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Protein
Submitted name:

UBE2C protein

Gene

UBE2C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei114Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseSAAS annotation
Biological processUbl conjugation pathwayUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
UBE2C proteinImported
Submitted name:
Ubiquitin-conjugating enzyme E2CImported
Submitted name:
Ubiquitin-conjugating enzyme E2C, isoform CRA_eImported
Gene namesi
Name:UBE2CImported
ORF Names:hCG_38372Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000175063.16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38057

Expressioni

Gene expression databases

BgeeiENSG00000175063 Expressed in 179 organ(s), highest expression level in oocyte

Interactioni

Protein-protein interaction databases

IntActiQ5TZN3, 3 interactors
Q5TZN3, 3 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 158UBIQUITIN_CONJUGAT_2InterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0421 Eukaryota
ENOG4111IGV LUCA
HOVERGENiHBG063308
KOiK06688
OMAiELMQLMM
OrthoDBiEOG091G0M7S

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5TZN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASQNRDPAA TSVAAARKGA EPSGGAARGP VGKRLQQELM TLMMSGDKGI
60 70 80 90 100
SAFPESDNLF KWVGTIHGAA GTVYEDLRYK LSLEFPSGYP YNAPTVKFLT
110 120 130 140 150
PCYHPNVDTQ GNICLDILKE KWSALYDVRT ILLSIQSLLG EPNIDSPLNT
160 170
HAAELWKNPT AFKKYLQETY SKQVTSQEP
Length:179
Mass (Da):19,652
Last modified:May 10, 2005 - v1
Checksum:i0B6F58A1F0665D9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020165 mRNA Translation: AAV38967.1
BT020166 mRNA Translation: AAV38968.1
CR456988 mRNA Translation: CAG33269.1
CH471077 Genomic DNA Translation: EAW75809.1
RefSeqiNP_008950.1, NM_007019.3
UniGeneiHs.93002

Genome annotation databases

GeneIDi11065
KEGGihsa:11065
UCSCiuc002xpm.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020165 mRNA Translation: AAV38967.1
BT020166 mRNA Translation: AAV38968.1
CR456988 mRNA Translation: CAG33269.1
CH471077 Genomic DNA Translation: EAW75809.1
RefSeqiNP_008950.1, NM_007019.3
UniGeneiHs.93002

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5TZN3, 3 interactors
Q5TZN3, 3 interactors

Protocols and materials databases

DNASUi11065
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11065
KEGGihsa:11065
UCSCiuc002xpm.4 human

Organism-specific databases

CTDi11065
EuPathDBiHostDB:ENSG00000175063.16
PharmGKBiPA38057

Phylogenomic databases

eggNOGiKOG0421 Eukaryota
ENOG4111IGV LUCA
HOVERGENiHBG063308
KOiK06688
OMAiELMQLMM
OrthoDBiEOG091G0M7S

Miscellaneous databases

ChiTaRSiUBE2C human
GenomeRNAii11065

Gene expression databases

BgeeiENSG00000175063 Expressed in 179 organ(s), highest expression level in oocyte

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5TZN3_HUMAN
AccessioniPrimary (citable) accession number: Q5TZN3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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