Delta-like protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calcium ion binding Source: InterPro
• Notch binding Source: InterPro

GO - Biological processⁱ

• establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• exocrine pancreas development Source: ZFIN <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Endoderm Jagged induces liver and pancreas duct lineage in zebrafish."
    Zhang D., Gates K.P., Barske L., Wang G., Lancman J.J., Zeng X.I., Groff M., Wang K., Parsons M.J., Crump J.G., Dong P.D.S.
    Nat Commun 8:769-769(2017) [PubMed] [Europe PMC] [Abstract]
• heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• intrahepatic bile duct development Source: ZFINInferred from genetic interactionⁱ
  • "Endoderm Jagged induces liver and pancreas duct lineage in zebrafish."
    Zhang D., Gates K.P., Barske L., Wang G., Lancman J.J., Zeng X.I., Groff M., Wang K., Parsons M.J., Crump J.G., Dong P.D.S.
    Nat Commun 8:769-769(2017) [PubMed] [Europe PMC] [Abstract]
• liver development Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy."
    Lorent K., Yeo S.Y., Oda T., Chandrasekharappa S., Chitnis A., Matthews R.P., Pack M.
    Development 131:5753-5766(2004) [PubMed] [Europe PMC] [Abstract]
• Notch signaling pathway Source: InterPro
• pancreas development Source: ZFINInferred from genetic interactionⁱ
  • "Exocrine pancreas development in zebrafish."
    Yee N.S., Lorent K., Pack M.
    Dev Biol 284:84-101(2005) [PubMed] [Europe PMC] [Abstract]
• pronephros development Source: ZFINInferred from mutant phenotypeⁱ
  • "Notch signaling controls the differentiation of transporting epithelia and multiciliated cells in the zebrafish pronephros."
    Liu Y., Pathak N., Kramer-Zucker A., Drummond I.A.
    Development 134:1111-1122(2007) [PubMed] [Europe PMC] [Abstract]
• spinal cord motor neuron differentiation Source: ZFINInferred from mutant phenotypeⁱ
  • "Jagged-mediated Notch signaling maintains proliferating neural progenitors and regulates cell diversity in the ventral spinal cord."
    Yeo S.Y., Chitnis A.B.
    Proc Natl Acad Sci U S A 104:5913-5918(2007) [PubMed] [Europe PMC] [Abstract]
• ventral spinal cord interneuron differentiation Source: ZFINInferred from mutant phenotypeⁱ
  • "Jagged-mediated Notch signaling maintains proliferating neural progenitors and regulates cell diversity in the ventral spinal cord."
    Yeo S.Y., Chitnis A.B.
    Proc Natl Acad Sci U S A 104:5913-5918(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• Notch binding Source: InterPro

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MWNCIRIRNW LPIACLLLTM WTKVSQSSGY FELQLIAVEN VNGELWDGEC 
        60         70         80         90        100
CDSTRNSQDQ RCVRDECDTY FKVCLKEYQS EVTTTGQCTF GSGSTDVLGG 
       110        120        130        140        150
NIISFKTAKN SPSKTSDVGK IIIPFHFAWP RSYTLILEAW DWDNSTQNNG 
       160        170        180        190        200
EENLIERHIH ASMVNPGDHW QSIRHPGITA HIEYRIRVRC DENYYGSKCN 
       210        220        230        240        250
KQCRPRDDYF GHYRCDPSGN IVCLDGWMGE DCRTAICKQG CNLIHGGCAV 
       260        270        280        290        300
PGECKCNYGW QGQFCDECLP YPGCLHGTCV MPWQCTCEKN WGGLLCDKDL 
       310        320        330        340        350
NYCGTHHPCV NGGTCMNSEP DEYNCACPEG YSGKNCEIAE HACVSNPCAN 
       360        370        380        390        400
GGTCHEVPTG FECHCPPGWE GPTCAKDMDE CASSPCAQGG TCIDLENGFE 
       410        420        430        440        450
CVCPPQWVGK TCQIDLNGCH GQCQNGATCK ELVHGGYHCQ CPAGFVGLHC 
       460        470        480        490        500
EVSRNKCASG PCQNGGRCHV ILDSFVCECP SNYAGMLCEV ESLSHPNPCE 
       510        520        530        540        550
PNPCQNTALC YSLPGDFYCA CPEDYEGKTC ENRKDHCKMT PCQVIDSCTI 
       560        570        580        590        600
AVASNSSDGG VRHINSNVCG PHGRCISQPG GNFTCTCELG FTGTYCHENV 
       610        620        630        640        650
NDCVSNPCRN GGTCIDGISS FQCFCPDGWE GDLCSINVNE CSRSPCKNGG 
       660        670        680        690        700
HCVDLVNDFY CECANGWKGK TCHSRESQCD SSTCSNGGTC YDHGDAFRCA 
       710        720        730        740        750
CPPGWEGSTC NTAKNSTCAS GPCLNGGTCV GGGDTFTCIC KDGWEGATCA 
       760        770        780        790        800
QNTNDCNPHP CYNGGICVDG VNWFRCECAP GFAGPDCRIN IDECQSSPCA 
       810        820        830        840        850
YGATCVDEIN GFRCVCPLGR TGPQCQEFIG IGKTCHYAGL QFPHGSRWEE 
       860        870        880        890        900
ECNTCQCVNG KVECTKVVCG RKPCLLPGTP GRELHYCPGG RECLEHNFLT 
       910        920        930        940        950
CLSPPCHQWG FCSSPETPPT LQTKCEPNSV YLDKSCARIT LIFNRDKLPT 
       960        970        980        990       1000
GTTVENVCSE LRYMPATRSL AKDHKLLVLC DLSYKNQDAV EVAISFQQDE 
      1010       1020       1030       1040       1050
QPSHSQIQEA ASTIVSTLSK RHNSTVMLAV IEVKVEMPVT SQPVDYLVPV 
      1060       1070       1080       1090       1100
LCVVLCVLWV FCVIVCVWWT RKRRKERERC ERVPVEESVN NQWEPLRPVT 
      1110       1120       1130       1140       1150
RPQHKDNRDA QFERTKLMGS PDRTCNSGDD EEDMEEDELE LVEEWCGTEG 
      1160       1170       1180       1190       1200
GKHPVQKYSK SAARTKNGLI CTTRSTSGSS SPSLKAAYWT GFSPKDNNCK 
      1210 
NVNNATAGQE HKEHCV                                      

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ