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UniProtKB - Q5U2V0 (Q5U2V0_RAT)
Protein
Submitted name:
GATA-binding protein 5
Gene
Gata5
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
- transcription cis-regulatory region binding Source: RGD
- zinc ion binding Source: InterPro
GO - Biological processi
- aortic valve morphogenesis Source: RGD
- cardiac muscle tissue development Source: GO_Central
- cell fate commitment Source: GO_Central
- cellular response to BMP stimulus Source: RGD
- endocardial cushion fusion Source: RGD
- intestinal epithelial cell differentiation Source: RGD
- negative regulation of cardiac muscle hypertrophy Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of cardiac endothelial to mesenchymal transition Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of Notch signaling pathway involved in heart induction Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of transcription from RNA polymerase II promoter involved in heart development Source: RGD
- regulation of transcription, DNA-templated Source: RGD
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingARBA annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-983231, Factors involved in megakaryocyte development and platelet production |
Names & Taxonomyi
Protein namesi | Submitted name: GATA-binding protein 5ImportedSubmitted name: Similar to Transcription factor GATA-5 (GATA binding factor-5)Imported |
Gene namesi | ORF Names:rCG_38545Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1561365, Gata5 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000058983, Expressed in jejunum and 15 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 190 – 244 | GATA-typeInterPro annotationAdd BLAST | 55 | |
Domaini | 244 – 297 | GATA-typeInterPro annotationAdd BLAST | 54 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 70 – 110 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 293 – 359 | DisorderedSequence analysisAdd BLAST | 67 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 307 – 359 | Polar residuesSequence analysisAdd BLAST | 53 |
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1601, Eukaryota |
GeneTreei | ENSGT00940000160139 |
HOGENOMi | CLU_027524_0_0_1 |
OMAi | PSWTAGH |
OrthoDBi | 807790at2759 |
TreeFami | TF315391 |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 2 hits |
Gene3Di | 3.30.50.10, 2 hits |
InterProi | View protein in InterPro IPR008013, GATA_N IPR016375, TF_GATA_4/5/6 IPR039355, Transcription_factor_GATA IPR000679, Znf_GATA IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR10071, PTHR10071, 1 hit |
Pfami | View protein in Pfam PF00320, GATA, 2 hits PF05349, GATA-N, 1 hit |
PIRSFi | PIRSF003028, TF_GATA_4/5/6, 1 hit |
PRINTSi | PR00619, GATAZNFINGER |
SMARTi | View protein in SMART SM00401, ZnF_GATA, 2 hits |
PROSITEi | View protein in PROSITE PS00344, GATA_ZN_FINGER_1, 2 hits PS50114, GATA_ZN_FINGER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q5U2V0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYQSLALAQS PGQGTYADSG PFLHSSGAGS PVFVAPTRVP SMLPYLPSCE
60 70 80 90 100
PGSQPPALAA HSSWTQAVSA ESSAFGSGSP HPPATHPPGA TAFPFAHSPS
110 120 130 140 150
GSGSGGSAGV RDGAAFQSAL LAREQYPTAL GRPMSASYPT TYPAYVSPDV
160 170 180 190 200
APSWTSGPFD SSILHGLQGR PGGLPGRRTT FVPDFLEEFP GEGRECVNCG
210 220 230 240 250
ALSTPLWRRD GTGHYLCNAC GLYHKMNGVN RPLVRPQKRL SSSRRSGLCC
260 270 280 290 300
SNCHTATTTL WRRNAEGEPV CNACGLYMKL HGVPRPLAMK KESIQTRKRK
310 320 330 340 350
PKNPAKIKGS SGSTANSTAS SPTLLNTESS ATTLKAESSL ASPGCAGPTI
360 370 380 390 400
TSQASSPADE SLASSHLEFK FEPEDFVFTS SSLSPQAGLS GVLRQEAWCA
LALA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC115322 Genomic DNA No translation available. BC085855 mRNA Translation: AAH85855.1 CH474066 Genomic DNA Translation: EDL88812.1 |
RefSeqi | NP_001019487.1, NM_001024316.1 |
Genome annotation databases
Ensembli | ENSRNOT00000089971; ENSRNOP00000073661; ENSRNOG00000058983 |
GeneIDi | 499951 |
KEGGi | rno:499951 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC115322 Genomic DNA No translation available. BC085855 mRNA Translation: AAH85855.1 CH474066 Genomic DNA Translation: EDL88812.1 |
RefSeqi | NP_001019487.1, NM_001024316.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000007896 |
Genome annotation databases
Ensembli | ENSRNOT00000089971; ENSRNOP00000073661; ENSRNOG00000058983 |
GeneIDi | 499951 |
KEGGi | rno:499951 |
Organism-specific databases
CTDi | 140628 |
RGDi | 1561365, Gata5 |
Phylogenomic databases
eggNOGi | KOG1601, Eukaryota |
GeneTreei | ENSGT00940000160139 |
HOGENOMi | CLU_027524_0_0_1 |
OMAi | PSWTAGH |
OrthoDBi | 807790at2759 |
TreeFami | TF315391 |
Enzyme and pathway databases
Reactomei | R-RNO-983231, Factors involved in megakaryocyte development and platelet production |
Gene expression databases
Bgeei | ENSRNOG00000058983, Expressed in jejunum and 15 other tissues |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 2 hits |
Gene3Di | 3.30.50.10, 2 hits |
InterProi | View protein in InterPro IPR008013, GATA_N IPR016375, TF_GATA_4/5/6 IPR039355, Transcription_factor_GATA IPR000679, Znf_GATA IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR10071, PTHR10071, 1 hit |
Pfami | View protein in Pfam PF00320, GATA, 2 hits PF05349, GATA-N, 1 hit |
PIRSFi | PIRSF003028, TF_GATA_4/5/6, 1 hit |
PRINTSi | PR00619, GATAZNFINGER |
SMARTi | View protein in SMART SM00401, ZnF_GATA, 2 hits |
PROSITEi | View protein in PROSITE PS00344, GATA_ZN_FINGER_1, 2 hits PS50114, GATA_ZN_FINGER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5U2V0_RAT | |
Accessioni | Q5U2V0Primary (citable) accession number: Q5U2V0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 7, 2004 |
Last sequence update: | December 7, 2004 | |
Last modified: | January 19, 2022 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |