Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 134 (16 Oct 2019)
Sequence version 1 (07 Dec 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Rootletin

Gene

CROCC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cilium biogenesis/degradation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q5TZA2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rootletin
Alternative name(s):
Ciliary rootlet coiled-coil protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CROCCImported
Synonyms:KIAA0445Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21299 CROCC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615776 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TZA2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9696

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134911945

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5TZA2

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CROCC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74746681

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002399431 – 2017RootletinAdd BLAST2017

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1460PhosphoserineCombined sources1
Modified residuei1470PhosphoserineBy similarity1
Modified residuei1476PhosphoserineCombined sources1
Modified residuei1483PhosphoserineBy similarity1
Modified residuei1486PhosphoserineBy similarity1
Modified residuei1490PhosphoserineBy similarity1
Modified residuei1496PhosphoserineBy similarity1
Modified residuei1575PhosphoserineBy similarity1
Modified residuei1660PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by NEK2 which may regulate its association with centrosomes.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5TZA2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5TZA2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5TZA2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5TZA2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TZA2

PeptideAtlas

More...
PeptideAtlasi
Q5TZA2

PRoteomics IDEntifications database

More...
PRIDEi
Q5TZA2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65215 [Q5TZA2-1]
65216 [Q5TZA2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TZA2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TZA2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5TZA2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000058453 Expressed in 185 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5TZA2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5TZA2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021191
HPA021762

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homopolymer.

Interacts with KLC3, NEK2 and the N-terminus of CEP250.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115048, 28 interactors

Database of interacting proteins

More...
DIPi
DIP-61715N

Protein interaction database and analysis system

More...
IntActi
Q5TZA2, 24 interactors

Molecular INTeraction database

More...
MINTi
Q5TZA2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364691

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5TZA2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili70 – 262Sequence analysisAdd BLAST193
Coiled coili318 – 444Sequence analysisAdd BLAST127
Coiled coili546 – 1058Sequence analysisAdd BLAST513
Coiled coili1091 – 1438Sequence analysisAdd BLAST348
Coiled coili1505 – 1704Sequence analysisAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1921 – 1999Gln-richSequence analysisAdd BLAST79

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the rootletin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFAN Eukaryota
ENOG410XPG3 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231187

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TZA2

KEGG Orthology (KO)

More...
KOi
K16469

Database of Orthologous Groups

More...
OrthoDBi
76868at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TZA2

TreeFam database of animal gene trees

More...
TreeFami
TF101138

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026733 Rootletin

The PANTHER Classification System

More...
PANTHERi
PTHR23159:SF34 PTHR23159:SF34, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q5TZA2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLGLARAQE VELTLETVIQ TLESSVLCQE KGLGARDLAQ DAQITSLPAL
60 70 80 90 100
IREIVTRNLS QPESPVLLPA TEMASLLSLQ EENQLLQQEL SRVEDLLAQS
110 120 130 140 150
RAERDELAIK YNAVSERLEQ ALRLEPGELE TQEPRGLVRQ SVELRRQLQE
160 170 180 190 200
EQASYRRKLQ AYQEGQQRQA QLVQRLQGKI LQYKKRCSEL EQQLLERSGE
210 220 230 240 250
LEQQRLRDTE HSQDLESALI RLEEEQQRSA SLAQVNAMLR EQLDQAGSAN
260 270 280 290 300
QALSEDIRKV TNDWTRCRKE LEHREAAWRR EEESFNAYFS NEHSRLLLLW
310 320 330 340 350
RQVVGFRRLV SEVKMFTERD LLQLGGELAR TSRAVQEAGL GLSTGLRLAE
360 370 380 390 400
SRAEAALEKQ ALLQAQLEEQ LRDKVLREKD LAQQQMQSDL DKADLSARVT
410 420 430 440 450
ELGLAVKRLE KQNLEKDQVN KDLTEKLEAL ESLRLQEQAA LETEDGEGLQ
460 470 480 490 500
QTLRDLAQAV LSDSESGVQL SGSERTADAS NGSLRGLSGQ RTPSPPRRSS
510 520 530 540 550
PGRGRSPRRG PSPACSDSST LALIHSALHK RQLQVQDMRG RYEASQDLLG
560 570 580 590 600
TLRKQLSDSE SERRALEEQL QRLRDKTDGA MQAHEDAQRE VQRLRSANEL
610 620 630 640 650
LSREKSNLAH SLQVAQQQAE ELRQEREKLQ AAQEELRRQR DRLEEEQEDA
660 670 680 690 700
VQDGARVRRE LERSHRQLEQ LEGKRSVLAK ELVEVREALS RATLQRDMLQ
710 720 730 740 750
AEKAEVAEAL TKAEAGRVEL ELSMTKLRAE EASLQDSLSK LSALNESLAQ
760 770 780 790 800
DKLDLNRLVA QLEEEKSALQ GRQRQAEQEA TVAREEQERL EELRLEQEVA
810 820 830 840 850
RQGLEGSLRV AEQAQEALEQ QLPTLRHERS QLQEQLAQLS RQLSGREQEL
860 870 880 890 900
EQARREAQRQ VEALERAARE KEALAKEHAG LAVQLVAAER EGRTLSEEAT
910 920 930 940 950
RLRLEKEALE GSLFEVQRQL AQLEARREQL EAEGQALLLA KETLTGELAG
960 970 980 990 1000
LRQQIIATQE KASLDKELMA QKLVQAEREA QASLREQRAA HEEDLQRLQR
1010 1020 1030 1040 1050
EKEAAWRELE AERAQLQSQL QREQEELLAR LEAEKEELSE EIAALQQERD
1060 1070 1080 1090 1100
EGLLLAESEK QQALSLKESE KTALSEKLMG TRHSLATISL EMERQKRDAQ
1110 1120 1130 1140 1150
SRQEQDRSTV NALTSELRDL RAQREEAAAA HAQEVRRLQE QARDLGKQRD
1160 1170 1180 1190 1200
SCLREAEELR TQLRLLEDAR DGLRRELLEA QRKLRESQEG REVQRQEAGE
1210 1220 1230 1240 1250
LRRSLGEGAK EREALRRSNE ELRSAVKKAE SERISLKLAN EDKEQKLALL
1260 1270 1280 1290 1300
EEARTAVGKE AGELRTGLQE VERSRLEARR ELQELRRQMK MLDSENTRLG
1310 1320 1330 1340 1350
RELAELQGRL ALGERAEKES RRETLGLRQR LLKGEASLEV MRQELQVAQR
1360 1370 1380 1390 1400
KLQEQEGEFR TRERRLLGSL EEARGTEKQQ LDHARGLELK LEAARAEAAE
1410 1420 1430 1440 1450
LGLRLSAAEG RAQGLEAELA RVEVQRRAAE AQLGGLRSAL RRGLGLGRAP
1460 1470 1480 1490 1500
SPAPRPVPGS PARDAPAEGS GEGLNSPSTL ECSPGSQPPS PGPATSPASP
1510 1520 1530 1540 1550
DLDPEAVRGA LREFLQELRS AQRERDELRT QTSALNRQLA EMEAERDSAT
1560 1570 1580 1590 1600
SRARQLQKAV AESEEARRSV DGRLSGVQAE LALQEESVRR SERERRATLD
1610 1620 1630 1640 1650
QVATLERSLQ ATESELRASQ EKISKMKANE TKLEGDKRRL KEVLDASESR
1660 1670 1680 1690 1700
TVKLELQRRS LEGELQRSRL GLSDREAQAQ ALQDRVDSLQ RQVADSEVKA
1710 1720 1730 1740 1750
GTLQLTVERL NGALAKVEES EGALRDKVRG LTEALAQSSA SLNSTRDKNL
1760 1770 1780 1790 1800
HLQKALTACE HDRQVLQERL DAARQALSEA RKQSSSLGEQ VQTLRGEVAD
1810 1820 1830 1840 1850
LELQRVEAEG QLQQLREVLR QRQEGEAAAL NTVQKLQDER RLLQERLGSL
1860 1870 1880 1890 1900
QRALAQLEAE KREVERSALR LEKDRVALRR TLDKVEREKL RSHEDTVRLS
1910 1920 1930 1940 1950
AEKGRLDRTL TGAELELAEA QRQIQQLEAQ VVVLEQSHSP AQLEVDAQQQ
1960 1970 1980 1990 2000
QLELQQEVER LRSAQAQTER TLEARERAHR QRVRGLEEQV STLKGQLQQE
2010
LRRSSAPFSP PSGPPEK
Length:2,017
Mass (Da):228,523
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9711AC13AD9D7C07
GO
Isoform 21 Publication (identifier: Q5TZA2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-697: Missing.
     1984-1990: Missing.

Show »
Length:1,313
Mass (Da):148,256
Checksum:i00DC42FDE419EED1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AKD8B1AKD8_HUMAN
Rootletin
CROCC
1,311Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WW81A0A087WW81_HUMAN
Rootletin
CROCC
838Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU09A0A087WU09_HUMAN
Rootletin
CROCC
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0616267R → G. Corresponds to variant dbSNP:rs6586566Ensembl.1
Natural variantiVAR_061627372R → Q. Corresponds to variant dbSNP:rs57442576Ensembl.1
Natural variantiVAR_059628439A → V. Corresponds to variant dbSNP:rs4463721Ensembl.1
Natural variantiVAR_059629586D → H. Corresponds to variant dbSNP:rs9435714Ensembl.1
Natural variantiVAR_0596301097R → P. Corresponds to variant dbSNP:rs6669627Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0520691 – 697Missing in isoform 2. 2 PublicationsAdd BLAST697
Alternative sequenceiVSP_0520701984 – 1990Missing in isoform 2. 2 Publications7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ139275 mRNA Translation: ABA43896.1
BX284668, AL049569 Genomic DNA Translation: CAH70055.1
AL049569, BX284668 Genomic DNA Translation: CAI20363.1
AB007914 mRNA Translation: BAA32290.2
AF527734 mRNA Translation: AAP85633.1
BK005505 mRNA Translation: DAA05505.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30616.1 [Q5TZA2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_055490.4, NM_014675.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375541; ENSP00000364691; ENSG00000058453

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9696

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9696

UCSC genome browser

More...
UCSCi
uc001azt.2 human [Q5TZA2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ139275 mRNA Translation: ABA43896.1
BX284668, AL049569 Genomic DNA Translation: CAH70055.1
AL049569, BX284668 Genomic DNA Translation: CAI20363.1
AB007914 mRNA Translation: BAA32290.2
AF527734 mRNA Translation: AAP85633.1
BK005505 mRNA Translation: DAA05505.1
CCDSiCCDS30616.1 [Q5TZA2-1]
RefSeqiNP_055490.4, NM_014675.4

3D structure databases

SMRiQ5TZA2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115048, 28 interactors
DIPiDIP-61715N
IntActiQ5TZA2, 24 interactors
MINTiQ5TZA2
STRINGi9606.ENSP00000364691

PTM databases

iPTMnetiQ5TZA2
PhosphoSitePlusiQ5TZA2
SwissPalmiQ5TZA2

Polymorphism and mutation databases

BioMutaiCROCC
DMDMi74746681

Proteomic databases

EPDiQ5TZA2
jPOSTiQ5TZA2
MassIVEiQ5TZA2
MaxQBiQ5TZA2
PaxDbiQ5TZA2
PeptideAtlasiQ5TZA2
PRIDEiQ5TZA2
ProteomicsDBi65215 [Q5TZA2-1]
65216 [Q5TZA2-2]

Genome annotation databases

EnsembliENST00000375541; ENSP00000364691; ENSG00000058453
GeneIDi9696
KEGGihsa:9696
UCSCiuc001azt.2 human [Q5TZA2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9696
DisGeNETi9696

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CROCC
HGNCiHGNC:21299 CROCC
HPAiHPA021191
HPA021762
MIMi615776 gene
neXtProtiNX_Q5TZA2
PharmGKBiPA134911945

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFAN Eukaryota
ENOG410XPG3 LUCA
HOGENOMiHOG000231187
InParanoidiQ5TZA2
KOiK16469
OrthoDBi76868at2759
PhylomeDBiQ5TZA2
TreeFamiTF101138

Enzyme and pathway databases

SIGNORiQ5TZA2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CROCC human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Rootletin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9696
PharosiQ5TZA2

Protein Ontology

More...
PROi
PR:Q5TZA2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000058453 Expressed in 185 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ5TZA2 baseline and differential
GenevisibleiQ5TZA2 HS

Family and domain databases

InterProiView protein in InterPro
IPR026733 Rootletin
PANTHERiPTHR23159:SF34 PTHR23159:SF34, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCROCC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TZA2
Secondary accession number(s): Q2VHY3
, Q66GT7, Q7Z2L4, Q7Z5D7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 7, 2004
Last modified: October 16, 2019
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again