UniProtKB - Q5U0K8 (Q5U0K8_HUMAN)
Protein
Submitted name:
Sodium channel, voltage-gated, type II, beta
Gene
SCN2B
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- sodium channel regulator activity Source: InterPro
- voltage-gated sodium channel activity Source: Ensembl
GO - Biological processi
- nervous system development Source: Ensembl
- response to pyrethroid Source: Ensembl
Keywordsi
Molecular function | Ion channelImported |
Biological process | Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Sodium channel, voltage-gated, type II, betaImportedSubmitted name: cDNA, FLJ94526, Homo sapiens sodium channel, voltage-gated, type II, beta (SCN2B),mRNAImported |
Gene namesi | Name:SCN2BImported ORF Names:hCG_41149Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000149575.5 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- voltage-gated sodium channel complex Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 158 – 180 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_5014310135 | 30 – 215 | Sequence analysisAdd BLAST | 186 |
Expressioni
Gene expression databases
Bgeei | ENSG00000149575, Expressed in caudate nucleus and 164 other tissues |
ExpressionAtlasi | Q5U0K8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 131 | Ig-likeInterPro annotationAdd BLAST | 106 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 187 – 215 | DisorderedSequence analysisAdd BLAST | 29 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_090350_0_0_1 |
OMAi | TNPPDRH |
OrthoDBi | 1380581at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR000920, Myelin_P0-rel IPR029873, SCN2B |
PANTHERi | PTHR13869, PTHR13869, 1 hit PTHR13869:SF3, PTHR13869:SF3, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
PRINTSi | PR00213, MYELINP0 |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5U0K8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHRDAWLPRP AFSLTGLSLF FSLVPPGRSM EVTVPATLNV LNGSDARLPC
60 70 80 90 100
TFNSCYTVNH KQFSLNWTYQ ECNNCSEEMF LQFRMKIINL KLERFQDRVE
110 120 130 140 150
FSGNPSKYDV SVMLRNVQPE DEGIYNCYIM NPPDRHRGHG KIHLQVLMEE
160 170 180 190 200
PPERDSTVAV IVGASVGGFL AVVILVLMVV KCVRRKKEQK LSTDDLKTEE
210
EGKTDGEGNP DDGAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT019487 mRNA Translation: AAV38294.1 AK313891 mRNA Translation: BAG36614.1 CH471065 Genomic DNA Translation: EAW67353.1 |
RefSeqi | NP_004579.1, NM_004588.4 |
Genome annotation databases
GeneIDi | 6327 |
KEGGi | hsa:6327 |
UCSCi | uc001psf.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT019487 mRNA Translation: AAV38294.1 AK313891 mRNA Translation: BAG36614.1 CH471065 Genomic DNA Translation: EAW67353.1 |
RefSeqi | NP_004579.1, NM_004588.4 |
3D structure databases
SMRi | Q5U0K8 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 2511, 288 antibodies |
DNASUi | 6327 |
Genome annotation databases
GeneIDi | 6327 |
KEGGi | hsa:6327 |
UCSCi | uc001psf.3, human |
Organism-specific databases
CTDi | 6327 |
EuPathDBi | HostDB:ENSG00000149575.5 |
PharmGKBi | PA303 |
Phylogenomic databases
HOGENOMi | CLU_090350_0_0_1 |
OMAi | TNPPDRH |
OrthoDBi | 1380581at2759 |
Miscellaneous databases
BioGRID-ORCSi | 6327, 3 hits in 844 CRISPR screens |
ChiTaRSi | SCN2B, human |
GenomeRNAii | 6327 |
Gene expression databases
Bgeei | ENSG00000149575, Expressed in caudate nucleus and 164 other tissues |
ExpressionAtlasi | Q5U0K8, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR000920, Myelin_P0-rel IPR029873, SCN2B |
PANTHERi | PTHR13869, PTHR13869, 1 hit PTHR13869:SF3, PTHR13869:SF3, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
PRINTSi | PR00213, MYELINP0 |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5U0K8_HUMAN | |
Accessioni | Q5U0K8Primary (citable) accession number: Q5U0K8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |