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Entry version 53 (02 Dec 2020)
Sequence version 1 (07 Dec 2004)
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Protein

GRB10-interacting GYF protein 2

Gene

gigyf2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GRB10-interacting GYF protein 2
Alternative name(s):
PERQ amino acid-rich with GYF domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gigyf2
Synonyms:perq2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-5870341, gigyf2.S

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002708401 – 1239GRB10-interacting GYF protein 2Add BLAST1239

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 4EHP-GYF2 complex (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
105778, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q5U236, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5U236

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini488 – 536GYFPROSITE-ProRule annotationAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi121 – 214Arg-richAdd BLAST94
Compositional biasi383 – 442Pro-richAdd BLAST60
Compositional biasi566 – 612Gln-richAdd BLAST47
Compositional biasi686 – 853Glu-richAdd BLAST168
Compositional biasi855 – 982Gln-richAdd BLAST128

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GIGYF family.Curated

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
412069at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00072, GYF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003169, GYF
IPR035445, GYF-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02213, GYF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00444, GYF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55277, SSF55277, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50829, GYF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5U236-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAETQTLNF GPEWLRALSS GGSVISPPLS PALPKYKLAD FRYGREEMLA
60 70 80 90 100
LYVKDNKVPS DLLDKEFLPI LNDEPLLPLA LVSFTEEEQR NFSMSVNSAA
110 120 130 140 150
VLRLTNRGSS GGGGTVVGVP RGRSSSRGRG RGRGESGFYQ RSFDEVESGF
160 170 180 190 200
GRGAREMHRS QSWEERGDRR FEKPARKEPD GVRGSAWREI PDRRRRFDYD
210 220 230 240 250
LRESKDERGY RRPRSGSGIA EDERDSLPEW CLDDAEDETG TFDSSGAFLS
260 270 280 290 300
SKPSKKVQKE PIPEEQEIDF HPSVDGAEVS DSDGSQTEEA KETDPVQSQN
310 320 330 340 350
QDDDLSRNDH TVQAAPSPDH KTSSPVRRTD MTLDTAHQKA VSPHLSCKMD
360 370 380 390 400
AKSQSPSSPP TPSKHKEDAA SASHQGTREK AGPCLPHPQS PALSQRSPAR
410 420 430 440 450
QPDPHIVPAM SSVPVPQLDT PTVPIHSSVC AAPGMEPVPP EPDEDGLEHL
460 470 480 490 500
EQQAQQMVAY LQDGTLDDDH LLTKVLDQRV KGPSLDNQQK WYYKDPQGEI
510 520 530 540 550
QGPFSNREMA EWYQAGYFPM TLLLRRVCDE TFQPLGDIFK KWGRVPFSTP
560 570 580 590 600
PTPRLGDLDP ERLSRQQEIT ALYQMRHLHY QQLLFQQQYA VLAQQQKVAL
610 620 630 640 650
SSQQQQLPLP LQPLSMRIPE HTVIPPVVRA LSVPESTSLW ELPPAPTQPA
660 670 680 690 700
VWEGSSVWDL PVEPTTQGTT REQLAQMDKV KAAKMEQERR EAELRAKQEE
710 720 730 740 750
EEQHRRKEAE EERKRREEEE LARRKQEEAL QRQKELALQK QMEEEERQRK
760 770 780 790 800
KELQLLEERM RQEEERKRLE EERRRQEEER RKQLEERKRA EEERRRREEE
810 820 830 840 850
KKREEDERRQ LEEIQRKQEE AARWAREEEE AVRLLLEEAR LKAEEEERNK
860 870 880 890 900
REEAQRQKEL QRQRQQQQEA LRRLQLQQQQ QQLAQMKLPS SSTWGQQVTP
910 920 930 940 950
SAASQSALSL AEIQKLEEER ERQKLQEQRH QQQELKALQQ QQQQQQQKIP
960 970 980 990 1000
GWGTMSKPTG TTKSLLEIQQ EEAGQMQKNH QQPGRNRPAN ISLPVAPVVN
1010 1020 1030 1040 1050
NHISSPTVGN SGSSVWGSLN NNLSPQWSSD SMSSIWGSTD VKGSSVGFWD
1060 1070 1080 1090 1100
DAVKEVAPRN ATSKNKNNAS KSAGSNSRQS KKVEQEEKLL RLFQGANKCQ
1110 1120 1130 1140 1150
DDFTQWCEKT MHAINTAHSL DVPTFVSFLR EVESPYEVHD YVCAYLGDTP
1160 1170 1180 1190 1200
EAKDFSKQFI ERRTKQKTSQ HRPQQDVAWV TCQTSQANSQ PITLEAVQCA
1210 1220 1230
GRKKKKQKMV RADPSLLGFS VNASSERLNM GEIETAEDY
Length:1,239
Mass (Da):141,636
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C55179440DC8301
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC086295 mRNA Translation: AAH86295.1

NCBI Reference Sequences

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RefSeqi
NP_001088645.1, NM_001095176.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
495698

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:495698

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086295 mRNA Translation: AAH86295.1
RefSeqiNP_001088645.1, NM_001095176.1

3D structure databases

SMRiQ5U236
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi105778, 1 interactor
IntActiQ5U236, 1 interactor

Genome annotation databases

GeneIDi495698
KEGGixla:495698

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
495698
XenbaseiXB-GENE-5870341, gigyf2.S

Phylogenomic databases

OrthoDBi412069at2759

Family and domain databases

CDDicd00072, GYF, 1 hit
Gene3Di3.30.1490.40, 1 hit
InterProiView protein in InterPro
IPR003169, GYF
IPR035445, GYF-like_dom_sf
PfamiView protein in Pfam
PF02213, GYF, 1 hit
SMARTiView protein in SMART
SM00444, GYF, 1 hit
SUPFAMiSSF55277, SSF55277, 1 hit
PROSITEiView protein in PROSITE
PS50829, GYF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGGYF2_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5U236
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 7, 2004
Last modified: December 2, 2020
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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