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Protein

Eukaryotic translation initiation factor 3 subunit I

Gene

EIF3S2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factorUniRule annotationSAAS annotationImported
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit IUniRule annotationSAAS annotation
Short name:
eIF3iUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 2UniRule annotation
eIF-3-betaUniRule annotation
eIF3 p36UniRule annotation
Gene namesi
Name:EIF3S2UniRule annotationImported
Synonyms:EIF3IUniRule annotation
ORF Names:hCG_41608Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000084623.11

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162384875

PTM / Processingi

Post-translational modificationi

Phosphorylated by TGF-beta type II receptor.UniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000084623 Expressed in 231 organ(s), highest expression level in left adrenal gland

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.UniRule annotation

Protein-protein interaction databases

IntActiQ5U0F4, 1 interactor
Q5U0F4, 1 interactor

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 225WD_REPEATS_REGIONInterPro annotationAdd BLAST220
Repeati6 – 47WDPROSITE-ProRule annotationAdd BLAST42
Repeati48 – 89WDPROSITE-ProRule annotationAdd BLAST42
Repeati184 – 225WDPROSITE-ProRule annotationAdd BLAST42
Domaini281 – 325WD_REPEATS_REGIONInterPro annotationAdd BLAST45
Repeati281 – 311WDPROSITE-ProRule annotationAdd BLAST31

Sequence similaritiesi

Belongs to the eIF-3 subunit I family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, WD repeatPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0643 Eukaryota
ENOG410XQ3E LUCA
HOVERGENiHBG000900
KOiK03246
OMAiFETRFWH
OrthoDBiEOG091G0AIZ

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03008 eIF3i, 1 hit
InterProiView protein in InterPro
IPR027525 eIF3i
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19877 PTHR19877, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q5U0F4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPILLQGHE RSITQIKYNR EGDLLFTVAK DPIVNVWYSV NGERLGTYMG
60 70 80 90 100
HTGAVWCVDA DWDTKHVLTG SADNSCRLWD CETGKQLALL KTNSAVRTCG
110 120 130 140 150
FDFGGNIIMF STDKQMGYQC FVSFFDLRDP SQIDNNEPYM KIPCNDSKIT
160 170 180 190 200
SAVWGPLGEC IIAGHESGEL NQYSAKSGEV LVNVKEHSRQ INDIQLSRDM
210 220 230 240 250
TMFVTASKDN TAKLFDSTTL EHQKTFRTER PVNSAALSPN YDHVVLGGGQ
260 270 280 290 300
EAMDVTTTST RIGKFEARFF HLAFEEEFGR VKGHFGPINS VAFHPDGKSY
310 320
SSGGEDGYVR IHYFDPQYFE FEFEA
Length:325
Mass (Da):36,502
Last modified:February 5, 2008 - v1
Checksum:i02797BB72A752A96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT019597 mRNA Translation: AAV38404.1
AK289356 mRNA Translation: BAF82045.1
AK289882 mRNA Translation: BAF82571.1
CH471059 Genomic DNA Translation: EAX07553.1
RefSeqiNP_003748.1, NM_003757.3
UniGeneiHs.530096

Genome annotation databases

GeneIDi8668
KEGGihsa:8668
UCSCiuc009vuc.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT019597 mRNA Translation: AAV38404.1
AK289356 mRNA Translation: BAF82045.1
AK289882 mRNA Translation: BAF82571.1
CH471059 Genomic DNA Translation: EAX07553.1
RefSeqiNP_003748.1, NM_003757.3
UniGeneiHs.530096

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5U0F4, 1 interactor
Q5U0F4, 1 interactor

Protocols and materials databases

DNASUi8668
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8668
KEGGihsa:8668
UCSCiuc009vuc.4 human

Organism-specific databases

CTDi8668
EuPathDBiHostDB:ENSG00000084623.11
PharmGKBiPA162384875

Phylogenomic databases

eggNOGiKOG0643 Eukaryota
ENOG410XQ3E LUCA
HOVERGENiHBG000900
KOiK03246
OMAiFETRFWH
OrthoDBiEOG091G0AIZ

Miscellaneous databases

ChiTaRSiEIF3I human
GenomeRNAii8668

Gene expression databases

BgeeiENSG00000084623 Expressed in 231 organ(s), highest expression level in left adrenal gland

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03008 eIF3i, 1 hit
InterProiView protein in InterPro
IPR027525 eIF3i
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19877 PTHR19877, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ5U0F4_HUMAN
AccessioniPrimary (citable) accession number: Q5U0F4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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