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Entry version 125 (16 Oct 2019)
Sequence version 2 (14 Oct 2015)
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Protein

PRAME family member 5

Gene

PRAMEF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PRAME family member 5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRAMEF5Imported
Synonyms:PRAMEF23Imported, PRAMEF5LImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:27995 PRAMEF5

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TYX0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000270601

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671142

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5TYX0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRAMEF5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74756668

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001569791 – 476PRAME family member 5Add BLAST476

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q5TYX0

PeptideAtlas

More...
PeptideAtlasi
Q5TYX0

PRoteomics IDEntifications database

More...
PRIDEi
Q5TYX0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
1564
65213

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q5TYX0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TYX0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5TYX0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000270601 Expressed in 2 organ(s), highest expression level in blood

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q5TYX0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000480122

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati97 – 124LRR 1; degenerateBy similarityAdd BLAST28
Repeati179 – 203LRR 2; degenerateBy similarityAdd BLAST25
Repeati204 – 230LRR 3; degenerateBy similarityAdd BLAST27
Repeati231 – 266LRR 4; degenerateBy similarityAdd BLAST36
Repeati267 – 292LRR 5By similarityAdd BLAST26
Repeati293 – 324LRR 6By similarityAdd BLAST32
Repeati325 – 345LRR 7By similarityAdd BLAST21
Repeati349 – 376LRR 8By similarityAdd BLAST28
Repeati377 – 401LRR 9By similarityAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PRAME family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KDY5 Eukaryota
ENOG4111EBM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182686

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231112

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TYX0

Identification of Orthologs from Complete Genome Data

More...
OMAi
CSQLRYF

Database of Orthologous Groups

More...
OrthoDBi
631249at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332708

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038286 PRAME, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5TYX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIRTPPRLL ELAGRSLLRD QALAMSTLEE LPTELFPPLF MEAFSRRRCE
60 70 80 90 100
ALKLMVQAWP FRRLPLRPLI KMPCLEAFQA VLDGLDALLT QGVHPRRWKL
110 120 130 140 150
QVLDLQDVCE NFWMVWSEAM AHGCFLNAKR NKKPVQDCPR MRGQQPLTVF
160 170 180 190 200
VELWLKNRTL DEYLTCLLLW VKQRKDLLHL CCKKLKILGM PFRNIRSILK
210 220 230 240 250
MVNLDCIQEV EVNCKWVLPI LTQFTPYLGH MRNLQKLVLS HMDVSRYVSP
260 270 280 290 300
EQKKEIVTQF TTQFLKLCCL QKLSMNSVSF LEGHLDQLLS CLKTSLKVLT
310 320 330 340 350
ITNCVLLESD LKHLSQCPSI SQLKTLDLSG IRLTNYSLVP LQILLEKVAA
360 370 380 390 400
TLEYLDLDDC GIIDSQVNAI LPALSRCFEL NTFSFCGNPI SMATLENLLS
410 420 430 440 450
HTIILKNLCV ELYPAPRESY DADGTLCWSR FPQIRAELMK RVRDLRHPKR
460 470
ILFCTDCCPD CGNRSFYDLE ADQCCC
Length:476
Mass (Da):54,886
Last modified:October 14, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7479352E27ABF582
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16S → N in AAI01345 (PubMed:15489334).Curated1
Sequence conflicti41M → L in AAI30275 (PubMed:15489334).Curated1
Sequence conflicti41M → L in AAI30277 (PubMed:15489334).Curated1
Sequence conflicti144Q → R in AAI01345 (PubMed:15489334).Curated1
Sequence conflicti144Q → R in AAI30275 (PubMed:15489334).Curated1
Sequence conflicti144Q → R in AAI30277 (PubMed:15489334).Curated1
Sequence conflicti166C → Y in AAI01345 (PubMed:15489334).Curated1
Sequence conflicti166C → Y in AAI30275 (PubMed:15489334).Curated1
Sequence conflicti166C → Y in AAI30277 (PubMed:15489334).Curated1
Sequence conflicti344L → P in AAI01345 (PubMed:15489334).Curated1
Sequence conflicti344L → P in AAI30275 (PubMed:15489334).Curated1
Sequence conflicti344L → P in AAI30277 (PubMed:15489334).Curated1
Sequence conflicti416P → L in AAI30275 (PubMed:15489334).Curated1
Sequence conflicti416P → L in AAI30277 (PubMed:15489334).Curated1
Sequence conflicti432P → A in AAI01345 (PubMed:15489334).Curated1
Sequence conflicti432P → A in AAI30275 (PubMed:15489334).Curated1
Sequence conflicti432P → A in AAI30277 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC244216 Genomic DNA No translation available.
BC101344 mRNA Translation: AAI01345.1
BC130274 mRNA Translation: AAI30275.1
BC130276 mRNA Translation: AAI30277.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS72708.1

NCBI Reference Sequences

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RefSeqi
NP_001013425.2, NM_001013407.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000618079; ENSP00000478534; ENSG00000283150
ENST00000621481; ENSP00000482418; ENSG00000276420
ENST00000622421; ENSP00000480122; ENSG00000270601
ENST00000633074; ENSP00000488527; ENSG00000282424

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
343068

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:343068

UCSC genome browser

More...
UCSCi
uc001auu.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244216 Genomic DNA No translation available.
BC101344 mRNA Translation: AAI01345.1
BC130274 mRNA Translation: AAI30275.1
BC130276 mRNA Translation: AAI30277.1
CCDSiCCDS72708.1
RefSeqiNP_001013425.2, NM_001013407.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ5TYX0, 2 interactors
STRINGi9606.ENSP00000480122

PTM databases

iPTMnetiQ5TYX0
PhosphoSitePlusiQ5TYX0
SwissPalmiQ5TYX0

Polymorphism and mutation databases

BioMutaiPRAMEF5
DMDMi74756668

Proteomic databases

PaxDbiQ5TYX0
PeptideAtlasiQ5TYX0
PRIDEiQ5TYX0
ProteomicsDBi1564
65213

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
343068

Genome annotation databases

EnsembliENST00000618079; ENSP00000478534; ENSG00000283150
ENST00000621481; ENSP00000482418; ENSG00000276420
ENST00000622421; ENSP00000480122; ENSG00000270601
ENST00000633074; ENSP00000488527; ENSG00000282424
GeneIDi343068
KEGGihsa:343068
UCSCiuc001auu.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
343068

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRAMEF5
HGNCiHGNC:27995 PRAMEF5
neXtProtiNX_Q5TYX0
OpenTargetsiENSG00000270601
PharmGKBiPA142671142

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KDY5 Eukaryota
ENOG4111EBM LUCA
GeneTreeiENSGT00950000182686
HOGENOMiHOG000231112
InParanoidiQ5TYX0
OMAiCSQLRYF
OrthoDBi631249at2759
TreeFamiTF332708

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
343068
PharosiQ5TYX0

Protein Ontology

More...
PROi
PR:Q5TYX0

Gene expression databases

BgeeiENSG00000270601 Expressed in 2 organ(s), highest expression level in blood

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRAM5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TYX0
Secondary accession number(s): A0A087WWD0
, A2BDD6, A4FU31, A6NMV5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 14, 2015
Last modified: October 16, 2019
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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