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Protein

Peptidylprolyl isomerase

Gene

Fkbp5

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).PROSITE-ProRule annotation

GO - Molecular functioni

  • FK506 binding Source: GO_Central
  • heat shock protein binding Source: Ensembl
  • peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIsomerase, RotamasePROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-RNO-8939211 ESR-mediated signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidylprolyl isomerasePROSITE-ProRule annotation (EC:5.2.1.8PROSITE-ProRule annotation)
Gene namesi
Name:Fkbp5Imported
ORF Names:rCG_60597Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1309155 Fkbp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000022523 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ5U2T9, 1 interactor
Q5U2T9, 1 interactor
STRINGi10116.ENSRNOP00000034024

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 138PPIase FKBP-typeInterPro annotationAdd BLAST89
Domaini165 – 251PPIase FKBP-typeInterPro annotationAdd BLAST87
Repeati268 – 301TPRPROSITE-ProRule annotationAdd BLAST34
Domaini317 – 384TPR_REGIONInterPro annotationAdd BLAST68
Repeati317 – 350TPRPROSITE-ProRule annotationAdd BLAST34
Repeati351 – 384TPRPROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

RepeatSAAS annotation, TPR repeatPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0543 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00760000119159
HOGENOMiHOG000256916
HOVERGENiHBG051624
KOiK09571
OMAiNSEETPM
OrthoDBiEOG091G07OA
TreeFamiTF105292

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR031210 FKBP5
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PANTHERiPTHR10516 PTHR10516, 1 hit
PTHR10516:SF26 PTHR10516:SF26, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 2 hits
PF00515 TPR_1, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 2 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 2 hits
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q5U2T9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTDEGTSNN EENPAATVVE QGEDITTKKD RGVLKIVKRV GTSEETPMIG
60 70 80 90 100
DKVYVHYKGK LSNGKKFDSS RDRNEPFVFS LGKGQVIKAW DIGVSTMKKG
110 120 130 140 150
EICHLLCKPE YAYGSAGSLP KIPSNATLFF EIELLDFKGE DLFEDSGIIR
160 170 180 190 200
RIKRKGEGYS NPNEGATVEV HLEGCCAGRV FDCRDVVFVI GEGEDHDIPI
210 220 230 240 250
GIDKALEKMQ REEQCILYLG PQYGFGEAGK PKFGIEPNAE LMYEVTLKSF
260 270 280 290 300
EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM
310 320 330 340 350
EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN
360 370 380 390 400
EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISVCQRKAKE
410 420 430 440 450
HNERDRRVYA NMFKKFAEQD AKEEASKALS KKAVEGAAGK KHESQTMGEG

KAEGHV
Length:456
Mass (Da):50,965
Last modified:December 7, 2004 - v1
Checksum:iC63929D7A5FF2B85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072814 Genomic DNA No translation available.
AC106225 Genomic DNA No translation available.
BC085868 mRNA Translation: AAH85868.1
CH473988 Genomic DNA Translation: EDL96926.1
RefSeqiNP_001012174.1, NM_001012174.1
XP_006256286.1, XM_006256224.3
UniGeneiRn.144288

Genome annotation databases

EnsembliENSRNOT00000033119; ENSRNOP00000034024; ENSRNOG00000022523
GeneIDi361810
KEGGirno:361810
UCSCiRGD:1309155 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072814 Genomic DNA No translation available.
AC106225 Genomic DNA No translation available.
BC085868 mRNA Translation: AAH85868.1
CH473988 Genomic DNA Translation: EDL96926.1
RefSeqiNP_001012174.1, NM_001012174.1
XP_006256286.1, XM_006256224.3
UniGeneiRn.144288

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5U2T9, 1 interactor
Q5U2T9, 1 interactor
STRINGi10116.ENSRNOP00000034024

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000033119; ENSRNOP00000034024; ENSRNOG00000022523
GeneIDi361810
KEGGirno:361810
UCSCiRGD:1309155 rat

Organism-specific databases

CTDi2289
RGDi1309155 Fkbp5

Phylogenomic databases

eggNOGiKOG0543 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00760000119159
HOGENOMiHOG000256916
HOVERGENiHBG051624
KOiK09571
OMAiNSEETPM
OrthoDBiEOG091G07OA
TreeFamiTF105292

Enzyme and pathway databases

ReactomeiR-RNO-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-RNO-8939211 ESR-mediated signaling

Gene expression databases

BgeeiENSRNOG00000022523 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR031210 FKBP5
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PANTHERiPTHR10516 PTHR10516, 1 hit
PTHR10516:SF26 PTHR10516:SF26, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 2 hits
PF00515 TPR_1, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 2 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 2 hits
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5U2T9_RAT
AccessioniPrimary (citable) accession number: Q5U2T9
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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