EIF3S2

Functionⁱ

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.UniRule annotation

GO - Molecular functionⁱ

translation initiation factor activity Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

formation of cytoplasmic translation initiation complex Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Initiation factorUniRule annotationSAAS annotationImported
Biological process	Protein biosynthesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Eukaryotic translation initiation factor 3 subunit IUniRule annotationSAAS annotation Short name: eIF3iUniRule annotation Alternative name(s): Eukaryotic translation initiation factor 3 subunit 2UniRule annotation eIF-3-betaUniRule annotation eIF3 p36UniRule annotation
Gene namesⁱ	Name:EIF3S2UniRule annotationImported Synonyms:EIF3IUniRule annotation ORF Names:hCG_41608Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000084623.11

EuPathDBⁱ

HostDB:ENSG00000084623.11

Keywords - Cellular componentⁱ

CytoplasmUniRule annotationSAAS annotation

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA162384875

PharmGKBⁱ

PA162384875

PTM / Processingⁱ

Post-translational modificationⁱ

Phosphorylated by TGF-beta type II receptor.UniRule annotation

Keywords - PTMⁱ

PhosphoproteinUniRule annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000084623 Expressed in 231 organ(s), highest expression level in left adrenal gland

Bgeeⁱ

ENSG00000084623 Expressed in 231 organ(s), highest expression level in left adrenal gland

Interactionⁱ

Subunit structureⁱ

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.UniRule annotation

Protein-protein interaction databases

IntActⁱ	Q5U0F4, 1 interactor Q5U0F4, 1 interactor

IntActⁱ

Q5U0F4, 1 interactor
Q5U0F4, 1 interactor

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	6 – 225	WD_REPEATS_REGIONInterPro annotationAdd BLAST	220
Repeatⁱ	6 – 47	WDPROSITE-ProRule annotationAdd BLAST	42
Repeatⁱ	48 – 89	WDPROSITE-ProRule annotationAdd BLAST	42
Repeatⁱ	184 – 225	WDPROSITE-ProRule annotationAdd BLAST	42
Domainⁱ	281 – 325	WD_REPEATS_REGIONInterPro annotationAdd BLAST	45
Repeatⁱ	281 – 311	WDPROSITE-ProRule annotationAdd BLAST	31

Sequence similaritiesⁱ

Belongs to the eIF-3 subunit I family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

RepeatSAAS annotation, WD repeatPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG0643 Eukaryota ENOG410XQ3E LUCA
HOVERGENⁱ	HBG000900
KEGG Orthology (KO) More...KOⁱ	K03246
OMAⁱ	FETRFWH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AIZ

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
HAMAPⁱ	MF_03008 eIF3i, 1 hit
InterProⁱ	View protein in InterPro IPR027525 eIF3i IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR19877 PTHR19877, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400 WD40, 3 hits
SMARTⁱ	View protein in SMART SM00320 WD40, 5 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 1 hit PS50082 WD_REPEATS_2, 4 hits PS50294 WD_REPEATS_REGION, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5U0F4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKPILLQGHE RSITQIKYNR EGDLLFTVAK DPIVNVWYSV NGERLGTYMG 
        60         70         80         90        100
HTGAVWCVDA DWDTKHVLTG SADNSCRLWD CETGKQLALL KTNSAVRTCG 
       110        120        130        140        150
FDFGGNIIMF STDKQMGYQC FVSFFDLRDP SQIDNNEPYM KIPCNDSKIT 
       160        170        180        190        200
SAVWGPLGEC IIAGHESGEL NQYSAKSGEV LVNVKEHSRQ INDIQLSRDM 
       210        220        230        240        250
TMFVTASKDN TAKLFDSTTL EHQKTFRTER PVNSAALSPN YDHVVLGGGQ 
       260        270        280        290        300
EAMDVTTTST RIGKFEARFF HLAFEEEFGR VKGHFGPINS VAFHPDGKSY 
       310        320 
SSGGEDGYVR IHYFDPQYFE FEFEA

Length:325

Mass (Da):36,502

Last modified:February 5, 2008 - v1

Checksum:ⁱ02797BB72A752A96

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT019597 mRNA Translation: AAV38404.1 AK289356 mRNA Translation: BAF82045.1 AK289882 mRNA Translation: BAF82571.1 CH471059 Genomic DNA Translation: EAX07553.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003748.1, NM_003757.3
UniGeneⁱ	Hs.530096

Genome annotation databases

GeneIDⁱ	8668
KEGGⁱ	hsa:8668
UCSC genome browser More...UCSCⁱ	uc009vuc.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5U0F4	Eukaryotic translation initiation factor 3 subunit I		HUMAN		325	UniRef100_Q13347
Eukaryotic translation initiation factor 3 subunit I		RHIRO		387
Eukaryotic translation initiation factor 3 subunit I		PANTR		325
Eukaryotic translation initiation factor 3 subunit I		CALJA		325
Eukaryotic translation initiation factor 3 subunit I		MACMU		325
+15

Protein	Similar proteins		Species	Score	Length	Source
Q5U0F4	Eukaryotic translation initiation factor 3 subunit I		HUMAN		325	UniRef90_Q13347
Eukaryotic translation initiation factor 3 subunit I		RHIRO		387
Eukaryotic translation initiation factor 3 subunit I		PANTR		325
Eukaryotic translation initiation factor 3 subunit I		CALJA		325
Eukaryotic translation initiation factor 3 subunit I		MACMU		325
+17

Protein	Similar proteins		Species	Score	Length	Source
Q5U0F4	Eukaryotic translation initiation factor 3 subunit I		HUMAN		325	UniRef50_Q13347
Eukaryotic translation initiation factor 3 subunit I		RHIRO		387
Eukaryotic translation initiation factor 3 subunit I		PANTR		325
Eukaryotic translation initiation factor 3 subunit I		CALJA		325
Eukaryotic translation initiation factor 3 subunit I		MACMU		325
+21

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT019597 mRNA Translation: AAV38404.1 AK289356 mRNA Translation: BAF82045.1 AK289882 mRNA Translation: BAF82571.1 CH471059 Genomic DNA Translation: EAX07553.1
RefSeqⁱ	NP_003748.1, NM_003757.3
UniGeneⁱ	Hs.530096

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q5U0F4, 1 interactor Q5U0F4, 1 interactor

IntActⁱ

Q5U0F4, 1 interactor
Q5U0F4, 1 interactor

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8668
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	8668
KEGGⁱ	hsa:8668
UCSCⁱ	uc009vuc.4 human

Organism-specific databases

CTDⁱ	8668
EuPathDBⁱ	HostDB:ENSG00000084623.11
PharmGKBⁱ	PA162384875

Phylogenomic databases

eggNOGⁱ	KOG0643 Eukaryota ENOG410XQ3E LUCA
HOVERGENⁱ	HBG000900
KOⁱ	K03246
OMAⁱ	FETRFWH
OrthoDBⁱ	EOG091G0AIZ

Miscellaneous databases

ChiTaRSⁱ	EIF3I human
GenomeRNAiⁱ	8668

Gene expression databases

Bgeeⁱ	ENSG00000084623 Expressed in 231 organ(s), highest expression level in left adrenal gland

Bgeeⁱ

ENSG00000084623 Expressed in 231 organ(s), highest expression level in left adrenal gland

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
HAMAPⁱ	MF_03008 eIF3i, 1 hit
InterProⁱ	View protein in InterPro IPR027525 eIF3i IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR19877 PTHR19877, 1 hit
Pfamⁱ	View protein in Pfam PF00400 WD40, 3 hits
SMARTⁱ	View protein in SMART SM00320 WD40, 5 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 1 hit PS50082 WD_REPEATS_2, 4 hits PS50294 WD_REPEATS_REGION, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5U0F4_HUMAN
Accessionⁱ	Q5U0F4Primary (citable) accession number: Q5U0F4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 5, 2008
	Last sequence update:	February 5, 2008
	Last modified:	November 7, 2018
	This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - Q5U0F4 (Q5U0F4_HUMAN)

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Eukaryotic translation initiation factor 3 subunit I

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ