da):101,174
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64E4B33232CF09EB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC085671 mRNA Translation: AAH85671.1

NCBI Reference Sequences

More...
RefSeqi
NP_001007331.1, NM_001007330.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
492364

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:492364

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085671 mRNA Translation: AAH85671.1
RefSeqiNP_001007331.1, NM_001007330.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi492364
KEGGidre:492364

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
867
ZFINiZDB-GENE-041114-207, cbl

Phylogenomic databases

OrthoDBi540689at2759
PhylomeDBiQ5U376

Enzyme and pathway databases

UniPathwayiUPA00143

Family and domain databases

CDDicd16709, RING-HC_Cbl-b, 1 hit
cd09920, SH2_Cbl-b_TKB, 1 hit
Gene3Di1.20.930.20, 1 hit
3.30.40.10, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR024162, Adaptor_Cbl
IPR014741, Adaptor_Cbl_EF_hand-like
IPR036537, Adaptor_Cbl_N_dom_sf
IPR003153, Adaptor_Cbl_N_hlx
IPR014742, Adaptor_Cbl_SH2-like
IPR039520, CBL-B_RING-HC
IPR024159, Cbl_PTB
IPR011992, EF-hand-dom_pair
IPR036860, SH2_dom_sf
IPR015940, UBA
IPR009060, UBA-like_sf
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PANTHERiPTHR23007, PTHR23007, 1 hit
PfamiView protein in Pfam
PF02262, Cbl_N, 1 hit
PF02761, Cbl_N2, 1 hit
PF02762, Cbl_N3, 1 hit
SMARTiView protein in SMART
SM00184, RING, 1 hit
SM00165, UBA, 1 hit
SUPFAMiSSF46934, SSF46934, 1 hit
SSF47473, SSF47473, 1 hit
SSF47668, SSF47668, 1 hit
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51506, CBL_PTB, 1 hit
PS50030, UBA, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5U376_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5U376
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: December 2, 2020
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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