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Entry version 103 (02 Jun 2021)
Sequence version 1 (07 Dec 2004)
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Protein

Lebercilin

Gene

Lca5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lebercilin
Alternative name(s):
Leber congenital amaurosis 5 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lca5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
1308555, Lca5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895481 – 727LebercilinAdd BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7PhosphoserineBy similarity1
Modified residuei49PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5U2Y9

PRoteomics IDEntifications database

More...
PRIDEi
Q5U2Y9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5U2Y9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5U2Y9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000009580, Expressed in testis and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5U2Y9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5U2Y9, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NINL.

Interacts with OFD1.

Interacts with FAM161A.

Interacts with FAM161A.

Interacts with components of the IFT complex B.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000046841

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5U2Y9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 82DisorderedSequence analysisAdd BLAST82
Regioni381 – 409DisorderedSequence analysisAdd BLAST29
Regioni526 – 577DisorderedSequence analysisAdd BLAST52
Regioni613 – 692DisorderedSequence analysisAdd BLAST80

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili112 – 301Sequence analysisAdd BLAST190
Coiled coili449 – 480Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 21Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi24 – 50Polar residuesSequence analysisAdd BLAST27
Compositional biasi392 – 409Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi561 – 577Polar residuesSequence analysisAdd BLAST17
Compositional biasi613 – 652Polar residuesSequence analysisAdd BLAST40
Compositional biasi666 – 690Basic and acidic residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LCA5 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQG3, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00560000077266

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017042_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5U2Y9

Identification of Orthologs from Complete Genome Data

More...
OMAi
VQRLYHK

Database of Orthologous Groups

More...
OrthoDBi
344288at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5U2Y9

TreeFam database of animal gene trees

More...
TreeFami
TF323306

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026684, Lebercilin
IPR026188, Lebercilin-like
IPR028933, Lebercilin_dom

The PANTHER Classification System

More...
PANTHERi
PTHR16650, PTHR16650, 1 hit
PTHR16650:SF10, PTHR16650:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15619, Lebercilin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5U2Y9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGERDQSSDT DQERKGGKHP YSSHYSSDFG SSPQSSGPSS PVNTPPCASN
60 70 80 90 100
REKNPKRHLS DHHVRHQTVR KVSPKAIPNK KGVRVGFRSQ SLNREPLRKD
110 120 130 140 150
PDIVTKRVLS ARLLKITELQ NEVSELQVKL AQLLKENKAL KSLQYRQEKA
160 170 180 190 200
LSKFEDAENE ISQLIHRHNG EITALKERLR KSQEKERMAE KRVKDTEGEL
210 220 230 240 250
FRTKFSLQKL KKISEARHLP ERDDLAKKLV SAELKLDNTE RKIKELSKNL
260 270 280 290 300
ELSTNSFQRQ LLAERKRAFE AHDENKILQK ELQRLHHKLK EKEKELDIKN
310 320 330 340 350
IYANRLPKSS PKKEKEIARK HASCQSDFTD LCTKAVQTAE DFEPEEFPFT
360 370 380 390 400
AQTVLCYENR WDGSEYLPSY LEYQERNEHG SESLSSTLEQ EGKYSDDQDS
410 420 430 440 450
CTAKQETGKS ECEWEREELD KVKGKSSLLG RTEKLVLEAG SVQTESYQAQ
460 470 480 490 500
TIDKFQDEAE RLKTEMLLAK LNEINKELQD PQSLSRPLLP LLPNFESKLY
510 520 530 540 550
SPDRSLRPYT FSESLDRSFN GQHLSDMSFL TPRDEGQSPG LIRSPAPSDE
560 570 580 590 600
FSFGSYVPSF GKTPGKSNPP SQKNSLLDFQ SNMSEGLSKD SLDFISRKEK
610 620 630 640 650
KATLMEQLFG TSASASATNT SASTTTNTTT NTNTNTNTNT NTNCNVPSKS
660 670 680 690 700
IDSHFPAASR GDLDPLHFLS GDRSSRVREP DGEDEDLFLS EGRSFNPNRH
710 720
RLKHTSTKPT VTAVDSIDED IEEVTLR
Length:727
Mass (Da):82,610
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1332F2B14C7FC6B2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K802A0A0G2K802_RAT
Lebercilin
Lca5
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH83657 differs from that shown. Reason: Frameshift.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC083657 mRNA Translation: AAH83657.1 Frameshift.
BC085805 mRNA Translation: AAH85805.1

NCBI Reference Sequences

More...
RefSeqi
NP_001013976.1, NM_001013954.1
XP_008764471.1, XM_008766249.2
XP_008764472.1, XM_008766250.2
XP_008764473.1, XM_008766251.2
XP_008764474.1, XM_008766252.2
XP_008764475.1, XM_008766253.2
XP_008764477.1, XM_008766255.2
XP_008764478.1, XM_008766256.2
XP_008764479.1, XM_008766257.1
XP_008764480.1, XM_008766258.2
XP_017451064.1, XM_017595575.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000044931; ENSRNOP00000046841; ENSRNOG00000009580
ENSRNOT00000090139; ENSRNOP00000075180; ENSRNOG00000009580

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
300866

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:300866

UCSC genome browser

More...
UCSCi
RGD:1308555, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083657 mRNA Translation: AAH83657.1 Frameshift.
BC085805 mRNA Translation: AAH85805.1
RefSeqiNP_001013976.1, NM_001013954.1
XP_008764471.1, XM_008766249.2
XP_008764472.1, XM_008766250.2
XP_008764473.1, XM_008766251.2
XP_008764474.1, XM_008766252.2
XP_008764475.1, XM_008766253.2
XP_008764477.1, XM_008766255.2
XP_008764478.1, XM_008766256.2
XP_008764479.1, XM_008766257.1
XP_008764480.1, XM_008766258.2
XP_017451064.1, XM_017595575.1

3D structure databases

SMRiQ5U2Y9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046841

PTM databases

iPTMnetiQ5U2Y9
PhosphoSitePlusiQ5U2Y9

Proteomic databases

PaxDbiQ5U2Y9
PRIDEiQ5U2Y9

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
300866

Genome annotation databases

EnsembliENSRNOT00000044931; ENSRNOP00000046841; ENSRNOG00000009580
ENSRNOT00000090139; ENSRNOP00000075180; ENSRNOG00000009580
GeneIDi300866
KEGGirno:300866
UCSCiRGD:1308555, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
167691
RGDi1308555, Lca5

Phylogenomic databases

eggNOGiENOG502QQG3, Eukaryota
GeneTreeiENSGT00560000077266
HOGENOMiCLU_017042_0_0_1
InParanoidiQ5U2Y9
OMAiVQRLYHK
OrthoDBi344288at2759
PhylomeDBiQ5U2Y9
TreeFamiTF323306

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5U2Y9

Gene expression databases

BgeeiENSRNOG00000009580, Expressed in testis and 20 other tissues
ExpressionAtlasiQ5U2Y9, baseline and differential
GenevisibleiQ5U2Y9, RN

Family and domain databases

InterProiView protein in InterPro
IPR026684, Lebercilin
IPR026188, Lebercilin-like
IPR028933, Lebercilin_dom
PANTHERiPTHR16650, PTHR16650, 1 hit
PTHR16650:SF10, PTHR16650:SF10, 1 hit
PfamiView protein in Pfam
PF15619, Lebercilin, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLCA5_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5U2Y9
Secondary accession number(s): Q5XIM2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: December 7, 2004
Last modified: June 2, 2021
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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