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UniProtKB - Q5TZZ9 (Q5TZZ9_HUMAN)
Protein
Annexin
Gene
ANXA1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: UniProtKB-KW
- calcium ion binding Source: InterPro
- phospholipase A2 inhibitor activity Source: UniProtKB-KW
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- alpha-beta T cell differentiation Source: Ensembl
- arachidonic acid secretion Source: Ensembl
- cellular response to glucocorticoid stimulus Source: Ensembl
- inflammatory response Source: Ensembl
- myoblast migration involved in skeletal muscle regeneration Source: Ensembl
- neutrophil homeostasis Source: Ensembl
- phagocytosis Source: Ensembl
- positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
- positive regulation of neutrophil apoptotic process Source: Ensembl
- regulation of cell population proliferation Source: Ensembl
- regulation of inflammatory response Source: Ensembl
- regulation of interleukin-1 production Source: Ensembl
- regulation of leukocyte migration Source: Ensembl
- signal transduction Source: Ensembl
Keywordsi
Molecular function | Phospholipase A2 inhibitorARBA annotation |
Biological process | Adaptive immunityARBA annotation, Immunity |
Ligand | Calcium, Calcium/phospholipid-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: AnnexinUniRule annotation |
Gene namesi | Name:ANXA1Imported ORF Names:hCG_17305Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000135046 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Endosome
- Early endosome ARBA annotation
- Endosome membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Plasma membrane
- Apical cell membrane ARBA annotation
- Basolateral cell membrane ARBA annotation
- Cell membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Extracellular side ARBA annotation
- Lateral cell membrane ARBA annotation
Extracellular region or secreted
- extracellular exosome ARBA annotation
- extracellular space ARBA annotation
Other locations
- cilium ARBA annotation
- phagocytic cup ARBA annotation
- Cytoplasmic vesicle membrane ARBA annotation; Peripheral membrane protein ARBA annotation
- secretory vesicle lumen ARBA annotation
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Cytosol
- cytosol Source: HPA
Endosome
- early endosome Source: UniProtKB-SubCell
- endosome membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular space Source: UniProtKB-SubCell
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
- basolateral plasma membrane Source: UniProtKB-SubCell
- cornified envelope Source: Ensembl
- lateral plasma membrane Source: UniProtKB-SubCell
- phagocytic cup Source: UniProtKB-SubCell
- plasma membrane Source: HPA
- sarcolemma Source: Ensembl
Other locations
- motile cilium Source: Ensembl
Keywords - Cellular componenti
Cell membraneARBA annotation, Cell projection, CiliumARBA annotation, CytoplasmARBA annotation, Membrane, NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000135046, Expressed in esophagus and 240 other tissues |
Structurei
Family & Domainsi
Domaini
The full-length protein can bind eight Ca2+ ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca2+, these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.UniRule annotation
Sequence similaritiesi
Keywords - Domaini
AnnexinUniRule annotationARBA annotation, RepeatUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_025300_0_0_1 |
OMAi | AKADRCE |
OrthoDBi | 856254at2759 |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR002388, ANX1 |
PANTHERi | PTHR10502:SF17, PTHR10502:SF17, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN PR00197, ANNEXINI |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 3 hits PS51897, ANNEXIN_2, 4 hits |
i Sequence
Sequence statusi: Complete.
Q5TZZ9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA
60 70 80 90 100
LHKAIMVKGV DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL
110 120 130 140 150
TGHLEEVVLA LLKTPAQFDA DELRAAMKGL GTDEDTLIEI LASRTNKEIR
160 170 180 190 200
DINRVYREEL KRDLAKDITS DTSGDFRNAL LSLAKGDRSE DFGVNEDLAD
210 220 230 240 250
SDARALYEAG ERRKGTDVNV FNTILTTRSY PQLRRVFQKY TKYSKHDMNK
260 270 280 290 300
VLDLELKGDI EKCLTAIVKC ATSKPAFFAE KLHQAMKGVG TRHKALIRIM
310 320 330 340
VSRSEIDMND IKAFYQKMYG ISLCQAILDE TKGDYEKILV ALCGGN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT019896 mRNA Translation: AAV38699.1 BT019916 mRNA Translation: AAV38719.1 BT019917 mRNA Translation: AAV38720.1 GQ891377 mRNA Translation: ADO22239.1 GU997628 Genomic DNA Translation: ADZ76495.1 CR407684 mRNA Translation: CAG28612.1 CH471089 Genomic DNA Translation: EAW62545.1 CH471089 Genomic DNA Translation: EAW62547.1 CH471089 Genomic DNA Translation: EAW62549.1 CH471089 Genomic DNA Translation: EAW62550.1 GHIR01000001 Transcribed RNA Translation: MOY33937.1 GHIR01000012 Transcribed RNA Translation: MOY33948.1 GHIR01000018 Transcribed RNA Translation: MOY33953.1 |
RefSeqi | NP_000691.1, NM_000700.2 XP_011516911.1, XM_011518609.1 |
Genome annotation databases
GeneIDi | 301 |
KEGGi | hsa:301 |
MANE-Selecti | ENST00000257497.11; ENSP00000257497.6; NM_000700.3; NP_000691.1 |
UCSCi | uc004ajf.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT019896 mRNA Translation: AAV38699.1 BT019916 mRNA Translation: AAV38719.1 BT019917 mRNA Translation: AAV38720.1 GQ891377 mRNA Translation: ADO22239.1 GU997628 Genomic DNA Translation: ADZ76495.1 CR407684 mRNA Translation: CAG28612.1 CH471089 Genomic DNA Translation: EAW62545.1 CH471089 Genomic DNA Translation: EAW62547.1 CH471089 Genomic DNA Translation: EAW62549.1 CH471089 Genomic DNA Translation: EAW62550.1 GHIR01000001 Transcribed RNA Translation: MOY33937.1 GHIR01000012 Transcribed RNA Translation: MOY33948.1 GHIR01000018 Transcribed RNA Translation: MOY33953.1 |
RefSeqi | NP_000691.1, NM_000700.2 XP_011516911.1, XM_011518609.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q5TZZ9, 1 interactor |
Protocols and materials databases
Antibodypediai | 2190, 1195 antibodies from 51 providers |
DNASUi | 301 |
Genome annotation databases
GeneIDi | 301 |
KEGGi | hsa:301 |
MANE-Selecti | ENST00000257497.11; ENSP00000257497.6; NM_000700.3; NP_000691.1 |
UCSCi | uc004ajf.2, human |
Organism-specific databases
CTDi | 301 |
PharmGKBi | PA24823 |
VEuPathDBi | HostDB:ENSG00000135046 |
Phylogenomic databases
HOGENOMi | CLU_025300_0_0_1 |
OMAi | AKADRCE |
OrthoDBi | 856254at2759 |
Miscellaneous databases
BioGRID-ORCSi | 301, 11 hits in 1088 CRISPR screens |
ChiTaRSi | ANXA1, human |
GenomeRNAii | 301 |
Gene expression databases
Bgeei | ENSG00000135046, Expressed in esophagus and 240 other tissues |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR002388, ANX1 |
PANTHERi | PTHR10502:SF17, PTHR10502:SF17, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN PR00197, ANNEXINI |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 3 hits PS51897, ANNEXIN_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5TZZ9_HUMAN | |
Accessioni | Q5TZZ9Primary (citable) accession number: Q5TZZ9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | May 25, 2022 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |