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Protein

DNA repair protein RAD51 homolog

Gene

rad51

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-5685938 HDR through Single Strand Annealing (SSA)
R-DRE-5685942 HDR through Homologous Recombination (HRR)
R-DRE-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-DRE-5693579 Homologous DNA Pairing and Strand Exchange
R-DRE-5693616 Presynaptic phase of homologous DNA pairing and strand exchange

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein RAD51 homologUniRule annotation
Gene namesi
Name:rad51Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-040426-2286 rad51

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ5TYR1

Expressioni

Gene expression databases

BgeeiENSDARG00000041411 Expressed in 29 organ(s), highest expression level in paraxial mesoderm
ExpressionAtlasiQ5TYR1 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000060705

Structurei

3D structure databases

ProteinModelPortaliQ5TYR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 270RECA_2InterPro annotationAdd BLAST172
Domaini277 – 340RECA_3InterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the RecA family. RAD51 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1433 Eukaryota
COG0468 LUCA
GeneTreeiENSGT00890000139508
HOGENOMiHOG000227426
HOVERGENiHBG001504
InParanoidiQ5TYR1
KOiK04482
OMAiYNTDHQT
OrthoDBiEOG091G09QY
PhylomeDBiQ5TYR1
TreeFamiTF101218

Family and domain databases

CDDicd01123 Rad51_DMC1_radA, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011941 DNA_recomb/repair_Rad51
IPR013632 DNA_recomb/repair_Rad51_C
IPR016467 DNA_recomb/repair_RecA-like
IPR010995 DNA_repair_Rad51/TF_NusA_a-hlx
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd
IPR020587 RecA_monomer-monomer_interface
PfamiView protein in Pfam
PF08423 Rad51, 1 hit
PIRSFiPIRSF005856 Rad51, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF47794 SSF47794, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02239 recomb_RAD51, 1 hit
PROSITEiView protein in PROSITE
PS50162 RECA_2, 1 hit
PS50163 RECA_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q5TYR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMRNASRVE VEAEVEEEEN FGPQPVSRLE QSGISSSDIK KLEDGGFHTV
60 70 80 90 100
EAVAYAPKKE LLNIKGISEA KADKILTEAA KMVPMGFTTA TEFHQRRAEI
110 120 130 140 150
IQISTGSKEL DKLLQGGIET GSITEMFGEF RTGKTQLCHT LAVTCQLPID
160 170 180 190 200
QGGGEGKAMY IDTEGTFRPE RLLAVAERYG LVGSDVLDNV AYARAFNTDH
210 220 230 240 250
QTQLLYQASA MMTESRYALL IVDSATALYR TDYSGRGELS ARQGHLGRFL
260 270 280 290 300
RMLLRLADEF GVAVVITNQV VAQVDGAAMF SADPKKPIGG NILAHASTTR
310 320 330 340
LYLRKGRGET RICKIYDSPC LPEAEAMFAI NADGVGDAKD
Length:340
Mass (Da):37,024
Last modified:December 7, 2004 - v1
Checksum:i60F8589E55B0443A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TYR0Q5TYR0_DANRE
RAD51 recombinase
rad51
182Annotation score:
Q5TYR2Q5TYR2_DANRE
RAD51 recombinase
rad51
44Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936455 Genomic DNA No translation available.
CR855367 Genomic DNA No translation available.
RefSeqiNP_998371.2, NM_213206.2
UniGeneiDr.1514

Genome annotation databases

EnsembliENSDART00000060706; ENSDARP00000060705; ENSDARG00000041411
ENSDART00000185939; ENSDARP00000152302; ENSDARG00000111948
GeneIDi406487
KEGGidre:406487

Similar proteinsi

Entry informationi

Entry nameiQ5TYR1_DANRE
AccessioniPrimary (citable) accession number: Q5TYR1
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: September 12, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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