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Protein

PRAME family member 5

Gene

PRAMEF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 5Imported
Gene namesi
Name:PRAMEF5Imported
Synonyms:PRAMEF23Imported, PRAMEF5LImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000270601.4
HGNCiHGNC:27995 PRAMEF5
neXtProtiNX_Q5TYX0

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000270601
PharmGKBiPA142671142
PA162400010

Polymorphism and mutation databases

BioMutaiPRAMEF5
DMDMi74756668

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001569791 – 476PRAME family member 5Add BLAST476

Proteomic databases

PaxDbiQ5TYX0
PRIDEiQ5TYX0
ProteomicsDBi1564
65213

PTM databases

iPTMnetiQ5TYX0
PhosphoSitePlusiQ5TYX0

Expressioni

Gene expression databases

BgeeiENSG00000270601 Expressed in 2 organ(s), highest expression level in blood

Structurei

3D structure databases

ProteinModelPortaliQ5TYX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati97 – 124LRR 1; degenerateBy similarityAdd BLAST28
Repeati179 – 203LRR 2; degenerateBy similarityAdd BLAST25
Repeati204 – 230LRR 3; degenerateBy similarityAdd BLAST27
Repeati231 – 266LRR 4; degenerateBy similarityAdd BLAST36
Repeati267 – 292LRR 5By similarityAdd BLAST26
Repeati293 – 324LRR 6By similarityAdd BLAST32
Repeati325 – 345LRR 7By similarityAdd BLAST21
Repeati349 – 376LRR 8By similarityAdd BLAST28
Repeati377 – 401LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KDY5 Eukaryota
ENOG4111EBM LUCA
GeneTreeiENSGT00760000119028
HOGENOMiHOG000231112
HOVERGENiHBG006326
InParanoidiQ5TYX0
OMAiPRTICIS
OrthoDBiEOG091G05PP
TreeFamiTF332708

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5TYX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIRTPPRLL ELAGRSLLRD QALAMSTLEE LPTELFPPLF MEAFSRRRCE
60 70 80 90 100
ALKLMVQAWP FRRLPLRPLI KMPCLEAFQA VLDGLDALLT QGVHPRRWKL
110 120 130 140 150
QVLDLQDVCE NFWMVWSEAM AHGCFLNAKR NKKPVQDCPR MRGQQPLTVF
160 170 180 190 200
VELWLKNRTL DEYLTCLLLW VKQRKDLLHL CCKKLKILGM PFRNIRSILK
210 220 230 240 250
MVNLDCIQEV EVNCKWVLPI LTQFTPYLGH MRNLQKLVLS HMDVSRYVSP
260 270 280 290 300
EQKKEIVTQF TTQFLKLCCL QKLSMNSVSF LEGHLDQLLS CLKTSLKVLT
310 320 330 340 350
ITNCVLLESD LKHLSQCPSI SQLKTLDLSG IRLTNYSLVP LQILLEKVAA
360 370 380 390 400
TLEYLDLDDC GIIDSQVNAI LPALSRCFEL NTFSFCGNPI SMATLENLLS
410 420 430 440 450
HTIILKNLCV ELYPAPRESY DADGTLCWSR FPQIRAELMK RVRDLRHPKR
460 470
ILFCTDCCPD CGNRSFYDLE ADQCCC
Length:476
Mass (Da):54,886
Last modified:October 14, 2015 - v2
Checksum:i7479352E27ABF582
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JM45A0A0G2JM45_HUMAN
PRAME family member 5
PRAMEF5
476Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16S → N in AAI01345 (PubMed:15489334).Curated1
Sequence conflicti41M → L in AAI30275 (PubMed:15489334).Curated1
Sequence conflicti41M → L in AAI30277 (PubMed:15489334).Curated1
Sequence conflicti144Q → R in AAI01345 (PubMed:15489334).Curated1
Sequence conflicti144Q → R in AAI30275 (PubMed:15489334).Curated1
Sequence conflicti144Q → R in AAI30277 (PubMed:15489334).Curated1
Sequence conflicti166C → Y in AAI01345 (PubMed:15489334).Curated1
Sequence conflicti166C → Y in AAI30275 (PubMed:15489334).Curated1
Sequence conflicti166C → Y in AAI30277 (PubMed:15489334).Curated1
Sequence conflicti344L → P in AAI01345 (PubMed:15489334).Curated1
Sequence conflicti344L → P in AAI30275 (PubMed:15489334).Curated1
Sequence conflicti344L → P in AAI30277 (PubMed:15489334).Curated1
Sequence conflicti416P → L in AAI30275 (PubMed:15489334).Curated1
Sequence conflicti416P → L in AAI30277 (PubMed:15489334).Curated1
Sequence conflicti432P → A in AAI01345 (PubMed:15489334).Curated1
Sequence conflicti432P → A in AAI30275 (PubMed:15489334).Curated1
Sequence conflicti432P → A in AAI30277 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244216 Genomic DNA No translation available.
BC101344 mRNA Translation: AAI01345.1
BC130274 mRNA Translation: AAI30275.1
BC130276 mRNA Translation: AAI30277.1
CCDSiCCDS72708.1
RefSeqiNP_001013425.2, NM_001013407.2
UniGeneiHs.567864

Genome annotation databases

EnsembliENST00000618079; ENSP00000478534; ENSG00000283150
ENST00000621481; ENSP00000482418; ENSG00000276420
ENST00000622421; ENSP00000480122; ENSG00000270601
ENST00000633074; ENSP00000488527; ENSG00000282424
GeneIDi343068
KEGGihsa:343068
UCSCiuc001auu.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244216 Genomic DNA No translation available.
BC101344 mRNA Translation: AAI01345.1
BC130274 mRNA Translation: AAI30275.1
BC130276 mRNA Translation: AAI30277.1
CCDSiCCDS72708.1
RefSeqiNP_001013425.2, NM_001013407.2
UniGeneiHs.567864

3D structure databases

ProteinModelPortaliQ5TYX0
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ5TYX0
PhosphoSitePlusiQ5TYX0

Polymorphism and mutation databases

BioMutaiPRAMEF5
DMDMi74756668

Proteomic databases

PaxDbiQ5TYX0
PRIDEiQ5TYX0
ProteomicsDBi1564
65213

Protocols and materials databases

DNASUi343068
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000618079; ENSP00000478534; ENSG00000283150
ENST00000621481; ENSP00000482418; ENSG00000276420
ENST00000622421; ENSP00000480122; ENSG00000270601
ENST00000633074; ENSP00000488527; ENSG00000282424
GeneIDi343068
KEGGihsa:343068
UCSCiuc001auu.1 human

Organism-specific databases

CTDi343068
EuPathDBiHostDB:ENSG00000270601.4
GeneCardsiPRAMEF5
HGNCiHGNC:27995 PRAMEF5
neXtProtiNX_Q5TYX0
OpenTargetsiENSG00000270601
PharmGKBiPA142671142
PA162400010
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KDY5 Eukaryota
ENOG4111EBM LUCA
GeneTreeiENSGT00760000119028
HOGENOMiHOG000231112
HOVERGENiHBG006326
InParanoidiQ5TYX0
OMAiPRTICIS
OrthoDBiEOG091G05PP
TreeFamiTF332708

Miscellaneous databases

GenomeRNAii343068
PROiPR:Q5TYX0

Gene expression databases

BgeeiENSG00000270601 Expressed in 2 organ(s), highest expression level in blood

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRAM5_HUMAN
AccessioniPrimary (citable) accession number: Q5TYX0
Secondary accession number(s): A0A087WWD0
, A2BDD6, A4FU31, A6NMV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 14, 2015
Last modified: November 7, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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