UniProtKB - Q5U0N0 (Q5U0N0_HUMAN)
Protein
Beta-sarcoglycan
Gene
SGCB
Organism
Homo sapiens (Human)
Status
Functioni
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.ARBA annotation
GO - Biological processi
- cardiac muscle cell development Source: Ensembl
- muscle fiber development Source: Ensembl
- muscle organ development Source: InterPro
- vascular associated smooth muscle cell development Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: Beta-sarcoglycanARBA annotation |
Gene namesi | Name:SGCBImported ORF Names:hCG_20638Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000163069.12 |
Subcellular locationi
Plasma membrane
- sarcolemma ARBA annotation; Single-pass type II membrane protein ARBA annotation
Cytoskeleton
- cytoskeleton ARBA annotation
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Plasma Membrane
- sarcoglycan complex Source: Ensembl
- sarcolemma Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 64 – 90 | HelicalSequence analysisAdd BLAST | 27 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000163069, Expressed in tendon of biceps brachii and 244 other tissues |
ExpressionAtlasi | Q5U0N0, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 32 | DisorderedSequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Belongs to the sarcoglycan beta/delta/gamma/zeta family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_066515_1_0_1 |
OMAi | SVQYKIC |
OrthoDBi | 1214843at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR006875, Sarcoglycan IPR027659, Sgcb |
PANTHERi | PTHR21142, PTHR21142, 1 hit |
Pfami | View protein in Pfam PF04790, Sarcoglycan_1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5U0N0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAAAAAAE QQSSNGPVKK SMREKAVERR SVNKEHNSNF KAGYIPIDED
60 70 80 90 100
RLHKTGLRGR KGNLAICVII LLFILAVINL IITLVIWAVI RIGPNGCDSM
110 120 130 140 150
EFHESGLLRF KQVSDMGVIH PLYKSTVGGR RNENLVITGN NQPIVFQQGT
160 170 180 190 200
TKLSVENNKT SITSDIGMQF FDPRTQNILF STDYETHEFH LPSGVKSLNV
210 220 230 240 250
QKASTERITS NATSDLNIKV DGRAIVRGNE GVFIMGKTIE FHMGGNMELK
260 270 280 290 300
AENSIILNGS VMVSTTRLPS SSSGDQLGSG DWVRYKLCMC ADGTLFKVQV
310
TSQNMGCQIS DNPCGNTH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT019433 mRNA Translation: AAV38240.1 AK289892 mRNA Translation: BAF82581.1 CH471057 Genomic DNA Translation: EAX05429.1 CH471057 Genomic DNA Translation: EAX05430.1 |
RefSeqi | NP_000223.1, NM_000232.4 |
Genome annotation databases
GeneIDi | 6443 |
KEGGi | hsa:6443 |
UCSCi | uc003gzj.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT019433 mRNA Translation: AAV38240.1 AK289892 mRNA Translation: BAF82581.1 CH471057 Genomic DNA Translation: EAX05429.1 CH471057 Genomic DNA Translation: EAX05430.1 |
RefSeqi | NP_000223.1, NM_000232.4 |
3D structure databases
SMRi | Q5U0N0 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q5U0N0 |
Protocols and materials databases
Antibodypediai | 2557, 218 antibodies |
DNASUi | 6443 |
Genome annotation databases
GeneIDi | 6443 |
KEGGi | hsa:6443 |
UCSCi | uc003gzj.3, human |
Organism-specific databases
CTDi | 6443 |
PharmGKBi | PA35717 |
VEuPathDBi | HostDB:ENSG00000163069.12 |
Phylogenomic databases
HOGENOMi | CLU_066515_1_0_1 |
OMAi | SVQYKIC |
OrthoDBi | 1214843at2759 |
Miscellaneous databases
BioGRID-ORCSi | 6443, 2 hits in 873 CRISPR screens |
ChiTaRSi | SGCB, human |
GenomeRNAii | 6443 |
Gene expression databases
Bgeei | ENSG00000163069, Expressed in tendon of biceps brachii and 244 other tissues |
ExpressionAtlasi | Q5U0N0, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR006875, Sarcoglycan IPR027659, Sgcb |
PANTHERi | PTHR21142, PTHR21142, 1 hit |
Pfami | View protein in Pfam PF04790, Sarcoglycan_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5U0N0_HUMAN | |
Accessioni | Q5U0N0Primary (citable) accession number: Q5U0N0 Secondary accession number(s): A0A024RDA3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | February 10, 2021 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |