UniProtKB - Q5TZC3 (Q5TZC3_HUMAN)
Protein
Protein kinase C and casein kinase substrate in neurons protein 1
Gene
PACSIN1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cytoskeletal protein binding Source: Ensembl
- identical protein binding Source: Ensembl
- kinase activity Source: UniProtKB-KW
- phospholipid binding Source: Ensembl
GO - Biological processi
- actin filament organization Source: InterPro
- negative regulation of endocytosis Source: Ensembl
- neuron development Source: InterPro
- plasma membrane tubulation Source: Ensembl
- protein localization to membrane Source: Ensembl
- synaptic vesicle endocytosis Source: Ensembl
Keywordsi
Molecular function | KinaseImported, Transferase |
Names & Taxonomyi
Protein namesi | Recommended name: Protein kinase C and casein kinase substrate in neurons protein 1ARBA annotation |
Gene namesi | Name:PACSIN1Imported ORF Names:hCG_16082Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000124507.10 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
- ruffle membrane ARBA annotation
Other locations
- synaptosome ARBA annotation
- Cytoplasmic vesicle membrane ARBA annotation; Peripheral membrane protein ARBA annotation
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Plasma Membrane
- ruffle membrane Source: UniProtKB-SubCell
Other locations
- COPI-coated vesicle Source: Ensembl
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- neuron projection Source: UniProtKB-KW
- photoreceptor ribbon synapse Source: Ensembl
- presynaptic endocytic zone Source: Ensembl
Keywords - Cellular componenti
Cell junction, Cell projectionARBA annotation, Cytoplasmic vesicleARBA annotation, Synapse, SynaptosomeARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000124507, Expressed in brain and 220 other tissues |
ExpressionAtlasi | Q5TZC3, baseline and differential |
Interactioni
GO - Molecular functioni
- cytoskeletal protein binding Source: Ensembl
- identical protein binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 283 | F-BARInterPro annotationAdd BLAST | 271 | |
Domaini | 385 – 444 | SH3InterPro annotationAdd BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 175 – 194 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 309 – 386 | DisorderedSequence analysisAdd BLAST | 78 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 309 – 323 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 331 – 355 | PolarSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the PACSIN family.ARBA annotation
Keywords - Domaini
Coiled coilPROSITE-ProRule annotationARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_030752_0_0_1 |
OMAi | NDLMSCV |
OrthoDBi | 727724at2759 |
Family and domain databases
CDDi | cd07680, F-BAR_PACSIN1, 1 hit cd11998, SH3_PACSIN1-2, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR028518, PACSIN1 IPR035743, PACSIN1/PACSIN2_SH3 IPR037454, PACSIN1_F-BAR IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR23065:SF16, PTHR23065:SF16, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF14604, SH3_9, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00055, FCH, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS50002, SH3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5TZC3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSYDEASL APEETTDSFW EVGNYKRTVK RIDDGHRLCN DLMNCVQERA
60 70 80 90 100
KIEKAYGQQL TDWAKRWRQL IEKGPQYGSL ERAWGAIMTE ADKVSELHQE
110 120 130 140 150
VKNNLLNEDL EKVKNWQKDA YHKQIMGGFK ETKEAEDGFR KAQKPWAKKM
160 170 180 190 200
KELEAAKKAY HLACKEEKLA MTREMNSKTE QSVTPEQQKK LQDKVDKCKQ
210 220 230 240 250
DVQKTQEKYE KVLEDVGKTT PQYMENMEQV FEQCQQFEEK RLVFLKEVLL
260 270 280 290 300
DIKRHLNLAE NSSYIHVYRE LEQAIRGADA QEDLRWFRST SGPGMPMNWP
310 320 330 340 350
QFEEWNPDLP HTTTKKEKQP KKAEGVALTN ATGAVESTSQ AGDRGSVSSY
360 370 380 390 400
DRGQPYATEW SDDESGNPFG GSETNGGANP FEDDSKGVRV RALYDYDGQE
410 420 430 440
QDELSFKAGD ELTKLGEEDE QGWCRGRLDS GQLGLYPANY VEAI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK289956 mRNA Translation: BAF82645.1 CH471081 Genomic DNA Translation: EAX03785.1 CH471081 Genomic DNA Translation: EAX03786.1 CH471081 Genomic DNA Translation: EAX03787.1 |
RefSeqi | NP_001186512.1, NM_001199583.2 NP_065855.1, NM_020804.4 XP_011512843.1, XM_011514541.1 |
Genome annotation databases
GeneIDi | 29993 |
KEGGi | hsa:29993 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK289956 mRNA Translation: BAF82645.1 CH471081 Genomic DNA Translation: EAX03785.1 CH471081 Genomic DNA Translation: EAX03786.1 CH471081 Genomic DNA Translation: EAX03787.1 |
RefSeqi | NP_001186512.1, NM_001199583.2 NP_065855.1, NM_020804.4 XP_011512843.1, XM_011514541.1 |
3D structure databases
SMRi | Q5TZC3 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q5TZC3 |
Protocols and materials databases
Antibodypediai | 4091, 260 antibodies |
DNASUi | 29993 |
Genome annotation databases
GeneIDi | 29993 |
KEGGi | hsa:29993 |
Organism-specific databases
CTDi | 29993 |
PharmGKBi | PA32896 |
VEuPathDBi | HostDB:ENSG00000124507.10 |
Phylogenomic databases
HOGENOMi | CLU_030752_0_0_1 |
OMAi | NDLMSCV |
OrthoDBi | 727724at2759 |
Miscellaneous databases
BioGRID-ORCSi | 29993, 3 hits in 982 CRISPR screens |
ChiTaRSi | PACSIN1, human |
GenomeRNAii | 29993 |
Gene expression databases
Bgeei | ENSG00000124507, Expressed in brain and 220 other tissues |
ExpressionAtlasi | Q5TZC3, baseline and differential |
Family and domain databases
CDDi | cd07680, F-BAR_PACSIN1, 1 hit cd11998, SH3_PACSIN1-2, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR028518, PACSIN1 IPR035743, PACSIN1/PACSIN2_SH3 IPR037454, PACSIN1_F-BAR IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR23065:SF16, PTHR23065:SF16, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF14604, SH3_9, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00055, FCH, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5TZC3_HUMAN | |
Accessioni | Q5TZC3Primary (citable) accession number: Q5TZC3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | April 7, 2021 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |