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Protein

Olfactory receptor 2G6

Gene

OR2G6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2G6
Gene namesi
Name:OR2G6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188558.5
HGNCiHGNC:27019 OR2G6
neXtProtiNX_Q5TZ20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 316CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671228

Polymorphism and mutation databases

BioMutaiOR2G6
DMDMi74762248

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504781 – 316Olfactory receptor 2G6Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5TZ20
PeptideAtlasiQ5TZ20
PRIDEiQ5TZ20
ProteomicsDBi65214

PTM databases

iPTMnetiQ5TZ20
PhosphoSitePlusiQ5TZ20

Expressioni

Gene expression databases

BgeeiENSG00000188558 Expressed in 4 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_OR2G6
ExpressionAtlasiQ5TZ20 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi133856, 24 interactors
IntActiQ5TZ20, 1 interactor
STRINGi9606.ENSP00000341291

Structurei

3D structure databases

ProteinModelPortaliQ5TZ20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVUR Eukaryota
ENOG41117FE LUCA
GeneTreeiENSGT00760000118914
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ5TZ20
KOiK04257
OMAiKDKTMSY
OrthoDBiEOG091G0CU6
PhylomeDBiQ5TZ20
TreeFamiTF336512

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5TZ20-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEETNNSSEK GFLLLGFSDQ PQLERFLFAI ILYFYVLSLL GNTALILVCC
60 70 80 90 100
LDSRLHTPMY FFLSNLSCVD ICFTTSVAPQ LLVTMNKKDK TMSYGGCVAQ
110 120 130 140 150
LYVAMGLGSS ECILLAVMAY DRYAAVCRPL RYIAIMHPRF CASLAGGAWL
160 170 180 190 200
SGLITSLIQC SLTVQLPLCG HRTLDHIFCE VPVLIKLACV DTTFNEAELF
210 220 230 240 250
VASVVFLIVP VLLILVSYGF ITQAVLRIKS AAGRQKAFGT CSSHLVVVII
260 270 280 290 300
FYGTIIFMYL QPANRRSKNQ GKFVSLFYTI VTPLLNPIIY TLRNKDVKGA
310
LRTLILGSAA GQSHKD
Length:316
Mass (Da):34,890
Last modified:December 7, 2004 - v1
Checksum:i2702925101A6CA34
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06202059M → V. Corresponds to variant dbSNP:rs58955396Ensembl.1
Natural variantiVAR_053142258M → L. Corresponds to variant dbSNP:rs9330305Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537158 Genomic DNA No translation available.
CH471148 Genomic DNA Translation: EAW77231.1
BC137245 mRNA Translation: AAI37246.1
BC137266 mRNA Translation: AAI37267.1
CCDSiCCDS31119.1
RefSeqiNP_001013373.1, NM_001013355.1
UniGeneiHs.553784

Genome annotation databases

EnsembliENST00000343414; ENSP00000341291; ENSG00000188558
ENST00000641501; ENSP00000492940; ENSG00000188558
ENST00000641804; ENSP00000493355; ENSG00000188558
GeneIDi391211
KEGGihsa:391211
UCSCiuc001ien.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537158 Genomic DNA No translation available.
CH471148 Genomic DNA Translation: EAW77231.1
BC137245 mRNA Translation: AAI37246.1
BC137266 mRNA Translation: AAI37267.1
CCDSiCCDS31119.1
RefSeqiNP_001013373.1, NM_001013355.1
UniGeneiHs.553784

3D structure databases

ProteinModelPortaliQ5TZ20
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133856, 24 interactors
IntActiQ5TZ20, 1 interactor
STRINGi9606.ENSP00000341291

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ5TZ20
PhosphoSitePlusiQ5TZ20

Polymorphism and mutation databases

BioMutaiOR2G6
DMDMi74762248

Proteomic databases

PaxDbiQ5TZ20
PeptideAtlasiQ5TZ20
PRIDEiQ5TZ20
ProteomicsDBi65214

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343414; ENSP00000341291; ENSG00000188558
ENST00000641501; ENSP00000492940; ENSG00000188558
ENST00000641804; ENSP00000493355; ENSG00000188558
GeneIDi391211
KEGGihsa:391211
UCSCiuc001ien.1 human

Organism-specific databases

CTDi391211
EuPathDBiHostDB:ENSG00000188558.5
GeneCardsiOR2G6
HGNCiHGNC:27019 OR2G6
neXtProtiNX_Q5TZ20
PharmGKBiPA142671228
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVUR Eukaryota
ENOG41117FE LUCA
GeneTreeiENSGT00760000118914
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ5TZ20
KOiK04257
OMAiKDKTMSY
OrthoDBiEOG091G0CU6
PhylomeDBiQ5TZ20
TreeFamiTF336512

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR2G6
GenomeRNAii391211
PROiPR:Q5TZ20

Gene expression databases

BgeeiENSG00000188558 Expressed in 4 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_OR2G6
ExpressionAtlasiQ5TZ20 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR2G6_HUMAN
AccessioniPrimary (citable) accession number: Q5TZ20
Secondary accession number(s): B2RP33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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