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UniProtKB - Q5TZK7 (Q5TZK7_DANRE)
Protein
Delta-like protein
Gene
jag2b
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Putative Notch ligand involved in the mediation of Notch signaling.
UniRule annotationCaution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
- Notch binding Source: InterPro
GO - Biological processi
- establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
- exocrine pancreas development Source: ZFIN
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
- intrahepatic bile duct development Source: ZFIN
- liver development Source: ZFIN
- Notch signaling pathway Source: InterPro
- pancreas development Source: ZFIN
- pronephros development Source: ZFIN
- spinal cord motor neuron differentiation Source: ZFIN
- ventral spinal cord interneuron differentiation Source: ZFIN
Keywordsi
Molecular function | Developmental proteinUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Delta-like proteinUniRule annotation |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-011128-3, jag2b |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Single-pass type I membrane protein UniRule annotationARBA annotation
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: ZFIN
- protein-containing complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1046 – 1069 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_5004262654 | 27 – 1216 | Delta-like proteinSequence analysisAdd BLAST | 1190 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 190 ↔ 199 | PROSITE-ProRule annotation | ||
Disulfide bondi | 203 ↔ 215 | PROSITE-ProRule annotation | ||
Disulfide bondi | 223 ↔ 232 | PROSITE-ProRule annotation | ||
Disulfide bondi | 327 ↔ 336 | PROSITE-ProRule annotation | ||
Disulfide bondi | 365 ↔ 374 | PROSITE-ProRule annotation | ||
Disulfide bondi | 403 ↔ 412 | PROSITE-ProRule annotation | ||
Disulfide bondi | 419 ↔ 429 | PROSITE-ProRule annotation | ||
Disulfide bondi | 441 ↔ 450 | PROSITE-ProRule annotation | ||
Disulfide bondi | 479 ↔ 488 | PROSITE-ProRule annotation | ||
Disulfide bondi | 521 ↔ 530 | PROSITE-ProRule annotation | ||
Disulfide bondi | 587 ↔ 596 | PROSITE-ProRule annotation | ||
Disulfide bondi | 625 ↔ 634 | PROSITE-ProRule annotation | ||
Disulfide bondi | 663 ↔ 672 | PROSITE-ProRule annotation | ||
Disulfide bondi | 701 ↔ 710 | PROSITE-ProRule annotation | ||
Disulfide bondi | 740 ↔ 749 | PROSITE-ProRule annotation | ||
Disulfide bondi | 778 ↔ 787 | PROSITE-ProRule annotation | ||
Disulfide bondi | 816 ↔ 825 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000021389, Expressed in caudal fin and 70 other tissues |
ExpressionAtlasi | Q5TZK7, baseline |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 188 – 232 | DSLInterPro annotationAdd BLAST | 45 | |
Domaini | 299 – 337 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 339 – 375 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 377 – 413 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 415 – 451 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 453 – 489 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 495 – 531 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 558 – 597 | EGF-likeInterPro annotationAdd BLAST | 40 | |
Domaini | 599 – 635 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 637 – 673 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 675 – 711 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 714 – 750 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 752 – 788 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 790 – 826 | EGF-likeInterPro annotationAdd BLAST | 37 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1097 – 1132 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1099 – 1116 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatUniRule annotationARBA annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000164854 |
Family and domain databases
InterProi | View protein in InterPro IPR001774, DSL IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR033108, Jag1 IPR026219, Jagged/Serrate IPR011651, Notch_ligand_N IPR001007, VWF_dom |
PANTHERi | PTHR24049:SF18, PTHR24049:SF18, 2 hits |
Pfami | View protein in Pfam PF01414, DSL, 1 hit PF00008, EGF, 12 hits PF07657, MNNL, 1 hit |
PRINTSi | PR02059, JAGGEDFAMILY |
SMARTi | View protein in SMART SM00051, DSL, 1 hit SM00181, EGF, 15 hits SM00179, EGF_CA, 13 hits SM00215, VWC_out, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 6 hits PS51051, DSL, 1 hit PS00022, EGF_1, 14 hits PS01186, EGF_2, 9 hits PS50026, EGF_3, 13 hits PS01187, EGF_CA, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q5TZK7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWNCIRIRNW LPIACLLLTM WTKVSQSSGY FELQLIAVEN VNGELWDGEC
60 70 80 90 100
CDSTRNSQDQ RCVRDECDTY FKVCLKEYQS EVTTTGQCTF GSGSTDVLGG
110 120 130 140 150
NIISFKTAKN SPSKTSDVGK IIIPFHFAWP RSYTLILEAW DWDNSTQNNG
160 170 180 190 200
EENLIERHIH ASMVNPGDHW QSIRHPGITA HIEYRIRVRC DENYYGSKCN
210 220 230 240 250
KQCRPRDDYF GHYRCDPSGN IVCLDGWMGE DCRTAICKQG CNLIHGGCAV
260 270 280 290 300
PGECKCNYGW QGQFCDECLP YPGCLHGTCV MPWQCTCEKN WGGLLCDKDL
310 320 330 340 350
NYCGTHHPCV NGGTCMNSEP DEYNCACPEG YSGKNCEIAE HACVSNPCAN
360 370 380 390 400
GGTCHEVPTG FECHCPPGWE GPTCAKDMDE CASSPCAQGG TCIDLENGFE
410 420 430 440 450
CVCPPQWVGK TCQIDLNGCH GQCQNGATCK ELVHGGYHCQ CPAGFVGLHC
460 470 480 490 500
EVSRNKCASG PCQNGGRCHV ILDSFVCECP SNYAGMLCEV ESLSHPNPCE
510 520 530 540 550
PNPCQNTALC YSLPGDFYCA CPEDYEGKTC ENRKDHCKMT PCQVIDSCTI
560 570 580 590 600
AVASNSSDGG VRHINSNVCG PHGRCISQPG GNFTCTCELG FTGTYCHENV
610 620 630 640 650
NDCVSNPCRN GGTCIDGISS FQCFCPDGWE GDLCSINVNE CSRSPCKNGG
660 670 680 690 700
HCVDLVNDFY CECANGWKGK TCHSRESQCD SSTCSNGGTC YDHGDAFRCA
710 720 730 740 750
CPPGWEGSTC NTAKNSTCAS GPCLNGGTCV GGGDTFTCIC KDGWEGATCA
760 770 780 790 800
QNTNDCNPHP CYNGGICVDG VNWFRCECAP GFAGPDCRIN IDECQSSPCA
810 820 830 840 850
YGATCVDEIN GFRCVCPLGR TGPQCQEFIG IGKTCHYAGL QFPHGSRWEE
860 870 880 890 900
ECNTCQCVNG KVECTKVVCG RKPCLLPGTP GRELHYCPGG RECLEHNFLT
910 920 930 940 950
CLSPPCHQWG FCSSPETPPT LQTKCEPNSV YLDKSCARIT LIFNRDKLPT
960 970 980 990 1000
GTTVENVCSE LRYMPATRSL AKDHKLLVLC DLSYKNQDAV EVAISFQQDE
1010 1020 1030 1040 1050
QPSHSQIQEA ASTIVSTLSK RHNSTVMLAV IEVKVEMPVT SQPVDYLVPV
1060 1070 1080 1090 1100
LCVVLCVLWV FCVIVCVWWT RKRRKERERC ERVPVEESVN NQWEPLRPVT
1110 1120 1130 1140 1150
RPQHKDNRDA QFERTKLMGS PDRTCNSGDD EEDMEEDELE LVEEWCGTEG
1160 1170 1180 1190 1200
GKHPVQKYSK SAARTKNGLI CTTRSTSGSS SPSLKAAYWT GFSPKDNNCK
1210
NVNNATAGQE HKEHCV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5TZK8 | Q5TZK8_DANRE | Delta-like protein | jag2b jag2 | 1,254 | Annotation score: | ||
A0A0R4IAF3 | A0A0R4IAF3_DANRE | Delta-like protein | jag2b | 1,254 | Annotation score: | ||
A0A2R8QT22 | A0A2R8QT22_DANRE | Delta-like protein | jag2b | 1,216 | Annotation score: | ||
Q0P4F9 | Q0P4F9_DANRE | Jag2 protein | jag2b jag2 | 139 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX004766 Genomic DNA No translation available. |
RefSeqi | XP_005160542.1, XM_005160485.3 |
Genome annotation databases
Ensembli | ENSDART00000049586.6; ENSDARP00000049585.5; ENSDARG00000021389.10 |
GeneIDi | 140422 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX004766 Genomic DNA No translation available. |
RefSeqi | XP_005160542.1, XM_005160485.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000049586.6; ENSDARP00000049585.5; ENSDARG00000021389.10 |
GeneIDi | 140422 |
Organism-specific databases
CTDi | 140422 |
ZFINi | ZDB-GENE-011128-3, jag2b |
Phylogenomic databases
GeneTreei | ENSGT00940000164854 |
Gene expression databases
Bgeei | ENSDARG00000021389, Expressed in caudal fin and 70 other tissues |
ExpressionAtlasi | Q5TZK7, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR001774, DSL IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR033108, Jag1 IPR026219, Jagged/Serrate IPR011651, Notch_ligand_N IPR001007, VWF_dom |
PANTHERi | PTHR24049:SF18, PTHR24049:SF18, 2 hits |
Pfami | View protein in Pfam PF01414, DSL, 1 hit PF00008, EGF, 12 hits PF07657, MNNL, 1 hit |
PRINTSi | PR02059, JAGGEDFAMILY |
SMARTi | View protein in SMART SM00051, DSL, 1 hit SM00181, EGF, 15 hits SM00179, EGF_CA, 13 hits SM00215, VWC_out, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 6 hits PS51051, DSL, 1 hit PS00022, EGF_1, 14 hits PS01186, EGF_2, 9 hits PS50026, EGF_3, 13 hits PS01187, EGF_CA, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5TZK7_DANRE | |
Accessioni | Q5TZK7Primary (citable) accession number: Q5TZK7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 7, 2004 |
Last sequence update: | December 7, 2004 | |
Last modified: | May 25, 2022 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |