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Protein

Prostate tumor-overexpressed gene 1 protein homolog

Gene

Ptov1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation (By similarity).By similarity

Caution

Despite sequence similarity to MED25, to date this protein has not been identified as a component of the Mediator complex.Curated

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Prostate tumor-overexpressed gene 1 protein homolog
Gene namesi
Name:Ptov1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1306977 Ptov1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049671 – 416Prostate tumor-overexpressed gene 1 protein homologAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U2W6
PRIDEiQ5U2W6

Expressioni

Gene expression databases

BgeeiENSRNOG00000020358 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ5U2W6 RN

Interactioni

Subunit structurei

May interact with CREBBP. Interacts with FLOT1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027580

Structurei

3D structure databases

SMRiQ5U2W6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni184 – 416Interaction with FLOT1By similarityAdd BLAST233

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IHD9 Eukaryota
ENOG410Z0HI LUCA
GeneTreeiENSGT00520000055653
HOGENOMiHOG000115777
HOVERGENiHBG108306
InParanoidiQ5U2W6
OMAiELDCLTH
OrthoDBiEOG091G04LS
PhylomeDBiQ5U2W6
TreeFamiTF329598

Family and domain databases

Gene3Di2.40.290.30, 2 hits
InterProiView protein in InterPro
IPR021394 Med25_PTOV
IPR038196 PTOV_dom_sf
PfamiView protein in Pfam
PF11232 Med25, 2 hits

Sequencei

Sequence statusi: Complete.

Q5U2W6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRPRRAPHR SGAGGPLGGR GRPPRPLVVR AVRSRSWPAG PRGPQPPRIR
60 70 80 90 100
ARSAPPMEGA RVFGALGPIG PSSPGLTLGG LAVNEHRLSN KLLAWSGVLE
110 120 130 140 150
WQEKRRPFSD SAAKLKRTLP CQAYVNQGEN LETDQWPQKL IMQLIPQQLL
160 170 180 190 200
TTLGPLFRNS QLAQFHFTNR DCDSLKGLCR IMGNGFAGCM LFPHISPCEV
210 220 230 240 250
RVLMLLYSSK KKIFMGLIPY DQSGFVNAIR QVITTRKQAV GPGGVHSGPV
260 270 280 290 300
QIVNNKFLAW SGVMEWQEPR PEPNSRSKRW LPSHVYVNQG EILRTDQWPR
310 320 330 340 350
RLFMQLIPQQ LLTTLVPLFR NSRLVQFHFT KDMETLKSLC RIMDNGFAGC
360 370 380 390 400
VHFSYKASCE VRVLMLLYSS EKKIFIGLIP HDQSNFVNGI RRVIANQQQV
410
LQRSLEQEQQ QRGMGG
Length:416
Mass (Da):46,849
Last modified:December 7, 2004 - v1
Checksum:iBAEAE4B65CB58A10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085836 mRNA Translation: AAH85836.1
RefSeqiNP_001008305.1, NM_001008304.1
UniGeneiRn.2864

Genome annotation databases

EnsembliENSRNOT00000027580; ENSRNOP00000027580; ENSRNOG00000020358
GeneIDi292888
KEGGirno:292888
UCSCiRGD:1306977 rat

Similar proteinsi

Entry informationi

Entry nameiPTVO1_RAT
AccessioniPrimary (citable) accession number: Q5U2W6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 7, 2004
Last modified: September 12, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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